ATE342910T1 - Neues glykolipid, und heilmittel für autoimmunerkrankungen, das dieses als wirkstoff enthält - Google Patents

Neues glykolipid, und heilmittel für autoimmunerkrankungen, das dieses als wirkstoff enthält

Info

Publication number: ATE342910T1
Authority: AT; Austria
Prior art keywords: new; glycolipide; gen; cure; active ingredient
Prior art date: 2001-08-16

Application number

AT02760637T

Other languages

English (en)

Inventor

Takashi Yamamura

Sachiko Miyake

Original Assignee

Daiichi Asubio Pharma Co Ltd

Japan Government

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-08-16

Filing date

2002-08-14

Publication date

2006-11-15

2002-08-14 Application filed by Daiichi Asubio Pharma Co Ltd, Japan Government filed Critical Daiichi Asubio Pharma Co Ltd

2006-11-15 Application granted granted Critical

2006-11-15 Publication of ATE342910T1 publication Critical patent/ATE342910T1/de

Links

208000023275 Autoimmune disease Diseases 0.000 title 1
239000004480 active ingredient Substances 0.000 title 1
HVCOBJNICQPDBP-UHFFFAOYSA-N 3-[3-[3,5-dihydroxy-6-methyl-4-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxyoxan-2-yl]oxydecanoyloxy]decanoic acid;hydrate Chemical class O.OC1C(OC(CC(=O)OC(CCCCCCC)CC(O)=O)CCCCCCC)OC(C)C(O)C1OC1C(O)C(O)C(O)C(C)O1 HVCOBJNICQPDBP-UHFFFAOYSA-N 0.000 abstract 2
208000030767 Autoimmune encephalitis Diseases 0.000 abstract 1
238000011746 C57BL/6J (JAX™ mouse strain) Methods 0.000 abstract 1
230000002456 anti-arthritic effect Effects 0.000 abstract 1
230000003178 anti-diabetic effect Effects 0.000 abstract 1
230000003110 anti-inflammatory effect Effects 0.000 abstract 1
230000002682 anti-psoriatic effect Effects 0.000 abstract 1
230000003356 anti-rheumatic effect Effects 0.000 abstract 1
239000003472 antidiabetic agent Substances 0.000 abstract 1
239000003435 antirheumatic agent Substances 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
230000001553 hepatotropic effect Effects 0.000 abstract 1
230000001506 immunosuppresive effect Effects 0.000 abstract 1
230000010534 mechanism of action Effects 0.000 abstract 1
230000000324 neuroprotective effect Effects 0.000 abstract 1
YGOYMNMFBVUFOH-UHFFFAOYSA-N nonane-1,1,4-triol Chemical compound CCCCCC(O)CCC(O)O YGOYMNMFBVUFOH-UHFFFAOYSA-N 0.000 abstract 1
239000012873 virucide Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
- C07H15/10—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical containing unsaturated carbon-to-carbon bonds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Molecular Biology (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Immunology (AREA)
Bioinformatics & Cheminformatics (AREA)
Biotechnology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Crystallography & Structural Chemistry (AREA)
Epidemiology (AREA)
Transplantation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

AT02760637T 2001-08-16 2002-08-14 Neues glykolipid, und heilmittel für autoimmunerkrankungen, das dieses als wirkstoff enthält ATE342910T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP2001247055		2001-08-16

Publications (1)

Publication Number	Publication Date
ATE342910T1 true ATE342910T1 (de)	2006-11-15

Family

ID=19076468

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT02760637T ATE342910T1 (de)	2001-08-16	2002-08-14	Neues glykolipid, und heilmittel für autoimmunerkrankungen, das dieses als wirkstoff enthält

Country Status (15)

Country	Link
US (1)	US8367623B2 (de)
EP (1)	EP1437358B1 (de)
JP (1)	JP4064346B2 (de)
KR (1)	KR100880063B1 (de)
CN (1)	CN100439383C (de)
AT (1)	ATE342910T1 (de)
AU (1)	AU2002327097B2 (de)
BR (1)	BR0211968A (de)
CA (1)	CA2459482C (de)
DE (1)	DE60215530T2 (de)
DK (1)	DK1437358T3 (de)
ES (1)	ES2274080T3 (de)
HU (1)	HU229345B1 (de)
NO (1)	NO326398B1 (de)
WO (1)	WO2003016326A1 (de)

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US9809654B2 (en)	2002-09-27	2017-11-07	Vaccinex, Inc.	Targeted CD1d molecules
EP1619199B1 (de) *	2003-02-14	2013-12-18	Japan as represented by President of National Center of Neurology and Psychiatry Ministry of Health	Glykolipid-derivate, herstellungsverfahren dafür, zwischenprodukte für deren synthese und herstellungsverfahren für die zwischenprodukte
KR101377116B1 (ko) *	2004-08-27	2014-03-24	알버트 아인슈타인 컬리지 오브 메디신 오브 예쉬바 유니버시티	면역 및 자가면역의 조절제로서의 세라마이드 유도체
US8513008B2 (en)	2004-10-07	2013-08-20	Argos Therapeutics, Inc.	Mature dendritic cell compositions and methods for culturing same
US20080145931A1 (en)	2004-10-07	2008-06-19	Argos Therapeutics, Inc.	Mature Dendritic Cell Compositions and Methods of Culturing Same
US7923013B2 (en)	2004-12-28	2011-04-12	The Rockefeller University	Glycolipids and analogues thereof as antigens for NKT cells
EP1833489A4 (de) *	2004-12-28	2011-08-03	Univ Rockefeller	Glykolipide und analoga davon als antigene für nk-t-zellen
JP4909264B2 (ja) *	2005-04-01	2012-04-04	独立行政法人理化学研究所	経鼻ワクチン
WO2007004705A1 (ja) *	2005-07-01	2007-01-11	Japan As Represented By President Of National Center Of Neurology And Psychiatry	糖脂質誘導体及びそれを有効成分とする治療剤
CN101316599A (zh) *	2005-10-28	2008-12-03	国立精神神经中心主席代表的日本国	抑制nkt细胞的机能的糖脂衍生物作为有效成分的治疗剂
WO2007099999A1 (ja) *	2006-02-28	2007-09-07	Riken	新規糖脂質及びその用途
JP5564672B2 (ja)	2006-06-30	2014-07-30	ザスクリプスリサーチインスティテュート	アジュバント及びその使用方法
KR100868959B1 (ko) *	2006-12-30	2008-11-17	재단법인서울대학교산학협력재단	알파-갈락토실세라마이드 유도체, 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는면역보조용 약학적 조성물
JP5357782B2 (ja)	2007-02-21	2013-12-04	バクシネックスインコーポレーティッド	抗原負荷ＣＤ１ｄ分子によるＮＫＴ細胞活性の調節
CN102066394B (zh) *	2007-10-12	2015-04-01	路易吉·潘扎	用作免疫佐剂的糖脂的类似物
AU2010203451B2 (en) *	2009-01-08	2016-06-30	Albert Einstein College Of Medicine, Inc.	Bacterial vaccines with cell wall-associated ceramide-like glycolipids and uses thereof
US9371352B2 (en)	2013-02-08	2016-06-21	Vaccinex, Inc.	Modified glycolipids and methods of making and using the same
JP6202339B2 (ja) *	2013-12-19	2017-09-27	国立研究開発法人国立精神・神経医療研究センター	ＧＭ−ＣＳＦ産生Ｔ細胞制御剤、及びＴｈ１／Ｔｈ２免疫バランス調節剤
US10022401B2 (en)	2014-02-26	2018-07-17	National University Corporation Hokkaido University	Pharmaceutical containing dendritic cells, and method for producing same
WO2021010344A1 (ja)	2019-07-12	2021-01-21	国立大学法人九州大学	心筋収縮改善治療法および心筋細胞死抑制法の開発
AU2020475870A1 (en) *	2020-11-06	2023-06-15	National Center Of Neurology And Psychiatry	Therapeutic agent for progressive disease caused by increase in eomes-positive cd4-positive t cells
MX2023010240A (es)	2021-03-01	2023-11-24	Deciduous Therapeutics Inc	Compuestos para activar células t asesinas naturales invariantes y métodos de uso en la eliminación de células senescentes inflamatorias.

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JPS5827828A (ja) *	1981-08-11	1983-02-18	Mitsubishi Electric Corp	燃料噴射装置
DK84691D0 (da)	1991-05-07	1991-05-07	Karsten Buschard	Visse glycolipider og specifikke catchere for disse til anvendelse ved profylaxe eller terapi af diabetes, og/eller dermed forbundne komplikationer samt anvendelse af saadanne glycolipider til detektion af oe-celle-antistoffer (ica) i et individ og anvendelse af saadanne catchere til detektion af langerhans-oe-celler i pancreas-praeparater
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CA2142153A1 (en) *	1994-03-04	1995-09-05	Jacques Banville	Sulfated .beta.-glycolipid derivatives as cell adhesion inhibitors
CN1058498C (zh) *	1994-05-31	2000-11-15	生化学工业株式会社	糖脂类似物
DE19602108A1 (de) *	1996-01-22	1997-07-24	Beiersdorf Ag	Gegen Bakterien, Parasiten, Protozoen, Mycota und Viren wirksame Substanzen
JP4451933B2 (ja) *	1996-12-27	2010-04-14	住友化学株式会社	遺伝子操作による植物へのｐｐｏ阻害性除草剤耐性付与法
DE69840528D1 (de)	1997-04-10	2009-03-19	Kyowa Hakko Kirin Co Ltd	NKT-Zellenaktivatoren, die Alpha-Glycosylceramide enthalten
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TW575420B (en)	1997-09-22	2004-02-11	Kirin Brewery	Composition for enhancing cellular immunogenicity comprising alpha-glycosylceramides
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2002
- 2002-08-14 CA CA2459482A patent/CA2459482C/en not_active Expired - Lifetime
- 2002-08-14 DK DK02760637T patent/DK1437358T3/da active
- 2002-08-14 AU AU2002327097A patent/AU2002327097B2/en not_active Expired
- 2002-08-14 AT AT02760637T patent/ATE342910T1/de not_active IP Right Cessation
- 2002-08-14 WO PCT/JP2002/008280 patent/WO2003016326A1/ja not_active Ceased
- 2002-08-14 JP JP2003521248A patent/JP4064346B2/ja not_active Expired - Lifetime
- 2002-08-14 DE DE60215530T patent/DE60215530T2/de not_active Expired - Lifetime
- 2002-08-14 ES ES02760637T patent/ES2274080T3/es not_active Expired - Lifetime
- 2002-08-14 BR BR0211968-4A patent/BR0211968A/pt not_active IP Right Cessation
- 2002-08-14 EP EP02760637A patent/EP1437358B1/de not_active Expired - Lifetime
- 2002-08-14 KR KR1020047002291A patent/KR100880063B1/ko not_active Expired - Lifetime
- 2002-08-14 CN CNB028203615A patent/CN100439383C/zh not_active Expired - Lifetime
- 2002-08-14 HU HU0500127A patent/HU229345B1/hu unknown
- 2002-08-14 US US10/486,948 patent/US8367623B2/en not_active Expired - Fee Related
2004
- 2004-02-13 NO NO20040653A patent/NO326398B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
DE60215530T2 (de)	2007-05-31
ES2274080T3 (es)	2007-05-16
HUP0500127A2 (en)	2006-09-28
HU229345B1 (en)	2013-11-28
KR20040039287A (ko)	2004-05-10
US8367623B2 (en)	2013-02-05
HUP0500127A3 (en)	2009-12-28
JPWO2003016326A1 (ja)	2004-12-02
CN1568328A (zh)	2005-01-19
KR100880063B1 (ko)	2009-01-22
NO20040653L (no)	2004-05-07
AU2002327097B2 (en)	2007-05-24
DE60215530D1 (de)	2006-11-30
WO2003016326A1 (fr)	2003-02-27
BR0211968A (pt)	2004-09-28
EP1437358A1 (de)	2004-07-14
US20060148723A1 (en)	2006-07-06
EP1437358B1 (de)	2006-10-18
EP1437358A4 (de)	2004-11-24
NO326398B1 (no)	2008-11-24
JP4064346B2 (ja)	2008-03-19
DK1437358T3 (da)	2007-02-05
CN100439383C (zh)	2008-12-03
CA2459482C (en)	2010-09-28
CA2459482A1 (en)	2003-02-27

Legal Events

Date	Code	Title	Description
2007-04-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE60215530D1 (de)	2006-11-30	Neues glykolipid, und heilmittel für autoimmunerkrankungen, das dieses als wirkstoff enthält
CA2678795C (en)	2014-11-18	Antibacterial cyclohexylsulfanyl pleuromutilins
DE69634678D1 (de)	2005-06-09	Verbesserung oder heilung von durch ischämischen krankheiten hervorgerufenen symtomen und dafür verwendbare phenylpiperidinverbingungen
EP0613883A4 (de)	1994-12-07	Hydroxamsäure derivate.
UA94913C2 (ru)	2011-06-25	Применение эритропоэтина для лечения сахарного диабета
NO20051209L (no)	2005-04-15	Pyrazolderivater, medisinske sammensetninger inneholdende slike, medisinsk anvendelse derav samt intermediater for samme
HU9502811D0 (en)	1995-11-28	N-acyl-sulfamic acid esters (or thioesters), n-acyl-sulfonamides and n-sulfonyl-carbamic-acid-esters (or thioesters) as hypercholesterolemic agents
ID23495A (id)	2000-04-27	Zat-zat pengaktif sel nkt yang mengandung alpha-glikosilseramida
MY123244A (en)	2006-05-31	N-(substituted glycyl)-2-cyanopyrrolidines, pharmaceutical compositions containing them and their use in inhibiting dipeptidyl peptidase-iv
EP1836180A2 (de)	2007-09-26	Sulfonylpyrrolidine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
GT200000025A (es)	2001-08-22	Acidos oxamicos y derivados como ligandos de receptores tiroideos.
EP0267175A3 (en)	1989-03-01	Sulfone peroxycarboxylic acids
AU2008207170A1 (en)	2008-07-24	Use of substituted pyranone acid derivatives for the treatment of metabolic syndrome
WO2001081309A3 (en)	2002-01-17	4-benzyl-1-[2-(4-hydroxy-phenoxy)-ethyl]-piperidine-3,4-diol
ATE290526T1 (de)	2005-03-15	Vitamin-d3?-derivate und aus diesen hergestellte heilmittel gegen entzündliche erkrankungen der atemwege
NO20026014D0 (no)	2002-12-13	Vitamin D-derivater
AP9901698A0 (en)	1999-12-31	Novel process.
ES8400135A1 (es)	1983-10-16	"un procedimiento para la obtencion de polimeros de tres componentes portadores de grupos carboxilicos".
IL111849A (en)	2000-06-01	Dithiocarbonimide derivative fungicidal/insecticidal/acaricidal composition containing said derivative as active ingredient and process for producing said derivative
HUT54372A (en)	1991-02-28	Process for producing macrolide compounds and pharmaceutical compositions containing them as active components
DE602006009557D1 (de)	2009-11-12	Neue cholest-4-en-3-onoximderivate, pharmazeutische zusammensetzungen, die diese enthalten, und herstellungsverfahren
MY128818A (en)	2007-02-28	Ethanesulfonyl-piperidine derivatives
IL163344A (en)	2011-04-28	2-(4-(3-cyclopentyloxy-4-difluoromethoxyphenyl)-4-cyanopiperidin-1-yl)acetic acid derivative compounds, process for their synthesis and compositions comprising the compounds as the active ingredient
AU596434B2 (en)	1990-05-03	1,3,5-trithiane derivatives
EP1627866A4 (de)	2006-10-04	Carbonsäureverbindung und arzneimittel, das dieses enthält