ATE344289T1 - Polyethylenglykol-aldehydderivate - Google Patents

Polyethylenglykol-aldehydderivate

Info

Publication number: ATE344289T1
Authority: AT; Austria
Prior art keywords: polyethylene glycol; aldehyde derivatives; glycol aldehyde; derivatives; polyethylene
Prior art date: 2002-07-24

Application number

AT03766194T

Other languages

English (en)

Inventor

Chee-Youb Won

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-07-24

Filing date

2003-07-16

Publication date

2006-11-15

2003-07-16 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2006-11-15 Application granted granted Critical

2006-11-15 Publication of ATE344289T1 publication Critical patent/ATE344289T1/de

Links

WGCNASOHLSPBMP-UHFFFAOYSA-N Glycolaldehyde Chemical class OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 title 1
239000002202 Polyethylene glycol Substances 0.000 title 1
229920001223 polyethylene glycol Polymers 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
- C08G65/329—Polymers modified by chemical after-treatment with organic compounds
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
- C08G65/321—Polymers modified by chemical after-treatment with inorganic compounds
- C08G65/324—Polymers modified by chemical after-treatment with inorganic compounds containing oxygen
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/26—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds
- C08G65/2603—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds the other compounds containing oxygen
- C08G65/2615—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds the other compounds containing oxygen the other compounds containing carboxylic acid, ester or anhydride groups
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/26—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds
- C08G65/2618—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds the other compounds containing nitrogen
- C08G65/2621—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds the other compounds containing nitrogen containing amine groups
- C08G65/2624—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds the other compounds containing nitrogen containing amine groups containing aliphatic amine groups
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
- C08G65/329—Polymers modified by chemical after-treatment with organic compounds
- C08G65/331—Polymers modified by chemical after-treatment with organic compounds containing oxygen

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
Polymers & Plastics (AREA)
Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Inorganic Chemistry (AREA)
Polyethers (AREA)
Medicinal Preparation (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Saccharide Compounds (AREA)
Hydrogenated Pyridines (AREA)

AT03766194T 2002-07-24 2003-07-16 Polyethylenglykol-aldehydderivate ATE344289T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US39819602P	2002-07-24	2002-07-24

Publications (1)

Publication Number	Publication Date
ATE344289T1 true ATE344289T1 (de)	2006-11-15

Family

ID=31495721

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT03766194T ATE344289T1 (de)	2002-07-24	2003-07-16	Polyethylenglykol-aldehydderivate

Country Status (28)

Country	Link
US (2)	US7273909B2 (de)
EP (1)	EP1539857B1 (de)
JP (1)	JP4071238B2 (de)
KR (1)	KR100615753B1 (de)
CN (1)	CN1671769B (de)
AR (1)	AR040607A1 (de)
AT (1)	ATE344289T1 (de)
AU (1)	AU2003250971B2 (de)
BR (1)	BR0312863B1 (de)
CA (1)	CA2493221C (de)
DE (1)	DE60309482T2 (de)
DK (1)	DK1539857T3 (de)
ES (1)	ES2274277T3 (de)
GT (1)	GT200300154A (de)
HR (1)	HRP20050026A2 (de)
IL (1)	IL165920A0 (de)
JO (1)	JO2400B1 (de)
MX (1)	MXPA05000799A (de)
NO (1)	NO336974B1 (de)
PA (1)	PA8577601A1 (de)
PE (1)	PE20040703A1 (de)
PL (1)	PL214871B1 (de)
PT (1)	PT1539857E (de)
RU (1)	RU2288212C2 (de)
TW (1)	TWI276647B (de)
UY (1)	UY27902A1 (de)
WO (1)	WO2004013205A1 (de)
ZA (1)	ZA200410296B (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP4764630B2 (ja)	2002-09-09	2011-09-07	ネクターセラピューティックス	水溶性ポリマーアルカナール
US7569214B2 (en)	2002-09-09	2009-08-04	Nektar Therapeutics Al, Corporation	Method for preparing water-soluble polymer derivatives bearing a terminal carboxylic acid
US20050214250A1 (en)	2003-11-06	2005-09-29	Harris J M	Method of preparing carboxylic acid functionalized polymers
US7989554B2 (en) *	2006-01-10	2011-08-02	Enzon Pharmaceuticals, Inc.	Reacting polyalkylene oxide with base, tertiary alkyl haloacetate, then acid to prepare polyalkylene oxide carboxylic acid
WO2008051383A2 (en) *	2006-10-19	2008-05-02	Amgen Inc.	Use of alcohol co-solvents to improve pegylation reaction yields
WO2008048079A1 (en) *	2006-10-20	2008-04-24	Postech Academy-Industry Foundation	Long acting formulation of biopharmaceutical
US8247493B2 (en) *	2007-10-22	2012-08-21	Postech Academy-Industry Foundation	Long acting formulation of biopharmaceutical
KR100967833B1 (ko) *	2008-05-20	2010-07-05	아이디비켐(주)	고순도의 폴리에틸렌글리콜 알데하이드 유도체의 제조방법
EP2331139B1 (de) *	2008-09-11	2019-04-17	Nektar Therapeutics	Polymer-alpha-hydroxy-aldehyd und keton-reagenzien und konjugationsverfahren
RU2439091C1 (ru) *	2010-10-06	2012-01-10	Общество С Ограниченной Ответственностью "Форт" (Ооо "Форт")	Производные полиэтиленгликоля, содержащие ароматическую диазогруппу
EP2592103A1 (de)	2011-11-08	2013-05-15	Adriacell S.p.A.	Polymeraldehydderivate
CN110251683A (zh) *	2013-06-24	2019-09-20	Abl生物公司	具有改进的稳定性的抗体-药物缀合物及其用途
TWI689310B (zh) *	2014-07-11	2020-04-01	巨生生醫股份有限公司	治療鐵缺乏症之方法
KR102247701B1 (ko) *	2016-02-26	2021-05-03	한미정밀화학주식회사	폴리에틸렌글리콜 디알데히드 유도체의 제조방법
CN109071419A (zh) *	2016-03-07	2018-12-21	韩美药品株式会社	聚乙二醇衍生物及其用途
US11357861B2 (en)	2017-09-29	2022-06-14	Hanmi Pharm. Co., Ltd	Protein complex comprising non-peptidyl polymer-coupled fatty acid derivative compound as linker and preparation method therefor
AU2022409717A1 (en)	2021-12-16	2024-05-30	Pags Co., Ltd.	Cell penetrating polypeptides (cpps) and their use in human therapy
EP4480497A1 (de)	2023-06-21	2024-12-25	RDP Pharma AG	Biokonjugate für die onkologie

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5252714A (en) *	1990-11-28	1993-10-12	The University Of Alabama In Huntsville	Preparation and use of polyethylene glycol propionaldehyde
US5770577A (en) *	1994-11-14	1998-06-23	Amgen Inc.	BDNF and NT-3 polypeptides selectively linked to polyethylene glycol
CH690143A5 (de) *	1995-01-27	2000-05-15	Rieter Automotive Int Ag	Lambda/4-Schallabsorber.
US5672662A (en) *	1995-07-07	1997-09-30	Shearwater Polymers, Inc.	Poly(ethylene glycol) and related polymers monosubstituted with propionic or butanoic acids and functional derivatives thereof for biotechnical applications
US5990237A (en) *	1997-05-21	1999-11-23	Shearwater Polymers, Inc.	Poly(ethylene glycol) aldehyde hydrates and related polymers and applications in modifying amines
WO2000024697A1 (en) *	1998-10-26	2000-05-04	University Of Utah Research Foundation	Method for preparation of polyethylene glycol aldehyde derivatives
PE20010288A1 (es) *	1999-07-02	2001-03-07	Hoffmann La Roche	Derivados de eritropoyetina
EP1507755A4 (de)	2001-12-11	2006-05-17	Sun Bio Inc	Neue monofunktionelle polyethylengkykolaldehyde
KR100488351B1 (ko) *	2001-12-11	2005-05-11	선바이오(주)	신규한 폴리에틸렌글리콜-프로피온알데히드 유도체

2003
- 2003-07-16 AT AT03766194T patent/ATE344289T1/de active
- 2003-07-16 BR BRPI0312863-6A patent/BR0312863B1/pt not_active IP Right Cessation
- 2003-07-16 PL PL375266A patent/PL214871B1/pl unknown
- 2003-07-16 AU AU2003250971A patent/AU2003250971B2/en not_active Ceased
- 2003-07-16 PT PT03766194T patent/PT1539857E/pt unknown
- 2003-07-16 WO PCT/EP2003/007734 patent/WO2004013205A1/en not_active Ceased
- 2003-07-16 KR KR1020057001223A patent/KR100615753B1/ko not_active Expired - Fee Related
- 2003-07-16 HR HR20050026A patent/HRP20050026A2/hr not_active Application Discontinuation
- 2003-07-16 RU RU2005105568/04A patent/RU2288212C2/ru not_active IP Right Cessation
- 2003-07-16 DK DK03766194T patent/DK1539857T3/da active
- 2003-07-16 EP EP03766194A patent/EP1539857B1/de not_active Expired - Lifetime
- 2003-07-16 MX MXPA05000799A patent/MXPA05000799A/es active IP Right Grant
- 2003-07-16 ES ES03766194T patent/ES2274277T3/es not_active Expired - Lifetime
- 2003-07-16 CN CN038176491A patent/CN1671769B/zh not_active Expired - Fee Related
- 2003-07-16 DE DE60309482T patent/DE60309482T2/de not_active Expired - Lifetime
- 2003-07-16 CA CA002493221A patent/CA2493221C/en not_active Expired - Fee Related
- 2003-07-16 JP JP2004525223A patent/JP4071238B2/ja not_active Expired - Fee Related
- 2003-07-20 JO JO200383A patent/JO2400B1/en active
- 2003-07-21 US US10/623,978 patent/US7273909B2/en not_active Expired - Fee Related
- 2003-07-21 TW TW092119827A patent/TWI276647B/zh not_active IP Right Cessation
- 2003-07-21 PE PE2003000727A patent/PE20040703A1/es not_active Application Discontinuation
- 2003-07-21 AR AR20030102609A patent/AR040607A1/es not_active Application Discontinuation
- 2003-07-21 PA PA20038577601A patent/PA8577601A1/es unknown
- 2003-07-22 UY UY27902A patent/UY27902A1/es not_active Application Discontinuation
- 2003-07-23 GT GT200300154A patent/GT200300154A/es unknown
2004
- 2004-12-21 ZA ZA200410296A patent/ZA200410296B/en unknown
- 2004-12-22 IL IL16592004A patent/IL165920A0/xx not_active IP Right Cessation
2005
- 2005-01-03 NO NO20050019A patent/NO336974B1/no not_active IP Right Cessation
2007
- 2007-03-14 US US11/724,009 patent/US20070167606A1/en not_active Abandoned

Also Published As

Publication number	Publication date
CA2493221C (en)	2008-11-18
RU2288212C2 (ru)	2006-11-27
AU2003250971A1 (en)	2004-02-23
DK1539857T3 (da)	2007-03-12
PA8577601A1 (es)	2004-02-07
EP1539857A1 (de)	2005-06-15
EP1539857B1 (de)	2006-11-02
JP2005533913A (ja)	2005-11-10
JP4071238B2 (ja)	2008-04-02
PL214871B1 (pl)	2013-09-30
MXPA05000799A (es)	2005-04-19
GT200300154A (es)	2004-03-15
ZA200410296B (en)	2006-07-26
ES2274277T3 (es)	2007-05-16
KR100615753B1 (ko)	2006-08-25
US7273909B2 (en)	2007-09-25
DE60309482T2 (de)	2007-06-28
NO336974B1 (no)	2015-12-07
KR20050025974A (ko)	2005-03-14
UY27902A1 (es)	2003-12-31
US20040019157A1 (en)	2004-01-29
PT1539857E (pt)	2007-01-31
BR0312863B1 (pt)	2013-02-05
CA2493221A1 (en)	2004-02-12
IL165920A0 (en)	2006-01-15
CN1671769B (zh)	2010-05-12
HRP20050026A2 (en)	2006-02-28
AU2003250971B2 (en)	2008-04-03
DE60309482D1 (de)	2006-12-14
WO2004013205A1 (en)	2004-02-12
NO20050019L (no)	2005-02-23
PE20040703A1 (es)	2004-10-14
PL375266A1 (en)	2005-11-28
TWI276647B (en)	2007-03-21
US20070167606A1 (en)	2007-07-19
RU2005105568A (ru)	2005-10-20
AR040607A1 (es)	2005-04-13
BR0312863A (pt)	2005-06-14
JO2400B1 (en)	2007-06-17
CN1671769A (zh)	2005-09-21
TW200416241A (en)	2004-09-01

Legal Events

Date

Code

Title

Description

2007-07-15

UEP

Publication of translation of european patent specification

Ref document number: 1539857

Country of ref document: EP

Publication	Publication Date	Title
ATE478870T1 (de)	2010-09-15	Spiroindolinpiperidinderivate
ATE460418T1 (de)	2010-03-15	Heterocyclocarboxamidderivate
DK1551802T3 (da)	2010-03-15	Indol-3-svovlderivater
ATE467631T1 (de)	2010-05-15	Chinuclidinamidderivate
ATE438644T1 (de)	2009-08-15	Chinazolinderivate
IS7720A (is)	2005-03-01	Píperidín-N-oxíð-afleiður
DK1474408T3 (da)	2012-06-25	N-Phenyl-2-pyrimidinaminderivater
DK1594840T3 (da)	2007-02-05	Piperidin-benzensulfonamid-derivater
DE602004019245D1 (de)	2009-03-12	Polyethylenfolien
NO20032053D0 (no)	2003-05-07	Styreskinne
ATE352550T1 (de)	2007-02-15	Chinazolinderivate
ATE420066T1 (de)	2009-01-15	Amidoacetonitrilderivate
DK1606277T3 (da)	2008-08-18	Imidazol-4-yl-ethynyl-pyridinderivater
IS8180A (is)	2005-12-14	Nýjar besímídasólafleiður
DK1539857T3 (da)	2007-03-12	Polyethylenglycol-aldehydderivater
DE60307512D1 (de)	2006-09-21	3h-chinazoline -4-on derivaten
ATE354365T1 (de)	2007-03-15	N-thiazol-2-yl-benzamid-derivate
ATE423771T1 (de)	2009-03-15	Tetrahydrochinolinderivate
DK1706373T3 (da)	2010-01-18	Amidoacetonitrilderivater
IS8045A (is)	2005-09-26	Púrín-6-ón-afleiður
DE50306277D1 (de)	2007-02-22	4-alkyl-/4-alkenyl-/4-alkinylmethyl/-1-arylcyclohexylamin-derivate
DE60205924D1 (de)	2005-10-06	Mikrogreifer
NO20024789D0 (no)	2002-10-03	Stötfanger
IS7906A (is)	2005-06-22	Afleiður própargýl-tríflúorómetoxý-amínó-benzóþíazóls
SI1539857T1 (sl)	2007-02-28	Derivati polietilen glikol aldehidov