ATE349426T1 - Verbindungen mit aktivität am 5ht2c-rezeptor und anwendungen davon - Google Patents

Verbindungen mit aktivität am 5ht2c-rezeptor und anwendungen davon

Info

Publication number: ATE349426T1
Authority: AT; Austria
Prior art keywords: sub; alkyl; haloc; alkoxy; linked
Prior art date: 2003-04-07

Application number

AT04725697T

Other languages

English (en)

Inventor

Giorgio Bonanomi

Dieter Hamprecht

Fabrizio Micheli

Silvia Terreni

Original Assignee

Glaxo Group Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-04-07

Filing date

2004-04-05

Publication date

2007-01-15

2004-04-05 Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd

2007-01-15 Application granted granted Critical

2007-01-15 Publication of ATE349426T1 publication Critical patent/ATE349426T1/de

Links

150000001875 compounds Chemical class 0.000 title abstract 2
102000006902 5-HT2C Serotonin Receptor Human genes 0.000 title 1
108010072553 5-HT2C Serotonin Receptor Proteins 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 9
125000003545 alkoxy group Chemical group 0.000 abstract 6
229910052739 hydrogen Inorganic materials 0.000 abstract 5
239000001257 hydrogen Substances 0.000 abstract 5
125000003341 7 membered heterocyclic group Chemical group 0.000 abstract 4
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
125000003282 alkyl amino group Chemical group 0.000 abstract 3
125000004414 alkyl thio group Chemical group 0.000 abstract 3
125000004093 cyano group Chemical group *C#N 0.000 abstract 3
125000000000 cycloalkoxy group Chemical group 0.000 abstract 3
125000000753 cycloalkyl group Chemical group 0.000 abstract 3
229910052736 halogen Inorganic materials 0.000 abstract 3
150000002367 halogens Chemical class 0.000 abstract 3
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 3
125000003118 aryl group Chemical group 0.000 abstract 2
150000002431 hydrogen Chemical class 0.000 abstract 2
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
208000019901 Anxiety disease Diseases 0.000 abstract 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
230000036506 anxiety Effects 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
125000001589 carboacyl group Chemical group 0.000 abstract 1
125000001072 heteroaryl group Chemical group 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
-1 hydroxy, amino Chemical group 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 1
QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
229910052717 sulfur Inorganic materials 0.000 abstract 1
239000011593 sulfur Chemical group 0.000 abstract 1
238000002560 therapeutic procedure Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Indole Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT04725697T 2003-04-07 2004-04-05 Verbindungen mit aktivität am 5ht2c-rezeptor und anwendungen davon ATE349426T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GBGB0308025.6A GB0308025D0 (en)	2003-04-07	2003-04-07	Compounds

Publications (1)

Publication Number	Publication Date
ATE349426T1 true ATE349426T1 (de)	2007-01-15

Family

ID=9956353

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT04725697T ATE349426T1 (de)	2003-04-07	2004-04-05	Verbindungen mit aktivität am 5ht2c-rezeptor und anwendungen davon

Country Status (8)

Country	Link
US (1)	US20070191457A1 (de)
EP (1)	EP1611098B1 (de)
JP (1)	JP2006522065A (de)
AT (1)	ATE349426T1 (de)
DE (1)	DE602004003927T2 (de)
ES (1)	ES2277249T3 (de)
GB (1)	GB0308025D0 (de)
WO (1)	WO2004089897A1 (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TW200613272A (en)	2004-08-13	2006-05-01	Astrazeneca Ab	Isoindolone compounds and their use as metabotropic glutamate receptor potentiators
EP1792629A4 (de)	2004-08-25	2010-08-25	Takeda Pharmaceutical	Mittel zur prävention/behandlung von stressbedingter harninkontinenz und vorsorgeuntersuchungsverfahren dafür
MY148644A (en)	2005-07-18	2013-05-15	Orion Corp	New pharmaceutical compounds
US7807706B2 (en)	2005-08-12	2010-10-05	Astrazeneca Ab	Metabotropic glutamate-receptor-potentiating isoindolones
EP2727585A1 (de)	2006-05-16	2014-05-07	Takeda Pharmaceutical Company Limited	In-vivo Screening-Methode
TWI417100B (zh)	2007-06-07	2013-12-01	Astrazeneca Ab	二唑衍生物及其作為代謝型麩胺酸受體增效劑-８４２之用途
EP2216023A4 (de)	2007-11-15	2013-03-13	Takeda Pharmaceutical	Kondensiertes pyridinderivat und seine verwendung
US7790760B2 (en)	2008-06-06	2010-09-07	Astrazeneca Ab	Metabotropic glutamate receptor isoxazole ligands and their use as potentiators 286
TWI498323B (zh) *	2009-05-21	2015-09-01	Sumitomo Chemical Co	Method for the production of halogen substituted phthalocyanines
JPWO2011071136A1 (ja)	2009-12-11	2013-04-22	アステラス製薬株式会社	線維筋痛症治療剤
KR101273643B1 (ko)	2010-10-12	2013-06-11	한국화학연구원	5,6-디하이드로-피롤로［3,4-ｂ］피리딘-7-온 유도체 또는 이의 약학적으로 허용 가능한 염, 이의 제조방법 및 이를 유효성분으로 포함하는 약학적 조성물
KR101236188B1 (ko)	2011-03-10	2013-02-22	한국화학연구원	신규한 피롤로피리디논 유도체 및 그의 ｍｃｈ 수용체-1 관련 질환에 대한 치료학적 용도
CN103524457A (zh) *	2013-09-13	2014-01-22	江苏集贤绿色化学科技研究院有限公司	一种医药中间体乙酰基哌啶的合成方法
EP3527569B1 (de)	2014-02-03	2021-08-25	Vitae Pharmaceuticals, LLC	Dihydropyrrolopyridininhibitoren von ror-gamma zur behandlung von augentrockenheit
TWI675032B (zh)	2014-10-14	2019-10-21	美商維它藥物公司	ＲＯＲ-γ之二氫吡咯并吡啶抑制劑
US9845308B2 (en)	2014-11-05	2017-12-19	Vitae Pharmaceuticals, Inc.	Isoindoline inhibitors of ROR-gamma
US9663515B2 (en)	2014-11-05	2017-05-30	Vitae Pharmaceuticals, Inc.	Dihydropyrrolopyridine inhibitors of ROR-gamma
ES2856931T3 (es)	2015-08-05	2021-09-28	Vitae Pharmaceuticals Llc	Moduladores de ROR-gamma
EP3868750A1 (de)	2015-11-20	2021-08-25	Vitae Pharmaceuticals, LLC	Modulatoren von ror-gamma
TW202220968A (zh)	2016-01-29	2022-06-01	美商維它藥物有限責任公司	ＲＯＲ－γ調節劑
US9481674B1 (en)	2016-06-10	2016-11-01	Vitae Pharmaceuticals, Inc.	Dihydropyrrolopyridine inhibitors of ROR-gamma
WO2019018975A1 (en)	2017-07-24	2019-01-31	Vitae Pharmaceuticals, Inc.	INHIBITORS OF ROR GAMMA
MA49685A (fr)	2017-07-24	2021-04-14	Vitae Pharmaceuticals Llc	INHIBITEURS DE ROR gamma
JPWO2019131902A1 (ja)	2017-12-27	2020-12-10	武田薬品工業株式会社	腹圧性尿失禁および便失禁の治療薬
US12360348B2 (en)	2019-07-24	2025-07-15	Nippon Electric Glass Co., Ltd.	Infrared imaging lens

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4123543A (en) *	1971-09-16	1978-10-31	Ab Kabi	Derivatives of substituted indoline lactans with effect on the central nervous system
JPS5663961A (en) *	1979-10-05	1981-05-30	Tsutomu Kameyama	Novel isoindoline derivative and its preparation
ATE39483T1 (de) *	1982-04-02	1989-01-15	Takeda Chemical Industries Ltd	Kondensierte pyrrolinon-derivate, und ihre herstellung.
US6956047B1 (en) *	1995-06-06	2005-10-18	Pfizer Inc.	Corticotropin releasing factor antagonists
EP1465872A1 (de) *	2001-12-28	2004-10-13	Bayer Pharmaceuticals Corporation	4-sulfid/sulfoxid/sulfonyl-1h-pyrazolderivate zur behandlung von erkrankungen, die mit 5-ht2c rezeptoren verbunden sind
AU2003272030A1 (en) *	2002-11-08	2004-06-07	Warner-Lambert Company Llc	Phenylalkyl and pyridylalkyl piperazine derivatives

2003
- 2003-04-07 GB GBGB0308025.6A patent/GB0308025D0/en not_active Ceased
2004
- 2004-04-05 EP EP04725697A patent/EP1611098B1/de not_active Expired - Lifetime
- 2004-04-05 WO PCT/EP2004/003678 patent/WO2004089897A1/en not_active Ceased
- 2004-04-05 AT AT04725697T patent/ATE349426T1/de not_active IP Right Cessation
- 2004-04-05 US US10/551,904 patent/US20070191457A1/en not_active Abandoned
- 2004-04-05 ES ES04725697T patent/ES2277249T3/es not_active Expired - Lifetime
- 2004-04-05 DE DE602004003927T patent/DE602004003927T2/de not_active Expired - Fee Related
- 2004-04-05 JP JP2006505025A patent/JP2006522065A/ja active Pending

Also Published As

Publication number	Publication date
US20070191457A1 (en)	2007-08-16
DE602004003927D1 (de)	2007-02-08
GB0308025D0 (en)	2003-05-14
EP1611098A1 (de)	2006-01-04
EP1611098B1 (de)	2006-12-27
JP2006522065A (ja)	2006-09-28
ES2277249T3 (es)	2007-07-01
WO2004089897A1 (en)	2004-10-21
DE602004003927T2 (de)	2007-06-28

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Legal Events

Date	Code	Title	Description
2007-06-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties