ATE335741T1 - 8-fluorimidazo(1,2-a)pyridin derivative als liganden für gaba rezeptoren - Google Patents

8-fluorimidazo(1,2-a)pyridin derivative als liganden für gaba rezeptoren

Info

Publication number: ATE335741T1
Authority: AT; Austria
Prior art keywords: pyridine derivatives; ligands; fluorimidazo; gaba receptors; sub
Prior art date: 2002-05-24

Application number

AT03732655T

Other languages

English (en)

Inventor

Wesley Peter Blackaby

Pineiro Jose Luis Castro

Simon Charles Goodacre

David James Hallett

Alexander Charles Humphries

Philip Jones

Kevin John Merchant

Michael Reader

Original Assignee

Merck Sharp & Dohme

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-05-24

Filing date

2003-05-23

Publication date

2006-09-15

2003-05-23 Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme

2006-09-15 Application granted granted Critical

2006-09-15 Publication of ATE335741T1 publication Critical patent/ATE335741T1/de

Links

ITBDFOMJMRICLZ-UHFFFAOYSA-N 8-fluoroimidazo[1,2-a]pyridine Chemical class FC1=CC=CN2C=CN=C12 ITBDFOMJMRICLZ-UHFFFAOYSA-N 0.000 title abstract 2
239000003446 ligand Substances 0.000 title abstract 2
102000005915 GABA Receptors Human genes 0.000 title 1
108010005551 GABA Receptors Proteins 0.000 title 1
208000019901 Anxiety disease Diseases 0.000 abstract 1
206010010904 Convulsion Diseases 0.000 abstract 1
230000002411 adverse Effects 0.000 abstract 1
230000036506 anxiety Effects 0.000 abstract 1
210000003169 central nervous system Anatomy 0.000 abstract 1
208000010877 cognitive disease Diseases 0.000 abstract 1
230000036461 convulsion Effects 0.000 abstract 1
229960003692 gamma aminobutyric acid Drugs 0.000 abstract 1
BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 abstract 1
125000001072 heteroaryl group Chemical group 0.000 abstract 1
230000002265 prevention Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Steroid Compounds (AREA)

AT03732655T 2002-05-24 2003-05-23 8-fluorimidazo(1,2-a)pyridin derivative als liganden für gaba rezeptoren ATE335741T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GBGB0212049.1A GB0212049D0 (en)	2002-05-24	2002-05-24	Therapeutic agents

Publications (1)

Publication Number	Publication Date
ATE335741T1 true ATE335741T1 (de)	2006-09-15

Family

ID=9937397

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT03732655T ATE335741T1 (de)	2002-05-24	2003-05-23	8-fluorimidazo(1,2-a)pyridin derivative als liganden für gaba rezeptoren

Country Status (10)

Country	Link
US (1)	US7226926B2 (de)
EP (1)	EP1511748B1 (de)
JP (1)	JP2005535598A (de)
AT (1)	ATE335741T1 (de)
AU (1)	AU2003239687B2 (de)
CA (1)	CA2486753A1 (de)
DE (1)	DE60307462T2 (de)
ES (1)	ES2270044T3 (de)
GB (1)	GB0212049D0 (de)
WO (1)	WO2003099817A1 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7514563B2 (en) *	2005-06-09	2009-04-07	Board Of Trustees Of Michigan State University	Process for producing cyano substituted arene boranes and compounds
ES2391472T3 (es)	2005-12-20	2012-11-27	Astrazeneca Ab	Derivados de cinnolina sustituidos como moduladores del receptor de GABAA y método para su síntesis
US7465795B2 (en)	2005-12-20	2008-12-16	Astrazeneca Ab	Compounds and uses thereof
CN101679408B (zh)	2006-12-22	2016-04-27	Astex治疗学有限公司	作为fgfr抑制剂的双环杂环化合物
JP5442449B2 (ja)	2006-12-22	2014-03-12	アステックス、セラピューティックス、リミテッド	新規化合物
GB0720038D0 (en)	2007-10-12	2007-11-21	Astex Therapeutics Ltd	New compounds
GB0720041D0 (en)	2007-10-12	2007-11-21	Astex Therapeutics Ltd	New Compounds
GB0810902D0 (en)	2008-06-13	2008-07-23	Astex Therapeutics Ltd	New compounds
JP5640005B2 (ja)	2008-07-14	2014-12-10	ギリアードサイエンシーズ，インコーポレイテッド	Ｈｄａｃおよび／またはｃｄｋ阻害剤としてのイミダゾシルピリジン化合物
EP2303841A1 (de)	2008-07-14	2011-04-06	Gilead Sciences, Inc.	Oxindolylhemmerverbindungen
EP2303881A2 (de)	2008-07-14	2011-04-06	Gilead Sciences, Inc.	Kondensierte heterocyclische hemmer von histondeacetylase und/oder cyclin-abhängigen kinasen
KR20110038159A (ko)	2008-07-28	2011-04-13	길리애드 사이언시즈, 인코포레이티드	사이클로알킬리덴 및 헤테로사이클로알킬리덴 히스톤 데아세틸라아제 억제제 화합물
CA2755285C (en)	2009-03-20	2014-02-11	Yunxin Y. Bo	Inhibitors of pi3 kinase
GB0906472D0 (en)	2009-04-15	2009-05-20	Astex Therapeutics Ltd	New compounds
GB0906470D0 (en)	2009-04-15	2009-05-20	Astex Therapeutics Ltd	New compounds
ES2463826T3 (es)	2009-06-08	2014-05-29	Gilead Sciences, Inc.	Compuestos inhibidores de HDAC de cicloalquilcarbamato benzamida anilina
CA2763786C (en)	2009-06-08	2014-09-30	Gilead Sciences, Inc.	Alkanoylamino benzamide aniline hdac inihibitor compounds
US20150374705A1 (en)	2012-02-14	2015-12-31	Shanghai Institues for Biological Sciences	Substances for treatment or relief of pain
CA3089762A1 (en)	2018-01-29	2019-08-01	Merck Patent Gmbh	Gcn2 inhibitors and uses thereof
AU2019212969B2 (en) *	2018-01-29	2025-01-23	Merck Patent Gmbh	GCN2 inhibitors and uses thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9927687D0 (en) *	1999-11-23	2000-01-19	Merck Sharp & Dohme	Therapeutic agents
WO2001090108A1 (en)	2000-05-24	2001-11-29	Merck Sharp & Dohme Limited	3-phenyl-imidazo-pyrimidine derivatives as ligands for gaba receptors
US7030128B2 (en) *	2001-03-23	2006-04-18	Merck Sharp & Dohme Ltd.	Imidazo-pyrimidine derivatives as ligands for GABA receptors
ES2276048T3 (es) *	2002-03-05	2007-06-16	Eli Lilly And Company	Derivados de purina como inhibidores de cinasa.
GB0212048D0 (en) *	2002-05-24	2002-07-03	Merck Sharp & Dohme	Therapeutic agents

2002
- 2002-05-24 GB GBGB0212049.1A patent/GB0212049D0/en not_active Ceased
2003
- 2003-05-23 WO PCT/GB2003/002250 patent/WO2003099817A1/en not_active Ceased
- 2003-05-23 DE DE60307462T patent/DE60307462T2/de not_active Expired - Fee Related
- 2003-05-23 JP JP2004507474A patent/JP2005535598A/ja active Pending
- 2003-05-23 EP EP03732655A patent/EP1511748B1/de not_active Expired - Lifetime
- 2003-05-23 AT AT03732655T patent/ATE335741T1/de not_active IP Right Cessation
- 2003-05-23 ES ES03732655T patent/ES2270044T3/es not_active Expired - Lifetime
- 2003-05-23 CA CA002486753A patent/CA2486753A1/en not_active Abandoned
- 2003-05-23 US US10/515,165 patent/US7226926B2/en not_active Expired - Fee Related
- 2003-05-23 AU AU2003239687A patent/AU2003239687B2/en not_active Ceased

Also Published As

Publication number	Publication date
CA2486753A1 (en)	2003-12-04
DE60307462D1 (de)	2006-09-21
AU2003239687A1 (en)	2003-12-12
EP1511748B1 (de)	2006-08-09
AU2003239687B2 (en)	2009-01-29
JP2005535598A (ja)	2005-11-24
DE60307462T2 (de)	2007-08-02
EP1511748A1 (de)	2005-03-09
US20060052385A1 (en)	2006-03-09
ES2270044T3 (es)	2007-04-01
US7226926B2 (en)	2007-06-05
WO2003099817A1 (en)	2003-12-04
GB0212049D0 (en)	2002-07-03

Legal Events

Date	Code	Title	Description
2007-02-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE60307462D1 (de)	2006-09-21	8-fluorimidazo(1,2-a)pyridin derivative als liganden für gaba rezeptoren
ATE338758T1 (de)	2006-09-15	Imidazopyrimidin-derivate als liganden für gaba- rezeptoren
DE60304572D1 (de)	2006-05-24	Imidazopyridin derivate als liganden für gaba rezeptoren
ATE270672T1 (de)	2004-07-15	Imidazopyridinderivate als liganden für gaba- rezeptoren
ATE310002T1 (de)	2005-12-15	Imidazotriazin-derivate als gaba-rezeptor- liganden
ATE310740T1 (de)	2005-12-15	Imidazotriazin-derivate als liganden für gaba- rezeptoren
ATE255109T1 (de)	2003-12-15	Imidazopyridinderivate als gaba rezeptor liganden
DE60016566D1 (de)	2005-01-13	Triazolopyridazinderivate als liganden für gaba-rezeptoren
DE60312701T8 (de)	2008-08-21	Darstellung von 1h-imidazo[4,5-c]chinolin-4-aminen über neue 1h-imidazo[4,5-c] chinolin-4-cyano- und 1h-imidazo[4,5-c]chinolin-4-carboxamid intermediate
DE60006260D1 (de)	2003-12-04	Imidazotriazinderivate als gaba rezeptor-liganden
PL334084A1 (en)	2000-01-31	Methods of obtaining 9,11-epoxysteroides and their useful intermediate compounds
ATE420867T1 (de)	2009-01-15	Phenylpyridazin derivative als liganden für gaba- rezeptoren
ATE250062T1 (de)	2003-10-15	Triazolopiridazinederivate als gaba rezeptor- liganden
IL157641A0 (en)	2004-03-28	Imidazo-pyrimidine derivatives as ligands for gaba receptors
EP1566384A4 (de)	2007-11-21	Neue azolderivate
Sugimori et al.	1998	Synthesis and antitumor activity of ring A-and F-modified hexacyclic camptothecin analogues
ATE249457T1 (de)	2003-09-15	Indolderivate und ihre verwendung als serotoninrezeptor-liganden
Mekouar et al.	2000	New pyridone approach: total synthesis of mappicine ketone (nothapodytine B)
TW200609218A (en)	2006-03-16	Bicyclic compounds
MXPA05014191A (es)	2006-02-24	Procedimiento para preparar derivado de acido 3-acilaminobenzofuran-2-carboxilico.
ATE359269T1 (de)	2007-05-15	4-arylsulphonylpiperidin-derivate als 5-ht2a - rezeptor antagonisten
Bartolomé-Nebreda et al.	2001	5-(Tryptophyl) amino-1, 3-dioxoperhydropyrido [1, 2-c] pyrimidine-Based Potent and Selective CCK1 Receptor Antagonists: Structure− Activity Relationship Studies on the Central 1, 3-Dioxoperhydropyrido [1, 2-c] pyrimidine Scaffold
JO2312B1 (en)	2005-09-12	Imidazo-pyrimidine derivatives as associative groups of JABA receptors
PE44299A1 (es)	1999-05-06	Derivados sustituidos de triazolo-piridacina como ligandos para receptores gaba