ATE347563T1 - Il-6-antagonist peptide - Google Patents

Il-6-antagonist peptide

Info

Publication number
ATE347563T1
ATE347563T1 AT99926326T AT99926326T ATE347563T1 AT E347563 T1 ATE347563 T1 AT E347563T1 AT 99926326 T AT99926326 T AT 99926326T AT 99926326 T AT99926326 T AT 99926326T AT E347563 T1 ATE347563 T1 AT E347563T1
Authority
AT
Austria
Prior art keywords
seq
present
antagonist peptides
peptide
peptides
Prior art date
Application number
AT99926326T
Other languages
English (en)
Inventor
Ottaviano Serlupi-Crescenzi
Alessandro Bressan
Pietra Linda Della
Anna Rita Pezzotti
Original Assignee
Applied Research Systems
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applied Research Systems filed Critical Applied Research Systems
Application granted granted Critical
Publication of ATE347563T1 publication Critical patent/ATE347563T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5412—IL-6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT99926326T 1998-05-18 1999-05-18 Il-6-antagonist peptide ATE347563T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP98108997A EP0972780A1 (de) 1998-05-18 1998-05-18 Il-6-Antagonistische Peptide

Publications (1)

Publication Number Publication Date
ATE347563T1 true ATE347563T1 (de) 2006-12-15

Family

ID=8231951

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99926326T ATE347563T1 (de) 1998-05-18 1999-05-18 Il-6-antagonist peptide

Country Status (14)

Country Link
US (2) US6599875B1 (de)
EP (2) EP0972780A1 (de)
JP (1) JP4468578B2 (de)
AT (1) ATE347563T1 (de)
AU (1) AU749616B2 (de)
CA (2) CA2690399C (de)
CY (1) CY1105865T1 (de)
DE (1) DE69934308T2 (de)
DK (1) DK1078001T3 (de)
ES (1) ES2273492T3 (de)
IL (2) IL139575A0 (de)
PT (1) PT1078001E (de)
SI (1) SI1078001T1 (de)
WO (1) WO1999060013A2 (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0972780A1 (de) * 1998-05-18 2000-01-19 Applied Research Systems ARS Holding N.V. Il-6-Antagonistische Peptide
US7488590B2 (en) 1998-10-23 2009-02-10 Amgen Inc. Modified peptides as therapeutic agents
HK1042114B (zh) 1998-10-23 2006-09-29 Amgen K-A, Inc. 与mp1受体结合并具有血小板生成活性的模拟二聚体血小板生成素肽
CA2572765C (en) 2004-07-08 2013-05-21 Amgen Inc. Compound having improved bioefficiency when administered in a multidose regimen
US20070036788A1 (en) * 2004-09-22 2007-02-15 Ahmed Sheriff Use of a compound for reducing the biological effectiveness of il-6
US7442778B2 (en) 2004-09-24 2008-10-28 Amgen Inc. Modified Fc molecules
US8008453B2 (en) 2005-08-12 2011-08-30 Amgen Inc. Modified Fc molecules
EP2025346B1 (de) 2006-04-07 2016-08-10 Osaka University Mittel zur förderung der muskelregeneration
US9283260B2 (en) 2006-04-21 2016-03-15 Amgen Inc. Lyophilized therapeutic peptibody formulations
KR101508019B1 (ko) 2007-01-23 2015-04-06 고쿠리츠 다이가쿠 호우징 신슈 다이가쿠 만성 거부반응 억제제
TWI528973B (zh) 2008-06-05 2016-04-11 Chugai Pharmaceutical Co Ltd Nerve infiltration inhibitor
MX2011005411A (es) 2008-11-25 2011-06-16 Alder Biopharmaceuticals Inc Anticuerpos de il-6 y uso de los mismos.
SI2578231T1 (sl) 2010-05-28 2023-01-31 Chugai Seiyaku Kabushiki Kaisha Okrepljen protitumorski T celični odzivnik
CA2818814A1 (en) 2010-11-23 2012-05-31 Alder Biopharmaceuticals, Inc. Anti-il-6 antibodies for the treatment of anemia
ES2778053T3 (es) 2011-01-18 2020-08-07 Bioniz Llc Composiciones para modular la actividad de la citocina gamma-c
WO2015089217A2 (en) 2013-12-10 2015-06-18 Bionz, Llc Methods of developing selective peptide antagonists
US9327023B2 (en) 2011-10-25 2016-05-03 The Regents Of The University Of Michigan HER2 targeting agent treatment in non-HER2-amplified cancers having HER2 expressing cancer stem cells
CN103923182A (zh) * 2014-01-17 2014-07-16 南通诚信氨基酸有限公司 白介素-6多肽抑制剂及其应用
EP3359556B1 (de) 2015-10-09 2021-05-26 Bioniz, LLC Modulation der gamma-c-zytokin-aktivität
KR20240142577A (ko) 2017-04-07 2024-09-30 바이오니즈 테라퓨틱스, 아이엔씨. 감마-c-사이토카인 활성의 안정한 조절자
US11851486B2 (en) 2017-05-02 2023-12-26 National Center Of Neurology And Psychiatry Method for predicting and evaluating therapeutic effect in diseases related to IL-6 and neutrophils
US11692037B2 (en) 2017-10-20 2023-07-04 Hyogo College Of Medicine Anti-IL-6 receptor antibody-containing medicinal composition for preventing post-surgical adhesion
WO2019151418A1 (ja) 2018-01-31 2019-08-08 元一 加藤 Ｉｌ－６阻害剤を含有する喘息の治療剤
US20220177978A1 (en) 2019-04-02 2022-06-09 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods of predicting and preventing cancer in patients having premalignant lesions
WO2020213665A1 (ja) 2019-04-17 2020-10-22 国立大学法人広島大学 Ｉｌ－６阻害剤及びｃｃｒ２阻害剤を組み合わせて投与することを特徴とする泌尿器がんの治療剤
JP2022530677A (ja) 2019-05-03 2022-06-30 バイオニズ リミテッド ライアビリティー カンパニー 脱毛症および脱毛症関連障害の治療ための、γｃサイトカインのシグナル伝達の効果の調節
CN116003530B (zh) * 2022-12-27 2023-12-15 西湖大学 一种针对白细胞介素-6的d-蛋白抑制剂及其应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4420782C1 (de) * 1994-06-15 1995-08-17 Fluegge Ulf Ingo Prof Dr DNA-Sequenz, kodierend einen 2-Oxoglutarat/Malat-Translokator, Plasmide, Bakterien, Hefen und Pflanzen enthaltend diesen Transporter
WO1996009411A1 (en) * 1994-09-21 1996-03-28 Cytogen Corporation Antigen binding peptides (abtides) from peptide libraries
WO1996023899A1 (en) * 1995-02-01 1996-08-08 University Of Massachusetts Medical Center Methods of selecting a random peptide that binds to a target protein
DK0824588T3 (da) * 1995-05-11 2004-08-16 Applied Research Systems Inhibitor af IL-6 aktivitet
WO1997004101A2 (de) * 1995-07-17 1997-02-06 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Enzym geeignet zur oxidation von cyclitolen und ihren derivaten
ES2319340T3 (es) * 1995-09-28 2009-05-06 Yeda Research And Development Co., Ltd. Peptidos sinteticos que inhiben la actividad de il-6.
AU3193097A (en) * 1996-06-20 1998-01-07 Koster, Henk W. Il-6 and il-6-receptor derived peptides having il-6 antagonistic or agonistic activity
EP0972780A1 (de) * 1998-05-18 2000-01-19 Applied Research Systems ARS Holding N.V. Il-6-Antagonistische Peptide

Also Published As

Publication number Publication date
JP4468578B2 (ja) 2010-05-26
PT1078001E (pt) 2007-01-31
EP1078001A2 (de) 2001-02-28
JP2002527354A (ja) 2002-08-27
CY1105865T1 (el) 2011-02-02
WO1999060013A3 (en) 2000-03-09
US6599875B1 (en) 2003-07-29
US20030186876A1 (en) 2003-10-02
SI1078001T1 (sl) 2007-04-30
DE69934308D1 (de) 2007-01-18
WO1999060013A2 (en) 1999-11-25
US6838433B2 (en) 2005-01-04
AU749616B2 (en) 2002-06-27
IL139575A0 (en) 2002-02-10
IL139575A (en) 2008-03-20
EP0972780A1 (de) 2000-01-19
AU4362799A (en) 1999-12-06
DK1078001T3 (da) 2007-02-19
CA2332817C (en) 2010-08-31
CA2690399A1 (en) 1999-11-25
DE69934308T2 (de) 2007-03-29
EP1078001B1 (de) 2006-12-06
CA2690399C (en) 2015-01-20
ES2273492T3 (es) 2007-05-01
CA2332817A1 (en) 1999-11-25

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