ATE338758T1 - Imidazopyrimidin-derivate als liganden für gaba- rezeptoren - Google Patents

Imidazopyrimidin-derivate als liganden für gaba- rezeptoren

Info

Publication number: ATE338758T1
Authority: AT; Austria
Prior art keywords: ligands; gaba receptors; sub; imidazopyrimidine derivatives; gaba
Prior art date: 2001-03-23

Application number

AT02706977T

Other languages

English (en)

Inventor

Wesley Peter Blackaby

Pineiro Jose Luis Castro

Mark Stuart Chambers

Simon Charles Goodacre

David James Hallett

Philip Jones

Richard Thomas Lewis

Angus Murray Macleod

Robert James Maxey

Kevin William Moore

Leslie Joseph Street

Original Assignee

Merck Sharp & Dohme

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-03-23

Filing date

2002-03-19

Publication date

2006-09-15

2001-03-23 Priority claimed from GB0107358A external-priority patent/GB0107358D0/en

2001-11-23 Priority claimed from GB0128157A external-priority patent/GB0128157D0/en

2002-03-19 Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme

2006-09-15 Application granted granted Critical

2006-09-15 Publication of ATE338758T1 publication Critical patent/ATE338758T1/de

Links

239000003446 ligand Substances 0.000 title abstract 2
102000005915 GABA Receptors Human genes 0.000 title 1
108010005551 GABA Receptors Proteins 0.000 title 1
150000005237 imidazopyrimidines Chemical class 0.000 title 1
208000019901 Anxiety disease Diseases 0.000 abstract 1
206010010904 Convulsion Diseases 0.000 abstract 1
230000002411 adverse Effects 0.000 abstract 1
230000036506 anxiety Effects 0.000 abstract 1
210000003169 central nervous system Anatomy 0.000 abstract 1
208000010877 cognitive disease Diseases 0.000 abstract 1
230000036461 convulsion Effects 0.000 abstract 1
229960003692 gamma aminobutyric acid Drugs 0.000 abstract 1
BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 abstract 1
125000001072 heteroaryl group Chemical group 0.000 abstract 1
INSWZAQOISIYDT-UHFFFAOYSA-N imidazo[1,2-a]pyrimidine Chemical class C1=CC=NC2=NC=CN21 INSWZAQOISIYDT-UHFFFAOYSA-N 0.000 abstract 1
230000002265 prevention Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Addiction (AREA)
Reproductive Health (AREA)
Epidemiology (AREA)
Diabetes (AREA)
Hospice & Palliative Care (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Endocrinology (AREA)
Pregnancy & Childbirth (AREA)
Gynecology & Obstetrics (AREA)
Nutrition Science (AREA)
Otolaryngology (AREA)
Hematology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

AT02706977T 2001-03-23 2002-03-19 Imidazopyrimidin-derivate als liganden für gaba- rezeptoren ATE338758T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB0107358A GB0107358D0 (en)	2001-03-23	2001-03-23	Therapeutic agents
GB0128157A GB0128157D0 (en)	2001-11-23	2001-11-23	Therapeutic agents

Publications (1)

Publication Number	Publication Date
ATE338758T1 true ATE338758T1 (de)	2006-09-15

Family

ID=26245889

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT02706977T ATE338758T1 (de)	2001-03-23	2002-03-19	Imidazopyrimidin-derivate als liganden für gaba- rezeptoren

Country Status (9)

Country	Link
US (1)	US7030128B2 (de)
EP (1)	EP1383768B1 (de)
JP (1)	JP2004531499A (de)
AT (1)	ATE338758T1 (de)
AU (1)	AU2002241139B2 (de)
CA (1)	CA2441455A1 (de)
DE (1)	DE60214532T2 (de)
ES (1)	ES2271221T3 (de)
WO (1)	WO2002076983A1 (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB0210127D0 (en)	2002-05-02	2002-06-12	Merck Sharp & Dohme	Therapeutic agents
GB0212049D0 (en) *	2002-05-24	2002-07-03	Merck Sharp & Dohme	Therapeutic agents
GB0218876D0 (en)	2002-08-13	2002-09-25	Merck Sharp & Dohme	Therapeutic agents
JP2006508102A (ja) *	2002-11-08	2006-03-09	ニューロジェン・コーポレイション	Ｇａｂａａ受容体のリガンドとしての４−イミダゾール−１−イルメチル−ピリミジン誘導体
EP1880998A1 (de) *	2003-07-25	2008-01-23	Neurogen Corporation	Imidazo-Pyrimide und Triazolo-Pyrimide: Benzodiazepin-Rezeptorliganden
AU2004261591A1 (en) *	2003-07-25	2005-02-10	Neurogen Corporation	Imidazo-pyrimidines and triazolo-pyrimidines: benzodiazepine receptor ligands
CN100457756C (zh) *	2003-07-25	2009-02-04	神经能质公司	咪唑-嘧啶类及三唑-嘧啶类:苯并二氮平受体配体
CA2577947A1 (en) *	2004-08-31	2006-03-09	Banyu Pharmaceutical Co., Ltd.	Novel substituted imidazole derivative
CN101098870B (zh)	2004-11-08	2010-11-03	万有制药株式会社	新型稠环咪唑衍生物
WO2006071940A2 (en)	2004-12-23	2006-07-06	Deciphera Pharmaceuticals, Llc	Enzyme modulators and treatments
US8188113B2 (en)	2006-09-14	2012-05-29	Deciphera Pharmaceuticals, Inc.	Dihydropyridopyrimidinyl, dihydronaphthyidinyl and related compounds useful as kinase inhibitors for the treatment of proliferative diseases
US20110189167A1 (en) *	2007-04-20	2011-08-04	Flynn Daniel L	Methods and Compositions for the Treatment of Myeloproliferative Diseases and other Proliferative Diseases
KR20100017184A (ko) *	2007-04-20	2010-02-16	데시페라 파마슈티칼스, 엘엘씨.	골수증식성 질환 및 다른 증식성 질환의 치료에 유용한 키나제 억제제
EP2786993B1 (de)	2007-08-13	2017-11-15	Monsanto Technology LLC	Zusammensetzungen und Verfahren zur Kontrolle von Nematoden
AU2013203846B2 (en) *	2007-08-13	2016-02-25	Monsanto Technology Llc	Compositions and methods for controlling nematodes
EA201170627A1 (ru) *	2008-10-29	2011-10-31	ДЕСИФЕРА ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи	Циклопропанамиды и аналоги, проявляющие противораковые и антипролиферативные активности
WO2010093650A2 (en)	2009-02-10	2010-08-19	Divergence, Inc.	Compositions and methods for controlling nematodes
CA2755285C (en) *	2009-03-20	2014-02-11	Yunxin Y. Bo	Inhibitors of pi3 kinase
HUE044447T2 (hu)	2010-09-02	2019-10-28	Monsanto Technology Llc	Új készítmények és eljárások fonálféreg kártevõk irtására
CN103906795B (zh) *	2011-06-13	2018-04-24	古德里奇公司	具有改进的振动阻尼的聚合物复合材料
US20150374705A1 (en)	2012-02-14	2015-12-31	Shanghai Institues for Biological Sciences	Substances for treatment or relief of pain
US8461179B1 (en)	2012-06-07	2013-06-11	Deciphera Pharmaceuticals, Llc	Dihydronaphthyridines and related compounds useful as kinase inhibitors for the treatment of proliferative diseases
WO2014060381A1 (de)	2012-10-18	2014-04-24	Bayer Cropscience Ag	Heterocyclische verbindungen als schädlingsbekämpfungsmittel
EP2914587A1 (de)	2012-10-31	2015-09-09	Bayer CropScience AG	Neue heterocylische verbindungen als schädlingsbekämpfungsmittel
UA118254C2 (uk)	2012-12-04	2018-12-26	Монсанто Текнолоджи Ллс	Нематоцидні водні композиції концентрату суспензії
US9173401B2 (en)	2013-03-15	2015-11-03	Monsanto Technology Llc	N-,C-disubstituted azoles and compositions and methods for controlling nematode pests
CN106188063A (zh) *	2015-05-08	2016-12-07	中国科学院上海药物研究所	用作Lp-PLA2抑制剂的双环类化合物、其制备方法及医药用途
CN106883185B (zh) *	2015-12-15	2021-07-09	重庆博腾制药科技股份有限公司	一种4-氯-2-三氟甲基嘧啶的制备方法

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TR199701219T1 (xx) *	1995-04-21	1998-03-21	Neurosearch A/S	Benzimidazol bile�ikleri, bu bile�ikleri i�eren ispen�iyar� bile�ikler.
EP1023286A1 (de) *	1997-10-10	2000-08-02	Neurosearch A/S	Benzimidazole derivate, pharmazeutische zusammensetzungen die sie enthalten und ihre verwendung
CA2397661C (en)	2000-03-01	2012-01-03	Janssen Pharmaceutica N.V.	2,4-disubstituted thiazolyl derivatives

2002
- 2002-03-19 CA CA002441455A patent/CA2441455A1/en not_active Abandoned
- 2002-03-19 WO PCT/GB2002/001354 patent/WO2002076983A1/en not_active Ceased
- 2002-03-19 JP JP2002576241A patent/JP2004531499A/ja not_active Ceased
- 2002-03-19 AU AU2002241139A patent/AU2002241139B2/en not_active Ceased
- 2002-03-19 ES ES02706977T patent/ES2271221T3/es not_active Expired - Lifetime
- 2002-03-19 EP EP02706977A patent/EP1383768B1/de not_active Expired - Lifetime
- 2002-03-19 AT AT02706977T patent/ATE338758T1/de not_active IP Right Cessation
- 2002-03-19 DE DE60214532T patent/DE60214532T2/de not_active Expired - Fee Related
- 2002-03-19 US US10/472,680 patent/US7030128B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
AU2002241139B2 (en)	2007-09-20
EP1383768B1 (de)	2006-09-06
DE60214532D1 (de)	2006-10-19
EP1383768A1 (de)	2004-01-28
JP2004531499A (ja)	2004-10-14
WO2002076983A1 (en)	2002-10-03
ES2271221T3 (es)	2007-04-16
US20040092533A1 (en)	2004-05-13
DE60214532T2 (de)	2007-04-12
CA2441455A1 (en)	2002-10-03
US7030128B2 (en)	2006-04-18

Legal Events

Date	Code	Title	Description
2007-03-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE338758T1 (de)	2006-09-15	Imidazopyrimidin-derivate als liganden für gaba- rezeptoren
ATE335741T1 (de)	2006-09-15	8-fluorimidazo(1,2-a)pyridin derivative als liganden für gaba rezeptoren
DE60115282D1 (de)	2005-12-29	Imidazotriazin-derivate als liganden für gaba-rezeptoren
DE60304572D1 (de)	2006-05-24	Imidazopyridin derivate als liganden für gaba rezeptoren
ATE270672T1 (de)	2004-07-15	Imidazopyridinderivate als liganden für gaba- rezeptoren
BG108166A (en)	2004-09-30	Imidazo-pyrimidine derivatives as liigands for gaba receptors
ATE310002T1 (de)	2005-12-15	Imidazotriazin-derivate als gaba-rezeptor- liganden
DE60006260D1 (de)	2003-12-04	Imidazotriazinderivate als gaba rezeptor-liganden
ATE255109T1 (de)	2003-12-15	Imidazopyridinderivate als gaba rezeptor liganden
EA199700156A1 (ru)	1997-12-30	Производные индола как антагонисты рецептора 5-нт
ATE250062T1 (de)	2003-10-15	Triazolopiridazinederivate als gaba rezeptor- liganden
ATE420867T1 (de)	2009-01-15	Phenylpyridazin derivative als liganden für gaba- rezeptoren
CA2359008A1 (en)	2000-08-03	Triazolo-pyridazine derivatives as ligands for gaba receptors
ATE249457T1 (de)	2003-09-15	Indolderivate und ihre verwendung als serotoninrezeptor-liganden
ATE325117T1 (de)	2006-06-15	3,4-dihydrochinolin-2(1h)-on verbindungen als nr2b rezeptor antagonisten
EA200300084A1 (ru)	2003-06-26	Производные индола, пригодные для лечения расстройств цнс
ATE359269T1 (de)	2007-05-15	4-arylsulphonylpiperidin-derivate als 5-ht2a - rezeptor antagonisten
JO2312B1 (en)	2005-09-12	Imidazo-pyrimidine derivatives as associative groups of JABA receptors
EP1235828A4 (de)	2003-01-22	Verfahren für die herstellung und zwischenprodukte von tetrahydro-[1,8]-naphthyridin
EA200200378A3 (ru)	2002-12-26	НОВЫЙ СПОСОБ СИНТЕЗА (3aS)-5,5-ДИОКСО-2,3,3а,4-ТЕТРАГИДРО-1H-ПИРРОЛО[2,1-c][1,2,4]БЕНЗОТИАДИАЗИНА
PE44299A1 (es)	1999-05-06	Derivados sustituidos de triazolo-piridacina como ligandos para receptores gaba
TR200401185T4 (tr)	2004-06-21	Yeni piridazin endotelin antagonistleri