ATE283049T1 - Antibakterielle verbindungen - Google Patents

Antibakterielle verbindungen

Info

Publication number
ATE283049T1
ATE283049T1 AT00936459T AT00936459T ATE283049T1 AT E283049 T1 ATE283049 T1 AT E283049T1 AT 00936459 T AT00936459 T AT 00936459T AT 00936459 T AT00936459 T AT 00936459T AT E283049 T1 ATE283049 T1 AT E283049T1
Authority
AT
Austria
Prior art keywords
antibacterial compounds
antibacterial
compounds
Prior art date
Application number
AT00936459T
Other languages
English (en)
Inventor
William H Miller
Kenneth A Newlander
Mark Seefeld
Original Assignee
Affinium Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Affinium Pharm Inc filed Critical Affinium Pharm Inc
Application granted granted Critical
Publication of ATE283049T1 publication Critical patent/ATE283049T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT00936459T 1999-06-01 2000-06-01 Antibakterielle verbindungen ATE283049T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13700499P 1999-06-01 1999-06-01
PCT/US2000/015154 WO2000072846A1 (en) 1999-06-01 2000-06-01 Antibacterial compounds

Publications (1)

Publication Number Publication Date
ATE283049T1 true ATE283049T1 (de) 2004-12-15

Family

ID=22475391

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00936459T ATE283049T1 (de) 1999-06-01 2000-06-01 Antibakterielle verbindungen

Country Status (23)

Country Link
US (2) US6573272B1 (de)
EP (1) EP1180030B1 (de)
JP (1) JP4733836B2 (de)
KR (1) KR20020005767A (de)
CN (1) CN1365280A (de)
AR (1) AR024158A1 (de)
AT (1) ATE283049T1 (de)
AU (1) AU773550B2 (de)
BR (1) BR0011121A (de)
CA (1) CA2375630A1 (de)
CO (1) CO5370679A1 (de)
CZ (1) CZ20014290A3 (de)
DE (1) DE60016198T2 (de)
HK (1) HK1045644A1 (de)
HU (1) HUP0201206A3 (de)
IL (1) IL146514A0 (de)
MX (1) MXPA01012326A (de)
NO (1) NO20015722D0 (de)
NZ (1) NZ515611A (de)
PL (1) PL351959A1 (de)
TR (1) TR200103485T2 (de)
WO (1) WO2000072846A1 (de)
ZA (1) ZA200109733B (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CO5180550A1 (es) 1999-04-19 2002-07-30 Smithkline Beecham Corp Inhibidores de fab i
AR024158A1 (es) 1999-06-01 2002-09-04 Smithkline Beecham Corp Compuestos antibacterianos
US6762201B1 (en) 1999-10-08 2004-07-13 Affinium Pharmaceuticals, Inc. Fab I inhibitors
US6730684B1 (en) * 1999-10-08 2004-05-04 Affinium Pharmaceuticals, Inc. Fab I inhibitors
ES2231275T3 (es) 1999-10-08 2005-05-16 Affinium Pharmaceuticals, Inc. Inhibidores de fab i.
JP4831907B2 (ja) * 1999-10-08 2011-12-07 アフィニアム・ファーマシューティカルズ・インコーポレイテッド ＦａｂＩ阻害剤
WO2002062339A1 (en) 2000-12-08 2002-08-15 Smithkline Beecham Corporation Antibacterial compounds
WO2002049576A2 (en) * 2000-12-21 2002-06-27 Rima Mcleod Fab i and inhibition of apicomplexan parasites
US7022856B2 (en) * 2001-02-12 2006-04-04 Lilly Icos Llc. Carboline derivatives
JP4387804B2 (ja) * 2001-04-06 2009-12-24 アフィニアム・ファーマシューティカルズ・インコーポレイテッド ＦａｂＩ阻害剤
PT1575951E (pt) * 2002-12-06 2014-09-15 Debiopharm Int Sa Compostos heterocíclicos, métodos para os preparar e sua utilização em terapia
EP1608377B1 (de) * 2003-03-17 2008-10-01 Affinium Pharmaceuticals, Inc. Pharmazeutische zusammensetzungen inhibitoren von fab i und weitere antibiotika enthaltend
ATE414082T1 (de) * 2003-04-29 2008-11-15 Oscient Pharmaceuticals Antibiotische tetrahydro-b-carbolinderivative
US8450307B2 (en) * 2004-06-04 2013-05-28 Affinium Pharmaceuticals, Inc. Therapeutic agents, and methods of making and using the same
US20090156578A1 (en) * 2005-12-05 2009-06-18 PAULS Henry 3-Heterocyclylacrylamide Compounds as Fab I Inhibitors and Antibacterial Agents
EP2054422B1 (de) * 2006-07-20 2017-06-14 Debiopharm International SA Acrylamidderivate als fab-i-inhibitoren
US7854963B2 (en) * 2006-10-13 2010-12-21 Solopower, Inc. Method and apparatus for controlling composition profile of copper indium gallium chalcogenide layers
WO2008098374A1 (en) * 2007-02-16 2008-08-21 Affinium Pharmaceuticals, Inc. Salts, prodrugs and polymorphs of fab i inhibitors
EP2225250A2 (de) 2007-11-30 2010-09-08 Biota Scientific Management Pty Ltd Bicyclische ppat-inhibitoren als antibakterielle mittel
KR101135179B1 (ko) * 2009-02-20 2012-04-16 한국생명공학연구원 ＦａｂＩ 저해 물질 비나산손을 포함하는 항균용 조성물
US9353113B2 (en) 2011-03-18 2016-05-31 Ono Pharmaceutical Co., Ltd. Tetrahydrocarboline derivative
EP2861608B8 (de) 2012-06-19 2019-06-19 Debiopharm International SA Prodrug-derivate von (e)-n-methyl-n-((3-methylbenzofuran-2-yl) methyl)-3- (7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl)acrylamid
DK3419628T3 (da) 2016-02-26 2021-01-11 Debiopharm Int Sa Medikament til behandling af diabetiske fodinfektioner
EP3836919A4 (de) 2018-08-16 2022-05-18 Recreo Pharmaceuticals Inc. 1,3,4,9-tetrahydro-2h-pyrido[3,4-b]indol-derivatverbindungen und verwendungen davon
ES2944535T3 (es) 2019-02-14 2023-06-22 Debiopharm Int Sa Formulación de afabicina, método para preparar la misma
UA129222C2 (uk) 2019-06-14 2025-02-12 Дебіофарм Інтернешнл С.А. Лікарський засіб і його застосування для лікування бактеріальних інфекцій, пов'язаних з біоплівкою

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3828068A (en) 1971-05-10 1974-08-06 Tenneco Chem ((substituted indazolyl)-n1-methyl)carbamates
US4154943A (en) 1977-12-29 1979-05-15 University Of Vermont Preparation of vincadifformine
US4267330A (en) * 1978-08-24 1981-05-12 Omnium Chimique Societe Anonyme Process for the synthesis of vincadifformine and related derivatives
FR2619111B1 (fr) * 1987-08-07 1991-01-11 Synthelabo Derives de (piperidinyl-4)methyl-2 tetrahydro-1,2,3,4 9h-pyrido (3,4-b) indole, leur preparation et leur application en therapeutique
FR2692575B1 (fr) 1992-06-23 1995-06-30 Sanofi Elf Nouveaux derives du pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant.
US5416193A (en) * 1993-04-30 1995-05-16 Pfizer Inc. Coupling reagent and method
MA23420A1 (fr) 1994-01-07 1995-10-01 Smithkline Beecham Corp Antagonistes bicycliques de fibrinogene.
US5614551A (en) 1994-01-24 1997-03-25 The Johns Hopkins University Inhibitors of fatty acid synthesis as antimicrobial agents
WO1996000730A1 (en) 1994-06-29 1996-01-11 Smithkline Beecham Corporation Vitronectin receptor antagonists
US6451816B1 (en) 1997-06-20 2002-09-17 Klinge Pharma Gmbh Use of pyridyl alkane, pyridyl alkene and/or pyridyl alkine acid amides in the treatment of tumors or for immunosuppression
DE19624659A1 (de) 1996-06-20 1998-01-08 Klinge Co Chem Pharm Fab Neue Pyridylalken- und Pyridylalkinsäureamide
JPH10310582A (ja) * 1997-03-13 1998-11-24 Sankyo Co Ltd ピペリジン環縮合カルバペネム化合物
JP2001518094A (ja) 1997-03-31 2001-10-09 デュポン ファーマシューティカルズ カンパニー Ｈｉｖプロテアーゼ阻害剤として有用なインダゾール−環式尿素
US6207679B1 (en) 1997-06-19 2001-03-27 Sepracor, Inc. Antimicrobial agents uses and compositions related thereto
US5932743A (en) 1997-08-21 1999-08-03 American Home Products Corporation Methods for the solid phase synthesis of substituted indole compounds
BR9814340B1 (pt) * 1997-12-24 2010-07-13 compostos derivados de indol, processo para a preparação dos mesmo e composição farmacêutica.
AU759310B2 (en) * 1998-08-20 2003-04-10 Agouron Pharmaceuticals, Inc. Non-peptide GnRH agents, methods and intermediates for their preparation
GT199900167A (es) * 1998-10-01 2001-03-21 Nuevos bis-benzimidazoles.
CO5180550A1 (es) 1999-04-19 2002-07-30 Smithkline Beecham Corp Inhibidores de fab i
AR024077A1 (es) 1999-05-25 2002-09-04 Smithkline Beecham Corp Compuestos antibacterianos
AR024158A1 (es) 1999-06-01 2002-09-04 Smithkline Beecham Corp Compuestos antibacterianos
CO5180605A1 (es) 1999-06-23 2002-07-30 Smithkline Beecham Corp Compuestos de indol
US6346391B1 (en) 1999-07-22 2002-02-12 Trustees Of Tufts College Methods of reducing microbial resistance to drugs
EP1225895B1 (de) 1999-10-08 2005-05-04 Affinium Pharmaceuticals, Inc. Fab i hemmer
ES2231275T3 (es) 1999-10-08 2005-05-16 Affinium Pharmaceuticals, Inc. Inhibidores de fab i.
JP4831907B2 (ja) 1999-10-08 2011-12-07 アフィニアム・ファーマシューティカルズ・インコーポレイテッド ＦａｂＩ阻害剤
CA2323008C (en) 1999-10-11 2005-07-12 Pfizer Inc. Pharmaceutically active compounds
US6656703B1 (en) 1999-12-29 2003-12-02 Millennium Pharamaceuticals, Inc. High throughput screen for inhibitors of fatty acid biosynthesis in bacteria
US6372752B1 (en) 2000-02-07 2002-04-16 Genzyme Corporation Inha inhibitors and methods of use thereof
EP1332131A2 (de) 2000-11-07 2003-08-06 Bristol-Myers Squibb Company Säurederivate und ihre verwendung als inhibitoren von serinproteasen
AU2002232558A1 (en) 2000-12-12 2002-06-24 Corvas International, Inc. Compounds, compositions and methods for treatment of parasitic infections

Also Published As

Publication number Publication date
NO20015722L (no) 2001-11-23
US6573272B1 (en) 2003-06-03
JP4733836B2 (ja) 2011-07-27
DE60016198D1 (de) 2004-12-30
EP1180030A1 (de) 2002-02-20
CZ20014290A3 (cs) 2002-05-15
AU5177400A (en) 2000-12-18
JP2003500448A (ja) 2003-01-07
US20030232850A1 (en) 2003-12-18
AU773550B2 (en) 2004-05-27
WO2000072846A1 (en) 2000-12-07
IL146514A0 (en) 2002-07-25
EP1180030B1 (de) 2004-11-24
HK1045644A1 (zh) 2002-12-06
CN1365280A (zh) 2002-08-21
PL351959A1 (en) 2003-07-14
EP1180030A4 (de) 2002-09-25
DE60016198T2 (de) 2005-12-01
HUP0201206A3 (en) 2003-07-28
KR20020005767A (ko) 2002-01-17
AR024158A1 (es) 2002-09-04
NO20015722D0 (no) 2001-11-23
CO5370679A1 (es) 2004-02-27
TR200103485T2 (tr) 2002-04-22
BR0011121A (pt) 2002-02-26
NZ515611A (en) 2004-05-28
CA2375630A1 (en) 2000-12-07
HUP0201206A2 (en) 2002-08-28
MXPA01012326A (es) 2002-07-30
US6964970B2 (en) 2005-11-15
ZA200109733B (en) 2002-09-11

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Legal Events

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