ATE347365T1 - Verwendung von öestrogen in kombination mit progestogen für die hormonsubstitutions-therapie - Google Patents
Verwendung von öestrogen in kombination mit progestogen für die hormonsubstitutions-therapieInfo
- Publication number
- ATE347365T1 ATE347365T1 AT02738962T AT02738962T ATE347365T1 AT E347365 T1 ATE347365 T1 AT E347365T1 AT 02738962 T AT02738962 T AT 02738962T AT 02738962 T AT02738962 T AT 02738962T AT E347365 T1 ATE347365 T1 AT E347365T1
- Authority
- AT
- Austria
- Prior art keywords
- component
- aforementioned
- formula
- progestogen
- estrogen
- Prior art date
Links
- 239000005556 hormone Substances 0.000 title abstract 2
- 229940088597 hormone Drugs 0.000 title abstract 2
- 229940011871 estrogen Drugs 0.000 title 1
- 239000000262 estrogen Substances 0.000 title 1
- 239000000583 progesterone congener Substances 0.000 title 1
- 238000006467 substitution reaction Methods 0.000 title 1
- 238000002560 therapeutic procedure Methods 0.000 title 1
- 230000001076 estrogenic effect Effects 0.000 abstract 3
- 239000000126 substance Substances 0.000 abstract 3
- 241000124008 Mammalia Species 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 239000002243 precursor Substances 0.000 abstract 2
- 230000000757 progestagenic effect Effects 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 230000001548 androgenic effect Effects 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 208000024891 symptom Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Endocrinology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01204377 | 2001-11-15 | ||
| EP02075695 | 2002-02-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE347365T1 true ATE347365T1 (de) | 2006-12-15 |
Family
ID=26077031
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02738962T ATE347365T1 (de) | 2001-11-15 | 2002-05-23 | Verwendung von öestrogen in kombination mit progestogen für die hormonsubstitutions-therapie |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US8026228B2 (de) |
| EP (1) | EP1446128B1 (de) |
| AT (1) | ATE347365T1 (de) |
| CA (1) | CA2467222C (de) |
| CY (1) | CY1105957T1 (de) |
| DE (1) | DE60216630T2 (de) |
| DK (1) | DK1446128T3 (de) |
| ES (1) | ES2278925T3 (de) |
| PT (1) | PT1446128E (de) |
| WO (1) | WO2003041718A1 (de) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040214807A1 (en) * | 1993-08-06 | 2004-10-28 | D'amato Robert J. | Estrogenic compounds as anti-mitotic agents |
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| EP1390042B1 (de) * | 2001-05-23 | 2007-11-28 | Pantarhei Bioscience B.V. | Tetrahydroxylierte estrogen enthaltendes arzneistoffverabreichungssystem zur verwendung in hormonalen kontrazeption |
| AU2003279624A1 (en) | 2002-11-08 | 2004-06-07 | Pantarhei Bioscience B.V. | Synthesis of estetrol via estrone derived steroids |
| EP1633367A2 (de) * | 2003-05-28 | 2006-03-15 | EntreMed, Inc. | Antiangiogene mittel |
| PT1635843E (pt) * | 2003-06-25 | 2009-04-07 | Bayer Schering Pharma Ag | Terapia de substituição hormonal e de depressão compreendendo dienogest |
| US20070004689A1 (en) * | 2004-03-12 | 2007-01-04 | Agoston Gregory E | Antiangiogenic agents |
| CA2558014A1 (en) | 2004-03-12 | 2005-09-29 | Entremed, Inc. | Antiangiogenic agents |
| JP2008521822A (ja) * | 2004-11-29 | 2008-06-26 | エントレメッド インコーポレイテッド | 抗血管形成剤を投与する方法、およびそれを用いて疾病を治療する方法 |
| WO2007059111A2 (en) * | 2005-11-14 | 2007-05-24 | Entremed, Inc. | Anti-angiogenic activity of 2-methoxyestradiol in combination with anti-cancer agents |
| US20070176403A1 (en) * | 2006-02-01 | 2007-08-02 | Dennis Calderone | Air adjustable seat |
| CA2646065C (en) * | 2006-03-20 | 2014-01-14 | Entremed, Inc. | Disease modifying anti-arthritic activity of 2-methoxyestradiol |
| WO2008019048A1 (en) * | 2006-08-04 | 2008-02-14 | Meditrina Pharmaceuticals | Use of aromatase inhibitors for thining the endometrium or treating menorrhagia |
| ATE473746T1 (de) * | 2007-01-08 | 2010-07-15 | Pantarhei Bioscience Bv | Verfahren zur behandlung oder prävention von unfruchtbarkeit bei weiblichen säugern und pharmazeutisches kit zur anwendung dieses verfahrens |
| WO2008094665A1 (en) * | 2007-01-31 | 2008-08-07 | Entremed, Inc. | Method of treating amyloidosis mediated diseases |
| WO2009075838A2 (en) * | 2007-12-10 | 2009-06-18 | Meditrina Pharmaceuticals, Inc. | Treatment of menorrhagia with aromatase inhibitor |
| US9446051B2 (en) * | 2009-10-19 | 2016-09-20 | The Population Council, Inc. | Neuroprotection and myelin repair using nestorone® |
| AU2010308308B2 (en) | 2009-10-19 | 2013-11-28 | The Population Council, Inc. | Neuroprotection and myelin repair using nestorone® |
| PT2714712T (pt) | 2011-06-01 | 2016-11-08 | Estetra Sprl | Processo para a produção de intermediários de estetrol |
| SG195118A1 (en) | 2011-06-01 | 2013-12-30 | Estetra S A | Process for the production of estetrol intermediates |
| EP2383279A1 (de) | 2011-07-19 | 2011-11-02 | Pantarhei Bioscience B.V. | Herstellungsverfahren für Esterol |
| US8633178B2 (en) | 2011-11-23 | 2014-01-21 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| US9301920B2 (en) | 2012-06-18 | 2016-04-05 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| US10806740B2 (en) | 2012-06-18 | 2020-10-20 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| US20150196640A1 (en) | 2012-06-18 | 2015-07-16 | Therapeuticsmd, Inc. | Progesterone formulations having a desirable pk profile |
| US20130338122A1 (en) | 2012-06-18 | 2013-12-19 | Therapeuticsmd, Inc. | Transdermal hormone replacement therapies |
| US10806697B2 (en) | 2012-12-21 | 2020-10-20 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| WO2013034780A2 (en) | 2012-12-20 | 2013-03-14 | Crystal Pharma, S.A.U. | Process for the preparation of estetrol and related compounds |
| US10471072B2 (en) | 2012-12-21 | 2019-11-12 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US9180091B2 (en) | 2012-12-21 | 2015-11-10 | Therapeuticsmd, Inc. | Soluble estradiol capsule for vaginal insertion |
| US10537581B2 (en) | 2012-12-21 | 2020-01-21 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US11266661B2 (en) | 2012-12-21 | 2022-03-08 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US11246875B2 (en) | 2012-12-21 | 2022-02-15 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10568891B2 (en) | 2012-12-21 | 2020-02-25 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| EP3046928B1 (de) | 2013-09-18 | 2017-02-08 | Crystal Pharma, S.A.U. | Verfahren zur herstellung von estetrol |
| JP6447931B2 (ja) | 2013-12-12 | 2019-01-09 | ドネスタ バイオサイエンス ビー.ブイ.Donesta Bioscience B.V. | エステトロール成分を含有する口腔内崩壊固体単位剤形 |
| EP3145489A1 (de) | 2014-05-22 | 2017-03-29 | TherapeuticsMD, Inc. | Natürliche kombinierte hormonersatzformulierungen und therapien |
| CR20180042A (es) * | 2015-06-18 | 2018-05-03 | Mithra Pharmaceuticals S A | Unidad de dosificación orodispersable que contiene un componente estetrol. |
| LT3310346T (lt) * | 2015-06-18 | 2021-06-10 | Estetra Sprl | Burnoje disperguojama tabletė, turinti estetrolio |
| DK3701944T3 (da) * | 2015-06-18 | 2022-03-14 | Estetra Srl | Oro-dispergerbar doseringsenhed indeholdende en estetrolkomponent |
| LT3310345T (lt) * | 2015-06-18 | 2021-06-25 | Estetra Sprl | Burnoje disperguojama tabletė, turinti estetrolio |
| US10328087B2 (en) | 2015-07-23 | 2019-06-25 | Therapeuticsmd, Inc. | Formulations for solubilizing hormones |
| WO2017173044A1 (en) | 2016-04-01 | 2017-10-05 | Therapeuticsmd Inc. | Steroid hormone compositions in medium chain oils |
| WO2017173071A1 (en) | 2016-04-01 | 2017-10-05 | Therapeuticsmd, Inc. | Steroid hormone pharmaceutical composition |
| KR102712911B1 (ko) | 2016-08-05 | 2024-10-04 | 에스테트라, 소시에떼 아 레스폰서빌리떼 리미떼 | 월경통 및 생리통의 관리방법 |
| US10285998B1 (en) | 2018-04-04 | 2019-05-14 | The Menopause Method, Inc. | Composition and method to aid in hormone replacement therapy |
| TWI801561B (zh) | 2018-04-19 | 2023-05-11 | 比利時商依思特拉私人有限責任公司 | 化合物及其用於緩解絕經相關症狀的用途 |
| CN111989105B (zh) * | 2018-04-19 | 2024-07-19 | 埃斯特拉私人有限责任公司 | 化合物以及它们在缓解绝经相关症状中的用途 |
| HU231240B1 (hu) | 2019-09-03 | 2022-04-28 | Richter Gedeon Nyrt. | Ipari eljárás nagytisztaságú ösztetrol hatóanyag előállítására |
| TWI893101B (zh) | 2020-04-16 | 2025-08-11 | 比利時商埃斯特拉有限責任公司 | 具有降低之副作用之避孕組成物 |
| EP4440541A1 (de) * | 2021-11-29 | 2024-10-09 | Estetra SRL | Zusammensetzungen zur vorbeugung oder behandlung von hautalterung |
| US12233074B2 (en) | 2022-02-10 | 2025-02-25 | Estetra Srl | Contraceptive methods with improved pearl index |
| HUP2400151A1 (hu) | 2024-02-28 | 2025-09-28 | Richter Gedeon Nyrt | Ösztetrol-monohidrát kristályosítási eljárás |
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| US3440320A (en) | 1964-06-18 | 1969-04-22 | Mortimer D Sackler | Chelated suppository and method of using same |
| US3797494A (en) | 1969-04-01 | 1974-03-19 | Alza Corp | Bandage for the administration of drug by controlled metering through microporous materials |
| DE2336434A1 (de) | 1973-07-13 | 1975-04-17 | Schering Ag | 1.3-oxygenierte 8 alpha-oestratriene |
| DE2426779A1 (de) | 1974-05-31 | 1975-12-18 | Schering Ag | 1.3-oxygenierte 8 alpha-oestratriene |
| DE2336433A1 (de) * | 1973-07-13 | 1975-04-03 | Schering Ag | 1.3-oxygenierte 8 alpha-oestratriene |
| US4722941A (en) | 1978-06-07 | 1988-02-02 | Kali-Chemie Pharma Gmbh | Readily absorbable pharmaceutical compositions of per se poorly absorbable pharmacologically active agents and preparation thereof |
| US4460372A (en) | 1981-02-17 | 1984-07-17 | Alza Corporation | Percutaneous absorption enhancer dispenser for use in coadministering drug and percutaneous absorption enhancer |
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| US5340585A (en) | 1991-04-12 | 1994-08-23 | University Of Southern California | Method and formulations for use in treating benign gynecological disorders |
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| DE4429374C1 (de) | 1994-08-12 | 1996-02-01 | Jenapharm Gmbh | Pharmazeutische Präparate zur Kontrazeption/Hormonsubstitution mit biogener Estrogenkomponente |
| ATE302018T1 (de) | 1997-06-20 | 2005-09-15 | Akzo Nobel Nv | Gonadotropin releasing hormon antagonist |
| DE19739916C2 (de) | 1997-09-11 | 2001-09-13 | Hesch Rolf Dieter | Verwendung einer Kombination aus einem Gestagen und einem Estrogen zur kontinuierlichen Ovulationshemmung und ggf. gleichzeitigen Behandlung und/oder Prophylaxe von Tumoren der Brustdrüsen |
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| AU5137900A (en) | 1999-05-28 | 2000-12-18 | University Of Cincinnati, The | Antisense oligonucleotides for fertility and menstrual cycle regulation and for chemopreventive and chemotherapeutic use |
| WO2001030356A1 (fr) | 1999-10-25 | 2001-05-03 | Laboratoire Theramex | Composition hormonale a base d'un progestatif et d'un estrogene et son utilisation |
| WO2001085154A2 (en) | 2000-05-12 | 2001-11-15 | Oregon Health Sciences University | Method of treating immune pathologies with low dose estrogen |
| US6936599B2 (en) | 2001-04-25 | 2005-08-30 | The Regents Of The University Of California | Estriol therapy for multiple sclerosis and other autoimmune diseases |
| EP1260225A1 (de) | 2001-05-18 | 2002-11-27 | Pantarhei Bioscience B.V. | Pharmazeutische Zusammensetzung für die Hormonersatztherapie |
-
2002
- 2002-05-23 US US10/495,707 patent/US8026228B2/en not_active Expired - Lifetime
- 2002-05-23 CA CA2467222A patent/CA2467222C/en not_active Expired - Lifetime
- 2002-05-23 DE DE60216630T patent/DE60216630T2/de not_active Expired - Lifetime
- 2002-05-23 EP EP02738962A patent/EP1446128B1/de not_active Expired - Lifetime
- 2002-05-23 WO PCT/NL2002/000332 patent/WO2003041718A1/en not_active Ceased
- 2002-05-23 DK DK02738962T patent/DK1446128T3/da active
- 2002-05-23 AT AT02738962T patent/ATE347365T1/de not_active IP Right Cessation
- 2002-05-23 ES ES02738962T patent/ES2278925T3/es not_active Expired - Lifetime
- 2002-05-23 PT PT02738962T patent/PT1446128E/pt unknown
-
2007
- 2007-01-29 CY CY20071100107T patent/CY1105957T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2003041718A1 (en) | 2003-05-22 |
| EP1446128A1 (de) | 2004-08-18 |
| CY1105957T1 (el) | 2011-04-06 |
| PT1446128E (pt) | 2007-03-30 |
| CA2467222A1 (en) | 2003-05-22 |
| CA2467222C (en) | 2010-06-08 |
| US8026228B2 (en) | 2011-09-27 |
| US20050070488A1 (en) | 2005-03-31 |
| ES2278925T3 (es) | 2007-08-16 |
| DE60216630D1 (de) | 2007-01-18 |
| EP1446128B1 (de) | 2006-12-06 |
| DE60216630T2 (de) | 2007-09-20 |
| DK1446128T3 (da) | 2007-04-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1446128 Country of ref document: EP |
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| REN | Ceased due to non-payment of the annual fee |