ATE512224T1 - Rekonstituierter menschlicher anti-hm.1 antikörper - Google Patents

Rekonstituierter menschlicher anti-hm.1 antikörper

Info

Publication number
ATE512224T1
ATE512224T1 AT97942246T AT97942246T ATE512224T1 AT E512224 T1 ATE512224 T1 AT E512224T1 AT 97942246 T AT97942246 T AT 97942246T AT 97942246 T AT97942246 T AT 97942246T AT E512224 T1 ATE512224 T1 AT E512224T1
Authority
AT
Austria
Prior art keywords
chain
human
antibody
antibodies
region
Prior art date
Application number
AT97942246T
Other languages
English (en)
Inventor
Koichiro Ono
Toshihiko Ohtomo
Masayuki Tsuchiya
Yasushi Yoshimura
Yasuo Koishihara
Masaaki Kosaka
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ATE512224T1 publication Critical patent/ATE512224T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3061—Blood cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Cell Biology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT97942246T 1996-10-04 1997-10-03 Rekonstituierter menschlicher anti-hm.1 antikörper ATE512224T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP26475696 1996-10-04
PCT/JP1997/003553 WO1998014580A1 (en) 1996-10-04 1997-10-03 Reconstituted human anti-hm1.24 antibody

Publications (1)

Publication Number Publication Date
ATE512224T1 true ATE512224T1 (de) 2011-06-15

Family

ID=17407753

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97942246T ATE512224T1 (de) 1996-10-04 1997-10-03 Rekonstituierter menschlicher anti-hm.1 antikörper

Country Status (19)

Country Link
US (2) US6699974B2 (de)
EP (1) EP0960936B1 (de)
KR (1) KR100388256B1 (de)
CN (2) CN1271205C (de)
AT (1) ATE512224T1 (de)
AU (1) AU715156B2 (de)
BR (1) BR9712488A (de)
CA (1) CA2267072C (de)
CZ (1) CZ296790B6 (de)
IL (1) IL129286A0 (de)
NO (1) NO325178B1 (de)
PL (1) PL187642B1 (de)
RU (1) RU2184147C2 (de)
SK (1) SK44399A3 (de)
TR (1) TR199900722T2 (de)
TW (1) TW530064B (de)
UA (1) UA76934C2 (de)
WO (1) WO1998014580A1 (de)
ZA (1) ZA978865B (de)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20000070989A (ko) * 1997-02-12 2000-11-25 나가야마 오사무 임파구계 종양의 치료제
EP0972524A4 (de) * 1997-02-28 2001-03-28 Chugai Pharmaceutical Co Ltd Lymphozyten aktivierungsinhibitoren
WO1999018997A1 (en) 1997-10-14 1999-04-22 Chugai Seiyaku Kabushiki Kaisha Potentiator for antibody against lymphoid tumor
JP3609026B2 (ja) * 1998-02-25 2005-01-12 中外製薬株式会社 抗ｈｍ１．２４抗体の免疫化学的測定方法
WO2000017395A1 (fr) 1998-09-18 2000-03-30 Chugai Seiyaku Kabushiki Kaisha Procede de detection ou de mesure de plasmocytomes
HK1045715B (zh) * 1999-05-10 2005-06-03 中外制药株式会社 培养细胞的方法
KR20020025990A (ko) 1999-08-23 2002-04-04 나가야마 오사무 에이치엠1.24 항원의 발현 증강제
WO2001077362A1 (fr) * 2000-04-06 2001-10-18 Chugai Seiyaku Kabushiki Kaisha Dosage immunologique d'anticorps anti hm1 . 24
US8632778B2 (en) 2000-08-11 2014-01-21 Chugai Seiyaku Kabushiki Kaisha Stabilized anti-interleukin-6 antibody-containing preparations
WO2002057316A1 (en) * 2000-12-28 2002-07-25 Kirin Beer Kabushiki Kaisha Novel monoclonal antibody
JP3986439B2 (ja) 2001-02-07 2007-10-03 中外製薬株式会社 造血器腫瘍の治療剤
ES2869895T3 (es) 2001-03-09 2021-10-26 Chugai Pharmaceutical Co Ltd Método de purificación de proteínas
CA2441228A1 (en) * 2001-03-23 2002-10-03 Aphton Corporation Combination treatment of pancreatic cancer
WO2002084290A1 (fr) 2001-04-13 2002-10-24 Chugai Seiyaku Kabushiki Kaisha Procede permettant de quantifier l'expression d'antigenes
US20090191232A1 (en) * 2001-05-04 2009-07-30 Gevas Philip C Combination therapy for the treatment of tumors
EP1411118B1 (de) * 2001-06-22 2008-09-03 Chugai Seiyaku Kabushiki Kaisha Zellproliferationsinhibitoren mit anti-glypican-3-antikörper
JP2004536835A (ja) * 2001-07-09 2004-12-09 アフトン コーポレーション 肝臓、肺および食道の癌性ならびに前癌性状態の治療および防止
WO2003068260A1 (fr) 2002-02-14 2003-08-21 Chugai Seiyaku Kabushiki Kaisha Produits pharmaceutiques en solution contenant des anticorps
US20080219974A1 (en) * 2002-03-01 2008-09-11 Bernett Matthew J Optimized antibodies that target hm1.24
EP1513879B1 (de) * 2002-06-03 2018-08-22 Genentech, Inc. Bibliotheken synthetischer antikörperphagen
WO2004019966A1 (ja) 2002-08-27 2004-03-11 Chugai Seiyaku Kabushiki Kaisha タンパク質溶液製剤の安定化方法
CN100522989C (zh) 2002-09-11 2009-08-05 中外制药株式会社 纯化蛋白质的方法
US20060020119A1 (en) * 2004-03-29 2006-01-26 Stephen Grimes Monoclonal antibodies to gastrin hormone
US7235376B2 (en) * 2003-03-28 2007-06-26 Receptor Biologix, Inc. Gastrin hormone immunoassays
US20070142627A1 (en) * 2003-08-01 2007-06-21 Chugai Seiyaku Kabushiki Kaisha Sugar-chain-altered anti-hm1.24 antibody
JP2007501011A (ja) * 2003-08-01 2007-01-25 ジェネンテック・インコーポレーテッド 制限多様性配列を有する結合型ポリペプチド
EP1693069B1 (de) * 2003-10-10 2013-07-24 Chugai Seiyaku Kabushiki Kaisha Mittel zur behandlung von soliden tumoren
HUE038955T2 (hu) 2003-11-05 2018-12-28 Roche Glycart Ag Antigén-kötõ molekulák fokozott Fc receptor-kötõ affinitással és effektor funkcióval
EP2168986A3 (de) * 2004-02-19 2010-07-28 Genentech, Inc. Antikörper mit korrigiertem CDR
EP2567974A3 (de) 2004-09-22 2013-05-22 Cancer Advances, Inc., Monoklonale Antikörper gegen Progastrin
AU2006290433B2 (en) * 2005-08-26 2012-06-07 Roche Glycart Ag Modified antigen binding molecules with altered cell signaling activity
AU2012216702B2 (en) * 2005-08-26 2014-12-04 Roche Glycart Ag Modified antigen binding molecules with altered cell signaling activity
EP1957531B1 (de) 2005-11-07 2016-04-13 Genentech, Inc. Bindungspolypeptide mit diversifizierten und konsensus-vh/vl-hypervariablen sequenzen
WO2007064919A2 (en) * 2005-12-02 2007-06-07 Genentech, Inc. Binding polypeptides with restricted diversity sequences
JP5231810B2 (ja) 2005-12-28 2013-07-10 中外製薬株式会社 抗体含有安定化製剤
EP2064240A2 (de) * 2006-09-18 2009-06-03 Xencor, Inc. Optimierte auf hm1.24 abzielende antikörper
PE20091174A1 (es) 2007-12-27 2009-08-03 Chugai Pharmaceutical Co Ltd Formulacion liquida con contenido de alta concentracion de anticuerpo
IN2015DN02826A (de) * 2009-09-03 2015-09-11 Merck Sharp & Dohme
AR080428A1 (es) 2010-01-20 2012-04-11 Chugai Pharmaceutical Co Ltd Formulaciones liquidas estabilizadas contentivas de anticuerpos
JP6176849B2 (ja) 2011-07-19 2017-08-09 中外製薬株式会社 アルギニンアミドまたはその類似化合物を含む安定なタンパク質含有製剤
CN103889555B (zh) 2011-09-01 2018-10-26 中外制药株式会社 通过超滤制备包含高度浓缩的抗体的组合物的方法
US10654933B2 (en) 2013-12-27 2020-05-19 Chugai Seiyaku Kabushiki Kaisha Method for purifying antibody having low isoelectric point
EP3185004A4 (de) 2014-08-20 2018-05-30 Chugai Seiyaku Kabushiki Kaisha Verfahren zur messung der viskosität einer proteinlösung
MA40764A (fr) 2014-09-26 2017-08-01 Chugai Pharmaceutical Co Ltd Agent thérapeutique induisant une cytotoxicité
US12150978B2 (en) 2017-06-15 2024-11-26 Cancer Advances Inc. Compositions and methods for preventing tumors and cancer
IL271427B2 (en) 2017-06-15 2025-08-01 Cancer Advances Inc Compositions and methods for inducing humoral and cellular immunities against tumors and cancer
CN109748964B (zh) * 2017-11-01 2020-11-17 深圳宾德生物技术有限公司 CD317单链抗体317scFv、其编码序列及制备方法和应用
WO2019195770A1 (en) 2018-04-06 2019-10-10 Atyr Pharma, Inc. Compositions and methods comprising anti-nrp2 antibodies
JP7549530B2 (ja) 2018-05-21 2024-09-11 中外製薬株式会社 ガラス容器に封入された凍結乾燥製剤
EP3805112A4 (de) 2018-05-28 2022-03-09 Chugai Seiyaku Kabushiki Kaisha Fülldüse
AU2020358854B2 (en) * 2019-10-03 2026-08-13 Atyr Pharma, Inc. Compositions and methods comprising anti-NRP2 antibodies
EP4413998A4 (de) 2021-10-08 2026-02-25 Chugai Pharmaceutical Co Ltd Verfahren zur herstellung einer vorgefüllten spritzenformulierung
WO2023091887A1 (en) 2021-11-16 2023-05-25 Genentech, Inc. Methods and compositions for treating systemic lupus erythematosus (sle) with mosunetuzumab
KR20250005335A (ko) 2022-04-26 2025-01-09 추가이 세이야쿠 가부시키가이샤 의약 제제 함유 필터 내장 시린지
WO2024214811A1 (ja) 2023-04-14 2024-10-17 中外製薬株式会社 タンパク質含有医薬製剤の安定化方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO873164L (no) * 1986-07-30 1988-02-01 Teijin Ltd Muse-humane kimaere antistoffer.
US5530101A (en) * 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
IL162181A (en) 1988-12-28 2006-04-10 Pdl Biopharma Inc A method of producing humanized immunoglubulin, and polynucleotides encoding the same
GB8928874D0 (en) * 1989-12-21 1990-02-28 Celltech Ltd Humanised antibodies
GB9014932D0 (en) * 1990-07-05 1990-08-22 Celltech Ltd Recombinant dna product and method
AU668349B2 (en) * 1991-04-25 1996-05-02 Chugai Seiyaku Kabushiki Kaisha Reconstituted human antibody against human interleukin 6 receptor
AU3272695A (en) * 1994-08-12 1996-03-07 Immunomedics Inc. Immunoconjugates and humanized antibodies specific for b-cell lymphoma and leukemia cells
KR20000070989A (ko) * 1997-02-12 2000-11-25 나가야마 오사무 임파구계 종양의 치료제
US20020034507A1 (en) * 1997-02-28 2002-03-21 Yasuo Koishihara Inhibitor of lymphocyte activation
AU750453B2 (en) * 1997-10-03 2002-07-18 Chugai Seiyaku Kabushiki Kaisha Natural human antibody
WO1999018997A1 (en) * 1997-10-14 1999-04-22 Chugai Seiyaku Kabushiki Kaisha Potentiator for antibody against lymphoid tumor
CN1678634A (zh) * 2002-06-28 2005-10-05 多曼蒂斯有限公司 免疫球蛋白单个变体抗原结合区及其特异性构建体

Also Published As

Publication number Publication date
IL129286A0 (en) 2000-02-17
BR9712488A (pt) 1999-10-19
US7892543B2 (en) 2011-02-22
NO325178B1 (no) 2008-02-11
PL332742A1 (en) 1999-10-11
TW530064B (en) 2003-05-01
SK44399A3 (en) 2000-05-16
US20030129185A1 (en) 2003-07-10
KR20000048884A (ko) 2000-07-25
KR100388256B1 (ko) 2003-06-19
UA76934C2 (en) 2006-10-16
WO1998014580A1 (en) 1998-04-09
CN1765928A (zh) 2006-05-03
CN1235639A (zh) 1999-11-17
EP0960936A1 (de) 1999-12-01
US20030045691A1 (en) 2003-03-06
CA2267072C (en) 2004-11-30
ZA978865B (en) 1998-04-20
CA2267072A1 (en) 1998-04-09
TR199900722T2 (xx) 1999-12-21
EP0960936B1 (de) 2011-06-08
RU2184147C2 (ru) 2002-06-27
US6699974B2 (en) 2004-03-02
HK1024261A1 (en) 2000-10-05
PL187642B1 (pl) 2004-08-31
CZ117399A3 (cs) 1999-09-15
NO991591L (no) 1999-06-01
NO991591D0 (no) 1999-03-31
AU715156B2 (en) 2000-01-20
EP0960936A4 (de) 2005-01-19
CN1271205C (zh) 2006-08-23
CZ296790B6 (cs) 2006-06-14
AU4399297A (en) 1998-04-24

Similar Documents

Publication Publication Date Title
NO991591L (no) Rekonstituert human anti-HM1.24 antistoff
ATE340590T1 (de) Gegen menschliches interleukin-8 gerichteter, rekonstituierter menschlicher antikörper
ATE373712T1 (de) Natürlicher menschlicher antikörper
AU692100B2 (en) Reconstituted human antibody against human interleukin 6 receptor
IL138801A0 (en) Humanized antibody against human tissue factor and process for the preparation thereof
FR12C0004I2 (fr) Anticorps contre l'antigene ctla-4 humain et utilisation
MXPA03009408A (es) Factor de crecimiento endotelial vascular 2.
EP0536275A4 (en) Tissue-derived tumor growth inhibitors, methods of preparation and uses thereof
EP0783525A4 (de) Chimäre mensch-mausantikörper gegen das respiratorische syncytialvirus
ATE166230T1 (de) Verwendung von anti-icam antikörpern zur herstellung eines präparats für die behandlung von endotoxinschock
DK0589840T3 (da) Omdannede monoklonale antistoffer mod en immunoglobulinisotype
WO1991010735A3 (fr) Recepteur humain de la tsh. sequence codant pour ce recepteur
SE9201281D0 (sv) New human monoclonal antibodies, and a method for preparation thereof
DE59207362D1 (de) Monoklonale Antikörper gegen den Plasmin-Antiplasmin Komplex, Verfahren zu ihrer Herstellung sowie ihre Verwendung

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties