ATE347355T1 - Polycyclische dianthrachinone als antikrebsmittel und antiangiogenesemittel - Google Patents

Polycyclische dianthrachinone als antikrebsmittel und antiangiogenesemittel

Info

Publication number: ATE347355T1
Authority: AT; Austria
Prior art keywords: hydroxy; alkyl; alkoxy; hydrogen; independently selected
Prior art date: 2000-01-31

Application number

AT01902613T

Other languages

English (en)

Inventor

Yehuda Mazur

Gad Lavie

Original Assignee

Yeda Res & Dev

Univ New York

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-01-31

Filing date

2001-01-31

Publication date

2006-12-15

2000-01-31 Priority claimed from US09/494,296 external-priority patent/US6229048B1/en

2001-01-31 Application filed by Yeda Res & Dev, Univ New York filed Critical Yeda Res & Dev

2006-12-15 Application granted granted Critical

2006-12-15 Publication of ATE347355T1 publication Critical patent/ATE347355T1/de

Links

239000004037 angiogenesis inhibitor Substances 0.000 title 1
230000001093 anti-cancer Effects 0.000 title 1
239000002246 antineoplastic agent Substances 0.000 title 1
125000000027 (C1-C10) alkoxy group Chemical group 0.000 abstract 4
229910052739 hydrogen Inorganic materials 0.000 abstract 4
239000001257 hydrogen Substances 0.000 abstract 4
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 4
125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 3
BTXNYTINYBABQR-UHFFFAOYSA-N hypericin Chemical compound C12=C(O)C=C(O)C(C(C=3C(O)=CC(C)=C4C=33)=O)=C2C3=C2C3=C4C(C)=CC(O)=C3C(=O)C3=C(O)C=C(O)C1=C32 BTXNYTINYBABQR-UHFFFAOYSA-N 0.000 abstract 3
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
230000033115 angiogenesis Effects 0.000 abstract 2
150000002431 hydrogen Chemical class 0.000 abstract 2
229940005608 hypericin Drugs 0.000 abstract 2
PHOKTTKFQUYZPI-UHFFFAOYSA-N hypericin Natural products Cc1cc(O)c2c3C(=O)C(=Cc4c(O)c5c(O)cc(O)c6c7C(=O)C(=Cc8c(C)c1c2c(c78)c(c34)c56)O)O PHOKTTKFQUYZPI-UHFFFAOYSA-N 0.000 abstract 2
SSKVDVBQSWQEGJ-UHFFFAOYSA-N pseudohypericin Natural products C12=C(O)C=C(O)C(C(C=3C(O)=CC(O)=C4C=33)=O)=C2C3=C2C3=C4C(C)=CC(O)=C3C(=O)C3=C(O)C=C(O)C1=C32 SSKVDVBQSWQEGJ-UHFFFAOYSA-N 0.000 abstract 2
206010027476 Metastases Diseases 0.000 abstract 1
206010028980 Neoplasm Diseases 0.000 abstract 1
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
125000001246 bromo group Chemical group Br* 0.000 abstract 1
125000001309 chloro group Chemical group Cl* 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
CJADAVIATOALFB-UHFFFAOYSA-N helianthrone Chemical compound C12=CC=CC(C(=O)C=3C4=CC=CC=3)=C2C4=C2C3=C1C=CC=C3C(=O)C1=CC=CC=C12 CJADAVIATOALFB-UHFFFAOYSA-N 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
208000037803 restenosis Diseases 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/136—Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Emergency Medicine (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Oncology (AREA)
Ophthalmology & Optometry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Steroid Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

AT01902613T 2000-01-31 2001-01-31 Polycyclische dianthrachinone als antikrebsmittel und antiangiogenesemittel ATE347355T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US09/494,296 US6229048B1 (en)	1997-07-31	2000-01-31	Helianthrone derivatives as anti-cancer agents

Publications (1)

Publication Number	Publication Date
ATE347355T1 true ATE347355T1 (de)	2006-12-15

Family

ID=23963894

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT01902613T ATE347355T1 (de)	2000-01-31	2001-01-31	Polycyclische dianthrachinone als antikrebsmittel und antiangiogenesemittel

Country Status (9)

Country	Link
US (2)	US6867235B2 (de)
EP (1)	EP1313459B1 (de)
AT (1)	ATE347355T1 (de)
AU (1)	AU3047001A (de)
CA (1)	CA2396704A1 (de)
DE (1)	DE60125048T2 (de)
ES (1)	ES2275647T3 (de)
IL (1)	IL150457A0 (de)
WO (1)	WO2001056558A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE347355T1 (de) *	2000-01-31	2006-12-15	Yeda Res & Dev	Polycyclische dianthrachinone als antikrebsmittel und antiangiogenesemittel
DE10261825A1 (de) *	2002-12-20	2004-07-01	Charité - Universitätsmedizin Berlin (Charité)	Verwendung von Hypericin und/oder dessen Derivaten zur Tumorprävention
US7553326B2 (en)	2003-11-24	2009-06-30	Sweet Richard M	Method and apparatus for preventing dialysis graft intimal hyperplasia
EP2571507B1 (de)	2010-05-04	2017-01-04	Soligenix, Inc.	Formulierungen und verfahren zur behandlung von hauterkrankungen
DK3423428T3 (da)	2016-03-01	2024-09-23	Soligenix Inc	Systemer og fremgangsmåder til fremstilling af syntetisk hypericin

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL93682A (en) *	1989-03-16	1996-06-18	Yeda Res & Dev	Polycyclic compounds with antigypical activity are used in the manufacture of medicines and pharmaceutical preparations containing them
DE4239959A1 (de) *	1992-11-27	1994-06-01	Schwabe Willmar Gmbh & Co	Johanniskraut-Trockenextrakt, Verfahren zu seiner Herstellung und seine Verwendung
US5824654A (en) *	1994-09-02	1998-10-20	New York University	Method for delivery of nucleic acids to cells using hypericin polyamine complexes
AU6714396A (en) *	1995-07-28	1997-02-26	Trustees Of Boston University	Methods and compositions for treating cell proliferative disorders
IL121440A0 (en) *	1997-07-31	1998-01-04	Yeda Res & Dev	The use of 1,3,4,6-tetrahydroxy-helianthrone and its derivatives in photodynamic therapy and certain such novel derivatives
ATE347355T1 (de) *	2000-01-31	2006-12-15	Yeda Res & Dev	Polycyclische dianthrachinone als antikrebsmittel und antiangiogenesemittel

2001
- 2001-01-31 AT AT01902613T patent/ATE347355T1/de not_active IP Right Cessation
- 2001-01-31 DE DE60125048T patent/DE60125048T2/de not_active Expired - Fee Related
- 2001-01-31 AU AU30470/01A patent/AU3047001A/en not_active Abandoned
- 2001-01-31 CA CA002396704A patent/CA2396704A1/en not_active Abandoned
- 2001-01-31 ES ES01902613T patent/ES2275647T3/es not_active Expired - Lifetime
- 2001-01-31 IL IL15045701A patent/IL150457A0/xx unknown
- 2001-01-31 EP EP01902613A patent/EP1313459B1/de not_active Expired - Lifetime
- 2001-01-31 WO PCT/IL2001/000091 patent/WO2001056558A1/en not_active Ceased
2002
- 2002-07-30 US US10/209,427 patent/US6867235B2/en not_active Expired - Lifetime
2004
- 2004-09-24 US US10/948,212 patent/US20050038115A1/en not_active Abandoned

Also Published As

Publication number	Publication date
US6867235B2 (en)	2005-03-15
IL150457A0 (en)	2002-12-01
WO2001056558A1 (en)	2001-08-09
EP1313459B1 (de)	2006-12-06
US20030105357A1 (en)	2003-06-05
DE60125048D1 (de)	2007-01-18
AU3047001A (en)	2001-08-14
EP1313459A1 (de)	2003-05-28
CA2396704A1 (en)	2001-08-09
DE60125048T2 (de)	2007-07-12
US20050038115A1 (en)	2005-02-17
ES2275647T3 (es)	2007-06-16

Legal Events

Date	Code	Title	Description
2007-06-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

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DE60121048D1 (de)	2006-08-03	PYRAZINOi1'2':1,6öPYRIDOi3,4-BöINDOLDERIVATE
ATE337320T1 (de)	2006-09-15	Indolderivate als pde5-inhibitoren
UY27544A1 (es)	2003-06-30	Derivados de piperazina desestabilizantes del receptor de andrógenos
ATE469882T1 (de)	2010-06-15	Neue verbindungen, die sich f r die behandlung von durch ppar vermittelten krankheiten eignen