ATE342910T1 - Neues glykolipid, und heilmittel für autoimmunerkrankungen, das dieses als wirkstoff enthält - Google Patents

Neues glykolipid, und heilmittel für autoimmunerkrankungen, das dieses als wirkstoff enthält

Info

Publication number: ATE342910T1
Authority: AT; Austria
Prior art keywords: new; glycolipide; gen; cure; active ingredient
Prior art date: 2001-08-16

Application number

AT02760637T

Other languages

English (en)

Inventor

Takashi Yamamura

Sachiko Miyake

Original Assignee

Daiichi Asubio Pharma Co Ltd

Japan Government

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-08-16

Filing date

2002-08-14

Publication date

2006-11-15

2002-08-14 Application filed by Daiichi Asubio Pharma Co Ltd, Japan Government filed Critical Daiichi Asubio Pharma Co Ltd

2006-11-15 Application granted granted Critical

2006-11-15 Publication of ATE342910T1 publication Critical patent/ATE342910T1/de

Links

208000023275 Autoimmune disease Diseases 0.000 title 1
239000004480 active ingredient Substances 0.000 title 1
HVCOBJNICQPDBP-UHFFFAOYSA-N 3-[3-[3,5-dihydroxy-6-methyl-4-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxyoxan-2-yl]oxydecanoyloxy]decanoic acid;hydrate Chemical class O.OC1C(OC(CC(=O)OC(CCCCCCC)CC(O)=O)CCCCCCC)OC(C)C(O)C1OC1C(O)C(O)C(O)C(C)O1 HVCOBJNICQPDBP-UHFFFAOYSA-N 0.000 abstract 2
208000030767 Autoimmune encephalitis Diseases 0.000 abstract 1
238000011746 C57BL/6J (JAX™ mouse strain) Methods 0.000 abstract 1
230000002456 anti-arthritic effect Effects 0.000 abstract 1
230000003178 anti-diabetic effect Effects 0.000 abstract 1
230000003110 anti-inflammatory effect Effects 0.000 abstract 1
230000002682 anti-psoriatic effect Effects 0.000 abstract 1
230000003356 anti-rheumatic effect Effects 0.000 abstract 1
239000003472 antidiabetic agent Substances 0.000 abstract 1
239000003435 antirheumatic agent Substances 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
230000001553 hepatotropic effect Effects 0.000 abstract 1
230000001506 immunosuppresive effect Effects 0.000 abstract 1
230000010534 mechanism of action Effects 0.000 abstract 1
230000000324 neuroprotective effect Effects 0.000 abstract 1
YGOYMNMFBVUFOH-UHFFFAOYSA-N nonane-1,1,4-triol Chemical compound CCCCCC(O)CCC(O)O YGOYMNMFBVUFOH-UHFFFAOYSA-N 0.000 abstract 1
239000012873 virucide Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
- C07H15/10—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical containing unsaturated carbon-to-carbon bonds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Molecular Biology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Immunology (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Crystallography & Structural Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Transplantation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

AT02760637T 2001-08-16 2002-08-14 Neues glykolipid, und heilmittel für autoimmunerkrankungen, das dieses als wirkstoff enthält ATE342910T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP2001247055		2001-08-16

Publications (1)

Publication Number	Publication Date
ATE342910T1 true ATE342910T1 (de)	2006-11-15

Family

ID=19076468

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT02760637T ATE342910T1 (de)	2001-08-16	2002-08-14	Neues glykolipid, und heilmittel für autoimmunerkrankungen, das dieses als wirkstoff enthält

Country Status (15)

Country	Link
US (1)	US8367623B2 (de)
EP (1)	EP1437358B1 (de)
JP (1)	JP4064346B2 (de)
KR (1)	KR100880063B1 (de)
CN (1)	CN100439383C (de)
AT (1)	ATE342910T1 (de)
AU (1)	AU2002327097B2 (de)
BR (1)	BR0211968A (de)
CA (1)	CA2459482C (de)
DE (1)	DE60215530T2 (de)
DK (1)	DK1437358T3 (de)
ES (1)	ES2274080T3 (de)
HU (1)	HU229345B1 (de)
NO (1)	NO326398B1 (de)
WO (1)	WO2003016326A1 (de)

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US9809654B2 (en)	2002-09-27	2017-11-07	Vaccinex, Inc.	Targeted CD1d molecules
ES2676345T3 (es)	2003-02-14	2018-07-18	Japan As Represented By President Of National Center Of Neurology And Psychiatry Ministry Of Health	Derivados del glicolípido, proceso para su producción, intermedios para la síntesis del mismo, y proceso para la producción de los intermedios
EP1784196B1 (de) *	2004-08-27	2016-12-21	Albert Einstein College Of Medicine Of Yeshiva University	Ceramid-derivate als modulatoren von immunität und autoimmunität
US8513008B2 (en)	2004-10-07	2013-08-20	Argos Therapeutics, Inc.	Mature dendritic cell compositions and methods for culturing same
WO2006042177A2 (en)	2004-10-07	2006-04-20	Argos Therapeutics, Inc.	Mature dendritic cell compositions and methods for culturing same
US7923013B2 (en)	2004-12-28	2011-04-12	The Rockefeller University	Glycolipids and analogues thereof as antigens for NKT cells
US7534434B2 (en) *	2004-12-28	2009-05-19	The Rockefeller University	Glycolipids and analogues thereof as antigens for NK T cells
US20090214596A1 (en) *	2005-04-01	2009-08-27	Riken	Nasal Vaccine
CA2613350A1 (en) *	2005-07-01	2007-01-11	Japan As Represented By President Of National Center Of Neurology And Ps Ychiatry	Glycolipid derivative and drug containing the same as active component
JPWO2007049819A1 (ja) *	2005-10-28	2009-04-30	国立精神・神経センター総長	Ｎｋｔ細胞の機能を抑制する糖脂質誘導体を有効成分とする治療剤
JP5126684B2 (ja) *	2006-02-28	2013-01-23	独立行政法人理化学研究所	新規糖脂質及びその用途
EP2040541B1 (de) *	2006-06-30	2016-03-23	The Scripps Research Institute	Hilfsstoffe und verwendungsverfahren
KR100868959B1 (ko) *	2006-12-30	2008-11-17	재단법인서울대학교산학협력재단	알파-갈락토실세라마이드 유도체, 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는면역보조용 약학적 조성물
AU2008219020B2 (en)	2007-02-21	2013-08-22	Vaccinex, Inc.	Modulation of NKT cell activity with antigen-loaded CDId molecules
ES2574825T3 (es)	2007-10-12	2016-06-22	Luigi Panza	Análogos de glicolípidos útiles como inmunoadyuvantes
CN102325875B (zh) *	2009-01-08	2018-04-10	阿尔伯爱因斯坦医学有限公司	具有细胞壁结合神经酰胺类糖脂的细菌疫苗及其应用
US9371352B2 (en)	2013-02-08	2016-06-21	Vaccinex, Inc.	Modified glycolipids and methods of making and using the same
JP6202339B2 (ja) *	2013-12-19	2017-09-27	国立研究開発法人国立精神・神経医療研究センター	ＧＭ−ＣＳＦ産生Ｔ細胞制御剤、及びＴｈ１／Ｔｈ２免疫バランス調節剤
EP3111945B1 (de)	2014-02-26	2021-07-14	National University Corporation Hokkaido University	Dendritische zellen zur verwendung in der behandlung von herzinfarkt
US20220273709A1 (en)	2019-07-12	2022-09-01	Kyushu University, National University Corporation	Development of therapy for improving myocardial contraction and method for inhibiting cardiomyocyte death
CA3200571A1 (en) *	2020-11-06	2022-05-12	National Center Of Neurology And Psychiatry	Therapeutic agent for progressive disease caused by increase in eomes-positive cd4-positive t cells
EP4301374A4 (de)	2021-03-01	2025-09-10	Deciduous Therapeutics Inc	Verbindungen zur aktivierung invarianter natürlicher killer-t-zellen und verfahren zur verwendung bei der beseitigung entzündlicher alternder zellen

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JPS5827828A (ja) *	1981-08-11	1983-02-18	Mitsubishi Electric Corp	燃料噴射装置
DK84691D0 (da) *	1991-05-07	1991-05-07	Karsten Buschard	Visse glycolipider og specifikke catchere for disse til anvendelse ved profylaxe eller terapi af diabetes, og/eller dermed forbundne komplikationer samt anvendelse af saadanne glycolipider til detektion af oe-celle-antistoffer (ica) i et individ og anvendelse af saadanne catchere til detektion af langerhans-oe-celler i pancreas-praeparater
US5936076A (en) *	1991-08-29	1999-08-10	Kirin Beer Kabushiki Kaisha	αgalactosylceramide derivatives
JPH0559081A (ja)	1991-08-29	1993-03-09	Kirin Brewery Co Ltd	新規スフインゴ糖脂質、その製造法および使用
GB9207182D0 (en) *	1992-04-01	1992-05-13	Enzymatix Ltd	Glycolipids and their preparation
TW261533B (de) *	1992-07-16	1995-11-01	Kirin Brewery
CA2142153A1 (en) *	1994-03-04	1995-09-05	Jacques Banville	Sulfated .beta.-glycolipid derivatives as cell adhesion inhibitors
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DE19602108A1 (de) *	1996-01-22	1997-07-24	Beiersdorf Ag	Gegen Bakterien, Parasiten, Protozoen, Mycota und Viren wirksame Substanzen
JP4451933B2 (ja) *	1996-12-27	2010-04-14	住友化学株式会社	遺伝子操作による植物へのｐｐｏ阻害性除草剤耐性付与法
JP3495740B2 (ja) *	1997-04-10	2004-02-09	麒麟麦酒株式会社	α−グリコシルセラミドを含有するＮＫＴ細胞活性化剤
US6589940B1 (en) *	1997-06-06	2003-07-08	Dynavax Technologies Corporation	Immunostimulatory oligonucleotides, compositions thereof and methods of use thereof
TW575420B (en) *	1997-09-22	2004-02-11	Kirin Brewery	Composition for enhancing cellular immunogenicity comprising alpha-glycosylceramides
US7273711B1 (en) *	1998-12-02	2007-09-25	The Regents Of The University Of California	Diagnosis of human glycosylation disorders
JP2002284692A (ja) *	2001-03-26	2002-10-03	Kirin Brewery Co Ltd	α−グリコシルセラミドによる移植片対宿主病（ＧＶＨＤ）の抑制

2002
- 2002-08-14 EP EP02760637A patent/EP1437358B1/de not_active Expired - Lifetime
- 2002-08-14 KR KR1020047002291A patent/KR100880063B1/ko not_active Expired - Lifetime
- 2002-08-14 DE DE60215530T patent/DE60215530T2/de not_active Expired - Lifetime
- 2002-08-14 DK DK02760637T patent/DK1437358T3/da active
- 2002-08-14 AU AU2002327097A patent/AU2002327097B2/en not_active Expired
- 2002-08-14 WO PCT/JP2002/008280 patent/WO2003016326A1/ja not_active Ceased
- 2002-08-14 US US10/486,948 patent/US8367623B2/en not_active Expired - Fee Related
- 2002-08-14 CN CNB028203615A patent/CN100439383C/zh not_active Expired - Lifetime
- 2002-08-14 BR BR0211968-4A patent/BR0211968A/pt not_active IP Right Cessation
- 2002-08-14 CA CA2459482A patent/CA2459482C/en not_active Expired - Lifetime
- 2002-08-14 AT AT02760637T patent/ATE342910T1/de not_active IP Right Cessation
- 2002-08-14 ES ES02760637T patent/ES2274080T3/es not_active Expired - Lifetime
- 2002-08-14 HU HU0500127A patent/HU229345B1/hu unknown
- 2002-08-14 JP JP2003521248A patent/JP4064346B2/ja not_active Expired - Lifetime
2004
- 2004-02-13 NO NO20040653A patent/NO326398B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
CA2459482A1 (en)	2003-02-27
DE60215530T2 (de)	2007-05-31
JPWO2003016326A1 (ja)	2004-12-02
JP4064346B2 (ja)	2008-03-19
EP1437358A4 (de)	2004-11-24
HUP0500127A3 (en)	2009-12-28
CN100439383C (zh)	2008-12-03
DE60215530D1 (de)	2006-11-30
CA2459482C (en)	2010-09-28
CN1568328A (zh)	2005-01-19
HU229345B1 (en)	2013-11-28
BR0211968A (pt)	2004-09-28
KR100880063B1 (ko)	2009-01-22
US8367623B2 (en)	2013-02-05
HUP0500127A2 (en)	2006-09-28
NO20040653L (no)	2004-05-07
DK1437358T3 (da)	2007-02-05
AU2002327097B2 (en)	2007-05-24
NO326398B1 (no)	2008-11-24
WO2003016326A1 (fr)	2003-02-27
EP1437358B1 (de)	2006-10-18
KR20040039287A (ko)	2004-05-10
EP1437358A1 (de)	2004-07-14
US20060148723A1 (en)	2006-07-06
ES2274080T3 (es)	2007-05-16

Legal Events

Date	Code	Title	Description
2007-04-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE342910T1 (de)	2006-11-15	Neues glykolipid, und heilmittel für autoimmunerkrankungen, das dieses als wirkstoff enthält
CA2678795C (en)	2014-11-18	Antibacterial cyclohexylsulfanyl pleuromutilins
EP0526642A4 (de)	1994-02-09
DE69634678D1 (de)	2005-06-09	Verbesserung oder heilung von durch ischämischen krankheiten hervorgerufenen symtomen und dafür verwendbare phenylpiperidinverbingungen
UA94913C2 (ru)	2011-06-25	Применение эритропоэтина для лечения сахарного диабета
NO20051209L (no)	2005-04-15	Pyrazolderivater, medisinske sammensetninger inneholdende slike, medisinsk anvendelse derav samt intermediater for samme
MY106596A (en)	1995-06-30	Antifungal agents based on amides containing a phenyl group
HU9502811D0 (en)	1995-11-28	N-acyl-sulfamic acid esters (or thioesters), n-acyl-sulfonamides and n-sulfonyl-carbamic-acid-esters (or thioesters) as hypercholesterolemic agents
NO307461B1 (no)	2000-04-10	Substituerte bifenyl-isoksazol-sulfonamider, anvendelse derav og farmasøytisk preparat
ID23495A (id)	2000-04-27	Zat-zat pengaktif sel nkt yang mengandung alpha-glikosilseramida
MY123244A (en)	2006-05-31	N-(substituted glycyl)-2-cyanopyrrolidines, pharmaceutical compositions containing them and their use in inhibiting dipeptidyl peptidase-iv
WO2006072393A2 (de)	2006-07-13	Sulfonylpyrrolidine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
GT200000025A (es)	2001-08-22	Acidos oxamicos y derivados como ligandos de receptores tiroideos.
IL84329A0 (en)	1988-04-29	Sulfone peroxycarboxylic acids
AU2008207170A1 (en)	2008-07-24	Use of substituted pyranone acid derivatives for the treatment of metabolic syndrome
WO2001081309A3 (en)	2002-01-17	4-benzyl-1-[2-(4-hydroxy-phenoxy)-ethyl]-piperidine-3,4-diol
IL178350A (en)	2010-11-30	Vitamin d derivatives
TR199902350T2 (xx)	2000-04-21	Yeni piridin t�revleri ve onlardan olu�an farmakotik bile�imler.
AP9901698A0 (en)	1999-12-31	Novel process.
IL111849A0 (en)	1995-03-15	Dithiocarbonimide derivative, fungicidal/insecticidal/acaricidal composition containing said derivative as active ingredient, intermediate for use in production of said derivative and process for producing said derivative from said intermediate
DE602006009557D1 (de)	2009-11-12	Neue cholest-4-en-3-onoximderivate, pharmazeutische zusammensetzungen, die diese enthalten, und herstellungsverfahren
DE60335788D1 (de)	2011-03-03	Piperidinderivatverbindungen und arzneimittel, die diese verbindungen als wirkstoff enthalten
NO157297C (no)	1988-02-24	Analogifremgangsmaate ved fremstilling av terapeutisk aktive 7alfa-acylthio-15,16-methylen-3-oxo-17alfa-pregna-1,4-dien-21,17-carbolactoner.
ATE297900T1 (de)	2005-07-15	Anilidverbindungen und medikamente, die diese enthalten
AU596434B2 (en)	1990-05-03	1,3,5-trithiane derivatives