ATE512224T1 - Rekonstituierter menschlicher anti-hm.1 antikörper - Google Patents

Rekonstituierter menschlicher anti-hm.1 antikörper

Info

Publication number
ATE512224T1
ATE512224T1 AT97942246T AT97942246T ATE512224T1 AT E512224 T1 ATE512224 T1 AT E512224T1 AT 97942246 T AT97942246 T AT 97942246T AT 97942246 T AT97942246 T AT 97942246T AT E512224 T1 ATE512224 T1 AT E512224T1
Authority
AT
Austria
Prior art keywords
chain
human
antibody
antibodies
region
Prior art date
Application number
AT97942246T
Other languages
English (en)
Inventor
Koichiro Ono
Toshihiko Ohtomo
Masayuki Tsuchiya
Yasushi Yoshimura
Yasuo Koishihara
Masaaki Kosaka
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ATE512224T1 publication Critical patent/ATE512224T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3061—Blood cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Cell Biology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT97942246T 1996-10-04 1997-10-03 Rekonstituierter menschlicher anti-hm.1 antikörper ATE512224T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP26475696 1996-10-04
PCT/JP1997/003553 WO1998014580A1 (en) 1996-10-04 1997-10-03 Reconstituted human anti-hm1.24 antibody

Publications (1)

Publication Number Publication Date
ATE512224T1 true ATE512224T1 (de) 2011-06-15

Family

ID=17407753

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97942246T ATE512224T1 (de) 1996-10-04 1997-10-03 Rekonstituierter menschlicher anti-hm.1 antikörper

Country Status (19)

Country Link
US (2) US6699974B2 (de)
EP (1) EP0960936B1 (de)
KR (1) KR100388256B1 (de)
CN (2) CN1765928A (de)
AT (1) ATE512224T1 (de)
AU (1) AU715156B2 (de)
BR (1) BR9712488A (de)
CA (1) CA2267072C (de)
CZ (1) CZ296790B6 (de)
IL (1) IL129286A0 (de)
NO (1) NO325178B1 (de)
PL (1) PL187642B1 (de)
RU (1) RU2184147C2 (de)
SK (1) SK44399A3 (de)
TR (1) TR199900722T2 (de)
TW (1) TW530064B (de)
UA (1) UA76934C2 (de)
WO (1) WO1998014580A1 (de)
ZA (1) ZA978865B (de)

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HUP0001136A3 (en) 1997-02-12 2002-02-28 Chugai Pharmaceutical Co Ltd Remedies for lymphocytic tumors
KR100370744B1 (ko) * 1997-02-28 2003-02-05 츄가이 세이야꾸 가부시키가이샤 임파구의 활성화 억제제
AU732306B2 (en) 1997-10-14 2001-04-12 Chugai Seiyaku Kabushiki Kaisha Potentiator for antibody against lymphoid tumor
EP1059533A4 (de) * 1998-02-25 2005-02-09 Chugai Pharmaceutical Co Ltd Methode zum immunologischen nachweis des anti-hm1.24 antikörpers
WO2000017395A1 (fr) 1998-09-18 2000-03-30 Chugai Seiyaku Kabushiki Kaisha Procede de detection ou de mesure de plasmocytomes
EP1176194B1 (de) 1999-05-10 2005-07-20 Chugai Seiyaku Kabushiki Kaisha Verfahren der zellkultivierung
ATE404216T1 (de) 1999-08-23 2008-08-15 Chugai Pharmaceutical Co Ltd Verstärker der hm1.24 antigen-expression
AU2001246846A1 (en) * 2000-04-06 2001-10-23 Chugai Seiyaku Kabushiki Kaisha Immunoassay of anti-hm1.24 antibody
JP5485489B2 (ja) 2000-08-11 2014-05-07 中外製薬株式会社 抗体含有安定化製剤
WO2002057316A1 (en) * 2000-12-28 2002-07-25 Kirin Beer Kabushiki Kaisha Novel monoclonal antibody
JP3986439B2 (ja) 2001-02-07 2007-10-03 中外製薬株式会社 造血器腫瘍の治療剤
EP3088412B1 (de) 2001-03-09 2021-05-05 Chugai Seiyaku Kabushiki Kaisha Proteinaufreinigungsverfahren
JP2005508838A (ja) * 2001-03-23 2005-04-07 アフトン コーポレーション 膵癌の組合せ治療
EP1378752A4 (de) * 2001-04-13 2004-08-04 Chugai Pharmaceutical Co Ltd Verfahren zur quantifizierung der antigenexpression
US20090191232A1 (en) * 2001-05-04 2009-07-30 Gevas Philip C Combination therapy for the treatment of tumors
EP1411118B1 (de) * 2001-06-22 2008-09-03 Chugai Seiyaku Kabushiki Kaisha Zellproliferationsinhibitoren mit anti-glypican-3-antikörper
AU2002326356A1 (en) * 2001-07-09 2003-01-29 Aphton Corporation Treatment and prevention of cancerous and pre-cancerous conditions of the liver, lung and esophagus
EP3192528A1 (de) * 2002-02-14 2017-07-19 Chugai Seiyaku Kabushiki Kaisha Formularierung anti-il-6r antikörper-enthaltender lösungen die einen zucker als stabilisator beinhalten
US20080219974A1 (en) * 2002-03-01 2008-09-11 Bernett Matthew J Optimized antibodies that target hm1.24
CA2488441C (en) * 2002-06-03 2015-01-27 Genentech, Inc. Synthetic antibody phage libraries
AU2003257536A1 (en) 2002-08-27 2004-03-19 Chugai Seiyaku Kabushiki Kaisha Method of stabilizing protein solution preparation
ES2626268T3 (es) 2002-09-11 2017-07-24 Chugai Seiyaku Kabushiki Kaisha Método de purificación de proteínas
WO2004088326A2 (en) * 2003-03-28 2004-10-14 Aphton Corporation Gastrin hormone immunoassays
US20060020119A1 (en) * 2004-03-29 2006-01-26 Stephen Grimes Monoclonal antibodies to gastrin hormone
US20070142627A1 (en) * 2003-08-01 2007-06-21 Chugai Seiyaku Kabushiki Kaisha Sugar-chain-altered anti-hm1.24 antibody
AU2004261980A1 (en) * 2003-08-01 2005-02-10 Genentech, Inc. Antibody CDR polypeptide sequences with restricted diversity
EP1693069B1 (de) * 2003-10-10 2013-07-24 Chugai Seiyaku Kabushiki Kaisha Mittel zur behandlung von soliden tumoren
PT1692182E (pt) 2003-11-05 2010-05-13 Roche Glycart Ag Anticorpos de cd20 com uma afinidade de ligação acrescida ao receptor fc e uma função efectora acrescida
CA2555820C (en) * 2004-02-19 2016-01-19 Genentech, Inc. Cdr-repaired antibodies
EP1794586B1 (de) 2004-09-22 2013-01-30 Cancer Advances, Inc., Monoklonale antikörper gegen progastrin
AU2012216702B2 (en) * 2005-08-26 2014-12-04 Roche Glycart Ag Modified antigen binding molecules with altered cell signaling activity
RU2482132C2 (ru) * 2005-08-26 2013-05-20 Роше Гликарт Аг Модифицированные антигенсвязывающие молекулы с измененной клеточной сигнальной активностью
EP1957531B1 (de) 2005-11-07 2016-04-13 Genentech, Inc. Bindungspolypeptide mit diversifizierten und konsensus-vh/vl-hypervariablen sequenzen
WO2007064919A2 (en) * 2005-12-02 2007-06-07 Genentech, Inc. Binding polypeptides with restricted diversity sequences
JP5231810B2 (ja) 2005-12-28 2013-07-10 中外製薬株式会社 抗体含有安定化製剤
CA2660795C (en) * 2006-09-18 2014-11-18 Xencor, Inc. Optimized antibodies that target hm1.24
PE20091174A1 (es) 2007-12-27 2009-08-03 Chugai Pharmaceutical Co Ltd Formulacion liquida con contenido de alta concentracion de anticuerpo
PT3023438T (pt) 2009-09-03 2020-05-08 Merck Sharp & Dohme Anticorpos anti-gitr
AR080428A1 (es) 2010-01-20 2012-04-11 Chugai Pharmaceutical Co Ltd Formulaciones liquidas estabilizadas contentivas de anticuerpos
WO2013012022A1 (ja) 2011-07-19 2013-01-24 中外製薬株式会社 アルギニンアミドまたはその類似化合物を含む安定なタンパク質含有製剤
KR101993488B1 (ko) 2011-09-01 2019-06-26 추가이 세이야쿠 가부시키가이샤 한외여과에 의해 고도로 농축된 항체를 포함하는 조성물의 제조 방법
KR102344170B1 (ko) 2013-12-27 2021-12-27 추가이 세이야쿠 가부시키가이샤 등전점이 낮은 항체의 정제방법
US20170362304A1 (en) 2014-08-20 2017-12-21 Chugai Seiyaku Kabushiki Kaisha Method for measuring viscosity of protein solution
MA40764A (fr) 2014-09-26 2017-08-01 Chugai Pharmaceutical Co Ltd Agent thérapeutique induisant une cytotoxicité
US12150978B2 (en) 2017-06-15 2024-11-26 Cancer Advances Inc. Compositions and methods for preventing tumors and cancer
KR102772810B1 (ko) 2017-06-15 2025-02-28 캔서 어드밴시스 아이엔씨 종양 및 암에 대한 체액성 및 세포 면역을 유도하기 위한 조성물 및 방법
CN109748964B (zh) * 2017-11-01 2020-11-17 深圳宾德生物技术有限公司 CD317单链抗体317scFv、其编码序列及制备方法和应用
US11505610B2 (en) 2018-04-06 2022-11-22 Atyr Pharma, Inc. Compositions and methods comprising anti-NRP2 antibodies
US20210196568A1 (en) 2018-05-21 2021-07-01 Chugai Seiyaku Kabushiki Kaisha Lyophilized formulation sealed in glass container
CN112243423B (zh) 2018-05-28 2022-11-04 中外制药株式会社 填充喷嘴
CN114746120B (zh) 2019-10-03 2024-07-30 Atyr医药公司 包含抗nrp2抗体的组合物和方法
MX2024004117A (es) 2021-10-08 2024-04-19 Chugai Pharmaceutical Co Ltd Metodo para preparar formulacion de jeringa precargada.
EP4433506A1 (de) 2021-11-16 2024-09-25 Genentech, Inc. Verfahren und zusammensetzungen zur behandlung von systemischem lupus erythematodes (sle) mit momonetuzumab
TW202400262A (zh) 2022-04-26 2024-01-01 日商中外製藥股份有限公司 含有醫藥製劑的內含過濾器之注射器
WO2024214811A1 (ja) 2023-04-14 2024-10-17 中外製薬株式会社 タンパク質含有医薬製剤の安定化方法

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IL162181A (en) 1988-12-28 2006-04-10 Pdl Biopharma Inc A method of producing humanized immunoglubulin, and polynucleotides encoding the same
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ES2134212T3 (es) * 1991-04-25 1999-10-01 Chugai Pharmaceutical Co Ltd Anticuerpo humano reconstituido contra el receptor de la interleuquina 6 humano.
AU3272695A (en) * 1994-08-12 1996-03-07 Immunomedics Inc. Immunoconjugates and humanized antibodies specific for b-cell lymphoma and leukemia cells
HUP0001136A3 (en) * 1997-02-12 2002-02-28 Chugai Pharmaceutical Co Ltd Remedies for lymphocytic tumors
US20020034507A1 (en) * 1997-02-28 2002-03-21 Yasuo Koishihara Inhibitor of lymphocyte activation
CA2305712A1 (en) * 1997-10-03 1999-04-15 Chugai Seiyaku Kabushiki Kaisha Natural humanized antibody
AU732306B2 (en) * 1997-10-14 2001-04-12 Chugai Seiyaku Kabushiki Kaisha Potentiator for antibody against lymphoid tumor
EP1600459A3 (de) * 2002-06-28 2005-12-07 Domantis Limited Ligand

Also Published As

Publication number Publication date
IL129286A0 (en) 2000-02-17
US7892543B2 (en) 2011-02-22
RU2184147C2 (ru) 2002-06-27
AU715156B2 (en) 2000-01-20
NO325178B1 (no) 2008-02-11
HK1024261A1 (en) 2000-10-05
ZA978865B (en) 1998-04-20
CN1235639A (zh) 1999-11-17
PL187642B1 (pl) 2004-08-31
AU4399297A (en) 1998-04-24
CA2267072A1 (en) 1998-04-09
US6699974B2 (en) 2004-03-02
EP0960936A4 (de) 2005-01-19
EP0960936A1 (de) 1999-12-01
TR199900722T2 (xx) 1999-12-21
US20030129185A1 (en) 2003-07-10
KR100388256B1 (ko) 2003-06-19
CN1271205C (zh) 2006-08-23
NO991591L (no) 1999-06-01
PL332742A1 (en) 1999-10-11
TW530064B (en) 2003-05-01
US20030045691A1 (en) 2003-03-06
NO991591D0 (no) 1999-03-31
WO1998014580A1 (en) 1998-04-09
EP0960936B1 (de) 2011-06-08
KR20000048884A (ko) 2000-07-25
CZ296790B6 (cs) 2006-06-14
CA2267072C (en) 2004-11-30
BR9712488A (pt) 1999-10-19
CZ117399A3 (cs) 1999-09-15
UA76934C2 (en) 2006-10-16
CN1765928A (zh) 2006-05-03
SK44399A3 (en) 2000-05-16

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Legal Events

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties