ATE323089T1 - Imidazopyridin derivate als liganden für gaba rezeptoren - Google Patents
Imidazopyridin derivate als liganden für gaba rezeptorenInfo
- Publication number
- ATE323089T1 ATE323089T1 AT03727692T AT03727692T ATE323089T1 AT E323089 T1 ATE323089 T1 AT E323089T1 AT 03727692 T AT03727692 T AT 03727692T AT 03727692 T AT03727692 T AT 03727692T AT E323089 T1 ATE323089 T1 AT E323089T1
- Authority
- AT
- Austria
- Prior art keywords
- sub
- ligands
- gaba receptors
- imidazopyridine derivatives
- gaba
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Addiction (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyridine Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0212048.3A GB0212048D0 (en) | 2002-05-24 | 2002-05-24 | Therapeutic agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE323089T1 true ATE323089T1 (de) | 2006-04-15 |
Family
ID=9937396
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03727692T ATE323089T1 (de) | 2002-05-24 | 2003-05-23 | Imidazopyridin derivate als liganden für gaba rezeptoren |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US7279580B2 (de) |
| EP (1) | EP1511747B1 (de) |
| JP (1) | JP2005531582A (de) |
| AT (1) | ATE323089T1 (de) |
| AU (1) | AU2003234022B2 (de) |
| CA (1) | CA2486750A1 (de) |
| DE (1) | DE60304572T2 (de) |
| ES (1) | ES2260623T3 (de) |
| GB (1) | GB0212048D0 (de) |
| WO (1) | WO2003099816A1 (de) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0212049D0 (en) * | 2002-05-24 | 2002-07-03 | Merck Sharp & Dohme | Therapeutic agents |
| EP2258358A3 (de) | 2005-08-26 | 2011-09-07 | Braincells, Inc. | Neurogenese mit Acetylcholinesterasehemmer |
| EP2275095A3 (de) | 2005-08-26 | 2011-08-17 | Braincells, Inc. | Neurogenese durch modulation des Muscarinrezeptors |
| AU2006308889A1 (en) | 2005-10-31 | 2007-05-10 | Braincells, Inc. | GABA receptor mediated modulation of neurogenesis |
| US7465795B2 (en) | 2005-12-20 | 2008-12-16 | Astrazeneca Ab | Compounds and uses thereof |
| US7425556B2 (en) | 2005-12-20 | 2008-09-16 | Astrazeneca Ab | Compounds and uses thereof |
| JP4913157B2 (ja) * | 2006-01-17 | 2012-04-11 | エフ．ホフマン−ラ ロシュ アーゲー | ＧＡＢＡレセプター経由でのアルツハイマー病の処置に有用なアリール−イソオキサゾール−４−イル−イミダゾ［１，２−ａ］ピリジン誘導体 |
| US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
| JP2009536667A (ja) | 2006-05-09 | 2009-10-15 | ブレインセルス，インコーポレイティド | ５ｈｔ受容体介在性の神経新生 |
| EP2382975A3 (de) | 2006-05-09 | 2012-02-29 | Braincells, Inc. | Neurogenese mittels Angiotensin-Modulation |
| US8227603B2 (en) * | 2006-08-01 | 2012-07-24 | Cytokinetics, Inc. | Modulating skeletal muscle |
| US8299248B2 (en) * | 2006-08-02 | 2012-10-30 | Cytokinetics, Incorporated | Certain 1H-imidazo[4,5-b]pyrazin-2(3H)-ones and 1H-imidazo[4,5-b]pyrazin-2-ols and methods for their use |
| PL2069352T3 (pl) * | 2006-08-02 | 2014-03-31 | Cytokinetics Inc | Określone cząstki chemiczne, kompozycje i sposoby |
| AU2007292848A1 (en) | 2006-09-08 | 2008-03-13 | Braincells, Inc. | Combinations containing a 4-acylaminopyridine derivative |
| HRP20150642T1 (hr) | 2006-12-22 | 2015-08-14 | Astex Therapeutics Limited | BICIKLIÄŚKE HETEROCIKLIÄŚKE TVARI KAO INHIBITORI FGFR-a |
| US8513276B2 (en) | 2006-12-22 | 2013-08-20 | Astex Therapeutics Limited | Imidazo[1,2-a]pyridine compounds for use in treating cancer |
| EP2139478A4 (de) | 2007-03-30 | 2010-05-05 | Cytokinetics Inc | Bestimmte chemische entitäten, zusammensetzungen und verfahren |
| GB0720038D0 (en) | 2007-10-12 | 2007-11-21 | Astex Therapeutics Ltd | New compounds |
| GB0720041D0 (en) | 2007-10-12 | 2007-11-21 | Astex Therapeutics Ltd | New Compounds |
| EP2231660A1 (de) * | 2007-12-21 | 2010-09-29 | Wyeth LLC | Imidazo [1,2-a] pyridinverbindungen |
| EP2244711A4 (de) * | 2008-02-04 | 2011-08-24 | Cytokinetics Inc | Bestimmte chemische stoffe, zusammensetzungen und verfahren |
| WO2010099217A1 (en) | 2009-02-25 | 2010-09-02 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
| AR076024A1 (es) | 2009-04-03 | 2011-05-11 | Schering Corp | Derivados de heterociclos biciclicos puenteados y metodos de uso de los mismos |
| GB0906472D0 (en) | 2009-04-15 | 2009-05-20 | Astex Therapeutics Ltd | New compounds |
| GB0906470D0 (en) | 2009-04-15 | 2009-05-20 | Astex Therapeutics Ltd | New compounds |
| BR112014000742A2 (pt) | 2011-07-13 | 2016-08-23 | Andrew A Wolff | terapia de combinação de als |
| US20150374705A1 (en) * | 2012-02-14 | 2015-12-31 | Shanghai Institues for Biological Sciences | Substances for treatment or relief of pain |
| EP3386983A1 (de) * | 2015-12-10 | 2018-10-17 | Pfizer Limited | 4-(biphen-3-yl)-1h-pyrazolo[3,4-c]pyridazin-derivate der formel (i) als gaba-rezeptormodulatoren zur verwendung bei der behandlung von epilepsie und schmerzen |
| BR112021004661A2 (pt) | 2018-09-13 | 2021-06-01 | Saniona A/S | composto, composição farmacêutica, método para tratamento de dor neuropática e/ou prurido, e, uso do composto |
| KR102793543B1 (ko) | 2018-10-11 | 2025-04-11 | 바이엘 악티엔게젤샤프트 | 이미다졸 유도체의 제조 방법 |
| EP3636645A1 (de) | 2018-10-11 | 2020-04-15 | Bayer Aktiengesellschaft | Verfahren zur herstellung schwefel-substituierter pyridinderivate |
| EP4359381A4 (de) * | 2021-06-21 | 2025-04-30 | Nimbus Clio, Inc. | Cbl-b-modulatoren und verwendungen davon |
| WO2025141131A1 (en) | 2023-12-27 | 2025-07-03 | Saniona A/S | A gabaa receptor ligand and the use thereof in medicine, in particular in the treatment of epilepsy |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK40192D0 (da) | 1992-03-26 | 1992-03-26 | Neurosearch As | Imidazolforbindelser, deres fremstilling og anvendelse |
| IL146403A0 (en) * | 1999-06-22 | 2002-07-25 | Neurosearch As | Novel benzimidazole derivatives and pharmaceutical compositions comprising these compounds |
| GB9927687D0 (en) | 1999-11-23 | 2000-01-19 | Merck Sharp & Dohme | Therapeutic agents |
| EP1294723A1 (de) | 2000-05-24 | 2003-03-26 | MERCK SHARP & DOHME LTD. | 3-phenyl-imidazo-pyrimidin derivate als liganden für gaba rezeptoren |
| CA2427779A1 (en) * | 2000-11-10 | 2002-05-16 | Merck Sharp & Dohme Limited | Imidazo-triazine derivatives as ligands for gaba receptors |
-
2002
- 2002-05-24 GB GBGB0212048.3A patent/GB0212048D0/en not_active Ceased
-
2003
- 2003-05-23 ES ES03727692T patent/ES2260623T3/es not_active Expired - Lifetime
- 2003-05-23 US US10/512,984 patent/US7279580B2/en not_active Expired - Fee Related
- 2003-05-23 JP JP2004507473A patent/JP2005531582A/ja active Pending
- 2003-05-23 AT AT03727692T patent/ATE323089T1/de not_active IP Right Cessation
- 2003-05-23 AU AU2003234022A patent/AU2003234022B2/en not_active Ceased
- 2003-05-23 WO PCT/GB2003/002236 patent/WO2003099816A1/en not_active Ceased
- 2003-05-23 CA CA002486750A patent/CA2486750A1/en not_active Abandoned
- 2003-05-23 EP EP03727692A patent/EP1511747B1/de not_active Expired - Lifetime
- 2003-05-23 DE DE60304572T patent/DE60304572T2/de not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US20050165048A1 (en) | 2005-07-28 |
| AU2003234022B2 (en) | 2009-06-25 |
| WO2003099816A1 (en) | 2003-12-04 |
| JP2005531582A (ja) | 2005-10-20 |
| EP1511747A1 (de) | 2005-03-09 |
| EP1511747B1 (de) | 2006-04-12 |
| AU2003234022A1 (en) | 2003-12-12 |
| DE60304572T2 (de) | 2006-12-14 |
| ES2260623T3 (es) | 2006-11-01 |
| DE60304572D1 (de) | 2006-05-24 |
| CA2486750A1 (en) | 2003-12-04 |
| US7279580B2 (en) | 2007-10-09 |
| GB0212048D0 (en) | 2002-07-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |