ATE323089T1 - Imidazopyridin derivate als liganden für gaba rezeptoren - Google Patents

Imidazopyridin derivate als liganden für gaba rezeptoren

Info

Publication number
ATE323089T1
ATE323089T1 AT03727692T AT03727692T ATE323089T1 AT E323089 T1 ATE323089 T1 AT E323089T1 AT 03727692 T AT03727692 T AT 03727692T AT 03727692 T AT03727692 T AT 03727692T AT E323089 T1 ATE323089 T1 AT E323089T1
Authority
AT
Austria
Prior art keywords
sub
ligands
gaba receptors
imidazopyridine derivatives
gaba
Prior art date
Application number
AT03727692T
Other languages
English (en)
Inventor
Simon Charles Goodacre
David James Hallett
Alexander Charles Humphries
Philip Jones
Sarah M Kelly
Kevin John Merchant
Kevin William Moore
Michael Reader
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Application granted granted Critical
Publication of ATE323089T1 publication Critical patent/ATE323089T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Pyridine Compounds (AREA)
AT03727692T 2002-05-24 2003-05-23 Imidazopyridin derivate als liganden für gaba rezeptoren ATE323089T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0212048.3A GB0212048D0 (en) 2002-05-24 2002-05-24 Therapeutic agents

Publications (1)

Publication Number Publication Date
ATE323089T1 true ATE323089T1 (de) 2006-04-15

Family

ID=9937396

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03727692T ATE323089T1 (de) 2002-05-24 2003-05-23 Imidazopyridin derivate als liganden für gaba rezeptoren

Country Status (10)

Country Link
US (1) US7279580B2 (de)
EP (1) EP1511747B1 (de)
JP (1) JP2005531582A (de)
AT (1) ATE323089T1 (de)
AU (1) AU2003234022B2 (de)
CA (1) CA2486750A1 (de)
DE (1) DE60304572T2 (de)
ES (1) ES2260623T3 (de)
GB (1) GB0212048D0 (de)
WO (1) WO2003099816A1 (de)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0212049D0 (en) * 2002-05-24 2002-07-03 Merck Sharp & Dohme Therapeutic agents
EP2258357A3 (de) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenese mit Acetylcholinesterasehemmer
EP2275096A3 (de) 2005-08-26 2011-07-13 Braincells, Inc. Neurogenese durch modulation des Muscarinrezeptors
EP2314289A1 (de) 2005-10-31 2011-04-27 Braincells, Inc. Gaba-rezeptor-vermittelte modulation von neurogenese
US7465795B2 (en) 2005-12-20 2008-12-16 Astrazeneca Ab Compounds and uses thereof
ES2391472T3 (es) 2005-12-20 2012-11-27 Astrazeneca Ab Derivados de cinnolina sustituidos como moduladores del receptor de GABAA y método para su síntesis
KR101062583B1 (ko) * 2006-01-17 2011-09-06 에프. 호프만-라 로슈 아게 Ｇａｂａ 수용체에 의해 알츠하이머병의 치료에 유용한아릴-아이속사졸-4-일-이미다조[1,2-ａ]피리딘
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
US7678808B2 (en) 2006-05-09 2010-03-16 Braincells, Inc. 5 HT receptor mediated neurogenesis
EP2021000A2 (de) 2006-05-09 2009-02-11 Braincells, Inc. Neurogenese mittels angiotensin-modulation
US8227603B2 (en) * 2006-08-01 2012-07-24 Cytokinetics, Inc. Modulating skeletal muscle
US8299248B2 (en) * 2006-08-02 2012-10-30 Cytokinetics, Incorporated Certain 1H-imidazo[4,5-b]pyrazin-2(3H)-ones and 1H-imidazo[4,5-b]pyrazin-2-ols and methods for their use
BRPI0714725B1 (pt) * 2006-08-02 2021-05-25 Cytokinetics, Inc Entidade química, composição farmaceuticamente aceitável, e, uso de uma entidade química
WO2008030651A1 (en) 2006-09-08 2008-03-13 Braincells, Inc. Combinations containing a 4-acylaminopyridine derivative
CN101679408B (zh) 2006-12-22 2016-04-27 Astex治疗学有限公司 作为fgfr抑制剂的双环杂环化合物
JP5442449B2 (ja) 2006-12-22 2014-03-12 アステックス、セラピューティックス、リミテッド 新規化合物
US7851484B2 (en) 2007-03-30 2010-12-14 Cytokinetics, Inc. Certain chemical entities, compositions, and methods
GB0720038D0 (en) 2007-10-12 2007-11-21 Astex Therapeutics Ltd New compounds
GB0720041D0 (en) 2007-10-12 2007-11-21 Astex Therapeutics Ltd New Compounds
WO2009086123A1 (en) * 2007-12-21 2009-07-09 Wyeth Imidazo [1,2-a] pyridine compounds
CA2713864A1 (en) * 2008-02-04 2009-08-13 Cytokinetics, Incorporated Certain chemical entities, compositions and methods
US20100216805A1 (en) 2009-02-25 2010-08-26 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
AR076024A1 (es) 2009-04-03 2011-05-11 Schering Corp Derivados de heterociclos biciclicos puenteados y metodos de uso de los mismos
GB0906472D0 (en) 2009-04-15 2009-05-20 Astex Therapeutics Ltd New compounds
GB0906470D0 (en) 2009-04-15 2009-05-20 Astex Therapeutics Ltd New compounds
CN109316480A (zh) 2011-07-13 2019-02-12 赛特凯恩蒂克公司 组合als疗法
US20150374705A1 (en) * 2012-02-14 2015-12-31 Shanghai Institues for Biological Sciences Substances for treatment or relief of pain
WO2017098367A1 (en) * 2015-12-10 2017-06-15 Pfizer Limited 4-(biphen-3-yl)-1h-pyrazolo[3,4-c]pyridazine derivatives of formula (i) as gaba receptor modulators for use in the treatment of epilepsy and pain
HUE060943T2 (hu) 2018-09-13 2023-04-28 Saniona As A gaba A receptor ligandum
EP3636645A1 (de) 2018-10-11 2020-04-15 Bayer Aktiengesellschaft Verfahren zur herstellung schwefel-substituierter pyridinderivate
KR102793543B1 (ko) 2018-10-11 2025-04-11 바이엘 악티엔게젤샤프트 이미다졸 유도체의 제조 방법
EP4359381A4 (de) * 2021-06-21 2025-04-30 Nimbus Clio, Inc. Cbl-b-modulatoren und verwendungen davon
AU2024411621A1 (en) 2023-12-27 2026-06-18 Saniona A/S A gabaa receptor ligand and the use thereof in medicine, in particular in the treatment of epilepsy

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK40192D0 (da) 1992-03-26 1992-03-26 Neurosearch As Imidazolforbindelser, deres fremstilling og anvendelse
BR0011823A (pt) 1999-06-22 2002-03-19 Neurosearch As Derivado de benzimidazol, composto, composição farmacêutica, uso de um derivado de benzimidazol, e, método para tratamento, prevenção ou alìvio de uma doença ou de um distúrbio ou de uma condição de um corpo animal vivo
GB9927687D0 (en) 1999-11-23 2000-01-19 Merck Sharp & Dohme Therapeutic agents
WO2001090108A1 (en) 2000-05-24 2001-11-29 Merck Sharp & Dohme Limited 3-phenyl-imidazo-pyrimidine derivatives as ligands for gaba receptors
AU1253002A (en) 2000-11-10 2002-05-21 Merck Sharp & Dohme Imidazo-triazine derivatives as ligands for gaba receptors

Also Published As

Publication number Publication date
EP1511747A1 (de) 2005-03-09
US7279580B2 (en) 2007-10-09
GB0212048D0 (en) 2002-07-03
ES2260623T3 (es) 2006-11-01
DE60304572T2 (de) 2006-12-14
AU2003234022A1 (en) 2003-12-12
AU2003234022B2 (en) 2009-06-25
US20050165048A1 (en) 2005-07-28
WO2003099816A1 (en) 2003-12-04
JP2005531582A (ja) 2005-10-20
CA2486750A1 (en) 2003-12-04
EP1511747B1 (de) 2006-04-12
DE60304572D1 (de) 2006-05-24

Similar Documents

Publication Publication Date Title
DE60304572D1 (de) Imidazopyridin derivate als liganden für gaba rezeptoren
DE60115282D1 (de) Imidazotriazin-derivate als liganden für gaba-rezeptoren
DE60012044D1 (de) Imidazopyridinderivate als liganden für gaba-rezeptoren
ATE310002T1 (de) Imidazotriazin-derivate als gaba-rezeptor- liganden
DE60205101D1 (de) Imidozo-pyrimidine derivate als liganden für gaba rezeptoren
DE60214532D1 (de) Imidazopyrimidin-derivate als liganden für gaba-rezeptoren
ATE335741T1 (de) 8-fluorimidazo(1,2-a)pyridin derivative als liganden für gaba rezeptoren
ATE371659T1 (de) Pyrazolotriazinderivate als gaba-rezeptorliganden
DE69739733D1 (de) 1-phenyl-benzimidazolverbindungen und ihre verwendung als modulatoren des gaba-a-rezeptors
ATE420867T1 (de) Phenylpyridazin derivative als liganden für gaba- rezeptoren
ATE284403T1 (de) Triazolopyridazinderivate als liganden für gaba- rezeptoren
DE60006260D1 (de) Imidazotriazinderivate als gaba rezeptor-liganden
DE69911374D1 (de) Triazolopiridazinederivate als gaba rezeptor-liganden
TW200609218A (en) Bicyclic compounds
ATE446948T1 (de) Alpha-ketoamidderivativ, herstellungsverfahren und verwendung davon
FR2828197B1 (fr) Nouveaux materiaux a base de derives de corrole pour le piegeage du monoxyde de carbone
ATE482931T1 (de) Somatostatinrezeptor-1- und/oder -4-selektive agonisten und antagonisten
JO2312B1 (en) Imidazo-pyrimidine derivatives as associative groups of JABA receptors
MY139258A (en) Carbamoyl-type benzofuran derivatives
ATE414692T1 (de) Pyridinketone mit herbizideffekt
AR061086A1 (es) Proceso para la preparacion de derivados de pirazol
ATE375724T1 (de) Cyanomethyl-trithiocarbonate als nematizide
AR056241A1 (es) Agentes inhibidores de quinasa p38

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties