ATE346917T1 - Verfahren zum screenen von verbindungen, welche die expression der menschlichen induzierbaren stickstoffoxidsynthase regulieren - Google Patents
Verfahren zum screenen von verbindungen, welche die expression der menschlichen induzierbaren stickstoffoxidsynthase regulierenInfo
- Publication number
- ATE346917T1 ATE346917T1 AT97941189T AT97941189T ATE346917T1 AT E346917 T1 ATE346917 T1 AT E346917T1 AT 97941189 T AT97941189 T AT 97941189T AT 97941189 T AT97941189 T AT 97941189T AT E346917 T1 ATE346917 T1 AT E346917T1
- Authority
- AT
- Austria
- Prior art keywords
- expression
- hinos
- gene
- oxide synthase
- transformant
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 230000001939 inductive effect Effects 0.000 title abstract 2
- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 title 3
- 238000000034 method Methods 0.000 title 1
- 238000012216 screening Methods 0.000 title 1
- 108700008625 Reporter Genes Proteins 0.000 abstract 3
- 108090000623 proteins and genes Proteins 0.000 abstract 3
- 230000005764 inhibitory process Effects 0.000 abstract 2
- 239000013612 plasmid Substances 0.000 abstract 2
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 108060001084 Luciferase Proteins 0.000 abstract 1
- 239000005089 Luciferase Substances 0.000 abstract 1
- 102000008299 Nitric Oxide Synthase Human genes 0.000 abstract 1
- 108010021487 Nitric Oxide Synthase Proteins 0.000 abstract 1
- 206010040047 Sepsis Diseases 0.000 abstract 1
- 108091036066 Three prime untranslated region Proteins 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 239000003443 antiviral agent Substances 0.000 abstract 1
- 210000005260 human cell Anatomy 0.000 abstract 1
- 239000000411 inducer Substances 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C50/00—Quinones
- C07C50/02—Quinones with monocyclic quinoid structure
- C07C50/06—Quinones with monocyclic quinoid structure with unsaturation outside the quinoid structure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C50/00—Quinones
- C07C50/26—Quinones containing groups having oxygen atoms singly bound to carbon atoms
- C07C50/30—Quinones containing groups having oxygen atoms singly bound to carbon atoms with polycyclic non-condensed quinoid structure
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
- C12N9/0073—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14) with NADH or NADPH as one donor, and incorporation of one atom of oxygen 1.14.13
- C12N9/0075—Nitric-oxide synthase (1.14.13.39)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biomedical Technology (AREA)
- Emergency Medicine (AREA)
- Immunology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP25069796 | 1996-09-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE346917T1 true ATE346917T1 (de) | 2006-12-15 |
Family
ID=17211706
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97941189T ATE346917T1 (de) | 1996-09-20 | 1997-09-18 | Verfahren zum screenen von verbindungen, welche die expression der menschlichen induzierbaren stickstoffoxidsynthase regulieren |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US6203982B1 (de) |
| EP (1) | EP0864648B1 (de) |
| JP (1) | JP4100712B2 (de) |
| AT (1) | ATE346917T1 (de) |
| DE (1) | DE69737014T2 (de) |
| ES (1) | ES2274548T3 (de) |
| WO (1) | WO1998012313A1 (de) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH11266872A (ja) * | 1998-03-20 | 1999-10-05 | Suntory Ltd | NF−κBの活性化を抑制する物質のスクリーニング方法 |
| CN1181817C (zh) | 1998-03-20 | 2004-12-29 | 第一三得利制药株式会社 | 以苯基甲苯醌为有效成分的NF-kB抑制剂 |
| AU5113499A (en) * | 1998-07-21 | 2000-02-14 | Duke University | Transgenic model of human oxidative stress |
| US6610503B1 (en) | 1999-03-17 | 2003-08-26 | Xenogen Corporation | Animal models for predicting sepsis mortality |
| US7078171B2 (en) * | 2000-04-28 | 2006-07-18 | Message Pharmaceutical, Inc. | Methods for identifying novel nucleic acid regulatory elements and compounds that affect the regulation |
| US8460864B2 (en) | 2003-01-21 | 2013-06-11 | Ptc Therapeutics, Inc. | Methods for identifying compounds that modulate untranslated region-dependent gene expression and methods of using same |
| US8426194B2 (en) * | 2003-01-21 | 2013-04-23 | Ptc Therapeutics, Inc. | Methods and agents for screening for compounds capable of modulating VEGF expression |
| US9068234B2 (en) * | 2003-01-21 | 2015-06-30 | Ptc Therapeutics, Inc. | Methods and agents for screening for compounds capable of modulating gene expression |
| MXPA06003666A (es) * | 2003-10-03 | 2006-08-31 | Johnson & Johnson | Gen 1 eliminado en tumores cerebrales malignos como marcador clinico, y usos del mismo. |
| US8283115B1 (en) | 2007-06-20 | 2012-10-09 | Ptc Therapeutics, Inc. | Methods of screening for compounds for treating muscular dystrophy using UTRN mRNA translation regulation |
| US8283116B1 (en) | 2007-06-22 | 2012-10-09 | Ptc Therapeutics, Inc. | Methods of screening for compounds for treating spinal muscular atrophy using SMN mRNA translation regulation |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2506337B2 (ja) * | 1986-06-06 | 1996-06-12 | サントリー株式会社 | フエニルメチルベンゾキノン誘導体 |
| EP0670902A1 (de) * | 1992-11-25 | 1995-09-13 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | FÜR MENSCHLICHE INDUZIERBARE STICKSTOFFOXYDESYTHASE KODIERENDE cDNA UND VERFAHREN ZUR HERSTELLUNG DAVON |
| GB9306386D0 (en) * | 1993-03-26 | 1993-05-19 | Wellcome Found | Gene expression |
| US5594032A (en) * | 1994-11-10 | 1997-01-14 | Gonzalez-Cadavid; Nestor F. | Amelioration of human erectile dysfunction by treatment with iNOS, inducers of iNOS or iNOS cDNA |
-
1997
- 1997-09-18 DE DE69737014T patent/DE69737014T2/de not_active Expired - Lifetime
- 1997-09-18 JP JP51451698A patent/JP4100712B2/ja not_active Expired - Fee Related
- 1997-09-18 EP EP97941189A patent/EP0864648B1/de not_active Expired - Lifetime
- 1997-09-18 AT AT97941189T patent/ATE346917T1/de active
- 1997-09-18 US US09/068,880 patent/US6203982B1/en not_active Expired - Fee Related
- 1997-09-18 ES ES97941189T patent/ES2274548T3/es not_active Expired - Lifetime
- 1997-09-18 WO PCT/JP1997/003303 patent/WO1998012313A1/ja not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| US6203982B1 (en) | 2001-03-20 |
| DE69737014T2 (de) | 2007-06-28 |
| EP0864648B1 (de) | 2006-11-29 |
| WO1998012313A1 (en) | 1998-03-26 |
| ES2274548T3 (es) | 2007-05-16 |
| DE69737014D1 (de) | 2007-01-11 |
| JP4100712B2 (ja) | 2008-06-11 |
| EP0864648A4 (de) | 2002-10-30 |
| EP0864648A1 (de) | 1998-09-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 0864648 Country of ref document: EP |
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| EEFA | Change of the company name |