ATE335741T1 - 8-fluorimidazo(1,2-a)pyridin derivative als liganden für gaba rezeptoren - Google Patents
8-fluorimidazo(1,2-a)pyridin derivative als liganden für gaba rezeptorenInfo
- Publication number
- ATE335741T1 ATE335741T1 AT03732655T AT03732655T ATE335741T1 AT E335741 T1 ATE335741 T1 AT E335741T1 AT 03732655 T AT03732655 T AT 03732655T AT 03732655 T AT03732655 T AT 03732655T AT E335741 T1 ATE335741 T1 AT E335741T1
- Authority
- AT
- Austria
- Prior art keywords
- pyridine derivatives
- ligands
- fluorimidazo
- gaba receptors
- sub
- Prior art date
Links
- ITBDFOMJMRICLZ-UHFFFAOYSA-N 8-fluoroimidazo[1,2-a]pyridine Chemical class FC1=CC=CN2C=CN=C12 ITBDFOMJMRICLZ-UHFFFAOYSA-N 0.000 title abstract 2
- 239000003446 ligand Substances 0.000 title abstract 2
- 102000005915 GABA Receptors Human genes 0.000 title 1
- 108010005551 GABA Receptors Proteins 0.000 title 1
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 206010010904 Convulsion Diseases 0.000 abstract 1
- 230000002411 adverse Effects 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 208000010877 cognitive disease Diseases 0.000 abstract 1
- 230000036461 convulsion Effects 0.000 abstract 1
- 229960003692 gamma aminobutyric acid Drugs 0.000 abstract 1
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0212049.1A GB0212049D0 (en) | 2002-05-24 | 2002-05-24 | Therapeutic agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE335741T1 true ATE335741T1 (de) | 2006-09-15 |
Family
ID=9937397
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03732655T ATE335741T1 (de) | 2002-05-24 | 2003-05-23 | 8-fluorimidazo(1,2-a)pyridin derivative als liganden für gaba rezeptoren |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US7226926B2 (de) |
| EP (1) | EP1511748B1 (de) |
| JP (1) | JP2005535598A (de) |
| AT (1) | ATE335741T1 (de) |
| AU (1) | AU2003239687B2 (de) |
| CA (1) | CA2486753A1 (de) |
| DE (1) | DE60307462T2 (de) |
| ES (1) | ES2270044T3 (de) |
| GB (1) | GB0212049D0 (de) |
| WO (1) | WO2003099817A1 (de) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006135705A1 (en) * | 2005-06-09 | 2006-12-21 | Michigan State University | Process for producing cyano substituted arene boranes and compounds |
| US7465795B2 (en) | 2005-12-20 | 2008-12-16 | Astrazeneca Ab | Compounds and uses thereof |
| WO2007073283A1 (en) | 2005-12-20 | 2007-06-28 | Astrazeneca Ab | Substituted cinnoline derivatives as gabaa-receptor modulators and method for their synthesis |
| CA2672213C (en) | 2006-12-22 | 2016-02-16 | Astex Therapeutics Limited | Bicyclic amine derivatives as protein tyrosine kinase inhibitors |
| US8895745B2 (en) | 2006-12-22 | 2014-11-25 | Astex Therapeutics Limited | Bicyclic heterocyclic compounds as FGFR inhibitors |
| GB0720041D0 (en) | 2007-10-12 | 2007-11-21 | Astex Therapeutics Ltd | New Compounds |
| GB0720038D0 (en) | 2007-10-12 | 2007-11-21 | Astex Therapeutics Ltd | New compounds |
| GB0810902D0 (en) | 2008-06-13 | 2008-07-23 | Astex Therapeutics Ltd | New compounds |
| WO2010009166A1 (en) | 2008-07-14 | 2010-01-21 | Gilead Colorado, Inc. | Oxindolyl inhibitor compounds |
| AU2009271019A1 (en) | 2008-07-14 | 2010-01-21 | Gilead Sciences, Inc. | Fused heterocyclyc inhibitors of histone deacetylase and/or cyclin-dependent kinases |
| WO2010009139A2 (en) | 2008-07-14 | 2010-01-21 | Gilead Colorado, Inc. | Imidazolyl pyrimidine inhibitor compounds |
| NZ590747A (en) | 2008-07-28 | 2012-11-30 | Gilead Sciences Inc | Cycloalkylidene and heterocycloalkylidene hdac inhibitor compounds |
| CA2755285C (en) | 2009-03-20 | 2014-02-11 | Yunxin Y. Bo | Inhibitors of pi3 kinase |
| GB0906472D0 (en) | 2009-04-15 | 2009-05-20 | Astex Therapeutics Ltd | New compounds |
| GB0906470D0 (en) | 2009-04-15 | 2009-05-20 | Astex Therapeutics Ltd | New compounds |
| NZ596863A (en) | 2009-06-08 | 2014-02-28 | Gilead Sciences Inc | Alkanoylamino benzamide aniline hdac inhibitor compounds |
| MX2011013166A (es) | 2009-06-08 | 2012-01-30 | Gilead Sciences Inc | Compuestos inhibidores de hdac de cicloalquilcarbamatobenzamida-an ilina. |
| US20150374705A1 (en) | 2012-02-14 | 2015-12-31 | Shanghai Institues for Biological Sciences | Substances for treatment or relief of pain |
| JP7377207B2 (ja) | 2018-01-29 | 2023-11-09 | メルク パテント ゲーエムベーハー | Ｇｃｎ２阻害剤およびその使用 |
| KR20200116481A (ko) | 2018-01-29 | 2020-10-12 | 메르크 파텐트 게엠베하 | Gcn2 억제제 및 이의 용도 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9927687D0 (en) * | 1999-11-23 | 2000-01-19 | Merck Sharp & Dohme | Therapeutic agents |
| JP2004501109A (ja) * | 2000-05-24 | 2004-01-15 | メルク シャープ エンド ドーム リミテッド | Ｇａｂａ受容体に対するリガンドとしての３−フェニル−イミダゾ−ピリミジン誘導体 |
| CA2441455A1 (en) * | 2001-03-23 | 2002-10-03 | Merck Sharp & Dohme Limited | Imidazo-pyrimidine derivatives as ligands for gaba receptors |
| ES2276048T3 (es) * | 2002-03-05 | 2007-06-16 | Eli Lilly And Company | Derivados de purina como inhibidores de cinasa. |
| GB0212048D0 (en) * | 2002-05-24 | 2002-07-03 | Merck Sharp & Dohme | Therapeutic agents |
-
2002
- 2002-05-24 GB GBGB0212049.1A patent/GB0212049D0/en not_active Ceased
-
2003
- 2003-05-23 JP JP2004507474A patent/JP2005535598A/ja active Pending
- 2003-05-23 CA CA002486753A patent/CA2486753A1/en not_active Abandoned
- 2003-05-23 WO PCT/GB2003/002250 patent/WO2003099817A1/en not_active Ceased
- 2003-05-23 US US10/515,165 patent/US7226926B2/en not_active Expired - Fee Related
- 2003-05-23 AU AU2003239687A patent/AU2003239687B2/en not_active Ceased
- 2003-05-23 DE DE60307462T patent/DE60307462T2/de not_active Expired - Fee Related
- 2003-05-23 ES ES03732655T patent/ES2270044T3/es not_active Expired - Lifetime
- 2003-05-23 AT AT03732655T patent/ATE335741T1/de not_active IP Right Cessation
- 2003-05-23 EP EP03732655A patent/EP1511748B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JP2005535598A (ja) | 2005-11-24 |
| EP1511748A1 (de) | 2005-03-09 |
| EP1511748B1 (de) | 2006-08-09 |
| US20060052385A1 (en) | 2006-03-09 |
| DE60307462T2 (de) | 2007-08-02 |
| AU2003239687A1 (en) | 2003-12-12 |
| US7226926B2 (en) | 2007-06-05 |
| CA2486753A1 (en) | 2003-12-04 |
| DE60307462D1 (de) | 2006-09-21 |
| ES2270044T3 (es) | 2007-04-01 |
| WO2003099817A1 (en) | 2003-12-04 |
| GB0212049D0 (en) | 2002-07-03 |
| AU2003239687B2 (en) | 2009-01-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |