ATE348589T1 - Verwendung von amylin, adrenomedullin und deren analoga zur behandlung von knorpeldefekten - Google Patents

Verwendung von amylin, adrenomedullin und deren analoga zur behandlung von knorpeldefekten

Info

Publication number: ATE348589T1
Authority: AT; Austria
Prior art keywords: adrenomedullin; amylin; analogues; treatment; cartilage defects
Prior art date: 1997-09-26

Application number

AT98946738T

Other languages

English (en)

Inventor

Ian Reginald Reid

Jillian Cornish

Original Assignee

Auckland Uniservices Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-09-26

Filing date

1998-09-25

Publication date

2007-01-15

1998-09-25 Application filed by Auckland Uniservices Ltd filed Critical Auckland Uniservices Ltd

2007-01-15 Application granted granted Critical

2007-01-15 Publication of ATE348589T1 publication Critical patent/ATE348589T1/de

Links

ULCUCJFASIJEOE-NPECTJMMSA-N adrenomedullin Chemical compound C([C@@H](C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)NCC(=O)N[C@@H]1C(N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CSSC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(N)=O)[C@@H](C)O)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](N)CC=1C=CC(O)=CC=1)C1=CC=CC=C1 ULCUCJFASIJEOE-NPECTJMMSA-N 0.000 title abstract 2
102000004379 Adrenomedullin Human genes 0.000 title 1
101800004616 Adrenomedullin Proteins 0.000 title 1
102000036770 Islet Amyloid Polypeptide Human genes 0.000 title 1
108010041872 Islet Amyloid Polypeptide Proteins 0.000 title 1
210000000845 cartilage Anatomy 0.000 title 1
210000001612 chondrocyte Anatomy 0.000 abstract 3
108010078680 adrenomedullin (27-52) Proteins 0.000 abstract 2
230000035755 proliferation Effects 0.000 abstract 2
208000015100 cartilage disease Diseases 0.000 abstract 1
230000004936 stimulating effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0655—Chondrocytes; Cartilage
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/38—Vitamins
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/34—Calcitonin; Calcitonin-gene related peptide [CGRO]; Amylin
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/998—Proteins not provided for elsewhere
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/84—Bones; tendons; teeth; cartilage

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
General Health & Medical Sciences (AREA)
Zoology (AREA)
Genetics & Genomics (AREA)
Rheumatology (AREA)
Medicinal Chemistry (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Wood Science & Technology (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Physical Education & Sports Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Cell Biology (AREA)
Biophysics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Microbiology (AREA)
Endocrinology (AREA)
Toxicology (AREA)
Gastroenterology & Hepatology (AREA)
General Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Orthopedic Medicine & Surgery (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Saccharide Compounds (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

AT98946738T 1997-09-26 1998-09-25 Verwendung von amylin, adrenomedullin und deren analoga zur behandlung von knorpeldefekten ATE348589T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
NZ32885397		1997-09-26

Publications (1)

Publication Number	Publication Date
ATE348589T1 true ATE348589T1 (de)	2007-01-15

Family

ID=19926460

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT98946738T ATE348589T1 (de)	1997-09-26	1998-09-25	Verwendung von amylin, adrenomedullin und deren analoga zur behandlung von knorpeldefekten

Country Status (7)

Country	Link
US (2)	US6869926B1 (de)
EP (1)	EP1027027B1 (de)
JP (1)	JP2001524454A (de)
AT (1)	ATE348589T1 (de)
AU (1)	AU9369098A (de)
DE (1)	DE69836689D1 (de)
WO (1)	WO1999016406A2 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6440421B1 (en) *	1996-04-18	2002-08-27	Auchkland Uniservices Limited	Treatment of bone disorders with adrenomedullin or adrenomedullin agonists
WO1999016406A2 (en) *	1997-09-26	1999-04-08	Auckland Uniservices Limited	Therapeutic method
US8168233B2 (en) *	2002-10-18	2012-05-01	Amylin Pharmaceuticals, Inc.	Treatment of pancreatitis with amylin
EP1878436B1 (de) *	2005-03-07	2014-07-23	National Cerebral and Cardiovascular Center	Verfahren zur regeneration oder reparatur von geschädigtem gewebe mit adrenomedulin
PT3067093T (pt) *	2015-03-12	2019-11-18	Fund Rioja Salud	Utilização de um inibidor de adrenomedulina para a produção de um fármaco útil na prevenção e tratamento de doenças que reduzem a densidade óssea
WO2016183479A1 (en)	2015-05-13	2016-11-17	The Board Of Regents Of The University Of Oklahoma	Variants of adrenomedullin and calcitonin gene-related peptide and methods of use

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5859208A (en) *	1988-07-06	1999-01-12	Fiddes; John C.	Human basic fibroblast growth factor analog
GB8915712D0 (en)	1989-07-08	1989-08-31	Macintyre Iain	Medical treatment
JP2774769B2 (ja)	1993-04-26	1998-07-09	賢治寒川	アドレノメデュリン
US5478847A (en)	1994-03-02	1995-12-26	Eli Lilly And Company	Methods of use for inhibiting bone loss and lowering serum cholesterol
AU2992295A (en) *	1994-07-13	1996-02-16	Auckland Uniservices Limited	Therapeutic method and compounds of use therein
US6544949B1 (en) *	1995-07-13	2003-04-08	Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S.	Analogs of parathyroid hormone
WO1997007214A1 (en) *	1995-08-18	1997-02-27	The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services	Functional role of adrenomedullin (am) and the gene-related product (pamp) in human pathology and physiology
US6440421B1 (en) *	1996-04-18	2002-08-27	Auchkland Uniservices Limited	Treatment of bone disorders with adrenomedullin or adrenomedullin agonists
US5888963A (en) *	1996-04-18	1999-03-30	Auckland Uniservices Limited	Treatment of bone disorders with adrenomedullin
US6821954B2 (en) *	1997-09-18	2004-11-23	Auckland Uniservices Limited	Compounds and uses thereof in treating bone disorders
WO1999016406A2 (en)	1997-09-26	1999-04-08	Auckland Uniservices Limited	Therapeutic method
US9602269B2 (en) *	2013-05-13	2017-03-21	Acer Incorporated	Dynamic time division duplexing method and apparatuses using the same

1998
- 1998-09-25 WO PCT/NZ1998/000145 patent/WO1999016406A2/en not_active Ceased
- 1998-09-25 EP EP98946738A patent/EP1027027B1/de not_active Expired - Lifetime
- 1998-09-25 US US09/509,306 patent/US6869926B1/en not_active Expired - Fee Related
- 1998-09-25 DE DE69836689T patent/DE69836689D1/de not_active Expired - Lifetime
- 1998-09-25 JP JP2000513546A patent/JP2001524454A/ja active Pending
- 1998-09-25 AT AT98946738T patent/ATE348589T1/de not_active IP Right Cessation
- 1998-09-25 AU AU93690/98A patent/AU9369098A/en not_active Abandoned
2005
- 2005-03-21 US US11/086,628 patent/US7208469B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
US6869926B1 (en)	2005-03-22
EP1027027A4 (de)	2004-10-27
JP2001524454A (ja)	2001-12-04
US7208469B2 (en)	2007-04-24
EP1027027B1 (de)	2006-12-20
WO1999016406A2 (en)	1999-04-08
DE69836689D1 (de)	2007-02-01
US20050171007A1 (en)	2005-08-04
AU9369098A (en)	1999-04-23
EP1027027A2 (de)	2000-08-16
WO1999016406A3 (en)	1999-07-08

Legal Events

Date	Code	Title	Description
2007-06-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

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DE10199020I2 (de)	2004-05-06	Galanthamin oder dessen Analoge zur Behandlung derAlzheimerschen Krankheit.
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DE60008753D1 (de)	2004-04-08	Verwendung von naaladase inhibitoren zur behandlung von angstzuständen und gedächtnisstörungen
ATE210447T1 (de)	2001-12-15	Verwendung von cck-b rezeptor antagonisten zur behandlung von schlafstörungen
ATE220923T1 (de)	2002-08-15	Rekombinante adenoviren und deren verwendung in der gentherapie zur behandlung von augenerkrankungen
DE69836689D1 (de)	2007-02-01	Verwendung von Amylin, Adrenomedullin und deren Analoga zur Behandlung von Knorpeldefekten