ATE344248T1 - Antibakterielle verbindungen - Google Patents

Antibakterielle verbindungen

Info

Publication number
ATE344248T1
ATE344248T1 AT00932760T AT00932760T ATE344248T1 AT E344248 T1 ATE344248 T1 AT E344248T1 AT 00932760 T AT00932760 T AT 00932760T AT 00932760 T AT00932760 T AT 00932760T AT E344248 T1 ATE344248 T1 AT E344248T1
Authority
AT
Austria
Prior art keywords
antibacterial compounds
antibacterial
compounds
Prior art date
Application number
AT00932760T
Other languages
English (en)
Inventor
Dirk Heerding
Kenneth A Newlander
Original Assignee
Affinium Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Affinium Pharm Inc filed Critical Affinium Pharm Inc
Application granted granted Critical
Publication of ATE344248T1 publication Critical patent/ATE344248T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT00932760T 1999-05-25 2000-05-24 Antibakterielle verbindungen ATE344248T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US13594899P 1999-05-25 1999-05-25

Publications (1)

Publication Number Publication Date
ATE344248T1 true ATE344248T1 (de) 2006-11-15

Family

ID=22470518

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00932760T ATE344248T1 (de) 1999-05-25 2000-05-24 Antibakterielle verbindungen

Country Status (9)

Country Link
US (2) US6559172B1 (de)
EP (1) EP1194144B1 (de)
JP (1) JP4948708B2 (de)
AR (1) AR024077A1 (de)
AT (1) ATE344248T1 (de)
AU (1) AU5043500A (de)
CO (1) CO5170486A1 (de)
DE (1) DE60031682T2 (de)
WO (1) WO2000071120A1 (de)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
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CO5180550A1 (es) 1999-04-19 2002-07-30 Smithkline Beecham Corp Inhibidores de fab i
CO5370679A1 (es) 1999-06-01 2004-02-27 Smithkline Beecham Corp Inhibidores fab 1
US6730684B1 (en) * 1999-10-08 2004-05-04 Affinium Pharmaceuticals, Inc. Fab I inhibitors
US6762201B1 (en) 1999-10-08 2004-07-13 Affinium Pharmaceuticals, Inc. Fab I inhibitors
HU230030B1 (hu) 1999-10-08 2015-05-28 Debiopharm International Sa Fab I inhibitorok
EP1560584B1 (de) * 2001-04-06 2009-01-14 Affinium Pharmaceuticals, Inc. Fab-i-inhibitoren
FR2825926A1 (fr) * 2001-06-14 2002-12-20 Sod Conseils Rech Applic Derives d'imidazoles modulant les canaux sodiques
WO2003022820A1 (en) * 2001-09-06 2003-03-20 Bristol-Myers Squibb Pharma Company. Heteroaromatic substituted cyclopropane as corticotropin releasing hormone
EP1575951B1 (de) * 2002-12-06 2014-06-25 Debiopharm International SA Heterozyclische verbindungen, verfahren zu deren herstellung und ihre verwendung als heilmittel
CA2514363A1 (en) * 2003-02-12 2004-08-26 Transtech Pharma, Inc. Substituted azole derivatives as therapeutic agents
WO2004082586A2 (en) * 2003-03-17 2004-09-30 Affinium Pharmaceuticals, Inc. Phamaceutical compositions comprising inhibitors of fab i and further antibiotics
CA2551909C (en) * 2004-02-12 2011-10-11 Transtech Pharma, Inc. Substituted azole derivatives, compositions, and methods of use
DK1828167T3 (da) * 2004-06-04 2014-10-20 Debiopharm Int Sa Acrylamidderivater som antibiotiske midler
WO2006092059A1 (en) * 2005-03-04 2006-09-08 Fan Wu Design and synthesis of novel antimicrobials
KR20080075027A (ko) * 2005-12-05 2008-08-13 아피늄 파마슈티컬스, 인크. Ｆａｂｉ 억제제 및 항박테리아제로서의헤테로시클릴아크릴아미드 화합물
CA2637312A1 (en) * 2006-01-27 2007-08-02 F. Hoffmann-La Roche Ag Use of substituted 2-imidazole of imidazoline derivatives
JP5468899B2 (ja) 2006-07-20 2014-04-09 アフィニウム ファーマシューティカルズ， インク． Ｆａｂｉインヒビターとしてのアクリルアミド誘導体
CA2667003A1 (en) * 2006-10-20 2008-05-02 Merck & Co., Inc. Substituted imidazoles as bombesin receptor subtype-3 modulators
US8106070B2 (en) * 2006-10-20 2012-01-31 Merck Sharp & Dohme Corp. Substituted imidazoles as bombesin receptor subtype-3 modulators
CA2666310C (en) * 2006-10-20 2012-07-31 Merck & Co., Inc. Substituted imidazoles as bombesin receptor subtype-3 modulators
EP2125802A4 (de) 2007-02-16 2014-08-20 Debiopharm Int Sa Salze, prodrugs und polymorphe von fab-i-inhibitoren
JP5313044B2 (ja) * 2008-08-08 2013-10-09 四国化成工業株式会社 銅または銅合金の表面処理剤及びその利用
JP5301218B2 (ja) * 2008-08-25 2013-09-25 四国化成工業株式会社 銅または銅合金の表面処理剤及びその利用
JP5484795B2 (ja) * 2008-09-03 2014-05-07 四国化成工業株式会社 ２−ベンジル−４−（３，４−ジクロロフェニル）−５−メチルイミダゾール化合物
JP5260367B2 (ja) * 2008-09-26 2013-08-14 四国化成工業株式会社 ２−（クロロベンジル）−４−フェニルイミダゾール化合物
WO2010041614A1 (en) * 2008-10-06 2010-04-15 Shikoku Chemicals Corporation 2-benzyl-4-(2,4-dichlorophenyl)-5-methylimidazole compound
JP5368244B2 (ja) * 2009-10-14 2013-12-18 四国化成工業株式会社 ２−（２，４−ジクロロベンジル）−４−アリール−５−メチルイミダゾール化合物
JP5368263B2 (ja) * 2009-11-04 2013-12-18 四国化成工業株式会社 ４−（２，４−ジクロロフェニル）−５−メチルイミダゾール化合物
JP5368271B2 (ja) * 2009-11-20 2013-12-18 四国化成工業株式会社 ４−（４−ビフェニリル）−２−（２，４−ジクロロベンジル）イミダゾールおよび表面処理液
JP5398076B2 (ja) * 2009-12-10 2014-01-29 四国化成工業株式会社 ２−（ブロモベンジル）−４−（ブロモフェニル）−５−メチルイミダゾール化合物
JP5398075B2 (ja) * 2010-01-13 2014-01-29 四国化成工業株式会社 ４−（ジクロロフェニル）−２−（４−フルオロベンジル）−５−メチルイミダゾール化合物
JP5615227B2 (ja) 2011-05-23 2014-10-29 四国化成工業株式会社 銅または銅合金の表面処理剤及びその利用
JP5615233B2 (ja) * 2011-06-20 2014-10-29 四国化成工業株式会社 銅または銅合金の表面処理剤及びその利用
AU2013279021C1 (en) 2012-06-19 2017-03-16 Debiopharm International Sa Prodrug derivatives of (E)-N-methyl-N-((3-methylbenzofuran-2-yl)methyl)-3-(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl)acrylamide
JP5892605B2 (ja) * 2012-08-17 2016-03-23 四国化成工業株式会社 ４−（２−チエニル）イミダゾール化合物
RS61312B1 (sr) 2016-02-26 2021-02-26 Debiopharm Int Sa Lek za lečenje infekcija dijabetskog stopala
CN118239937A (zh) 2017-08-09 2024-06-25 戴纳立制药公司 化合物、组合物及方法
DK3676297T3 (da) 2017-09-01 2023-08-14 Denali Therapeutics Inc Forbindelser, sammensætninger og fremgangsmåder
EP3749697A4 (de) 2018-02-05 2021-11-03 Bio-Rad Laboratories, Inc. Chromatografieharz mit einem liganden mit anionenaustausch-hydrophobem mischmodus
US12091392B2 (en) 2019-02-13 2024-09-17 Denali Therapeutics Inc. Compounds, compositions and methods
MA54953A (fr) 2019-02-13 2021-12-22 Denali Therapeutics Inc Composés, compositions et procédés
TN2021000159A1 (en) 2019-02-14 2023-04-04 Debiopharm Int Sa Afabicin formulation, method for making the same and uses thereof
US20220177456A1 (en) * 2019-03-06 2022-06-09 Denali Therapeutics Inc. Compounds, compositions and methods
SG11202113174SA (en) 2019-06-14 2021-12-30 Debiopharm Int Sa Medicament and use thereof for treating bacterial infections involving biofilm

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3657441A (en) * 1970-07-30 1972-04-18 Merck & Co Inc Method of inhibiting the formation of phenylethanolamine n-methyl transferase with imidazoles
FR2122395A1 (en) * 1971-01-19 1972-09-01 Berlin Chemie Veb Pharmacologically active imidazoles - by condensing alpha-aminoketones with formamide
US4218458A (en) * 1978-06-23 1980-08-19 Janssen Pharmaceutica, N.V. Heterocyclic derivatives of (4-aryloxy-methyl-1,3-dioxolan-2-yl)methyl-1H-imidazoles and 1H-1,2,4-triazoles
FR2482859A1 (fr) * 1980-05-22 1981-11-27 Fabre Sa Pierre Fluorhydrates d'heterocycles azotes insatures utilisables en therapeutique dentaire
DE4015535A1 (de) 1990-05-15 1991-11-21 Basf Ag Verfahren zur herstellung von n-substituierten imidazolen
CA2106337C (en) * 1992-09-26 1998-06-16 Hiroyuki Nakanishi Phenylimidazole derivatives, processes for production thereof, herbicides comprising said derivatives, and usages of said herbicides
JP3311858B2 (ja) * 1994-03-08 2002-08-05 四国化成工業株式会社 銅及び銅合金の表面処理剤
JPH10280162A (ja) * 1997-04-07 1998-10-20 Hideaki Yamaguchi プリント配線板の表面保護剤および表面保護膜の形成方法。
BR9810651A (pt) 1997-07-03 2000-10-03 Neurogen Corp Certos derivados de diarilimidazol; uma nova classe de ligantes npy especìficos

Also Published As

Publication number Publication date
JP2003500357A (ja) 2003-01-07
US6673941B2 (en) 2004-01-06
JP4948708B2 (ja) 2012-06-06
EP1194144A1 (de) 2002-04-10
WO2000071120A1 (en) 2000-11-30
AU5043500A (en) 2000-12-12
AR024077A1 (es) 2002-09-04
US6559172B1 (en) 2003-05-06
CO5170486A1 (es) 2002-06-27
EP1194144B1 (de) 2006-11-02
US20030149089A1 (en) 2003-08-07
EP1194144A4 (de) 2002-08-07
DE60031682T2 (de) 2007-09-06
DE60031682D1 (de) 2006-12-14

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