ATE345386T1 - Methode zum auffinden von abgeschwächten oder virulent-defekten mikroben - Google Patents

Methode zum auffinden von abgeschwächten oder virulent-defekten mikroben

Info

Publication number
ATE345386T1
ATE345386T1 AT02743053T AT02743053T ATE345386T1 AT E345386 T1 ATE345386 T1 AT E345386T1 AT 02743053 T AT02743053 T AT 02743053T AT 02743053 T AT02743053 T AT 02743053T AT E345386 T1 ATE345386 T1 AT E345386T1
Authority
AT
Austria
Prior art keywords
attenuated
virulent
finding
identification
microbes
Prior art date
Application number
AT02743053T
Other languages
English (en)
Inventor
Elke Freissler
Thilo M Fuchs
Heide S Niesalla
Heiko Apfel
Original Assignee
Creatogen Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Creatogen Ag filed Critical Creatogen Ag
Application granted granted Critical
Publication of ATE345386T1 publication Critical patent/ATE345386T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1082—Preparation or screening gene libraries by chromosomal integration of polynucleotide sequences, HR-, site-specific-recombination, transposons, viral vectors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/255—Salmonella (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Virology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
AT02743053T 2001-05-17 2002-05-17 Methode zum auffinden von abgeschwächten oder virulent-defekten mikroben ATE345386T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01112158 2001-05-17
EP01117866 2001-07-23

Publications (1)

Publication Number Publication Date
ATE345386T1 true ATE345386T1 (de) 2006-12-15

Family

ID=26076587

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02743053T ATE345386T1 (de) 2001-05-17 2002-05-17 Methode zum auffinden von abgeschwächten oder virulent-defekten mikroben

Country Status (5)

Country Link
US (1) US20040152099A1 (de)
EP (1) EP1407014B1 (de)
AT (1) ATE345386T1 (de)
DE (1) DE60216099D1 (de)
WO (1) WO2002092814A2 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7390620B2 (en) 2001-04-06 2008-06-24 Creatogen Laboratories Gmbh Screening method for anti-microbial drug targets by genome-saturating mutagenesis (GSM)
SE0300413D0 (sv) * 2003-02-15 2003-02-15 Innate Pharmaceuticals Ab Sätt att identifiera nya virulensassocierade gener

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4764370A (en) * 1984-09-12 1988-08-16 Scripps Clinic And Research Foundation Vaccine utilizing an avirulent strain of Salmonella typhimurium
US5434065A (en) * 1993-05-06 1995-07-18 President And Fellows Of Harvard College In vivo selection of microbial virulence genes
DE69526377T2 (de) * 1994-12-09 2002-11-07 Microscience Ltd Virulenzgene in der VGC2-Region von Salmonella
US6139817A (en) * 1996-10-15 2000-10-31 Smithkline Beecham Corporation Method for determining gene essentiality in a pathogen
US6207384B1 (en) * 1998-03-27 2001-03-27 The General Hospital Corporation Systematic identification of essential genes by in vitro transposon mutagenesis
ATE486940T1 (de) * 1998-09-04 2010-11-15 Emergent Product Dev Uk Ltd Abgeschwächte salmonella sp12 mutante als antigen-träger.
SE9901961D0 (sv) * 1999-05-28 1999-05-28 Anders Folkesson Fimbrial proteins
WO2000073502A2 (de) * 1999-05-31 2000-12-07 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Essentielle gene und genprodukte zur identifizierung, entwicklung und optimierung von immunologischen und pharmakologischen wirkstoffen zur behandlung mikrobieller infektionen
AU5559300A (en) * 1999-07-06 2001-01-22 Institut Pasteur Method of making and identifying attenuated microorganisms, compositions utilizing the sequences responsible for attenuation, and preparations containing attenuated microorganisms
US7390620B2 (en) * 2001-04-06 2008-06-24 Creatogen Laboratories Gmbh Screening method for anti-microbial drug targets by genome-saturating mutagenesis (GSM)

Also Published As

Publication number Publication date
EP1407014A2 (de) 2004-04-14
WO2002092814A2 (en) 2002-11-21
WO2002092814A3 (en) 2004-01-22
US20040152099A1 (en) 2004-08-05
DE60216099D1 (de) 2006-12-28
EP1407014B1 (de) 2006-11-15

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Legal Events

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