DK1165544T3 - Substituerede 1,4-dihydroindeno[1,2-c]pyrazoler som inhibitorer af tyrosinkinase - Google Patents

Substituerede 1,4-dihydroindeno[1,2-c]pyrazoler som inhibitorer af tyrosinkinase

Info

Publication number: DK1165544T3
Authority: DK; Denmark
Prior art keywords: pyrazoles; inhibitors; dihydroindeno; substituted; tyrosine kinase
Prior art date: 1999-04-06

Application number

DK00919742T

Other languages

English (en)

Inventor

Kevin J Doyle

Paul Rafferty

Robert W Steele

Allyson Turner

David J Wilkins

Lee D Arnold

Original Assignee

Abbott Gmbh & Co Kg

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-04-06

Filing date

2000-03-28

Publication date

2003-12-01

2000-03-28 Application filed by Abbott Gmbh & Co Kg filed Critical Abbott Gmbh & Co Kg

2003-12-01 Application granted granted Critical

2003-12-01 Publication of DK1165544T3 publication Critical patent/DK1165544T3/da

Links

239000003112 inhibitor Substances 0.000 title abstract 2
DGYDIEIMGSEYDK-UHFFFAOYSA-N 1,4-dihydroindeno[1,2-c]pyrazole Chemical class C12=CC=CC=C2CC2=C1NN=C2 DGYDIEIMGSEYDK-UHFFFAOYSA-N 0.000 title 1
102000004022 Protein-Tyrosine Kinases Human genes 0.000 title 1
108090000412 Protein-Tyrosine Kinases Proteins 0.000 title 1
150000003217 pyrazoles Chemical class 0.000 abstract 2
102000001253 Protein Kinase Human genes 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
108060006633 protein kinase Proteins 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Ophthalmology & Optometry (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Endocrinology (AREA)
Immunology (AREA)
Physical Education & Sports Medicine (AREA)
Dermatology (AREA)
Rheumatology (AREA)
Vascular Medicine (AREA)
Hematology (AREA)
Pulmonology (AREA)
Urology & Nephrology (AREA)
Emergency Medicine (AREA)
Pain & Pain Management (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Orthopedic Medicine & Surgery (AREA)
Obesity (AREA)
Gynecology & Obstetrics (AREA)
Reproductive Health (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

DK00919742T 1999-04-06 2000-03-28 Substituerede 1,4-dihydroindeno[1,2-c]pyrazoler som inhibitorer af tyrosinkinase DK1165544T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US12796399P	1999-04-06	1999-04-06
PCT/US2000/008192 WO2000059901A1 (en)	1999-04-06	2000-03-28	Substituted 1,4-dihydroindeno[1,2-c]pyrazoles as inhibitors of tyrosine kinase

Publications (1)

Publication Number	Publication Date
DK1165544T3 true DK1165544T3 (da)	2003-12-01

Family

ID=22432894

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK00919742T DK1165544T3 (da)	1999-04-06	2000-03-28	Substituerede 1,4-dihydroindeno[1,2-c]pyrazoler som inhibitorer af tyrosinkinase

Country Status (25)

Country	Link
EP (1)	EP1165544B1 (da)
JP (1)	JP2002541150A (da)
KR (1)	KR20020015034A (da)
CN (1)	CN1368970A (da)
AT (1)	ATE246684T1 (da)
AU (1)	AU4037800A (da)
BG (1)	BG106044A (da)
BR (1)	BR0009561A (da)
CA (1)	CA2368686A1 (da)
CZ (1)	CZ20013580A3 (da)
DE (1)	DE60004340T2 (da)
DK (1)	DK1165544T3 (da)
ES (1)	ES2207497T3 (da)
HK (1)	HK1045500A1 (da)
HU (1)	HUP0201514A3 (da)
IL (1)	IL145564A0 (da)
MX (1)	MXPA01010072A (da)
NO (1)	NO20014864L (da)
NZ (1)	NZ514269A (da)
PL (1)	PL350891A1 (da)
PT (1)	PT1165544E (da)
SK (1)	SK14112001A3 (da)
TR (1)	TR200103789T2 (da)
WO (1)	WO2000059901A1 (da)
ZA (1)	ZA200107838B (da)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6462036B1 (en)	1998-11-06	2002-10-08	Basf Aktiengesellschaft	Tricyclic pyrazole derivatives
US6297238B1 (en) *	1999-04-06	2001-10-02	Basf Aktiengesellschaft	Therapeutic agents
EP1444207A2 (en)	2001-09-19	2004-08-11	Pharmacia Corporation	Substituted pyrazolyl-compounds for the treatment of inflammation
JP2005507892A (ja)	2001-09-19	2005-03-24	ファルマシア・コーポレーション	炎症の治療のための置換されたピラゾリルベンゼンスルファミド化合物
ES2281633T3 (es) *	2002-02-19	2007-10-01	Pfizer Italia S.R.L.	Derivados triciclicos de pirazol, procedimiento para su preparacion y su uso como agentes antitumorales.
AU2003234567A1 (en)	2002-05-15	2003-12-02	Janssen Pharmaceutica N.V.	N-substituted tricyclic 3-aminopyrazoles as pdfg receptor inhibitors
BRPI0407544A (pt) *	2003-02-17	2006-02-14	Pharmacia Italia Spa	derivados de pirazol tetracìclicos como inibidores da cinase, processo para a sua preparação e composições farmacêuticas que os compreendem
PL378116A1 (pl) *	2003-02-27	2006-03-06	Abbott Laboratories	Heterocykliczne inhibitory kinazy
US7320986B2 (en)	2003-03-07	2008-01-22	Abbott Labortories	Fused tri and tetra-cyclic pyrazole kinase inhibitors
CA2517885A1 (en) *	2003-03-07	2004-09-23	Abbott Laboratories	Fused tri and tetra-cyclic pyrazole kinase inhibitors
MXPA06010904A (es)	2004-03-24	2007-06-11	Abbott Lab	Inhibidores de pirazol cinasa triciclicos.
AU2009248774B2 (en) *	2008-05-23	2012-05-31	Novartis Ag	Derivatives of quinolines and quinoxalines as protein tyrosine kinase inhibitors
AT507953B1 (de)	2009-03-05	2011-02-15	Apeptico Forschung & Entwicklung Gmbh	Verfahren zur vermeidung und zur behandlung einer hyperpermeabilität
US8853207B2 (en)	2012-04-12	2014-10-07	Development Center For Biotechnology	Heterocyclic pyrazole compounds, method for preparing the same and use thereof
CN104610149B (zh) *	2015-02-10	2017-04-05	山东大学	一种茚并吡唑类小分子微管蛋白抑制剂及其制备方法与应用
CN122349433A (zh) *	2023-08-10	2026-07-07	英矽智能科技知识产权有限公司	用于治疗子宫内膜异位症的方法和药物

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9226855D0 (en) *	1992-12-23	1993-02-17	Erba Carlo Spa	Vinylene-azaindole derivatives and process for their preparation
CN1278724A (zh) *	1997-10-06	2001-01-03	巴斯福股份公司	抑制酪氨酸激酶活性的茚并[1,2－c]吡唑衍生物
EP1127051A2 (en) *	1998-11-06	2001-08-29	Basf Aktiengesellschaft	Tricyclic pyrazole derivatives

2000
- 2000-03-28 WO PCT/US2000/008192 patent/WO2000059901A1/en not_active Ceased
- 2000-03-28 AT AT00919742T patent/ATE246684T1/de not_active IP Right Cessation
- 2000-03-28 HU HU0201514A patent/HUP0201514A3/hu unknown
- 2000-03-28 TR TR2001/03789T patent/TR200103789T2/xx unknown
- 2000-03-28 DE DE60004340T patent/DE60004340T2/de not_active Expired - Fee Related
- 2000-03-28 CN CN00808326A patent/CN1368970A/zh active Pending
- 2000-03-28 EP EP00919742A patent/EP1165544B1/en not_active Expired - Lifetime
- 2000-03-28 SK SK1411-2001A patent/SK14112001A3/sk unknown
- 2000-03-28 DK DK00919742T patent/DK1165544T3/da active
- 2000-03-28 CZ CZ20013580A patent/CZ20013580A3/cs unknown
- 2000-03-28 BR BR0009561-3A patent/BR0009561A/pt not_active IP Right Cessation
- 2000-03-28 MX MXPA01010072A patent/MXPA01010072A/es unknown
- 2000-03-28 NZ NZ514269A patent/NZ514269A/en unknown
- 2000-03-28 KR KR1020017012696A patent/KR20020015034A/ko not_active Ceased
- 2000-03-28 IL IL14556400A patent/IL145564A0/xx unknown
- 2000-03-28 AU AU40378/00A patent/AU4037800A/en not_active Abandoned
- 2000-03-28 JP JP2000609412A patent/JP2002541150A/ja not_active Withdrawn
- 2000-03-28 HK HK02104887.6A patent/HK1045500A1/zh unknown
- 2000-03-28 CA CA002368686A patent/CA2368686A1/en not_active Abandoned
- 2000-03-28 PT PT00919742T patent/PT1165544E/pt unknown
- 2000-03-28 PL PL00350891A patent/PL350891A1/xx not_active Application Discontinuation
- 2000-03-28 ES ES00919742T patent/ES2207497T3/es not_active Expired - Lifetime
2001
- 2001-09-21 ZA ZA200107838A patent/ZA200107838B/en unknown
- 2001-10-05 NO NO20014864A patent/NO20014864L/no not_active Application Discontinuation
- 2001-10-24 BG BG106044A patent/BG106044A/xx unknown

Also Published As

Publication number	Publication date
DE60004340T2 (de)	2004-06-09
HK1045500A1 (zh)	2002-11-29
IL145564A0 (en)	2002-06-30
ZA200107838B (en)	2003-03-24
CA2368686A1 (en)	2000-10-12
AU4037800A (en)	2000-10-23
DE60004340D1 (de)	2003-09-11
CN1368970A (zh)	2002-09-11
NO20014864L (no)	2001-12-05
NO20014864D0 (no)	2001-10-05
EP1165544A1 (en)	2002-01-02
WO2000059901A1 (en)	2000-10-12
MXPA01010072A (es)	2004-03-26
ATE246684T1 (de)	2003-08-15
SK14112001A3 (sk)	2002-04-04
BG106044A (en)	2002-05-31
BR0009561A (pt)	2002-04-16
HUP0201514A2 (en)	2002-08-28
PL350891A1 (en)	2003-02-10
JP2002541150A (ja)	2002-12-03
EP1165544B1 (en)	2003-08-06
PT1165544E (pt)	2003-12-31
TR200103789T2 (tr)	2002-04-22
CZ20013580A3 (cs)	2002-03-13
HUP0201514A3 (en)	2003-11-28
NZ514269A (en)	2003-10-31
ES2207497T3 (es)	2004-06-01
KR20020015034A (ko)	2002-02-27

Publication	Publication Date	Title
NO20005535D0 (no)	2000-11-02	Pyrazol-derivater som P-38 MAP kinase-inhibitorer
MXPA02011320A (es)	2004-09-10	Derivados de pirazol triciclico como inhibidores de cinasa.
MXPA03010207A (es)	2004-03-10	Nuevas 4-anilinoquinolin-3-carboxamidas.
EA200300248A1 (ru)	2003-08-28	Бициклопиразолы, активные в качестве ингибиторов киназы, способ их получения и включающие их фармацевтические композиции
MXPA03011638A (es)	2004-04-02	Nuevos derivados de 4-piperazinil indol con afinidad por el receptor 5-ht6.
BR0014225A (pt)	2002-05-21	Derivados de pirazol
TR200201505T2 (tr)	2003-01-21	Terapötik maddeler olarak pirazolopirimidinler
HK1053832A1 (zh)	2003-11-07	蛋白激酶抑制劑
BG66085B1 (bg)	2011-03-31	Фенилаланинови производни
MXPA02012033A (es)	2003-04-25	Derivados de 2-aminocarbonil-9h-purina.
NO20014864D0 (no)	2001-10-05	Substituerte 1,4-dihydro-inden [1,2-C] pyrazoler som inhibitorer av tyrosin kinase
ATE300541T1 (de)	2005-08-15	Pyrazolopyridinderivate
BRPI0407841A (pt)	2006-11-14	inibidores heterocìclicos de quinase
NO20040589L (no)	2004-03-19	Arylsulfonylderivater med 5-HT6 reseptor affinitet.
MXPA04005426A (es)	2004-10-11	Derivados de pirazol de anillos fuisionados.
MXPA04005809A (es)	2004-09-13	Inhibidores de proteinas quinasas.
BG106847A (bg)	2003-02-28	Заместени пиперазинови производни като инхибиторина микрозомалния триглицеридпренасящ протеин (mtp)
ATE253359T1 (de)	2003-11-15	Antithrombotische mittel
ATE274515T1 (de)	2004-09-15	Pyrazolopyridinderivate
NO983444D0 (no)	1998-07-24	Benzo(c)kinolizin derivater, deres fremstilling og anvendelse som 5<alfa>-reduktaseinhibitorer
WO2002018363A3 (en)	2002-06-27	3-phenyl-propanoic acid derivatives as protein tyrosine phosphatase inhibitors
ATE363481T1 (de)	2007-06-15	Pyrazolderivate als gnrh-inhibitoren