ATE342365T1 - Menschliche protease und verwendung davon für pharmazeutischen anwendungen und zur reduktion der allergisierenden wirkung von nicht- menschlichen proteinen - Google Patents

Menschliche protease und verwendung davon für pharmazeutischen anwendungen und zur reduktion der allergisierenden wirkung von nicht- menschlichen proteinen

Info

Publication number
ATE342365T1
ATE342365T1 AT99918548T AT99918548T ATE342365T1 AT E342365 T1 ATE342365 T1 AT E342365T1 AT 99918548 T AT99918548 T AT 99918548T AT 99918548 T AT99918548 T AT 99918548T AT E342365 T1 ATE342365 T1 AT E342365T1
Authority
AT
Austria
Prior art keywords
human
reducing
pharmaceutical applications
allergic effect
protease
Prior art date
Application number
AT99918548T
Other languages
English (en)
Inventor
David Estell
Original Assignee
Genencor Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genencor Int filed Critical Genencor Int
Application granted granted Critical
Publication of ATE342365T1 publication Critical patent/ATE342365T1/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • C12N9/54—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea bacteria being Bacillus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Plant Pathology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Detergent Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT99918548T 1998-04-15 1999-04-15 Menschliche protease und verwendung davon für pharmazeutischen anwendungen und zur reduktion der allergisierenden wirkung von nicht- menschlichen proteinen ATE342365T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/060,854 US6642011B2 (en) 1998-04-15 1998-04-15 Human protease and use of such protease for pharmaceutical applications and for reducing the allergenicity of non-human proteins

Publications (1)

Publication Number Publication Date
ATE342365T1 true ATE342365T1 (de) 2006-11-15

Family

ID=22032151

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99918548T ATE342365T1 (de) 1998-04-15 1999-04-15 Menschliche protease und verwendung davon für pharmazeutischen anwendungen und zur reduktion der allergisierenden wirkung von nicht- menschlichen proteinen

Country Status (14)

Country Link
US (2) US6642011B2 (de)
EP (1) EP1071792B1 (de)
JP (1) JP2002511272A (de)
KR (1) KR20010034785A (de)
CN (1) CN1297483A (de)
AT (1) ATE342365T1 (de)
AU (1) AU3643299A (de)
BR (1) BR9909639A (de)
CA (1) CA2325010A1 (de)
DE (1) DE69933551T2 (de)
DK (1) DK1071792T3 (de)
NO (1) NO20005152L (de)
PL (1) PL343711A1 (de)
WO (1) WO1999053078A2 (de)

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US6642011B2 (en) * 1998-04-15 2003-11-04 Genencor International, Inc. Human protease and use of such protease for pharmaceutical applications and for reducing the allergenicity of non-human proteins
CA2249648A1 (en) * 1998-11-04 2000-05-04 Nabil G. Seidah Mammalian subtilisin/kexin isozyme ski-1: a proprotein convertase with a unique cleavage specificity
CN1300849A (zh) * 1999-12-21 2001-06-27 复旦大学 一种新的多肽－枯草蛋白酶10和编码这种多肽的多核苷酸
JP2004502402A (ja) * 2000-01-06 2004-01-29 レキシコン・ジェネティクス・インコーポレーテッド 新規ヒトプロテアーゼおよびそれをコードするポリヌクレオチド
DE10041515A1 (de) * 2000-08-24 2002-03-14 Gerold Schuler Verfahren zur Herstellung gebrauchsfertiger, Antigen-beladener oder -unbeladener, kryokonservierter reifer dendritischer Zellen
CA2424720C (en) * 2000-10-02 2012-04-03 Genencor International, Inc. Proteins producing an altered immunogenic response and methods of making and using the same
EP1239032A1 (de) * 2001-03-02 2002-09-11 Société des Produits Nestlé S.A. Milchsäurebakterien als Mitteln zur Behandlung und Vorbeugung von Allergie
PL210859B1 (pl) * 2001-03-23 2012-03-30 Genencor Int Odmiana subtylizyny zawierająca zmieniony epitop limfocytów T, kwas nukleinowy kodujący tę odmianę subtylizyny, wektor ekspresyjny i komórka gospodarza zawierająca kwas nukleinowy oraz kompozycje zawierające tę odmianę subtylizyny
JP2005535284A (ja) * 2001-12-31 2005-11-24 ジェネンコー・インターナショナル・インク 免疫反応の変化を生じるプロテアーゼ、ならびにその製造および利用方法
AU2003213580A1 (en) * 2002-02-26 2003-09-09 Genencor International, Inc. Subtilisin carlsberg proteins with reduced immunogenicity
ATE532793T1 (de) * 2003-07-03 2011-11-15 Avatar Biotechnologies Inc Verfahren zur herstellung von molekülen mit verminderter immunogenität
US20090060933A1 (en) * 2004-06-14 2009-03-05 Estell David A Proteases producing an altered immunogenic response and methods of making and using the same
NZ563777A (en) * 2005-06-24 2010-08-27 Novozymes As Serine protease derived from Bacillus licheniformis optionally in combination with lipases and amylases for pharmaceutical use
EP1920053B1 (de) * 2005-08-16 2011-10-26 Novozymes A/S Subtilasen
AR079338A1 (es) * 2009-12-09 2012-01-18 Danisco Us Inc Variantes de proteasa de bacillus y acidos nucleicos que codifican dichas variantes
WO2016112350A1 (en) * 2015-01-09 2016-07-14 Oklahoma Medical Research Foundation Methods and compositions for diagnosing and treating lysosomal storage disorders

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US4404128A (en) 1981-05-29 1983-09-13 The Procter & Gamble Company Enzyme detergent composition
JPS58144105A (ja) 1982-02-12 1983-08-27 Kurabo Ind Ltd スケ−ル除去獣毛繊維の製法
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US5763257A (en) * 1984-05-29 1998-06-09 Genencor International, Inc. Modified subtilisins having amino acid alterations
US5185258A (en) 1984-05-29 1993-02-09 Genencor International, Inc. Subtilisin mutants
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Also Published As

Publication number Publication date
AU3643299A (en) 1999-11-01
WO1999053078A2 (en) 1999-10-21
CA2325010A1 (en) 1999-10-21
BR9909639A (pt) 2000-12-19
DE69933551T2 (de) 2007-09-06
US20020081703A1 (en) 2002-06-27
JP2002511272A (ja) 2002-04-16
US20040063177A1 (en) 2004-04-01
US6642011B2 (en) 2003-11-04
KR20010034785A (ko) 2001-04-25
WO1999053078A3 (en) 2000-04-20
DK1071792T3 (da) 2007-02-05
NO20005152D0 (no) 2000-10-13
EP1071792B1 (de) 2006-10-11
DE69933551D1 (de) 2006-11-23
PL343711A1 (en) 2001-08-27
CN1297483A (zh) 2001-05-30
NO20005152L (no) 2000-12-11
EP1071792A2 (de) 2001-01-31

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