ATE346838T1 - Verfahren zur herstellung von r-(-)-carnitin aus s-(-)-chlorbernsteinsäure oder aus einem ihrer derivate - Google Patents

Verfahren zur herstellung von r-(-)-carnitin aus s-(-)-chlorbernsteinsäure oder aus einem ihrer derivate

Info

Publication number: ATE346838T1
Authority: AT; Austria
Prior art keywords: acid; aspartic acid; ranging; chlorosuncric; carnitine
Prior art date: 1999-05-18

Application number

AT00927737T

Other languages

English (en)

Inventor

Piero Melloni

Alberto Cerri

Marco Santagostino

Original Assignee

Sigma Tau Ind Farmaceuti

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-05-18

Filing date

2000-05-12

Publication date

2006-12-15

1999-05-18 Priority claimed from IT1999RM000310 external-priority patent/IT1306142B1/it

1999-10-29 Priority claimed from IT1999RM000670 external-priority patent/IT1306737B1/it

2000-02-10 Priority claimed from IT2000RM000061 external-priority patent/IT1316989B1/it

2000-05-12 Application filed by Sigma Tau Ind Farmaceuti filed Critical Sigma Tau Ind Farmaceuti

2006-12-15 Application granted granted Critical

2006-12-15 Publication of ATE346838T1 publication Critical patent/ATE346838T1/de

Links

PHIQHXFUZVPYII-ZCFIWIBFSA-N (R)-carnitine Chemical compound C[N+](C)(C)C[C@H](O)CC([O-])=O PHIQHXFUZVPYII-ZCFIWIBFSA-N 0.000 title 1
239000002253 acid Substances 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 4
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 abstract 4
239000011780 sodium chloride Substances 0.000 abstract 2
LPXPTNMVRIOKMN-UHFFFAOYSA-M sodium nitrite Chemical compound [Na+].[O-]N=O LPXPTNMVRIOKMN-UHFFFAOYSA-M 0.000 abstract 2
238000006243 chemical reaction Methods 0.000 abstract 1
239000007795 chemical reaction product Substances 0.000 abstract 1
238000001816 cooling Methods 0.000 abstract 1
238000002955 isolation Methods 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
238000001556 precipitation Methods 0.000 abstract 1
238000002360 preparation method Methods 0.000 abstract 1
239000011541 reaction mixture Substances 0.000 abstract 1
235000010288 sodium nitrite Nutrition 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/30—Preparation of optical isomers
- C07C227/32—Preparation of optical isomers by stereospecific synthesis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/63—Esters of sulfonic acids
- C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
- C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
- C07C309/66—Methanesulfonates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/04—Formation of amino groups in compounds containing carboxyl groups
- C07C227/06—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid
- C07C227/08—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid by reaction of ammonia or amines with acids containing functional groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
- C07C51/377—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by splitting-off hydrogen or functional groups; by hydrogenolysis of functional groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/42—Separation; Purification; Stabilisation; Use of additives
- C07C51/48—Separation; Purification; Stabilisation; Use of additives by liquid-liquid treatment
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/54—Preparation of carboxylic acid anhydrides
- C07C51/56—Preparation of carboxylic acid anhydrides from organic acids, their salts, their esters or their halides, e.g. by carboxylation
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/62—Halogen-containing esters
- C07C69/63—Halogen-containing esters of saturated acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Oil, Petroleum & Natural Gas (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Vascular Medicine (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Pain & Pain Management (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Urology & Nephrology (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Furan Compounds (AREA)

AT00927737T 1999-05-18 2000-05-12 Verfahren zur herstellung von r-(-)-carnitin aus s-(-)-chlorbernsteinsäure oder aus einem ihrer derivate ATE346838T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
IT1999RM000310 IT1306142B1 (it)	1999-05-18	1999-05-18	Procedimento per la preparazione di r-(-)-carnitina a partiredall'acido s-(-)-clorosuccinico.
IT1999RM000670 IT1306737B1 (it)	1999-10-29	1999-10-29	Procedimento per la preparazione di acidi carbossilici chirali.
IT2000RM000061 IT1316989B1 (it)	2000-02-10	2000-02-10	Procedimento per la preparazione di r-(-)- carnitina a partire daacido s-(-)- clorosuccinico o da un suo derivato.

Publications (1)

Publication Number	Publication Date
ATE346838T1 true ATE346838T1 (de)	2006-12-15

Family

ID=27274166

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT00927737T ATE346838T1 (de)	1999-05-18	2000-05-12	Verfahren zur herstellung von r-(-)-carnitin aus s-(-)-chlorbernsteinsäure oder aus einem ihrer derivate

Country Status (19)

Country	Link
US (3)	US6677476B1 (de)
EP (2)	EP1468979A1 (de)
JP (2)	JP4584464B2 (de)
KR (2)	KR100789468B1 (de)
CN (1)	CN1158244C (de)
AT (1)	ATE346838T1 (de)
AU (1)	AU4612100A (de)
CA (1)	CA2372424A1 (de)
CY (1)	CY1107566T1 (de)
CZ (1)	CZ20013816A3 (de)
DE (1)	DE60032139T2 (de)
DK (1)	DK1187805T3 (de)
ES (1)	ES2277838T3 (de)
HU (1)	HUP0201418A3 (de)
MX (1)	MXPA01011758A (de)
PL (1)	PL203993B1 (de)
PT (1)	PT1187805E (de)
SK (1)	SK286155B6 (de)
WO (1)	WO2000069808A1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TWI367882B (en)	2003-03-26	2012-07-11	Du Pont	Preparation and use of 2-substituted-5-oxo-3-pyrazolidinecarboxylates
WO2007139238A1 (en) *	2006-05-26	2007-12-06	Enzytech, Ltd.	Process for l-carnitine and acetyl l-carnitine hydrochloride
WO2008056827A1 (fr)	2006-11-09	2008-05-15	Mitsubishi Rayon Co., Ltd.	Procédé pour la production d'une bétaïne
EP2325164A1 (de) *	2009-11-18	2011-05-25	Lonza Ltd.	Verfahren zur Herstellung von L-Carnitin
US8310256B2 (en)	2009-12-22	2012-11-13	Teradyne, Inc.	Capacitive opens testing in low signal environments
JP6034287B2 (ja) *	2010-07-21	2016-11-30	ロンザリミテッドＬｏｎｚａＬｉｍｉｔｅｄ	β−ラクトンからのカルニチンの製造のためのプロセス
KR101110206B1 (ko) *	2011-05-02	2012-02-15	송명호	개폐가 용이하도록 완충기가 구비된 진동선별장치
CN118638020B (zh) *	2024-08-08	2024-11-19	杭州海尔希畜牧科技有限公司	L-天门冬氨酸l(-)肉碱(1:1)的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL45594A (en) *	1973-11-12	1977-12-30	Stauffer Chemical Co	Bis-substituted succinamides and their use as herbicides
GB1513257A (en) *	1975-02-03	1978-06-07	Stauffer Chemical Co	Bis-substituted succinamides and the use thereof as herbicides
US4265247A (en) *	1979-11-07	1981-05-05	Research Corporation	Malic acid polymers
ZA826022B (en) *	1981-08-21	1983-08-31	Univ Miami	Novel complex amido and imido derivatives of carboxyalkyl peptides and thioethers and ethers of peptides
DE3144698A1 (de) *	1981-11-11	1983-05-19	Bayer Ag, 5090 Leverkusen	Verfahren zur herstellung von hydantoinen
DE3144697A1 (de) *	1981-11-11	1983-05-19	Bayer Ag, 5090 Leverkusen	Verfahren zur herstellung von hydantoinen
US5473104A (en) *	1994-09-13	1995-12-05	Neurocrine Biosciences, Inc.	Process for the preparation of L-carnitine
KR100255039B1 (ko) *	1997-07-28	2000-05-01	박영구	L-카르니틴의제조방법

2000
- 2000-05-12 KR KR1020067021556A patent/KR100789468B1/ko not_active Expired - Fee Related
- 2000-05-12 EP EP04013530A patent/EP1468979A1/de not_active Withdrawn
- 2000-05-12 CA CA002372424A patent/CA2372424A1/en not_active Abandoned
- 2000-05-12 ES ES00927737T patent/ES2277838T3/es not_active Expired - Lifetime
- 2000-05-12 DE DE60032139T patent/DE60032139T2/de not_active Expired - Lifetime
- 2000-05-12 PL PL351646A patent/PL203993B1/pl not_active IP Right Cessation
- 2000-05-12 AT AT00927737T patent/ATE346838T1/de not_active IP Right Cessation
- 2000-05-12 CZ CZ20013816A patent/CZ20013816A3/cs unknown
- 2000-05-12 PT PT00927737T patent/PT1187805E/pt unknown
- 2000-05-12 DK DK00927737T patent/DK1187805T3/da active
- 2000-05-12 MX MXPA01011758A patent/MXPA01011758A/es active IP Right Grant
- 2000-05-12 CN CNB008076502A patent/CN1158244C/zh not_active Expired - Fee Related
- 2000-05-12 WO PCT/IT2000/000187 patent/WO2000069808A1/en not_active Ceased
- 2000-05-12 KR KR1020017014397A patent/KR100684379B1/ko not_active Expired - Fee Related
- 2000-05-12 SK SK1601-2001A patent/SK286155B6/sk not_active IP Right Cessation
- 2000-05-12 JP JP2000618226A patent/JP4584464B2/ja not_active Expired - Fee Related
- 2000-05-12 HU HU0201418A patent/HUP0201418A3/hu unknown
- 2000-05-12 EP EP00927737A patent/EP1187805B1/de not_active Expired - Lifetime
- 2000-05-12 US US09/959,717 patent/US6677476B1/en not_active Expired - Fee Related
- 2000-05-12 AU AU46121/00A patent/AU4612100A/en not_active Abandoned
2003
- 2003-11-20 US US10/716,453 patent/US6984739B2/en not_active Expired - Fee Related
2005
- 2005-07-07 US US11/175,356 patent/US7247747B2/en not_active Expired - Fee Related
2007
- 2007-02-26 CY CY20071100268T patent/CY1107566T1/el unknown
2010
- 2010-07-06 JP JP2010153891A patent/JP2010229157A/ja active Pending

Also Published As

Publication number	Publication date
US20040102645A1 (en)	2004-05-27
JP2002544252A (ja)	2002-12-24
WO2000069808A1 (en)	2000-11-23
CY1107566T1 (el)	2013-03-13
HUP0201418A2 (en)	2002-08-28
US6677476B1 (en)	2004-01-13
JP4584464B2 (ja)	2010-11-24
MXPA01011758A (es)	2002-05-14
DE60032139T2 (de)	2007-09-27
KR100684379B1 (ko)	2007-02-20
PL351646A1 (en)	2003-05-19
PT1187805E (pt)	2007-01-31
KR20060114044A (ko)	2006-11-03
JP2010229157A (ja)	2010-10-14
KR100789468B1 (ko)	2008-01-02
US20050245762A1 (en)	2005-11-03
US6984739B2 (en)	2006-01-10
DK1187805T3 (da)	2007-04-16
CN1352630A (zh)	2002-06-05
PL203993B1 (pl)	2009-11-30
AU4612100A (en)	2000-12-05
CZ20013816A3 (cs)	2002-02-13
CN1158244C (zh)	2004-07-21
EP1468979A1 (de)	2004-10-20
ES2277838T3 (es)	2007-08-01
DE60032139D1 (de)	2007-01-11
HUP0201418A3 (en)	2002-11-28
EP1187805A1 (de)	2002-03-20
KR20020009609A (ko)	2002-02-01
CA2372424A1 (en)	2000-11-23
EP1187805B1 (de)	2006-11-29
SK16012001A3 (sk)	2002-04-04
US7247747B2 (en)	2007-07-24
SK286155B6 (sk)	2008-04-07

Legal Events

Date

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2007-11-15

UEP

Publication of translation of european patent specification

Ref document number: 1187805

Country of ref document: EP

2012-02-15

REN

Ceased due to non-payment of the annual fee

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