ATE344234T1 - Salicylamid-derivate - Google Patents
Salicylamid-derivateInfo
- Publication number
- ATE344234T1 ATE344234T1 AT00951914T AT00951914T ATE344234T1 AT E344234 T1 ATE344234 T1 AT E344234T1 AT 00951914 T AT00951914 T AT 00951914T AT 00951914 T AT00951914 T AT 00951914T AT E344234 T1 ATE344234 T1 AT E344234T1
- Authority
- AT
- Austria
- Prior art keywords
- salicylamide derivatives
- formulae
- same
- salicylamide
- derivatives represented
- Prior art date
Links
- SKZKKFZAGNVIMN-UHFFFAOYSA-N Salicilamide Chemical class NC(=O)C1=CC=CC=C1O SKZKKFZAGNVIMN-UHFFFAOYSA-N 0.000 title abstract 3
- 230000000694 effects Effects 0.000 abstract 2
- 239000004480 active ingredient Substances 0.000 abstract 1
- 229940121363 anti-inflammatory agent Drugs 0.000 abstract 1
- 239000002260 anti-inflammatory agent Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940125721 immunosuppressive agent Drugs 0.000 abstract 1
- 239000003018 immunosuppressive agent Substances 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 230000007076 release of cytoplasmic sequestered NF-kappaB Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/14—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by free hydroxyl radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/36—Compounds containing oxirane rings with hydrocarbon radicals, substituted by nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/336—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having three-membered rings, e.g. oxirane, fumagillin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
- A61K31/609—Amides, e.g. salicylamide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/38—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to a carbon atom of a ring other than a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/40—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
- C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
- C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/32—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by aldehydo- or ketonic radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Epoxy Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP22738999 | 1999-08-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE344234T1 true ATE344234T1 (de) | 2006-11-15 |
Family
ID=16860062
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00951914T ATE344234T1 (de) | 1999-08-11 | 2000-08-09 | Salicylamid-derivate |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6566394B1 (de) |
| EP (1) | EP1219596B1 (de) |
| JP (1) | JP4691295B2 (de) |
| KR (1) | KR100709317B1 (de) |
| CN (1) | CN1185212C (de) |
| AT (1) | ATE344234T1 (de) |
| AU (1) | AU774221B2 (de) |
| CA (1) | CA2393883C (de) |
| DE (1) | DE60031705T2 (de) |
| WO (1) | WO2001012588A1 (de) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101849953B (zh) * | 2000-12-18 | 2012-04-25 | 株式会社医药分子设计研究所 | 炎症性细胞因子产生游离抑制剂 |
| DE10222895A1 (de) * | 2002-05-23 | 2003-12-11 | Bosch Gmbh Robert | Hochdruckspeicher für Kraftstoffeinspritzsysteme mit integriertem Druckregelventil |
| US20060019958A1 (en) * | 2002-06-05 | 2006-01-26 | Susumu Muto | Immunity-related protein kinase inhibitors |
| JPWO2003103648A1 (ja) * | 2002-06-05 | 2005-10-06 | 株式会社医薬分子設計研究所 | 糖尿病治療薬 |
| WO2003103647A1 (ja) * | 2002-06-05 | 2003-12-18 | 株式会社医薬分子設計研究所 | Ａｐ−１及びｎｆａｔ活性化阻害剤 |
| CN1658872B (zh) * | 2002-06-06 | 2010-09-22 | 株式会社医药分子设计研究所 | 抗过敏药 |
| AU2003242118B2 (en) * | 2002-06-06 | 2008-09-11 | Institute Of Medicinal Molecular Design, Inc | O-substituted hydroxyaryl derivatives |
| CA2488974A1 (en) * | 2002-06-10 | 2003-12-18 | Institute Of Medicinal Molecular Design, Inc. | Medicament for treatment of cancer |
| EP1535609A4 (de) * | 2002-06-10 | 2009-01-07 | Inst Med Molecular Design Inc | Nf-kb-aktivierungshemmer |
| EP1555018A4 (de) * | 2002-06-11 | 2009-01-07 | Inst Med Molecular Design Inc | Mittel zur behandlung von neurodegenerativen erkrankungen |
| JPWO2004002465A1 (ja) * | 2002-06-26 | 2005-10-27 | 株式会社シグナル・クリエーション | ＮＦ−κＢ阻害剤を含む医薬組成物 |
| EP1561978B1 (de) * | 2002-11-12 | 2008-04-09 | Nok Corporation | Gummiartiges elastisches teil |
| JPWO2004072056A1 (ja) * | 2003-02-14 | 2006-06-01 | 学校法人 慶應義塾 | 医薬組成物 |
| EP1656936A4 (de) * | 2003-08-06 | 2010-03-17 | Signal Creation Inc | Makrophagen-aktivierungs-hemmer |
| JP2007182397A (ja) * | 2006-01-05 | 2007-07-19 | Keio Gijuku | ＮＦ−κＢ阻害剤 |
| US8629164B2 (en) * | 2009-03-27 | 2014-01-14 | Profectus Biosciences, Inc. | Inhibitors of NF-κB |
| US20120046357A1 (en) * | 2009-05-01 | 2012-02-23 | Profectus Biosciences, Inc. | Benzamide and Napthamide Derivatives Inhibiting Nuclear Factor-Kappa (B) - (NK-kB) |
| EP2443103A1 (de) | 2009-06-18 | 2012-04-25 | Profectus Biosciences, Inc. | Oxabicyclo [4.1.o]hept-b-en-s-ylcarbamoylderivate als hemmer des nuklearfaktors-kappa(b) - (nf-kb) |
| CN103588731B (zh) * | 2013-12-02 | 2015-09-02 | 深圳万和制药有限公司 | 水杨酸酰胺衍生物及制备方法 |
| CN103588732B (zh) * | 2013-12-02 | 2015-03-25 | 深圳万和制药有限公司 | 水杨酸酰胺衍生物的结晶 |
| RU2703735C1 (ru) * | 2018-11-09 | 2019-10-22 | Общество с ограниченной ответственностью "ПеритонТрит" | Фармацевтическая композиция, содержащая DHMEQ или его аналоги |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6445738A (en) * | 1987-08-13 | 1989-02-20 | Fujikura Ltd | Production of optical fiber preform |
| JPH09157266A (ja) * | 1995-12-04 | 1997-06-17 | Microbial Chem Res Found | 新規抗生物質エポキシキノマイシンａおよびｂとその製造法 |
| JPH1045738A (ja) * | 1996-07-29 | 1998-02-17 | Microbial Chem Res Found | 抗生物質エポキシキノマイシンｃおよびｄとその製造法ならびに抗リウマチ剤 |
-
2000
- 2000-08-09 US US10/049,158 patent/US6566394B1/en not_active Expired - Fee Related
- 2000-08-09 CA CA2393883A patent/CA2393883C/en not_active Expired - Fee Related
- 2000-08-09 KR KR1020027001552A patent/KR100709317B1/ko not_active Expired - Fee Related
- 2000-08-09 WO PCT/JP2000/005332 patent/WO2001012588A1/ja not_active Ceased
- 2000-08-09 AT AT00951914T patent/ATE344234T1/de not_active IP Right Cessation
- 2000-08-09 CN CNB008114870A patent/CN1185212C/zh not_active Expired - Lifetime
- 2000-08-09 AU AU64727/00A patent/AU774221B2/en not_active Ceased
- 2000-08-09 EP EP00951914A patent/EP1219596B1/de not_active Expired - Lifetime
- 2000-08-09 JP JP2001516889A patent/JP4691295B2/ja not_active Expired - Fee Related
- 2000-08-09 DE DE60031705T patent/DE60031705T2/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| KR20020031402A (ko) | 2002-05-01 |
| EP1219596A4 (de) | 2004-08-18 |
| CA2393883C (en) | 2010-07-06 |
| WO2001012588A1 (en) | 2001-02-22 |
| CN1368954A (zh) | 2002-09-11 |
| DE60031705D1 (de) | 2006-12-14 |
| US6566394B1 (en) | 2003-05-20 |
| CN1185212C (zh) | 2005-01-19 |
| EP1219596A1 (de) | 2002-07-03 |
| CA2393883A1 (en) | 2001-02-22 |
| EP1219596B1 (de) | 2006-11-02 |
| JP4691295B2 (ja) | 2011-06-01 |
| KR100709317B1 (ko) | 2007-04-20 |
| AU774221B2 (en) | 2004-06-17 |
| AU6472700A (en) | 2001-03-13 |
| DE60031705T2 (de) | 2007-10-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |