ATE344257T1 - Benzimidazolverbindungen und ihre verwendung als gaba a receptor komplex modulatoren - Google Patents

Benzimidazolverbindungen und ihre verwendung als gaba a receptor komplex modulatoren

Info

Publication number: ATE344257T1
Authority: AT; Austria
Prior art keywords: phenyl; disorders; gaba; receptor complex; benzimidazole compounds
Prior art date: 1995-04-21

Application number

AT96912025T

Other languages

English (en)

Inventor

Lene Teuber

Frank Waetjen

Original Assignee

Neurosearch As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-04-21

Filing date

1996-04-19

Publication date

2006-11-15

1996-04-19 Application filed by Neurosearch As filed Critical Neurosearch As

2006-11-15 Application granted granted Critical

2006-11-15 Publication of ATE344257T1 publication Critical patent/ATE344257T1/de

Links

102000004300 GABA-A Receptors Human genes 0.000 title 1
108090000839 GABA-A Receptors Proteins 0.000 title 1
150000001556 benzimidazoles Chemical class 0.000 title 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 4
125000003545 alkoxy group Chemical group 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
229910052736 halogen Inorganic materials 0.000 abstract 2
150000002367 halogens Chemical class 0.000 abstract 2
125000001424 substituent group Chemical group 0.000 abstract 2
208000019901 Anxiety disease Diseases 0.000 abstract 1
206010010904 Convulsion Diseases 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
208000026139 Memory disease Diseases 0.000 abstract 1
125000002252 acyl group Chemical group 0.000 abstract 1
125000004442 acylamino group Chemical group 0.000 abstract 1
230000036506 anxiety Effects 0.000 abstract 1
125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 abstract 1
208000015114 central nervous system disease Diseases 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
206010015037 epilepsy Diseases 0.000 abstract 1
125000002541 furyl group Chemical group 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000000842 isoxazolyl group Chemical group 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
208000019116 sleep disease Diseases 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A61P25/12—Antiepileptics; Anticonvulsants for grand-mal
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D521/00—Heterocyclic compounds containing unspecified hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Anesthesiology (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT96912025T 1995-04-21 1996-04-19 Benzimidazolverbindungen und ihre verwendung als gaba a receptor komplex modulatoren ATE344257T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DK46095		1995-04-21

Publications (1)

Publication Number	Publication Date
ATE344257T1 true ATE344257T1 (de)	2006-11-15

Family

ID=8093808

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT96914932T ATE210132T1 (de)	1995-04-21	1996-04-17	Benzmidazolverbindungen und ihre verwendung als modulatoren des gabaa-rezeptor-komplexes
AT96912025T ATE344257T1 (de)	1995-04-21	1996-04-19	Benzimidazolverbindungen und ihre verwendung als gaba a receptor komplex modulatoren

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
AT96914932T ATE210132T1 (de)	1995-04-21	1996-04-17	Benzmidazolverbindungen und ihre verwendung als modulatoren des gabaa-rezeptor-komplexes

Country Status (22)

Country	Link
US (2)	US5922724A (de)
EP (3)	EP1164134A1 (de)
JP (2)	JP3342874B2 (de)
KR (2)	KR100297445B1 (de)
CN (2)	CN1072669C (de)
AT (2)	ATE210132T1 (de)
AU (2)	AU695957B2 (de)
BR (1)	BR9608048A (de)
CA (2)	CA2218493C (de)
CZ (1)	CZ287545B6 (de)
DE (2)	DE69617665T2 (de)
EE (1)	EE04310B1 (de)
HU (1)	HUP9801692A3 (de)
IS (1)	IS1959B (de)
NO (1)	NO314504B1 (de)
NZ (1)	NZ307521A (de)
PL (1)	PL183853B1 (de)
RU (1)	RU2135493C1 (de)
SK (1)	SK282425B6 (de)
TR (1)	TR199701218T2 (de)
UA (1)	UA54393C2 (de)
WO (2)	WO1996033194A1 (de)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU726447B2 (en)	1996-10-21	2000-11-09	Neurosearch A/S	1-phenyl-benzimidazole compounds and their use as BAGA-A receptor modulators
GB9622370D0 (en)	1996-10-28	1997-01-08	Merck Sharp & Dohme	Therapeutic agents
GB9702524D0 (en) *	1997-02-07	1997-03-26	Merck Sharp & Dohme	Therapeutic agents
US6162804A (en) *	1997-09-26	2000-12-19	Merck & Co., Inc.	Tyrosine kinase inhibitors
US6465484B1 (en)	1997-09-26	2002-10-15	Merck & Co., Inc.	Angiogenesis inhibitors
AU764479B2 (en) *	1998-10-29	2003-08-21	Bristol-Myers Squibb Company	Compounds derived from an amine nucleus that are inhibitors of IMPDH enzyme
EP1132087A4 (de)	1998-11-13	2002-06-26	Fujisawa Pharmaceutical Co	Heilmittel gegen polyzystisches-eierstock-syndrom
US6271241B1 (en)	1999-04-02	2001-08-07	Neurogen Corporation	Cycloalkyl and aryl fused aminoalkyl-imidazole derivatives: modulators and GLP-1 receptors
US6627624B1 (en)	1999-04-02	2003-09-30	Neurogen Corporation	Aryl fused aminoalkyl-imidazole derivatives: selective modulators of GABAa receptors
US6358949B1 (en)	1999-04-02	2002-03-19	Neurogen Corporation	Aryl and hetroaryl fused aminoalkyl-imidazole derivatives: selective modulators of bradykinin B2 receptors
ES2226812T3 (es) *	1999-04-02	2005-04-01	Neurogen Corporation	Derivados de aminoalquilimidazol condensados con arilo y heteroarilo:moduladores selesctivos de los preseptores gabaa.
US6380210B1 (en)	1999-04-02	2002-04-30	Neurogen Corporation	Heteroaryl fused aminoalkyl-imidazole derivatives: selective modulators of GABAa receptors
US6281237B1 (en)	1999-04-02	2001-08-28	Neurogen Corporation	N-phenyl benzimidazolecarboxamide and N-phenyl indolecarboxamide derivatives
DE60025604T2 (de)	1999-06-22	2006-07-27	Neurosearch A/S	Benzimidazol-derivate und diese enthaltende pharmazeutische zusammensetzungen
DE60006541D1 (de)	1999-06-30	2003-12-18	Merck & Co Inc	Src-kinase hemmende verbindungen
US6316444B1 (en)	1999-06-30	2001-11-13	Merck & Co., Inc.	SRC kinase inhibitor compounds
WO2001000207A1 (en) *	1999-06-30	2001-01-04	Merck & Co., Inc.	Src kinase inhibitor compounds
US6660753B2 (en) *	1999-08-19	2003-12-09	Nps Pharmaceuticals, Inc.	Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists
SK2512002A3 (en) *	1999-08-19	2002-07-02	Nps Pharma Inc	Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists
PA8535601A1 (es) *	2000-12-21	2002-11-28	Pfizer	Derivados benzimidazol y piridilimidazol como ligandos para gabaa
GB0208394D0 (en) *	2002-04-11	2002-05-22	Merck Sharp & Dohme	Therapeutic agents
JP2006516626A (ja) *	2003-01-28	2006-07-06	スミスクラインビーチャムコーポレーション	化学的化合物
US7335777B2 (en)	2003-04-03	2008-02-26	Neurosearch A/S	Benzimidazole derivatives and their use for modulating the GABAA receptor complex
JP2006522070A (ja)	2003-04-03	2006-09-28	ニューロサーチ、アクティーゼルスカブ	ベンズイミダゾール誘導体及びこれをｇａｂａａ受容体複合体をモジュレートするために使用する方法
US7700638B2 (en) *	2003-10-23	2010-04-20	N. V. Organon	1,5,7-trisubstituted benzimidazole derivatives and their use for modulating the GABAA receptor complex
CA2604516A1 (en)	2005-04-13	2006-10-19	Neurosearch A/S	Benzimidazole derivatives and their use for modulating the gabaa receptor complex
US20070015782A1 (en) *	2005-04-15	2007-01-18	Eisai Co., Ltd.	Benzimidazole compound
JP2009506069A (ja)	2005-08-26	2009-02-12	ブレインセルス，インコーポレイティド	ムスカリン性受容体調節による神経発生
EP2258359A3 (de)	2005-08-26	2011-04-06	Braincells, Inc.	Neurogenese durch Modulation des Muscarinrezeptors mit Sabcomelin
JP2009512711A (ja)	2005-10-21	2009-03-26	ブレインセルス，インコーポレイティド	Ｐｄｅ阻害による神経新生の調節
EP2314289A1 (de)	2005-10-31	2011-04-27	Braincells, Inc.	Gaba-rezeptor-vermittelte modulation von neurogenese
US7923464B2 (en)	2005-12-05	2011-04-12	Neurosearch A/S	Benzimidazole derivatives and their use for modulating the GABAA receptor complex
US20100216734A1 (en)	2006-03-08	2010-08-26	Braincells, Inc.	Modulation of neurogenesis by nootropic agents
TWI391381B (zh)	2006-03-24	2013-04-01	Neurosearch As	新穎的苯并咪唑衍生物、含有其之醫藥組成物、及其於製造藥物之用途
CA2651862A1 (en)	2006-05-09	2007-11-22	Braincells, Inc.	5 ht receptor mediated neurogenesis
AU2007249399A1 (en)	2006-05-09	2007-11-22	Braincells, Inc.	Neurogenesis by modulating angiotensin
WO2008030651A1 (en)	2006-09-08	2008-03-13	Braincells, Inc.	Combinations containing a 4-acylaminopyridine derivative
MX373178B (es) *	2007-04-03	2020-04-22	Fmc Corp Star	Fungicidas de benceno sustituido.
CA2694216A1 (en)	2007-07-24	2009-01-29	Astellas Pharma Inc.	Benzimidazole derivative
KR20090024998A (ko) *	2007-09-05	2009-03-10	제일모직주식회사	분자 내에 정공수송기와 전자수송기를 동시에 가지는바이폴라 유기화합물을 포함하는 유기광전소자용 재료 및이를 이용한 유기광전소자
WO2010055126A1 (en) *	2008-11-14	2010-05-20	Neurosearch A/S	Benzimidazole derivatives and their use for modulating the gabaa receptor complex
WO2010087319A1 (ja)	2009-01-27	2010-08-05	アステラス製薬株式会社	前立腺癌治療剤として有効な物質のスクリーニング方法
US20100216805A1 (en)	2009-02-25	2010-08-26	Braincells, Inc.	Modulation of neurogenesis using d-cycloserine combinations
AU2010218714A1 (en) *	2009-02-26	2011-09-08	Eisai R&D Management Co., Ltd.	Nitrogen-containing fused heterocyclic compounds and their use as beta amyloid production inhibitors
WO2011047315A1 (en)	2009-10-15	2011-04-21	Concert Pharmaceuticals, Inc.	Subsitituted benzimidazoles
EP2903980B1 (de) *	2012-10-01	2017-07-19	F. Hoffmann-La Roche AG	Benzimidazole verwendbar als zns-wirksame mittel
WO2014096965A2 (en)	2012-12-21	2014-06-26	Rvx Therapeutics Inc.	Novel heterocyclic compounds as bromodomain inhibitors
TWI606048B (zh) *	2013-01-31	2017-11-21	帝人製藥股份有限公司	唑苯衍生物
SG11201510409QA (en)	2013-06-21	2016-01-28	Zenith Epigenetics Corp	Novel bicyclic bromodomain inhibitors
WO2015004533A2 (en)	2013-06-21	2015-01-15	Zenith Epigenetics Corp.	Novel substituted bicyclic compounds as bromodomain inhibitors
WO2015015318A2 (en)	2013-07-31	2015-02-05	Zenith Epigenetics Corp.	Novel quinazolinones as bromodomain inhibitors
US10710992B2 (en)	2014-12-01	2020-07-14	Zenith Epigenetics Ltd.	Substituted pyridinones as bromodomain inhibitors
EP3227280B1 (de)	2014-12-01	2019-04-24	Zenith Epigenetics Ltd.	Substituierte pyridine als bromdomänenhemmer
JP2017537946A (ja)	2014-12-11	2017-12-21	ゼニス・エピジェネティクス・リミテッドＺｅｎｉｔｈＥｐｉｇｅｎｅｔｉｃｓＬｔｄ．	ブロモドメイン阻害剤としての置換複素環
HK1245247A1 (zh) *	2014-12-17	2018-08-24	恒翼生物医药科技(上海)有限公司	溴结构域的抑制剂
KR102446529B1 (ko) *	2017-01-10	2022-09-23	에테하 취리히	세포 보호 화합물 및 이의 용도

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2964942D1 (en) *	1978-04-17	1983-04-07	Basab Materialhantering Ab	A device for raising and transport of goods
DE2853765A1 (de) *	1978-12-13	1980-06-26	Bayer Ag	Verfahren zur herstellung von benzimidazolylbenzofuranen
US4329348A (en) *	1979-02-26	1982-05-11	Ciba-Geigy Corporation	N-Oxacyclic-alkylpiperidines as psychostimulants
PH30434A (en) *	1989-04-07	1997-05-09	Janssen Pharmaceutica Nv	Hydroxyalkylfuranyl derivatives
US5554630A (en) *	1993-03-24	1996-09-10	Neurosearch A/S	Benzimidazole compounds
AU675484B2 (en) *	1993-03-24	1997-02-06	Neurosearch A/S	Benzimidazole compounds, their use and preparation

1996
- 1996-04-17 PL PL96322892A patent/PL183853B1/pl not_active IP Right Cessation
- 1996-04-17 AT AT96914932T patent/ATE210132T1/de not_active IP Right Cessation
- 1996-04-17 SK SK1399-97A patent/SK282425B6/sk unknown
- 1996-04-17 HU HU9801692A patent/HUP9801692A3/hu unknown
- 1996-04-17 KR KR1019970707465A patent/KR100297445B1/ko not_active Expired - Fee Related
- 1996-04-17 RU RU97119173A patent/RU2135493C1/ru not_active IP Right Cessation
- 1996-04-17 CZ CZ19973292A patent/CZ287545B6/cs not_active IP Right Cessation
- 1996-04-17 EP EP01112476A patent/EP1164134A1/de not_active Withdrawn
- 1996-04-17 AU AU56891/96A patent/AU695957B2/en not_active Ceased
- 1996-04-17 NZ NZ307521A patent/NZ307521A/en unknown
- 1996-04-17 EP EP96914932A patent/EP0821684B1/de not_active Expired - Lifetime
- 1996-04-17 CN CN96193419A patent/CN1072669C/zh not_active Expired - Fee Related
- 1996-04-17 WO PCT/EP1996/001606 patent/WO1996033194A1/en not_active Ceased
- 1996-04-17 UA UA97115591A patent/UA54393C2/uk unknown
- 1996-04-17 CA CA002218493A patent/CA2218493C/en not_active Expired - Fee Related
- 1996-04-17 BR BR9608048-5A patent/BR9608048A/pt not_active IP Right Cessation
- 1996-04-17 TR TR97/01218T patent/TR199701218T2/xx unknown
- 1996-04-17 DE DE69617665T patent/DE69617665T2/de not_active Expired - Lifetime
- 1996-04-17 JP JP53146496A patent/JP3342874B2/ja not_active Expired - Fee Related
- 1996-04-17 US US08/945,023 patent/US5922724A/en not_active Expired - Lifetime
- 1996-04-17 EE EE9700283A patent/EE04310B1/xx not_active IP Right Cessation
- 1996-04-19 US US08/930,216 patent/US5902813A/en not_active Expired - Lifetime
- 1996-04-19 KR KR1019970707464A patent/KR19990007941A/ko not_active Abandoned
- 1996-04-19 CA CA002217601A patent/CA2217601C/en not_active Expired - Fee Related
- 1996-04-19 EP EP96912025A patent/EP0821683B1/de not_active Expired - Lifetime
- 1996-04-19 AT AT96912025T patent/ATE344257T1/de not_active IP Right Cessation
- 1996-04-19 JP JP8531487A patent/JP3040485B2/ja not_active Expired - Fee Related
- 1996-04-19 CN CN96193420A patent/CN1182426A/zh active Pending
- 1996-04-19 DE DE69636670T patent/DE69636670T2/de not_active Expired - Lifetime
- 1996-04-19 AU AU55014/96A patent/AU5501496A/en not_active Abandoned
- 1996-04-19 WO PCT/EP1996/001654 patent/WO1996033192A1/en not_active Ceased
1997
- 1997-10-13 IS IS4588A patent/IS1959B/is unknown
- 1997-10-20 NO NO19974844A patent/NO314504B1/no unknown

Also Published As

Publication number	Publication date
TR199701218T2 (xx)	1998-08-21
DE69636670T2 (de)	2007-02-08
CA2217601C (en)	2002-04-16
WO1996033194A1 (en)	1996-10-24
UA54393C2 (uk)	2003-03-17
DE69636670D1 (de)	2006-12-14
DE69617665T2 (de)	2002-05-08
NZ307521A (en)	1999-04-29
BR9608048A (pt)	1999-11-30
AU5689196A (en)	1996-11-07
NO974844D0 (no)	1997-10-20
ATE210132T1 (de)	2001-12-15
IS1959B (is)	2004-11-15
KR19990007942A (ko)	1999-01-25
US5922724A (en)	1999-07-13
EP0821684B1 (de)	2001-12-05
EP0821683B1 (de)	2006-11-02
EP0821684A1 (de)	1998-02-04
KR19990007941A (ko)	1999-01-25
PL183853B1 (pl)	2002-07-31
HUP9801692A3 (en)	2001-11-28
SK139997A3 (en)	1998-05-06
HUP9801692A2 (hu)	1999-03-29
RU2135493C1 (ru)	1999-08-27
EP0821683A1 (de)	1998-02-04
HK1015674A1 (en)	1999-10-22
NO974844L (no)	1997-12-16
US5902813A (en)	1999-05-11
IS4588A (is)	1997-10-13
JP3342874B2 (ja)	2002-11-11
JPH11501321A (ja)	1999-02-02
CA2218493C (en)	2005-02-22
CZ287545B6 (en)	2000-12-13
CA2218493A1 (en)	1996-10-24
EE04310B1 (et)	2004-06-15
CN1072669C (zh)	2001-10-10
CA2217601A1 (en)	1996-10-24
KR100297445B1 (ko)	2001-10-25
AU5501496A (en)	1996-11-07
EE9700283A (et)	1998-06-15
CN1182426A (zh)	1998-05-20
CZ329297A3 (cs)	1998-03-18
CN1182427A (zh)	1998-05-20
DE69617665D1 (de)	2002-01-17
EP1164134A1 (de)	2001-12-19
WO1996033192A1 (en)	1996-10-24
NO314504B1 (no)	2003-03-31
JPH11501320A (ja)	1999-02-02
SK282425B6 (sk)	2002-01-07
AU695957B2 (en)	1998-08-27
PL322892A1 (en)	1998-03-02
JP3040485B2 (ja)	2000-05-15

Legal Events

Date	Code	Title	Description
2007-05-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE69636670D1 (de)	2006-12-14	Benzimidazolverbindungen und ihre verwendung als gaba a receptor komplex modulatoren
ATE194836T1 (de)	2000-08-15	Benzimidazolverbindungen und ihre verwendung als modulatoren des gabaa-rezeptorkomplexes
ATE454375T1 (de)	2010-01-15	1-phenyl-benzimidazolverbindungen und ihre verwendung als modulatoren des gaba-a-rezeptors
NO941052L (no)	1994-09-26	Benzimidazolforbindelser, deres anvendelse og fremstilling
ATE164837T1 (de)	1998-04-15	Acetamidderivate und ihre verwendung als modifizierungsmittel des verhaltens der verdauung
ATE194340T1 (de)	2000-07-15	Aminomethylen substituierte heterocyclische verbindungen und ihre verwendung alssubstanz p antagonisten
DE69418789D1 (de)	1999-07-08	2-(Piperidin-4-yl, Pyridin-4-yl und Tetrahydropyridin-4-yl)-benzofuran-7-carbamat Derivate, ihre Herstellung und Verwendung als Acetylcholinesterase Inhibitoren
DE69412016D1 (de)	1998-09-03	Substituierte arylalkoxybenzyl-aminopropanamide, ihre herstellung und verwendung als antiepileptische, neuroprotektive und antidepressive mittel
ATE412628T1 (de)	2008-11-15	N- (1-dimethylaminocycloalkyl)methyl benzamid- derivate
CY1108837T1 (el)	2014-07-02	ΝΕΑ ΠΑΡΑΓΩΓΑ ΑΜΙΝΟΠΥΡΙΔΙΝΗΣ ΩΣ ΑΝΤΑΓΩΝΙΣΤΕΣ mGluR5
DE69402935D1 (de)	1997-06-05	Substituierte arylalkylaminobenzyl-aminopropanamide, ihre herstellung und verwendung als antiepileptische, neuroprotektive und antidepressive mittel
ATE266026T1 (de)	2004-05-15	Benzofurancarboxamide und deren therapeutische verwendung
MX9708096A (es)	1998-01-31	Compuestos de bencimidazol y su uso para preparar composiciones utiles como moduladores del complejo receptor de gabaa.
DE69316392D1 (de)	1998-02-19	Azanoradamantane
ATE202100T1 (de)	2001-06-15	Triazolderivate
DE69626624D1 (de)	2003-04-17	Medikamente gegen trhombocytopenie