ATE344257T1 - Benzimidazolverbindungen und ihre verwendung als gaba a receptor komplex modulatoren - Google Patents

Benzimidazolverbindungen und ihre verwendung als gaba a receptor komplex modulatoren

Info

Publication number: ATE344257T1
Authority: AT; Austria
Prior art keywords: phenyl; disorders; gaba; receptor complex; benzimidazole compounds
Prior art date: 1995-04-21

Application number

AT96912025T

Other languages

English (en)

Inventor

Lene Teuber

Frank Waetjen

Original Assignee

Neurosearch As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-04-21

Filing date

1996-04-19

Publication date

2006-11-15

1996-04-19 Application filed by Neurosearch As filed Critical Neurosearch As

2006-11-15 Application granted granted Critical

2006-11-15 Publication of ATE344257T1 publication Critical patent/ATE344257T1/de

Links

102000004300 GABA-A Receptors Human genes 0.000 title 1
108090000839 GABA-A Receptors Proteins 0.000 title 1
150000001556 benzimidazoles Chemical class 0.000 title 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 4
125000003545 alkoxy group Chemical group 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
229910052736 halogen Inorganic materials 0.000 abstract 2
150000002367 halogens Chemical class 0.000 abstract 2
125000001424 substituent group Chemical group 0.000 abstract 2
208000019901 Anxiety disease Diseases 0.000 abstract 1
206010010904 Convulsion Diseases 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
208000026139 Memory disease Diseases 0.000 abstract 1
125000002252 acyl group Chemical group 0.000 abstract 1
125000004442 acylamino group Chemical group 0.000 abstract 1
230000036506 anxiety Effects 0.000 abstract 1
125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 abstract 1
208000015114 central nervous system disease Diseases 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
206010015037 epilepsy Diseases 0.000 abstract 1
125000002541 furyl group Chemical group 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000000842 isoxazolyl group Chemical group 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
208000019116 sleep disease Diseases 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A61P25/12—Antiepileptics; Anticonvulsants for grand-mal
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D521/00—Heterocyclic compounds containing unspecified hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Anesthesiology (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT96912025T 1995-04-21 1996-04-19 Benzimidazolverbindungen und ihre verwendung als gaba a receptor komplex modulatoren ATE344257T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DK46095		1995-04-21

Publications (1)

Publication Number	Publication Date
ATE344257T1 true ATE344257T1 (de)	2006-11-15

Family

ID=8093808

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT96914932T ATE210132T1 (de)	1995-04-21	1996-04-17	Benzmidazolverbindungen und ihre verwendung als modulatoren des gabaa-rezeptor-komplexes
AT96912025T ATE344257T1 (de)	1995-04-21	1996-04-19	Benzimidazolverbindungen und ihre verwendung als gaba a receptor komplex modulatoren

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
AT96914932T ATE210132T1 (de)	1995-04-21	1996-04-17	Benzmidazolverbindungen und ihre verwendung als modulatoren des gabaa-rezeptor-komplexes

Country Status (22)

Country	Link
US (2)	US5922724A (de)
EP (3)	EP1164134A1 (de)
JP (2)	JP3342874B2 (de)
KR (2)	KR100297445B1 (de)
CN (2)	CN1072669C (de)
AT (2)	ATE210132T1 (de)
AU (2)	AU695957B2 (de)
BR (1)	BR9608048A (de)
CA (2)	CA2218493C (de)
CZ (1)	CZ287545B6 (de)
DE (2)	DE69617665T2 (de)
EE (1)	EE04310B1 (de)
HU (1)	HUP9801692A3 (de)
IS (1)	IS1959B (de)
NO (1)	NO314504B1 (de)
NZ (1)	NZ307521A (de)
PL (1)	PL183853B1 (de)
RU (1)	RU2135493C1 (de)
SK (1)	SK282425B6 (de)
TR (1)	TR199701218T2 (de)
UA (1)	UA54393C2 (de)
WO (2)	WO1996033194A1 (de)

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CN105473581B (zh)	2013-06-21	2019-04-23	齐尼思表观遗传学有限公司	作为溴结构域抑制剂的新取代的双环化合物
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WO1979000936A1 (en) *	1978-04-17	1979-11-15	Basab Materialhantering Ab	A device for raising and transport of goods
DE2853765A1 (de) *	1978-12-13	1980-06-26	Bayer Ag	Verfahren zur herstellung von benzimidazolylbenzofuranen
US4329348A (en) *	1979-02-26	1982-05-11	Ciba-Geigy Corporation	N-Oxacyclic-alkylpiperidines as psychostimulants
PH30434A (en) *	1989-04-07	1997-05-09	Janssen Pharmaceutica Nv	Hydroxyalkylfuranyl derivatives
US5554630A (en) *	1993-03-24	1996-09-10	Neurosearch A/S	Benzimidazole compounds
AU675484B2 (en) *	1993-03-24	1997-02-06	Neurosearch A/S	Benzimidazole compounds, their use and preparation

1996
- 1996-04-17 CA CA002218493A patent/CA2218493C/en not_active Expired - Fee Related
- 1996-04-17 TR TR97/01218T patent/TR199701218T2/xx unknown
- 1996-04-17 EP EP01112476A patent/EP1164134A1/de not_active Withdrawn
- 1996-04-17 JP JP53146496A patent/JP3342874B2/ja not_active Expired - Fee Related
- 1996-04-17 NZ NZ307521A patent/NZ307521A/en unknown
- 1996-04-17 AU AU56891/96A patent/AU695957B2/en not_active Ceased
- 1996-04-17 DE DE69617665T patent/DE69617665T2/de not_active Expired - Lifetime
- 1996-04-17 PL PL96322892A patent/PL183853B1/pl not_active IP Right Cessation
- 1996-04-17 WO PCT/EP1996/001606 patent/WO1996033194A1/en not_active Ceased
- 1996-04-17 BR BR9608048-5A patent/BR9608048A/pt not_active IP Right Cessation
- 1996-04-17 AT AT96914932T patent/ATE210132T1/de not_active IP Right Cessation
- 1996-04-17 RU RU97119173A patent/RU2135493C1/ru not_active IP Right Cessation
- 1996-04-17 SK SK1399-97A patent/SK282425B6/sk unknown
- 1996-04-17 US US08/945,023 patent/US5922724A/en not_active Expired - Lifetime
- 1996-04-17 UA UA97115591A patent/UA54393C2/uk unknown
- 1996-04-17 EP EP96914932A patent/EP0821684B1/de not_active Expired - Lifetime
- 1996-04-17 KR KR1019970707465A patent/KR100297445B1/ko not_active Expired - Fee Related
- 1996-04-17 EE EE9700283A patent/EE04310B1/xx not_active IP Right Cessation
- 1996-04-17 HU HU9801692A patent/HUP9801692A3/hu unknown
- 1996-04-17 CN CN96193419A patent/CN1072669C/zh not_active Expired - Fee Related
- 1996-04-17 CZ CZ19973292A patent/CZ287545B6/cs not_active IP Right Cessation
- 1996-04-19 CN CN96193420A patent/CN1182426A/zh active Pending
- 1996-04-19 US US08/930,216 patent/US5902813A/en not_active Expired - Lifetime
- 1996-04-19 WO PCT/EP1996/001654 patent/WO1996033192A1/en not_active Ceased
- 1996-04-19 KR KR1019970707464A patent/KR19990007941A/ko not_active Abandoned
- 1996-04-19 CA CA002217601A patent/CA2217601C/en not_active Expired - Fee Related
- 1996-04-19 AU AU55014/96A patent/AU5501496A/en not_active Abandoned
- 1996-04-19 AT AT96912025T patent/ATE344257T1/de not_active IP Right Cessation
- 1996-04-19 JP JP8531487A patent/JP3040485B2/ja not_active Expired - Fee Related
- 1996-04-19 EP EP96912025A patent/EP0821683B1/de not_active Expired - Lifetime
- 1996-04-19 DE DE69636670T patent/DE69636670T2/de not_active Expired - Lifetime
1997
- 1997-10-13 IS IS4588A patent/IS1959B/is unknown
- 1997-10-20 NO NO19974844A patent/NO314504B1/no unknown

Also Published As

Publication number	Publication date
JPH11501320A (ja)	1999-02-02
US5902813A (en)	1999-05-11
NO974844D0 (no)	1997-10-20
JP3040485B2 (ja)	2000-05-15
EE9700283A (et)	1998-06-15
EP0821684B1 (de)	2001-12-05
CN1072669C (zh)	2001-10-10
EP0821683A1 (de)	1998-02-04
CZ287545B6 (en)	2000-12-13
IS4588A (is)	1997-10-13
CA2217601A1 (en)	1996-10-24
US5922724A (en)	1999-07-13
HUP9801692A3 (en)	2001-11-28
KR19990007941A (ko)	1999-01-25
CZ329297A3 (cs)	1998-03-18
KR19990007942A (ko)	1999-01-25
BR9608048A (pt)	1999-11-30
DE69617665T2 (de)	2002-05-08
PL322892A1 (en)	1998-03-02
CN1182427A (zh)	1998-05-20
DE69636670T2 (de)	2007-02-08
JPH11501321A (ja)	1999-02-02
JP3342874B2 (ja)	2002-11-11
DE69636670D1 (de)	2006-12-14
AU5689196A (en)	1996-11-07
EP0821683B1 (de)	2006-11-02
AU695957B2 (en)	1998-08-27
CA2218493C (en)	2005-02-22
CN1182426A (zh)	1998-05-20
SK139997A3 (en)	1998-05-06
KR100297445B1 (ko)	2001-10-25
UA54393C2 (uk)	2003-03-17
HK1015674A1 (en)	1999-10-22
SK282425B6 (sk)	2002-01-07
AU5501496A (en)	1996-11-07
NZ307521A (en)	1999-04-29
EE04310B1 (et)	2004-06-15
PL183853B1 (pl)	2002-07-31
ATE210132T1 (de)	2001-12-15
CA2217601C (en)	2002-04-16
RU2135493C1 (ru)	1999-08-27
TR199701218T2 (xx)	1998-08-21
CA2218493A1 (en)	1996-10-24
NO974844L (no)	1997-12-16
IS1959B (is)	2004-11-15
EP0821684A1 (de)	1998-02-04
NO314504B1 (no)	2003-03-31
WO1996033194A1 (en)	1996-10-24
WO1996033192A1 (en)	1996-10-24
EP1164134A1 (de)	2001-12-19
HUP9801692A2 (hu)	1999-03-29
DE69617665D1 (de)	2002-01-17

Legal Events

Date	Code	Title	Description
2007-05-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

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