ATE335741T1 - 8-fluorimidazo(1,2-a)pyridin derivative als liganden für gaba rezeptoren - Google Patents
8-fluorimidazo(1,2-a)pyridin derivative als liganden für gaba rezeptorenInfo
- Publication number
- ATE335741T1 ATE335741T1 AT03732655T AT03732655T ATE335741T1 AT E335741 T1 ATE335741 T1 AT E335741T1 AT 03732655 T AT03732655 T AT 03732655T AT 03732655 T AT03732655 T AT 03732655T AT E335741 T1 ATE335741 T1 AT E335741T1
- Authority
- AT
- Austria
- Prior art keywords
- pyridine derivatives
- ligands
- fluorimidazo
- gaba receptors
- sub
- Prior art date
Links
- ITBDFOMJMRICLZ-UHFFFAOYSA-N 8-fluoroimidazo[1,2-a]pyridine Chemical class FC1=CC=CN2C=CN=C12 ITBDFOMJMRICLZ-UHFFFAOYSA-N 0.000 title abstract 2
- 239000003446 ligand Substances 0.000 title abstract 2
- 102000005915 GABA Receptors Human genes 0.000 title 1
- 108010005551 GABA Receptors Proteins 0.000 title 1
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 206010010904 Convulsion Diseases 0.000 abstract 1
- 230000002411 adverse Effects 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 208000010877 cognitive disease Diseases 0.000 abstract 1
- 230000036461 convulsion Effects 0.000 abstract 1
- 229960003692 gamma aminobutyric acid Drugs 0.000 abstract 1
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0212049.1A GB0212049D0 (en) | 2002-05-24 | 2002-05-24 | Therapeutic agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE335741T1 true ATE335741T1 (de) | 2006-09-15 |
Family
ID=9937397
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03732655T ATE335741T1 (de) | 2002-05-24 | 2003-05-23 | 8-fluorimidazo(1,2-a)pyridin derivative als liganden für gaba rezeptoren |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US7226926B2 (de) |
| EP (1) | EP1511748B1 (de) |
| JP (1) | JP2005535598A (de) |
| AT (1) | ATE335741T1 (de) |
| AU (1) | AU2003239687B2 (de) |
| CA (1) | CA2486753A1 (de) |
| DE (1) | DE60307462T2 (de) |
| ES (1) | ES2270044T3 (de) |
| GB (1) | GB0212049D0 (de) |
| WO (1) | WO2003099817A1 (de) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7514563B2 (en) * | 2005-06-09 | 2009-04-07 | Board Of Trustees Of Michigan State University | Process for producing cyano substituted arene boranes and compounds |
| US7425556B2 (en) | 2005-12-20 | 2008-09-16 | Astrazeneca Ab | Compounds and uses thereof |
| US7465795B2 (en) | 2005-12-20 | 2008-12-16 | Astrazeneca Ab | Compounds and uses thereof |
| HRP20150642T1 (hr) | 2006-12-22 | 2015-08-14 | Astex Therapeutics Limited | BICIKLIÄŚKE HETEROCIKLIÄŚKE TVARI KAO INHIBITORI FGFR-a |
| US8513276B2 (en) | 2006-12-22 | 2013-08-20 | Astex Therapeutics Limited | Imidazo[1,2-a]pyridine compounds for use in treating cancer |
| GB0720041D0 (en) | 2007-10-12 | 2007-11-21 | Astex Therapeutics Ltd | New Compounds |
| GB0720038D0 (en) | 2007-10-12 | 2007-11-21 | Astex Therapeutics Ltd | New compounds |
| GB0810902D0 (en) | 2008-06-13 | 2008-07-23 | Astex Therapeutics Ltd | New compounds |
| WO2010009166A1 (en) | 2008-07-14 | 2010-01-21 | Gilead Colorado, Inc. | Oxindolyl inhibitor compounds |
| CA2729909A1 (en) | 2008-07-14 | 2010-01-21 | Gilead Sciences, Inc. | Imidazolyl pyrimidine inhibitor compounds |
| US8124764B2 (en) | 2008-07-14 | 2012-02-28 | Gilead Sciences, Inc. | Fused heterocyclyc inhibitor compounds |
| CN102123987A (zh) | 2008-07-28 | 2011-07-13 | 吉里德科学公司 | 亚环烷基和亚杂环烷基组蛋白脱乙酰酶抑制剂化合物 |
| JP2012521354A (ja) | 2009-03-20 | 2012-09-13 | アムジエン・インコーポレーテツド | Ｐｉ３キナーゼの阻害薬 |
| GB0906472D0 (en) | 2009-04-15 | 2009-05-20 | Astex Therapeutics Ltd | New compounds |
| GB0906470D0 (en) | 2009-04-15 | 2009-05-20 | Astex Therapeutics Ltd | New compounds |
| US8283357B2 (en) | 2009-06-08 | 2012-10-09 | Gilead Sciences, Inc. | Cycloalkylcarbamate benzamide aniline HDAC inhibitor compounds |
| KR20120031170A (ko) | 2009-06-08 | 2012-03-30 | 길리애드 사이언시즈, 인코포레이티드 | 알카노일아미노 벤즈아미드 아닐린 ｈｄａｃ 저해제 화합물 |
| US20150374705A1 (en) | 2012-02-14 | 2015-12-31 | Shanghai Institues for Biological Sciences | Substances for treatment or relief of pain |
| BR112020015396A2 (pt) * | 2018-01-29 | 2020-12-08 | Merck Patent Gmbh | Inididores de gcn2 e usos dos mesmos |
| JP7229257B2 (ja) | 2018-01-29 | 2023-02-28 | メルク パテント ゲーエムベーハー | Ｇｃｎ２阻害剤およびその使用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9927687D0 (en) * | 1999-11-23 | 2000-01-19 | Merck Sharp & Dohme | Therapeutic agents |
| EP1294723A1 (de) * | 2000-05-24 | 2003-03-26 | MERCK SHARP & DOHME LTD. | 3-phenyl-imidazo-pyrimidin derivate als liganden für gaba rezeptoren |
| ATE338758T1 (de) | 2001-03-23 | 2006-09-15 | Merck Sharp & Dohme | Imidazopyrimidin-derivate als liganden für gaba- rezeptoren |
| WO2003076442A1 (en) * | 2002-03-05 | 2003-09-18 | Eli Lilly And Company | Purine derivatives as kinase inhibitors |
| GB0212048D0 (en) * | 2002-05-24 | 2002-07-03 | Merck Sharp & Dohme | Therapeutic agents |
-
2002
- 2002-05-24 GB GBGB0212049.1A patent/GB0212049D0/en not_active Ceased
-
2003
- 2003-05-23 EP EP03732655A patent/EP1511748B1/de not_active Expired - Lifetime
- 2003-05-23 AU AU2003239687A patent/AU2003239687B2/en not_active Ceased
- 2003-05-23 AT AT03732655T patent/ATE335741T1/de not_active IP Right Cessation
- 2003-05-23 US US10/515,165 patent/US7226926B2/en not_active Expired - Fee Related
- 2003-05-23 WO PCT/GB2003/002250 patent/WO2003099817A1/en not_active Ceased
- 2003-05-23 CA CA002486753A patent/CA2486753A1/en not_active Abandoned
- 2003-05-23 ES ES03732655T patent/ES2270044T3/es not_active Expired - Lifetime
- 2003-05-23 DE DE60307462T patent/DE60307462T2/de not_active Expired - Fee Related
- 2003-05-23 JP JP2004507474A patent/JP2005535598A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AU2003239687B2 (en) | 2009-01-29 |
| JP2005535598A (ja) | 2005-11-24 |
| GB0212049D0 (en) | 2002-07-03 |
| DE60307462D1 (de) | 2006-09-21 |
| DE60307462T2 (de) | 2007-08-02 |
| EP1511748A1 (de) | 2005-03-09 |
| ES2270044T3 (es) | 2007-04-01 |
| WO2003099817A1 (en) | 2003-12-04 |
| CA2486753A1 (en) | 2003-12-04 |
| US7226926B2 (en) | 2007-06-05 |
| US20060052385A1 (en) | 2006-03-09 |
| EP1511748B1 (de) | 2006-08-09 |
| AU2003239687A1 (en) | 2003-12-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |