ATE348615T1 - 2-(4-(2-hydroxymethyl-phenylamino)-piperidin-1- yl)-n-(9h-carbazol-3-yl) - acetamid derivate und verwandte verbindungen als neuropeptide y5 (npy5) liganden zur behandlung von fettleibigkeit - Google Patents

2-(4-(2-hydroxymethyl-phenylamino)-piperidin-1- yl)-n-(9h-carbazol-3-yl) - acetamid derivate und verwandte verbindungen als neuropeptide y5 (npy5) liganden zur behandlung von fettleibigkeit

Info

Publication number: ATE348615T1
Authority: AT; Austria
Prior art keywords: npy5; carbazol; neuropeptide; phenylamino; obesity
Prior art date: 2003-07-30

Application number

AT04741322T

Other languages

English (en)

Inventor

Jover Antoni Torrens

Prio Josep Mas

Zueras Alberto Dordal

Escasany Maria Angeles Fisas

Helmut Heinrich Buschmann

Original Assignee

Esteve Labor Dr

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-07-30

Filing date

2004-07-29

Publication date

2007-01-15

2004-07-29 Application filed by Esteve Labor Dr filed Critical Esteve Labor Dr

2007-01-15 Application granted granted Critical

2007-01-15 Publication of ATE348615T1 publication Critical patent/ATE348615T1/de

Links

208000008589 Obesity Diseases 0.000 title 1
150000001875 compounds Chemical class 0.000 title 1
239000003446 ligand Substances 0.000 title 1
GXYZYLVOXZTOFN-UHFFFAOYSA-N n-(9h-carbazol-3-yl)-2-[4-[2-(hydroxymethyl)anilino]piperidin-1-yl]acetamide Chemical class OCC1=CC=CC=C1NC1CCN(CC(=O)NC=2C=C3C4=CC=CC=C4NC3=CC=2)CC1 GXYZYLVOXZTOFN-UHFFFAOYSA-N 0.000 title 1
235000020824 obesity Nutrition 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
- C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
- C04B35/00—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
- C04B35/622—Forming processes; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
- C04B35/626—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B
- C04B35/63—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B using additives specially adapted for forming the products, e.g.. binder binders
- C04B35/632—Organic additives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Diabetes (AREA)
Manufacturing & Machinery (AREA)
Pain & Pain Management (AREA)
Ceramic Engineering (AREA)
Hematology (AREA)
Obesity (AREA)
Psychiatry (AREA)
Cardiology (AREA)
Inorganic Chemistry (AREA)
Heart & Thoracic Surgery (AREA)
Structural Engineering (AREA)
Materials Engineering (AREA)
Rheumatology (AREA)
Immunology (AREA)
Endocrinology (AREA)
Nutrition Science (AREA)
Child & Adolescent Psychology (AREA)
Physical Education & Sports Medicine (AREA)
Orthopedic Medicine & Surgery (AREA)
Hospice & Palliative Care (AREA)
Emergency Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT04741322T 2003-07-30 2004-07-29 2-(4-(2-hydroxymethyl-phenylamino)-piperidin-1- yl)-n-(9h-carbazol-3-yl) - acetamid derivate und verwandte verbindungen als neuropeptide y5 (npy5) liganden zur behandlung von fettleibigkeit ATE348615T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
ES200301813A ES2222833B1 (es)	2003-07-30	2003-07-30	Compuestos piperidinicos 1,4-disustituidos, su preparacion y su uso como medicamentos.

Publications (1)

Publication Number	Publication Date
ATE348615T1 true ATE348615T1 (de)	2007-01-15

Family

ID=34130546

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT04741322T ATE348615T1 (de)	2003-07-30	2004-07-29	2-(4-(2-hydroxymethyl-phenylamino)-piperidin-1- yl)-n-(9h-carbazol-3-yl) - acetamid derivate und verwandte verbindungen als neuropeptide y5 (npy5) liganden zur behandlung von fettleibigkeit
AT04763608T ATE348614T1 (de)	2003-07-30	2004-07-29	2-(4-(phenylamino)-piperidin-1-yl)-n-phenyl- acetamid derivate und verwandte verbindungen als neuropeptid y5 (npy5) liganden zur behandlung von fettleibigkeit

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
AT04763608T ATE348614T1 (de)	2003-07-30	2004-07-29	2-(4-(phenylamino)-piperidin-1-yl)-n-phenyl- acetamid derivate und verwandte verbindungen als neuropeptid y5 (npy5) liganden zur behandlung von fettleibigkeit

Country Status (19)

Country	Link
US (4)	US7888510B2 (de)
EP (2)	EP1651220B1 (de)
JP (2)	JP2007500169A (de)
CN (2)	CN1832745A (de)
AR (1)	AR045154A1 (de)
AT (2)	ATE348615T1 (de)
AU (2)	AU2004262482A1 (de)
BR (2)	BRPI0413091A (de)
CA (2)	CA2534096A1 (de)
DE (2)	DE602004003831T2 (de)
ES (3)	ES2222833B1 (de)
MX (2)	MXPA06001140A (de)
MY (1)	MY136965A (de)
NO (2)	NO20060553L (de)
PE (1)	PE20050332A1 (de)
PT (2)	PT1651220E (de)
RU (2)	RU2006105711A (de)
TW (1)	TW200510379A (de)
WO (2)	WO2005013990A1 (de)

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US9560804B1 (en)	2010-12-15	2017-02-07	Marion Calmer	Stalk roll with flutes defining a recess
ES2222833B1 (es) *	2003-07-30	2006-03-01	Laboratorios Del Dr. Esteve, S.A.	Compuestos piperidinicos 1,4-disustituidos, su preparacion y su uso como medicamentos.
EP1918281A1 (de) *	2006-11-02	2008-05-07	Laboratorios del Dr. Esteve S.A.	Phenylamino-substituierte piperidine Verbindungen, ihre Herstellung und Verwendung als Arzneimittel
EP2129219A4 (de)	2007-02-16	2012-08-29	Synta Pharmaceuticals Corp	Substituierte annelierte verbindungen für entzündungs- und immunbedingte verwendung
CN102272120B (zh) *	2008-11-07	2013-12-25	H.隆德贝克有限公司	生物活性酰胺
AU2021324684A1 (en) *	2020-08-11	2023-04-20	Board Of Trustees Of Michigan State University	Proteasome enhancers and uses thereof

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AU1328197A (en)	1995-12-01	1997-06-19	Synaptic Pharmaceutical Corporation	Aryl sulfonamide and sulfamide derivatives and uses thereof
US6043246A (en)	1996-12-03	2000-03-28	Banyu Pharmaceutical Co., Ltd.	Urea derivatives
US6048900A (en) *	1998-02-13	2000-04-11	Bayer Corporation	Amide derivatives and methods for using the same as selective neuropeptide Y receptor antagonists
WO1998035957A1 (en) *	1997-02-14	1998-08-20	Bayer Corporation	Amide derivatives as selective neuropeptide y receptor antagonists
AU6309698A (en)	1997-03-12	1998-09-29	Banyu Pharmaceutical Co., Ltd.	Drugs containing aminopyridine derivatives as the active ingredient
US7534857B2 (en) *	1997-12-19	2009-05-19	Centegen, Inc.	Methods and compositions for the treatment and prevention of staphylococcal infections
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NZ510988A (en)	1998-10-07	2005-01-28	Ortho Mcneil Pharm Inc	N-aralkylaminotetralins useful as ligands for the neuropeptide Y5 receptor
WO2001007409A1 (en) *	1999-07-23	2001-02-01	Astrazeneca Uk Limited	Carbazole derivatives and their use as neuropeptide y5 receptor ligands
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WO2001013917A1 (en)	1999-08-26	2001-03-01	Bristol-Myers Squibb Company	Npy antagonists: spiroisoquinolinone derivatives
KR100890676B1 (ko) *	2001-07-24	2009-03-26	리히데 게데온 베기에스제티 기아르 알티	신규한 카르복시산 아미드 화합물
US7067549B2 (en) *	2001-12-31	2006-06-27	Actelion Pharmaceuticals Ag	Pyrrolidone carboxamides
ES2193875B2 (es) *	2002-04-09	2005-03-01	Laboratorios Del Dr. Esteve, S.A.	Derivados de benzoxazinona, su preparacion y su aplicacion como medicamentos.
ES2228267B1 (es) *	2003-07-30	2006-07-01	Laboratorios Del Dr. Esteve, S.A.	Combinacion de sustancias activas conteniendo al menos un compuesto con afinidad por el receptor del neuropeptido y (npy) y al menos un compuesto con afinidad por el receptor 5-ht6.
ES2222833B1 (es) *	2003-07-30	2006-03-01	Laboratorios Del Dr. Esteve, S.A.	Compuestos piperidinicos 1,4-disustituidos, su preparacion y su uso como medicamentos.

2003
- 2003-07-30 ES ES200301813A patent/ES2222833B1/es not_active Expired - Fee Related
2004
- 2004-07-29 ES ES04741322T patent/ES2279400T3/es not_active Expired - Lifetime
- 2004-07-29 AR ARP040102696A patent/AR045154A1/es unknown
- 2004-07-29 BR BRPI0413091-0A patent/BRPI0413091A/pt not_active Application Discontinuation
- 2004-07-29 US US10/565,979 patent/US7888510B2/en not_active Expired - Fee Related
- 2004-07-29 CN CNA2004800222637A patent/CN1832745A/zh active Pending
- 2004-07-29 DE DE602004003831T patent/DE602004003831T2/de not_active Expired - Lifetime
- 2004-07-29 MY MYPI20043075A patent/MY136965A/en unknown
- 2004-07-29 AU AU2004262482A patent/AU2004262482A1/en not_active Abandoned
- 2004-07-29 RU RU2006105711/04A patent/RU2006105711A/ru unknown
- 2004-07-29 EP EP04741322A patent/EP1651220B1/de not_active Expired - Lifetime
- 2004-07-29 AU AU2004262491A patent/AU2004262491A1/en not_active Abandoned
- 2004-07-29 RU RU2006105792/04A patent/RU2006105792A/ru unknown
- 2004-07-29 PT PT04741322T patent/PT1651220E/pt unknown
- 2004-07-29 CA CA002534096A patent/CA2534096A1/en not_active Abandoned
- 2004-07-29 BR BRPI0412860-5A patent/BRPI0412860A/pt not_active IP Right Cessation
- 2004-07-29 WO PCT/EP2004/008517 patent/WO2005013990A1/en not_active Ceased
- 2004-07-29 PT PT04763608T patent/PT1648458E/pt unknown
- 2004-07-29 EP EP04763608A patent/EP1648458B1/de not_active Expired - Lifetime
- 2004-07-29 MX MXPA06001140A patent/MXPA06001140A/es not_active Application Discontinuation
- 2004-07-29 US US10/566,399 patent/US20070105853A1/en not_active Abandoned
- 2004-07-29 AT AT04741322T patent/ATE348615T1/de not_active IP Right Cessation
- 2004-07-29 JP JP2006521533A patent/JP2007500169A/ja active Pending
- 2004-07-29 CA CA002534101A patent/CA2534101A1/en not_active Abandoned
- 2004-07-29 DE DE602004003829T patent/DE602004003829T2/de not_active Expired - Lifetime
- 2004-07-29 MX MXPA06001226A patent/MXPA06001226A/es not_active Application Discontinuation
- 2004-07-29 ES ES04763608T patent/ES2279419T3/es not_active Expired - Lifetime
- 2004-07-29 CN CNA2004800219418A patent/CN1829516A/zh active Pending
- 2004-07-29 JP JP2006521526A patent/JP2007500162A/ja active Pending
- 2004-07-29 WO PCT/EP2004/008508 patent/WO2005013988A1/en not_active Ceased
- 2004-07-29 TW TW093122665A patent/TW200510379A/zh unknown
- 2004-07-29 AT AT04763608T patent/ATE348614T1/de not_active IP Right Cessation
- 2004-08-02 PE PE2004000734A patent/PE20050332A1/es not_active Application Discontinuation
2006
- 2006-02-02 NO NO20060553A patent/NO20060553L/no not_active Application Discontinuation
- 2006-02-07 NO NO20060605A patent/NO20060605L/no not_active Application Discontinuation
2010
- 2010-07-12 US US12/834,211 patent/US20100280072A1/en not_active Abandoned
2011
- 2011-01-06 US US12/985,646 patent/US20110172270A1/en not_active Abandoned

Also Published As

Publication number	Publication date
DE602004003831T2 (de)	2007-10-25
CA2534096A1 (en)	2005-02-17
US7888510B2 (en)	2011-02-15
US20100280072A1 (en)	2010-11-04
ES2279419T3 (es)	2007-08-16
BRPI0413091A (pt)	2006-10-03
MXPA06001226A (es)	2006-05-15
AR045154A1 (es)	2005-10-19
EP1648458B1 (de)	2006-12-20
WO2005013988A8 (en)	2006-11-09
EP1651220A1 (de)	2006-05-03
CN1832745A (zh)	2006-09-13
MY136965A (en)	2008-12-31
NO20060553L (no)	2006-02-02
WO2005013988A1 (en)	2005-02-17
ES2222833A1 (es)	2005-02-01
MXPA06001140A (es)	2006-04-24
CN1829516A (zh)	2006-09-06
CA2534101A1 (en)	2005-02-17
US20070105853A1 (en)	2007-05-10
EP1651220B1 (de)	2006-12-20
JP2007500162A (ja)	2007-01-11
ES2222833B1 (es)	2006-03-01
DE602004003829T2 (de)	2007-09-20
PT1651220E (pt)	2007-03-30
TW200510379A (en)	2005-03-16
US20110172270A1 (en)	2011-07-14
DE602004003829D1 (de)	2007-02-01
DE602004003831D1 (de)	2007-02-01
RU2006105711A (ru)	2007-09-20
BRPI0412860A (pt)	2006-10-03
JP2007500169A (ja)	2007-01-11
AU2004262482A1 (en)	2005-02-17
AU2004262491A1 (en)	2005-02-17
WO2005013990A1 (en)	2005-02-17
PT1648458E (pt)	2007-03-30
US20080119516A1 (en)	2008-05-22
PE20050332A1 (es)	2005-06-12
RU2006105792A (ru)	2007-09-20
ATE348614T1 (de)	2007-01-15
ES2279400T3 (es)	2007-08-16
EP1648458A1 (de)	2006-04-26
NO20060605L (no)	2006-02-07

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Publication	Publication Date	Title
ATE365039T1 (de)	2007-07-15	4-(4-(heterocyclylalkoxy phenyl)-1-(heterocyclyl- carbonyl)piperidin derivate und verwandte verbindungen als histamin h3 antagonsiten zur behandlung von neurologischen erkrankungen wie alzheimer's
DE602004009323D1 (de)	2007-11-15	1-(2-amino-benzoyl)-piperazin-derivate als glycin-aufnahmehemmer zur behandlung von psychosen
ATE516286T1 (de)	2011-07-15	5-(ä1,3,4üoxadiazol-2-yl)-1h-indazol und 5-(ä1,3, 4üthiadiazol-2-yl)-1h-indazol derivate als sgk- inhibitoren zur behandlung von diabetes
ATE447559T1 (de)	2009-11-15	4-(phenylamino)-6-oxo-1,6-dihydropyridazine-3- carboxamid derivate als mek inhibitoren zur behandlung von hyperproliferativen erkrankungen
NO20055714D0 (no)	2005-12-02	Inhibitorer av fosfatidylinositol 3-kinase
DE602006008945D1 (de)	2009-10-15	Isochinolinderivate als inhibitoren von rho-kinase
DE602004022187D1 (de)	2009-09-03	4-(pyrazol-3-ylamino)pyrimidinderivate zur verwendung bei der behandlung von krebs
ATE367161T1 (de)	2007-08-15	(3-oxo-3,4-dihydro-chinoxalin-2-yl-amino)- benzamid-derivate und verwandte verbindungen als glykogen-phosphorylase-hemmer zur behandlung von diabetes und adipositas
DE602005026984D1 (de)	2011-04-28	Chinolin-derivate zur behandlung von latenter tuberkulose
DE60208221D1 (de)	2006-01-26	Heterozyklische verbindungen zur behandlung von harnwegserkrankungen
ATE405553T1 (de)	2008-09-15	Heterocyclische verbindungen als inhibitoren von faktor viia
DE602006017980D1 (de)	2010-12-16	3,4-substituierte pyrrolidin-derivate zur behandlung von hypertonie
NO20080265L (no)	2008-01-15	2-(1H-indolylsulfanyl)-arylaminderivater
MA28394B1 (fr)	2007-01-02	Derives d'heteroaryle pour traitement des virus
DE60332862D1 (de)	2010-07-15	17beta-hydroxysteroid dehydrogenase typ-3 hemmer zur behandlung von androgen abhängigen erkrankungen
ATE446754T1 (de)	2009-11-15	Verbindungen zur behandlung von schizophrenie und/oder glucoregulatorische auffälligkeiten
ATE435217T1 (de)	2009-07-15	4-(3- (2-phenyl-oxazol-4-ylmethoxy)- cyclohexyloxy)-butansäure derivate und verwandte verbindungen als ppar modulatoren zur behandlung von typ 2 diabetes und atherosklerose
DE60232719D1 (de)	2009-08-06	Kombination enthaltend einen inhibitor der signaltransduktion und ein epothilonderivat
ATE504580T1 (de)	2011-04-15	Malonsäureamidderivate als inhibitoren von g- sekretase zur behandlung von alzheimer-krankheit
DE602004006118D1 (de)	2007-06-06	2,3,4,5-TETRAHYDROBENZOiFöi1,4öOXAZEPIN-5-CARBONSÄUREAMID DERIVATE ALS GAMMA-SECRETASE INHIBITOREN ZUR BEHANDLUNG VON ALZHEIMER
ATE348614T1 (de)	2007-01-15	2-(4-(phenylamino)-piperidin-1-yl)-n-phenyl- acetamid derivate und verwandte verbindungen als neuropeptid y5 (npy5) liganden zur behandlung von fettleibigkeit
MX2009003974A (es)	2009-04-27	N-(2-hidroxietil)-n-metil-4-(quinolin-8-il(1-(tiazol-4-ilmetil)pi peridin-4-ilideno)metil)benzamida, el proceso para su sintesis, asi como su uso para el tratamiento del dolor, la ansiedad y la depresion.
DE502005006955D1 (de)	2009-05-07	N-(phenyl-oxazol-4-ylmethoxymethyl)-cyclohexyl-bernsteinsäureamid derivate und verwandte verbindungen als ppar-liganden (peroxisomen-proliferatoren-aktivierte rezeptoren) zur behandlung von hyperlipidämie und diabetes
ATE337779T1 (de)	2006-09-15	N-'4-(2-imino-pyrrolidin-1-yl)phenyl)-acetemid- und entsprechende piperidinderivate als faktor xa inhibitoren zur behandlung von thromboembolischen erkrankungen
ATE556053T1 (de)	2012-05-15	Piperidinderivate zur behandlung von alzheimer- krankheit