ATE323089T1 - Imidazopyridin derivate als liganden für gaba rezeptoren - Google Patents
Imidazopyridin derivate als liganden für gaba rezeptorenInfo
- Publication number
- ATE323089T1 ATE323089T1 AT03727692T AT03727692T ATE323089T1 AT E323089 T1 ATE323089 T1 AT E323089T1 AT 03727692 T AT03727692 T AT 03727692T AT 03727692 T AT03727692 T AT 03727692T AT E323089 T1 ATE323089 T1 AT E323089T1
- Authority
- AT
- Austria
- Prior art keywords
- sub
- ligands
- gaba receptors
- imidazopyridine derivatives
- gaba
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Addiction (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0212048.3A GB0212048D0 (en) | 2002-05-24 | 2002-05-24 | Therapeutic agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE323089T1 true ATE323089T1 (de) | 2006-04-15 |
Family
ID=9937396
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03727692T ATE323089T1 (de) | 2002-05-24 | 2003-05-23 | Imidazopyridin derivate als liganden für gaba rezeptoren |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US7279580B2 (de) |
| EP (1) | EP1511747B1 (de) |
| JP (1) | JP2005531582A (de) |
| AT (1) | ATE323089T1 (de) |
| AU (1) | AU2003234022B2 (de) |
| CA (1) | CA2486750A1 (de) |
| DE (1) | DE60304572T2 (de) |
| ES (1) | ES2260623T3 (de) |
| GB (1) | GB0212048D0 (de) |
| WO (1) | WO2003099816A1 (de) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0212049D0 (en) * | 2002-05-24 | 2002-07-03 | Merck Sharp & Dohme | Therapeutic agents |
| WO2007025177A2 (en) | 2005-08-26 | 2007-03-01 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation |
| EP2258359A3 (de) | 2005-08-26 | 2011-04-06 | Braincells, Inc. | Neurogenese durch Modulation des Muscarinrezeptors mit Sabcomelin |
| EP1942879A1 (de) | 2005-10-31 | 2008-07-16 | Braincells, Inc. | Gaba-rezeptor-vermittelte modulation von neurogenese |
| US7465795B2 (en) | 2005-12-20 | 2008-12-16 | Astrazeneca Ab | Compounds and uses thereof |
| WO2007073283A1 (en) | 2005-12-20 | 2007-06-28 | Astrazeneca Ab | Substituted cinnoline derivatives as gabaa-receptor modulators and method for their synthesis |
| AU2007207053B2 (en) * | 2006-01-17 | 2012-05-24 | F. Hoffmann-La Roche Ag | Aryl-isoxazol-4-yl-imidazo[1,2-a]pyridine useful for the treatment of Alzheimer's disease via GABA receptors |
| US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
| EP2021000A2 (de) | 2006-05-09 | 2009-02-11 | Braincells, Inc. | Neurogenese mittels angiotensin-modulation |
| MX2008014320A (es) | 2006-05-09 | 2009-03-25 | Braincells Inc | Neurogenesis mediada por el receptor de 5-hidroxitriptamina. |
| US8227603B2 (en) * | 2006-08-01 | 2012-07-24 | Cytokinetics, Inc. | Modulating skeletal muscle |
| EA017925B1 (ru) * | 2006-08-02 | 2013-04-30 | Цитокинетикс, Инкорпорэйтед | ПРОИЗВОДНЫЕ 1Н-ИМИДАЗО[4,5-b]ПИРАЗИНА |
| US8299248B2 (en) * | 2006-08-02 | 2012-10-30 | Cytokinetics, Incorporated | Certain 1H-imidazo[4,5-b]pyrazin-2(3H)-ones and 1H-imidazo[4,5-b]pyrazin-2-ols and methods for their use |
| BRPI0716604A2 (pt) | 2006-09-08 | 2013-04-09 | Braincells Inc | combinaÇÕes contendo um derivado de 4-acilaminopiridina |
| US8895745B2 (en) | 2006-12-22 | 2014-11-25 | Astex Therapeutics Limited | Bicyclic heterocyclic compounds as FGFR inhibitors |
| CA2672213C (en) | 2006-12-22 | 2016-02-16 | Astex Therapeutics Limited | Bicyclic amine derivatives as protein tyrosine kinase inhibitors |
| US7851484B2 (en) | 2007-03-30 | 2010-12-14 | Cytokinetics, Inc. | Certain chemical entities, compositions, and methods |
| GB0720038D0 (en) | 2007-10-12 | 2007-11-21 | Astex Therapeutics Ltd | New compounds |
| GB0720041D0 (en) | 2007-10-12 | 2007-11-21 | Astex Therapeutics Ltd | New Compounds |
| CA2710452A1 (en) * | 2007-12-21 | 2009-07-09 | Wyeth Llc | Imidazo [1,2-a] pyridine compounds |
| MX2010008518A (es) * | 2008-02-04 | 2010-11-10 | Cytokinetics Inc | Ciertas entidades quimicas, composiciones y metodos. |
| WO2010099217A1 (en) | 2009-02-25 | 2010-09-02 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
| AR076024A1 (es) | 2009-04-03 | 2011-05-11 | Schering Corp | Derivados de heterociclos biciclicos puenteados y metodos de uso de los mismos |
| GB0906470D0 (en) | 2009-04-15 | 2009-05-20 | Astex Therapeutics Ltd | New compounds |
| GB0906472D0 (en) | 2009-04-15 | 2009-05-20 | Astex Therapeutics Ltd | New compounds |
| US10272082B2 (en) | 2011-07-13 | 2019-04-30 | Cytokinetics, Inc. | Combination ALS therapy |
| US20150374705A1 (en) | 2012-02-14 | 2015-12-31 | Shanghai Institues for Biological Sciences | Substances for treatment or relief of pain |
| WO2017098367A1 (en) * | 2015-12-10 | 2017-06-15 | Pfizer Limited | 4-(biphen-3-yl)-1h-pyrazolo[3,4-c]pyridazine derivatives of formula (i) as gaba receptor modulators for use in the treatment of epilepsy and pain |
| HUE060943T2 (hu) | 2018-09-13 | 2023-04-28 | Saniona As | A gaba A receptor ligandum |
| EP3636645A1 (de) | 2018-10-11 | 2020-04-15 | Bayer Aktiengesellschaft | Verfahren zur herstellung schwefel-substituierter pyridinderivate |
| IL282036B2 (en) | 2018-10-11 | 2024-03-01 | Bayer Ag | Process for preparing imidazole derivatives |
| WO2022272248A1 (en) * | 2021-06-21 | 2022-12-29 | Nimbus Clio, Inc. | Cbl-b modulators and uses thereof |
| WO2025141131A1 (en) | 2023-12-27 | 2025-07-03 | Saniona A/S | A gabaa receptor ligand and the use thereof in medicine, in particular in the treatment of epilepsy |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK40192D0 (da) | 1992-03-26 | 1992-03-26 | Neurosearch As | Imidazolforbindelser, deres fremstilling og anvendelse |
| BR0011823A (pt) * | 1999-06-22 | 2002-03-19 | Neurosearch As | Derivado de benzimidazol, composto, composição farmacêutica, uso de um derivado de benzimidazol, e, método para tratamento, prevenção ou alìvio de uma doença ou de um distúrbio ou de uma condição de um corpo animal vivo |
| GB9927687D0 (en) * | 1999-11-23 | 2000-01-19 | Merck Sharp & Dohme | Therapeutic agents |
| JP2004501109A (ja) | 2000-05-24 | 2004-01-15 | メルク シャープ エンド ドーム リミテッド | Ｇａｂａ受容体に対するリガンドとしての３−フェニル−イミダゾ−ピリミジン誘導体 |
| ATE310740T1 (de) | 2000-11-10 | 2005-12-15 | Merck Sharp & Dohme | Imidazotriazin-derivate als liganden für gaba- rezeptoren |
-
2002
- 2002-05-24 GB GBGB0212048.3A patent/GB0212048D0/en not_active Ceased
-
2003
- 2003-05-23 CA CA002486750A patent/CA2486750A1/en not_active Abandoned
- 2003-05-23 ES ES03727692T patent/ES2260623T3/es not_active Expired - Lifetime
- 2003-05-23 WO PCT/GB2003/002236 patent/WO2003099816A1/en not_active Ceased
- 2003-05-23 EP EP03727692A patent/EP1511747B1/de not_active Expired - Lifetime
- 2003-05-23 DE DE60304572T patent/DE60304572T2/de not_active Expired - Fee Related
- 2003-05-23 JP JP2004507473A patent/JP2005531582A/ja active Pending
- 2003-05-23 AU AU2003234022A patent/AU2003234022B2/en not_active Ceased
- 2003-05-23 US US10/512,984 patent/US7279580B2/en not_active Expired - Fee Related
- 2003-05-23 AT AT03727692T patent/ATE323089T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE60304572D1 (de) | 2006-05-24 |
| AU2003234022B2 (en) | 2009-06-25 |
| JP2005531582A (ja) | 2005-10-20 |
| CA2486750A1 (en) | 2003-12-04 |
| US7279580B2 (en) | 2007-10-09 |
| US20050165048A1 (en) | 2005-07-28 |
| WO2003099816A1 (en) | 2003-12-04 |
| ES2260623T3 (es) | 2006-11-01 |
| DE60304572T2 (de) | 2006-12-14 |
| AU2003234022A1 (en) | 2003-12-12 |
| GB0212048D0 (en) | 2002-07-03 |
| EP1511747B1 (de) | 2006-04-12 |
| EP1511747A1 (de) | 2005-03-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |