ATE339495T1 - Gefrierkonservierte hepatocyten und verfahren für ihre herstellung - Google Patents

Gefrierkonservierte hepatocyten und verfahren für ihre herstellung

Info

Publication number
ATE339495T1
ATE339495T1 AT96924541T AT96924541T ATE339495T1 AT E339495 T1 ATE339495 T1 AT E339495T1 AT 96924541 T AT96924541 T AT 96924541T AT 96924541 T AT96924541 T AT 96924541T AT E339495 T1 ATE339495 T1 AT E339495T1
Authority
AT
Austria
Prior art keywords
hepatocytes
containers
production
cryopreserved
minus
Prior art date
Application number
AT96924541T
Other languages
English (en)
Inventor
Hugo O Jauregui
Donna Trenkler
Henry Santangini
Sharda Naik
Timothy Jon Perlman
Shawn P Cain
Claudy Jean Paul Mullon
Original Assignee
Arbios Systems Inc
Rhode Island Hospital
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arbios Systems Inc, Rhode Island Hospital filed Critical Arbios Systems Inc
Application granted granted Critical
Publication of ATE339495T1 publication Critical patent/ATE339495T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A01N1/12—Chemical aspects of preservation
    • A01N1/122—Preservation or perfusion media
    • A01N1/125—Freeze protecting agents, e.g. cryoprotectants or osmolarity regulators
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A01N1/12—Chemical aspects of preservation
    • A01N1/122—Preservation or perfusion media
    • A01N1/126—Physiologically active agents, e.g. antioxidants or nutrients
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A01N1/14—Mechanical aspects of preservation; Apparatus or containers therefor
    • A01N1/146—Non-refrigerated containers specially adapted for transporting or storing living parts whilst preserving
    • A01N1/147—Carriers for immersion in cryogenic fluid for slow freezing or vitrification
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A01N1/16—Physical preservation processes
    • A01N1/162—Temperature processes, e.g. following predefined temperature changes over time
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3895—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells using specific culture conditions, e.g. stimulating differentiation of stem cells, pulsatile flow conditions

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Environmental Sciences (AREA)
  • Dermatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Botany (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Cell Biology (AREA)
  • Public Health (AREA)
  • Urology & Nephrology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Vascular Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • External Artificial Organs (AREA)
AT96924541T 1996-04-04 1996-07-16 Gefrierkonservierte hepatocyten und verfahren für ihre herstellung ATE339495T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/627,446 US5795711A (en) 1996-04-04 1996-04-04 Cryopreserved hepatocytes and high viability and metabolic activity

Publications (1)

Publication Number Publication Date
ATE339495T1 true ATE339495T1 (de) 2006-10-15

Family

ID=24514676

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96924541T ATE339495T1 (de) 1996-04-04 1996-07-16 Gefrierkonservierte hepatocyten und verfahren für ihre herstellung

Country Status (9)

Country Link
US (2) US5795711A (de)
EP (2) EP0832192B1 (de)
JP (1) JP4191798B2 (de)
AT (1) ATE339495T1 (de)
AU (1) AU711552B2 (de)
CA (1) CA2223558A1 (de)
DE (1) DE69636545T2 (de)
ES (1) ES2270439T3 (de)
WO (1) WO1997038092A1 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5875598A (en) * 1997-02-05 1998-08-26 University Of Hertfordshire Preparation of spheroids and their use in medicin or diagnosis
US6176089B1 (en) * 1998-10-27 2001-01-23 Modex Th{acute over (e)}rapeutics Methods and compositions for cryopreservation of cells and tissues
AU779706B2 (en) 1999-01-19 2005-02-10 University Of North Carolina At Chapel Hill, The Human liver progenitors
AU2002246747A1 (en) * 2000-12-27 2002-08-06 Ortec International, Inc. Processes for making cryopreserved composite living constructs and products resulting therefrom
US7604930B1 (en) * 2001-07-26 2009-10-20 University Of Kentucky Research Foundation Methods and devices for cryopreservation of biological cells and tissues
WO2005028640A1 (en) * 2003-09-19 2005-03-31 Newsouth Innovations Pty Limited Method for isolating hepatocytes
CN1910275B (zh) * 2003-12-01 2011-04-27 威特克斯医药股份有限公司 包含胎儿肝细胞的组合物及其用于hcv感染的方法
US7604929B2 (en) 2005-04-21 2009-10-20 In Vitro Technologies, Inc. Cellular compositions and methods for their preparation
DE102005057106A1 (de) * 2005-11-25 2007-06-06 Cytonet Gmbh & Co. Kg Kryokonservierung von Hepatocyten
JP5841322B2 (ja) 2010-04-22 2016-01-13 オレゴン ヘルス アンド サイエンス ユニバーシティ フマリルアセト酢酸ヒドロラーゼ（ｆａｈ）欠損性ブタおよびその使用
EP2747551B1 (de) 2011-08-26 2020-02-12 Yecuris Corporation Fumarylacetoacetat-hydrolase (fah)-defiziente und immundefiziente ratten sowie ihre verwendung
US9078430B2 (en) * 2012-09-18 2015-07-14 Albert Li Cell preparation method
JP6317089B2 (ja) * 2013-10-15 2018-04-25 テルモ株式会社 凍結保存細胞からの生存細胞回収量予測方法
DK3644728T3 (da) 2017-06-28 2022-10-31 Sci Group As Frysning af biologisk materiale
CN107287117B (zh) * 2017-07-21 2021-07-23 华北理工大学 肝细胞大规模培养和冷冻的装置
GB2582521B (en) * 2017-11-14 2022-07-13 Cook Biotech Inc Preserved tissue products and related methods
US20220095609A1 (en) * 2018-12-28 2022-03-31 Sci-Group As Freezing of biological material
US12453805B2 (en) 2020-09-24 2025-10-28 Everest Medical Innovation GmbH Cryoprotective compositions, surgical kits, and methods for protection of a surgical site during cryosurgery
US12426594B2 (en) 2020-09-24 2025-09-30 Everest Medical Innovation GmbH Cryoprotective compositions and methods for protection of a surgical site during cryosurgery
CN112690272B (zh) * 2021-01-18 2022-08-02 南昌五元生物科技有限公司 一种低温保存液及其保存方法
AU2022218710A1 (en) * 2021-02-09 2023-08-10 Takeda Pharmaceutical Company Limited Methods and compositions for freezing and thawing mammalian cells
TW202245598A (zh) 2021-02-09 2022-12-01 美商千禧製藥公司 用於冷凍及解凍哺乳動物細胞的方法及組成物
US20260015580A1 (en) 2022-07-25 2026-01-15 The Regents Of The University Of California Methods of Producing and Using Avian Embryonic Stem Cells and Avian Telencephalic Organoids

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4963489A (en) * 1987-04-14 1990-10-16 Marrow-Tech, Inc. Three-dimensional cell and tissue culture system

Also Published As

Publication number Publication date
EP0832192A4 (de) 1998-05-06
ES2270439T3 (es) 2007-04-01
EP1705244A2 (de) 2006-09-27
WO1997038092A1 (en) 1997-10-16
DE69636545T2 (de) 2007-01-11
AU6496396A (en) 1997-10-29
US6136525A (en) 2000-10-24
CA2223558A1 (en) 1997-10-16
JP4191798B2 (ja) 2008-12-03
EP0832192A1 (de) 1998-04-01
DE69636545D1 (de) 2006-10-26
JPH11506687A (ja) 1999-06-15
US5795711A (en) 1998-08-18
EP1705244A3 (de) 2006-10-11
AU711552B2 (en) 1999-10-14
EP0832192B1 (de) 2006-09-13

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