ATE348097T1 - Guanidinoverbindungen als melanocortin-4-rezeptor (mc4-r) agonisten - Google Patents
Guanidinoverbindungen als melanocortin-4-rezeptor (mc4-r) agonistenInfo
- Publication number
- ATE348097T1 ATE348097T1 AT02719463T AT02719463T ATE348097T1 AT E348097 T1 ATE348097 T1 AT E348097T1 AT 02719463 T AT02719463 T AT 02719463T AT 02719463 T AT02719463 T AT 02719463T AT E348097 T1 ATE348097 T1 AT E348097T1
- Authority
- AT
- Austria
- Prior art keywords
- melanocortin
- agonists
- receptor
- group
- guanidine compounds
- Prior art date
Links
- 102000001796 Melanocortin 4 receptors Human genes 0.000 title abstract 5
- 108010021436 Type 4 Melanocortin Receptor Proteins 0.000 title abstract 5
- 239000000556 agonist Substances 0.000 title abstract 2
- ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical class NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 title 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical class N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 229910005965 SO 2 Inorganic materials 0.000 abstract 2
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 229910052717 sulfur Inorganic materials 0.000 abstract 2
- 208000008589 Obesity Diseases 0.000 abstract 1
- 150000001721 carbon Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/08—Radicals containing only hydrogen and carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/10—Radicals substituted by halogen atoms or nitro radicals
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Cosmetics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28284701P | 2001-04-09 | 2001-04-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE348097T1 true ATE348097T1 (de) | 2007-01-15 |
Family
ID=23083379
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02719463T ATE348097T1 (de) | 2001-04-09 | 2002-04-08 | Guanidinoverbindungen als melanocortin-4-rezeptor (mc4-r) agonisten |
Country Status (10)
| Country | Link |
|---|---|
| US (4) | US7456183B2 (de) |
| EP (2) | EP1767525A1 (de) |
| JP (1) | JP4172541B2 (de) |
| AT (1) | ATE348097T1 (de) |
| CY (1) | CY1107442T1 (de) |
| DE (1) | DE60216747T2 (de) |
| DK (1) | DK1385823T3 (de) |
| ES (1) | ES2278016T3 (de) |
| PT (1) | PT1385823E (de) |
| WO (1) | WO2002081443A1 (de) |
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-
2002
- 2002-04-08 EP EP06025693A patent/EP1767525A1/de not_active Withdrawn
- 2002-04-08 PT PT02719463T patent/PT1385823E/pt unknown
- 2002-04-08 AT AT02719463T patent/ATE348097T1/de not_active IP Right Cessation
- 2002-04-08 ES ES02719463T patent/ES2278016T3/es not_active Expired - Lifetime
- 2002-04-08 JP JP2002579431A patent/JP4172541B2/ja not_active Expired - Fee Related
- 2002-04-08 EP EP02719463A patent/EP1385823B1/de not_active Expired - Lifetime
- 2002-04-08 DK DK02719463T patent/DK1385823T3/da active
- 2002-04-08 WO PCT/US2002/010965 patent/WO2002081443A1/en not_active Ceased
- 2002-04-08 US US10/474,331 patent/US7456183B2/en not_active Expired - Fee Related
- 2002-04-08 US US10/118,730 patent/US6716840B2/en not_active Expired - Fee Related
- 2002-04-08 DE DE60216747T patent/DE60216747T2/de not_active Expired - Lifetime
-
2003
- 2003-04-30 US US10/426,937 patent/US6960582B2/en not_active Expired - Fee Related
-
2004
- 2004-04-05 US US10/818,187 patent/US7189727B2/en not_active Expired - Fee Related
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2007
- 2007-02-15 CY CY20071100208T patent/CY1107442T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US6960582B2 (en) | 2005-11-01 |
| WO2002081443A1 (en) | 2002-10-17 |
| US20020193595A1 (en) | 2002-12-19 |
| US20040248895A1 (en) | 2004-12-09 |
| EP1385823A1 (de) | 2004-02-04 |
| US7189727B2 (en) | 2007-03-13 |
| EP1385823A4 (de) | 2005-02-16 |
| CY1107442T1 (el) | 2012-12-19 |
| PT1385823E (pt) | 2007-01-31 |
| DE60216747D1 (de) | 2007-01-25 |
| US20040024211A1 (en) | 2004-02-05 |
| US7456183B2 (en) | 2008-11-25 |
| EP1385823B1 (de) | 2006-12-13 |
| JP2004535378A (ja) | 2004-11-25 |
| DE60216747T2 (de) | 2007-10-04 |
| DK1385823T3 (da) | 2007-03-26 |
| EP1767525A1 (de) | 2007-03-28 |
| US6716840B2 (en) | 2004-04-06 |
| US20050038027A1 (en) | 2005-02-17 |
| ES2278016T3 (es) | 2007-08-01 |
| JP4172541B2 (ja) | 2008-10-29 |
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