NO20005152L - Human protease og anvendelse av slik protease for farmasöytiske anvendelser og for reduksjon av allergenisiteten til ikke-humane proteiner - Google Patents

Human protease og anvendelse av slik protease for farmasöytiske anvendelser og for reduksjon av allergenisiteten til ikke-humane proteiner

Info

Publication number
NO20005152L
NO20005152L NO20005152A NO20005152A NO20005152L NO 20005152 L NO20005152 L NO 20005152L NO 20005152 A NO20005152 A NO 20005152A NO 20005152 A NO20005152 A NO 20005152A NO 20005152 L NO20005152 L NO 20005152L
Authority
NO
Norway
Prior art keywords
protease
human
allergenicity
reduction
pharmaceutical applications
Prior art date
Application number
NO20005152A
Other languages
English (en)
Other versions
NO20005152D0 (no
Inventor
David A Estell
Original Assignee
Genencor Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genencor Int filed Critical Genencor Int
Publication of NO20005152D0 publication Critical patent/NO20005152D0/no
Publication of NO20005152L publication Critical patent/NO20005152L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • C12N9/54—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea bacteria being Bacillus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Plant Pathology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Detergent Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
NO20005152A 1998-04-15 2000-10-13 Human protease og anvendelse av slik protease for farmasöytiske anvendelser og for reduksjon av allergenisiteten til ikke-humane proteiner NO20005152L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/060,854 US6642011B2 (en) 1998-04-15 1998-04-15 Human protease and use of such protease for pharmaceutical applications and for reducing the allergenicity of non-human proteins
PCT/US1999/008177 WO1999053078A2 (en) 1998-04-15 1999-04-15 Human protease and use of such protease for pharmaceutical applications and for reducing the allergenicity of non-human proteins

Publications (2)

Publication Number Publication Date
NO20005152D0 NO20005152D0 (no) 2000-10-13
NO20005152L true NO20005152L (no) 2000-12-11

Family

ID=22032151

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20005152A NO20005152L (no) 1998-04-15 2000-10-13 Human protease og anvendelse av slik protease for farmasöytiske anvendelser og for reduksjon av allergenisiteten til ikke-humane proteiner

Country Status (14)

Country Link
US (2) US6642011B2 (no)
EP (1) EP1071792B1 (no)
JP (1) JP2002511272A (no)
KR (1) KR20010034785A (no)
CN (1) CN1297483A (no)
AT (1) ATE342365T1 (no)
AU (1) AU3643299A (no)
BR (1) BR9909639A (no)
CA (1) CA2325010A1 (no)
DE (1) DE69933551T2 (no)
DK (1) DK1071792T3 (no)
NO (1) NO20005152L (no)
PL (1) PL343711A1 (no)
WO (1) WO1999053078A2 (no)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6838269B1 (en) * 1998-04-15 2005-01-04 Genencor International, Inc. Proteins producing an altered immunogenic response and methods of making and using the same
US6642011B2 (en) * 1998-04-15 2003-11-04 Genencor International, Inc. Human protease and use of such protease for pharmaceutical applications and for reducing the allergenicity of non-human proteins
CA2249648A1 (en) * 1998-11-04 2000-05-04 Nabil G. Seidah Mammalian subtilisin/kexin isozyme ski-1: a proprotein convertase with a unique cleavage specificity
CN1300849A (zh) * 1999-12-21 2001-06-27 复旦大学 一种新的多肽－枯草蛋白酶10和编码这种多肽的多核苷酸
AU783923B2 (en) * 2000-01-06 2005-12-22 Lexicon Genetics Incorporated Novel human proteases and polynucleotides encoding the same
DE10041515A1 (de) * 2000-08-24 2002-03-14 Gerold Schuler Verfahren zur Herstellung gebrauchsfertiger, Antigen-beladener oder -unbeladener, kryokonservierter reifer dendritischer Zellen
CA2424720C (en) * 2000-10-02 2012-04-03 Genencor International, Inc. Proteins producing an altered immunogenic response and methods of making and using the same
EP1239032A1 (en) * 2001-03-02 2002-09-11 Société des Produits Nestlé S.A. Lactic acid bacteria as agents for treating and preventing allergy
PL210859B1 (pl) * 2001-03-23 2012-03-30 Genencor Int Odmiana subtylizyny zawierająca zmieniony epitop limfocytów T, kwas nukleinowy kodujący tę odmianę subtylizyny, wektor ekspresyjny i komórka gospodarza zawierająca kwas nukleinowy oraz kompozycje zawierające tę odmianę subtylizyny
BR0215383A (pt) * 2001-12-31 2006-11-28 Genencor Int proteases que produzem resposta imunogênica alterada e métodos de fabricação e uso das mesmas
US20050239043A1 (en) * 2002-02-26 2005-10-27 Harding Fiona A Subtilisin carlsberg proteins with reduced immunogenicity
AU2004293371A1 (en) * 2003-07-03 2005-06-09 Avatar Biotechnologies, Inc. Methods for obtaining molecules with reduced immunogenicity
US20090060933A1 (en) * 2004-06-14 2009-03-05 Estell David A Proteases producing an altered immunogenic response and methods of making and using the same
AU2006261443A1 (en) * 2005-06-24 2006-12-28 Novozymes A/S Proteases for pharmaceutical use
CN101243182B (zh) * 2005-08-16 2014-08-06 诺维信公司 枯草蛋白酶
JP5863666B2 (ja) * 2009-12-09 2016-02-17 ダニスコ・ユーエス・インク プロテアーゼ変異体を含む組成物及び方法
WO2016112350A1 (en) * 2015-01-09 2016-07-14 Oklahoma Medical Research Foundation Methods and compositions for diagnosing and treating lysosomal storage disorders

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4261868A (en) 1979-08-08 1981-04-14 Lever Brothers Company Stabilized enzymatic liquid detergent composition containing a polyalkanolamine and a boron compound
US4404128A (en) 1981-05-29 1983-09-13 The Procter & Gamble Company Enzyme detergent composition
JPS58144105A (ja) 1982-02-12 1983-08-27 Kurabo Ind Ltd スケ−ル除去獣毛繊維の製法
US4760025A (en) 1984-05-29 1988-07-26 Genencor, Inc. Modified enzymes and methods for making same
US5155033A (en) 1989-01-06 1992-10-13 Genencor, Inc. Subtilisins modified at position 225 resulting in a shift in catalytic activity
US5182204A (en) 1984-05-29 1993-01-26 Genencor International, Inc. Non-human carbonyl hydrolase mutants, vectors encoding same and hosts transformed with said vectors
US5763257A (en) * 1984-05-29 1998-06-09 Genencor International, Inc. Modified subtilisins having amino acid alterations
US5204015A (en) 1984-05-29 1993-04-20 Genencor International, Inc. Subtilisin mutants
US5185258A (en) 1984-05-29 1993-02-09 Genencor International, Inc. Subtilisin mutants
US5264366A (en) 1984-05-29 1993-11-23 Genencor, Inc. Protease deficient bacillus
DE3750916T2 (de) * 1986-04-30 1995-06-01 Genencor Int Mutante einer nicht menschlichen Carbonyl-Hydrolase, für diese kodierende DNS-Sequenzen und Vektoren und durch diese Vektoren transformierte Wirte.
US4914031A (en) 1987-04-10 1990-04-03 Amgen, Inc. Subtilisin analogs
US5314692A (en) 1987-08-24 1994-05-24 Cultor Ltd. Enzyme premix for feed and method
DK6488D0 (da) 1988-01-07 1988-01-07 Novo Industri As Enzymer
CN1056187C (zh) 1988-02-11 2000-09-06 金克克国际有限公司 新的蛋白水解酶及其在洗涤剂中的应用
DE3841152A1 (de) 1988-12-07 1990-06-13 Hoechst Ag Verwendung von bakterienlysierendem enzymprodukt als zusatzstoff zur verbesserung der futterverwertung in der tierproduktion
SE8903427L (sv) 1989-10-18 1991-04-19 Vest Nova Ab Staedapparat
EP0785273A1 (en) * 1990-11-26 1997-07-23 Genetics Institute, Inc. Paired basic amino acid converting enzyme and DNA sequence encoding it
CA2095852C (en) 1990-12-05 2001-05-08 Uffe Lovborg Proteins with changed epitopes and methods for the production thereof
US5766898A (en) * 1990-12-05 1998-06-16 Novo Nordisk A/S Proteins with changed epitopes and methods for the production thereof
JP4157160B2 (ja) * 1991-12-13 2008-09-24 ゾーマ テクノロジー リミテッド 改変抗体可変領域の調製のための方法
CA2131549A1 (en) * 1992-03-09 1993-09-16 Philip J. Barr Compositions and methods for pace 4 and 4.1 gene and polypeptides in cells
DK132892D0 (da) 1992-10-30 1992-10-30 Novo Nordisk As Proteiner
US5585250A (en) * 1993-08-20 1996-12-17 The United States Of America As Represented By The Department Of Health & Human Services Dampening of an immunodominant epitope of an antigen for use in plant, animal and human compositions and immunotherapies
US5840299A (en) * 1994-01-25 1998-11-24 Athena Neurosciences, Inc. Humanized antibodies against leukocyte adhesion molecule VLA-4
GB9416841D0 (en) 1994-08-19 1994-10-12 Finnfeeds Int Ltd An enzyme feed additive and animal feed including it
AU697440B2 (en) 1994-12-07 1998-10-08 Novozymes A/S Polypeptide with reduced allergenicity
US5837517A (en) * 1995-05-05 1998-11-17 Novo Nordisk A/S Protease variants and compositions
DE69637907D1 (de) * 1995-05-05 2009-06-04 Novozymes As Protease-varianten und verbindungen
CZ283972B6 (cs) * 1995-05-17 1998-07-15 František Mudr. Trnka Farmaceutický prostředek s modulačním účinkem na zhoubné nádory a jeho použití
AU5893696A (en) 1995-06-07 1996-12-30 Novo Nordisk A/S Modification of polypeptides
CN1273589C (zh) 1996-02-15 2006-09-06 诺沃奇梅兹有限公司 多肽缀合
US6835550B1 (en) 1998-04-15 2004-12-28 Genencor International, Inc. Mutant proteins having lower allergenic response in humans and methods for constructing, identifying and producing such proteins
US6642011B2 (en) * 1998-04-15 2003-11-04 Genencor International, Inc. Human protease and use of such protease for pharmaceutical applications and for reducing the allergenicity of non-human proteins

Also Published As

Publication number Publication date
CA2325010A1 (en) 1999-10-21
WO1999053078A3 (en) 2000-04-20
WO1999053078A2 (en) 1999-10-21
NO20005152D0 (no) 2000-10-13
BR9909639A (pt) 2000-12-19
JP2002511272A (ja) 2002-04-16
AU3643299A (en) 1999-11-01
ATE342365T1 (de) 2006-11-15
US20040063177A1 (en) 2004-04-01
PL343711A1 (en) 2001-08-27
CN1297483A (zh) 2001-05-30
EP1071792A2 (en) 2001-01-31
DE69933551T2 (de) 2007-09-06
DK1071792T3 (da) 2007-02-05
US6642011B2 (en) 2003-11-04
KR20010034785A (ko) 2001-04-25
DE69933551D1 (de) 2006-11-23
US20020081703A1 (en) 2002-06-27
EP1071792B1 (en) 2006-10-11

Similar Documents

Publication Publication Date Title
NO20005152D0 (no) Human protease og anvendelse av slik protease for farmasøytiske anvendelser og for reduksjon av allergenisiteten til ikke-humane proteiner
NO20005153L (no) Mutantprotein som har lavere allergenisk respons i mennesker og fremgangsmåter for konstruksjon, identifisering og fremstilling av slike proteiner
PL364138A1 (en) Proteins producing an altered immunogenic response and methods of making and using the same
DK1149905T3 (da) Fremgangsmåder og præparat til polypeptidteknologi
ATE374822T1 (de) Mutanter apre promoter
CY1107628T1 (el) Ανθρωπινα ctla-4 αντισωματα και χρησεις αυτων
DK1530637T3 (da) Carlsberg-subtilisin-proteiner med nedsat immunogenitet
BR9508981A (pt) Mutantes de subtilisina isentos de cálcio
IL172854A0 (en) Autologous self-tolerance inducing cells of monocytic origin and their use in pharmaceutical preparations
DK1204738T3 (da) Fremgangsmåde til nedsættelse af skumdannelsen under dyrkning af en mikroorganisme
ATE366582T1 (de) Optimierte minigene und dadurch kodierte peptide
ECSP055584A (es) Proceso para la preparación de fibrinógeno
ATE374814T1 (de) Proteinsyntheseverfahren mit zellfreiem proteinsynthesesystem
EP1412388A4 (en) HUMANIZED ANTIBODIES DERIVED FROM DD-3B6 / 22, SPECIFIC OF THE FIBRIN D-DIMER FRAGMENT
CY1113871T1 (el) Διαδικασια παρασκευης γκαμπαπεντινης
ATE349531T1 (de) Isolierung und charakterisierung des csa-operons (etec-cs4 pili) und verfahren zu dessen anwendung
ATE557034T1 (de) Identifikation von epitopen und erniedrigung der allergenität von nahrungsmittelproteinen
AU2002257597A1 (en) Immunomodulating agents from parasitic worms and method for isolation thereof
MXPA03008438A (es) Toxina insecticida de bacillus thuringiensis modificada sensible a pepsina.
WO2002055080A3 (en) Method of immunomodulation using thione-forming disulfides
GB0220199D0 (en) Mutant protein and refolding method
ATE437650T1 (de) Tyrosinasemutante und verfahren zur verwendung davon
DE69739223D1 (de) Oden und anwendungen
MXPA04001128A (es) Metodo para identificar sustancias que afectan realmente condiciones inflamatorias.

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application