ATE340174T1 - Verfahren zur umwandlung von dihidroisoxazol derivate in gamma-hydroxaminsäurederivate, z.b monatins - Google Patents
Verfahren zur umwandlung von dihidroisoxazol derivate in gamma-hydroxaminsäurederivate, z.b monatinsInfo
- Publication number
- ATE340174T1 ATE340174T1 AT03005268T AT03005268T ATE340174T1 AT E340174 T1 ATE340174 T1 AT E340174T1 AT 03005268 T AT03005268 T AT 03005268T AT 03005268 T AT03005268 T AT 03005268T AT E340174 T1 ATE340174 T1 AT E340174T1
- Authority
- AT
- Austria
- Prior art keywords
- derivatives
- monatins
- gamma
- dihidroisoxazole
- converting
- Prior art date
Links
- 239000002253 acid Substances 0.000 title abstract 2
- 238000009903 catalytic hydrogenation reaction Methods 0.000 abstract 2
- YBKZKMWNFKMYEX-UHFFFAOYSA-N 5-(1h-indol-2-ylmethyl)-4h-1,2-oxazole-3,5-dicarboxylic acid Chemical compound C1C(C(=O)O)=NOC1(C(O)=O)CC1=CC2=CC=CC=C2N1 YBKZKMWNFKMYEX-UHFFFAOYSA-N 0.000 abstract 1
- 125000005048 dihydroisoxazolyl group Chemical class O1N(CC=C1)* 0.000 abstract 1
- 235000003599 food sweetener Nutrition 0.000 abstract 1
- 239000004615 ingredient Substances 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 239000003765 sweetening agent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
- A23L27/30—Artificial sweetening agents
- A23L27/31—Artificial sweetening agents containing amino acids, nucleotides, peptides or derivatives
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Food Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Nutrition Science (AREA)
- Polymers & Plastics (AREA)
- Health & Medical Sciences (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2002098515A JP2003292484A (ja) | 2002-04-01 | 2002-04-01 | γ−ヒドロキシアミノ酸誘導体及びモナティン類の製造方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE340174T1 true ATE340174T1 (de) | 2006-10-15 |
Family
ID=28035889
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03005268T ATE340174T1 (de) | 2002-04-01 | 2003-03-10 | Verfahren zur umwandlung von dihidroisoxazol derivate in gamma-hydroxaminsäurederivate, z.b monatins |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US7329427B2 (de) |
| EP (1) | EP1350791B1 (de) |
| JP (1) | JP2003292484A (de) |
| AT (1) | ATE340174T1 (de) |
| CA (1) | CA2423691C (de) |
| DE (1) | DE60308435T2 (de) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100966035B1 (ko) * | 2001-11-30 | 2010-06-25 | 아지노모토 가부시키가이샤 | 모나틴의 비천연형 입체이성체 염의 결정 및 이의 사용 |
| CN100465156C (zh) * | 2001-12-27 | 2009-03-04 | 味之素株式会社 | 谷氨酸化合物及其制备中间体的制造方法与为此所用的新型中间体 |
| US7297800B2 (en) * | 2001-12-27 | 2007-11-20 | Ajinomoto Co., Inc. | Process of producing glutamate derivatives |
| JP2003292484A (ja) | 2002-04-01 | 2003-10-15 | Ajinomoto Co Inc | γ−ヒドロキシアミノ酸誘導体及びモナティン類の製造方法 |
| US8372989B2 (en) | 2002-04-23 | 2013-02-12 | Cargill, Incorporated | Polypeptides and biosynthetic pathways for the production of monatin and its precursors |
| US7572607B2 (en) * | 2002-04-23 | 2009-08-11 | Cargill, Incorporated | Polypeptides and biosynthetic pathways for the production of monatin and its precursors |
| CA2484871C (en) * | 2002-08-26 | 2010-11-30 | Ajinomoto Co., Inc. | Novel aldolase and production process of substituted .alpha.-keto acids |
| AU2003289264A1 (en) | 2002-12-09 | 2004-06-30 | Ajinomoto Co., Inc. | Mutant d-aminotransferase and process for producing optically active glutamic acid derivative using the same |
| KR101160473B1 (ko) * | 2003-01-09 | 2012-06-28 | 아지노모토 가부시키가이샤 | 글루탐산 유도체 및 피로글루탐산 유도체의 제조 방법 및신규 제조 중간체 |
| EP1648248A2 (de) | 2003-08-01 | 2006-04-26 | Cargill, Incorporated | Monatin-süssstoffzusammensetzungen für den tisch und verfahren zur herstellung davon |
| KR101194132B1 (ko) * | 2003-08-14 | 2012-10-25 | 카아길, 인코포레이팃드 | 모나틴을 포함하는 추잉검 조성물 및 이의 제조 방법 |
| US20050106305A1 (en) * | 2003-08-25 | 2005-05-19 | Cargill, Inc. | Beverage compositions comprising monatin and methods of making same |
| US8206955B2 (en) | 2003-10-21 | 2012-06-26 | Cargill, Incorporated | Production of monatin and monatin precursors |
| JP5113978B2 (ja) * | 2003-11-21 | 2013-01-09 | 味の素株式会社 | グルタミン酸誘導体の有機アミン塩及びその利用 |
| JP5319885B2 (ja) * | 2004-02-27 | 2013-10-16 | 味の素株式会社 | モナティンの製造方法 |
| US7935377B2 (en) * | 2004-06-04 | 2011-05-03 | Ajinomoto Co., Inc. | Crystals of free (2R, 4R)-monatin and use thereof |
| CA2506247C (en) * | 2004-06-07 | 2012-02-21 | Ajinomoto Co., Inc. | Novel aldolase, and method for producing optically active ihog and monatin |
| JPWO2006038520A1 (ja) * | 2004-10-05 | 2008-05-15 | 味の素株式会社 | ヒドロキシイミノ酸からのアミノ酸誘導体製造方法 |
| CN101035442B (zh) * | 2004-10-15 | 2012-04-11 | 味之素株式会社 | 甜味剂组合物 |
| US8158389B2 (en) | 2005-04-20 | 2012-04-17 | Cargill, Incorporated | Products and methods for in vivo secretion of monatin |
| EP1883817A4 (de) | 2005-04-20 | 2009-09-23 | Cargill Inc | Produkte und verfahren zur in-vivo-sekretion von monatin |
| US8076108B2 (en) | 2005-04-26 | 2011-12-13 | Cargill, Incorporated | Polypeptides and biosynthetic pathways for the production of stereoisomers of monatin and their precursors |
| US7582455B2 (en) | 2005-04-26 | 2009-09-01 | Cargill, Incorporated | Polypeptides and biosynthetic pathways for the production of stereoisomers of monatin and their precursors |
| AU2006341528A1 (en) * | 2005-04-26 | 2007-12-06 | Cargill, Incorporated | Polypeptides and biosynthetic pathways for the production of stereoisomers of monatin and their precursors |
| US9101160B2 (en) | 2005-11-23 | 2015-08-11 | The Coca-Cola Company | Condiments with high-potency sweetener |
| ES2416104T3 (es) | 2006-03-07 | 2013-07-30 | Cargill, Incorporated | Aldolasas, ácidos nucleicos que las codifican y métodos para producir y usar las mismas |
| JP2009538145A (ja) | 2006-05-24 | 2009-11-05 | カーギル・インコーポレイテッド | 平衡反応の収量を増加させるための方法およびシステム |
| US20090198072A1 (en) * | 2006-05-24 | 2009-08-06 | Cargill, Incorporated | Methods and systems for increasing production of equilibrium reactions |
| US8017168B2 (en) | 2006-11-02 | 2011-09-13 | The Coca-Cola Company | High-potency sweetener composition with rubisco protein, rubiscolin, rubiscolin derivatives, ace inhibitory peptides, and combinations thereof, and compositions sweetened therewith |
| US8076107B2 (en) * | 2007-10-01 | 2011-12-13 | Cargill, Incorporated | Production of monatin stereoisomers |
| US8367847B2 (en) | 2007-10-01 | 2013-02-05 | Cargill, Incorporated | Production of monatin enantiomers |
| US8003361B2 (en) | 2007-10-01 | 2011-08-23 | Cargill Incorporated | Production of monatin enantiomers |
| EP2107053A1 (de) | 2008-03-11 | 2009-10-07 | Ajinomoto Co., Inc. | Hydratkristalle von (2R,4R)-Monatin Mononatrium-Salz |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2063443T3 (es) * | 1990-01-19 | 1995-01-01 | Technology Finance Corp | Procedimiento para la produccion de 3-(1-amino-1,3-dicarboxi-3-hidroxi-but-4-il) indol. |
| US5994559A (en) | 1998-08-06 | 1999-11-30 | The Board Of Governors For Higher Education, State Of Rhode Island And Providence Plantations | Synthesis of monatin-A high intensity natural sweetener |
| JP2002060382A (ja) * | 2000-08-22 | 2002-02-26 | Ajinomoto Co Inc | モナティンの立体異性体及びその使用、並びにモナティン類の製造方法及びそのための中間体 |
| JP2003292484A (ja) | 2002-04-01 | 2003-10-15 | Ajinomoto Co Inc | γ−ヒドロキシアミノ酸誘導体及びモナティン類の製造方法 |
-
2002
- 2002-04-01 JP JP2002098515A patent/JP2003292484A/ja active Pending
-
2003
- 2003-03-10 DE DE60308435T patent/DE60308435T2/de not_active Expired - Lifetime
- 2003-03-10 EP EP03005268A patent/EP1350791B1/de not_active Expired - Lifetime
- 2003-03-10 AT AT03005268T patent/ATE340174T1/de not_active IP Right Cessation
- 2003-03-27 US US10/397,407 patent/US7329427B2/en not_active Expired - Fee Related
- 2003-03-27 CA CA2423691A patent/CA2423691C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE60308435D1 (de) | 2006-11-02 |
| EP1350791B1 (de) | 2006-09-20 |
| CA2423691C (en) | 2010-09-14 |
| DE60308435T2 (de) | 2007-05-03 |
| EP1350791A1 (de) | 2003-10-08 |
| CA2423691A1 (en) | 2003-10-01 |
| US20030228403A1 (en) | 2003-12-11 |
| JP2003292484A (ja) | 2003-10-15 |
| US7329427B2 (en) | 2008-02-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |