ATE343401T1 - Radiokonjugation von internalizierungsantikörpern - Google Patents

Radiokonjugation von internalizierungsantikörpern

Info

Publication number
ATE343401T1
ATE343401T1 AT99967161T AT99967161T ATE343401T1 AT E343401 T1 ATE343401 T1 AT E343401T1 AT 99967161 T AT99967161 T AT 99967161T AT 99967161 T AT99967161 T AT 99967161T AT E343401 T1 ATE343401 T1 AT E343401T1
Authority
AT
Austria
Prior art keywords
antibodies
radioconjugation
internalizing antibodies
label
release
Prior art date
Application number
AT99967161T
Other languages
English (en)
Inventor
Michael R Zalutsky
Original Assignee
Univ Duke
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Duke filed Critical Univ Duke
Application granted granted Critical
Publication of ATE343401T1 publication Critical patent/ATE343401T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0058—Antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Optics & Photonics (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT99967161T 1998-12-01 1999-11-30 Radiokonjugation von internalizierungsantikörpern ATE343401T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/203,676 US6998106B1 (en) 1998-12-01 1998-12-01 Radioconjugation of internalizing antibodies

Publications (1)

Publication Number Publication Date
ATE343401T1 true ATE343401T1 (de) 2006-11-15

Family

ID=22754871

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99967161T ATE343401T1 (de) 1998-12-01 1999-11-30 Radiokonjugation von internalizierungsantikörpern

Country Status (10)

Country Link
US (2) US6998106B1 (de)
EP (1) EP1135170B1 (de)
AT (1) ATE343401T1 (de)
AU (1) AU766458B2 (de)
CA (1) CA2353468C (de)
DE (1) DE69933788T2 (de)
DK (1) DK1135170T3 (de)
ES (1) ES2274655T3 (de)
PT (1) PT1135170E (de)
WO (1) WO2000032240A2 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2380998B (en) * 2001-08-03 2004-10-20 Marc Kvansakul D-amino acid peptide for security tagging
WO2004005320A2 (en) * 2002-07-03 2004-01-15 The Curators Of The University Of Missouri ErbB-2 RECEPTOR TARGETING PEPTIDE
US20040225214A1 (en) * 2003-05-07 2004-11-11 General Electric Company Method of high-throughput quantitative pet for small animal imaging using a large-bore pet scanner for the assessment of pet tracer performance
US6987270B2 (en) 2003-05-07 2006-01-17 General Electric Company Method to account for event losses due to positron range in positron emission tomography and assay of positron-emitting isotopes
US20070286865A1 (en) * 2006-01-04 2007-12-13 Richard Moore Use of HE4 and other biochemical markers for assessment of ovarian cancers
US20140271453A1 (en) 2013-03-14 2014-09-18 Abbott Laboratories Methods for the early detection of lung cancer
EP4274596A4 (de) * 2021-01-08 2024-12-25 NoNO Inc. Plasminresistente peptide für verbesserten therapeutischen index

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3464252D1 (en) * 1983-06-03 1987-07-23 Hoffmann La Roche Labelled molecules for fluorescence immunoassays and processes and intermediates for their preparation
US5045303A (en) 1985-05-17 1991-09-03 Neorx Corporation Radiohalogenated small molecules for protein labeling
US5541297A (en) 1988-04-01 1996-07-30 Immunomedics, Inc. Therapeutic conjugates of toxins and drugs
US5302700A (en) 1988-05-23 1994-04-12 Duke University Radiohalogenation conjugate technology
JPH04501266A (ja) * 1988-10-12 1992-03-05 セントコアー，インコーポレーテッド ヨード―１２５で標識された放射線療法用接合体
CA2045578A1 (en) * 1989-01-31 1990-08-01 Megumi Kawai Anaphylatoxin-receptor ligands
US5891418A (en) * 1995-06-07 1999-04-06 Rhomed Incorporated Peptide-metal ion pharmaceutical constructs and applications
US6558669B1 (en) 1996-08-28 2003-05-06 Immunomedics, Inc. Stable radioiodine conjugates and methods for their synthesis
AU718859B2 (en) 1996-08-28 2000-04-20 Immunomedics Inc. Stable radioiodine conjugates and methods for their synthesis
DE69837095T2 (de) * 1997-09-03 2007-11-22 Immunomedics, Inc. Fluorierung von proteinen und peptiden für positronemissionstomographie

Also Published As

Publication number Publication date
ES2274655T3 (es) 2007-05-16
EP1135170A2 (de) 2001-09-26
AU766458B2 (en) 2003-10-16
US6998106B1 (en) 2006-02-14
DE69933788D1 (de) 2006-12-07
CA2353468A1 (en) 2000-06-08
PT1135170E (pt) 2007-01-31
WO2000032240A3 (en) 2000-12-28
EP1135170B1 (de) 2006-10-25
WO2000032240A2 (en) 2000-06-08
WO2000032240B1 (en) 2001-03-01
CA2353468C (en) 2012-02-28
DK1135170T3 (da) 2007-02-26
DE69933788T2 (de) 2007-08-16
US6426400B1 (en) 2002-07-30
AU2349900A (en) 2000-06-19

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