ATE350388T1 - Verfahren zur herstellung von n-neohexyl-(a)- aspartyl-l-phenylalaninmethylester aus zwischenverbindungen die imidazolidin-4-on enthalten - Google Patents

Verfahren zur herstellung von n-neohexyl-(a)- aspartyl-l-phenylalaninmethylester aus zwischenverbindungen die imidazolidin-4-on enthalten

Info

Publication number: ATE350388T1
Authority: AT; Austria
Prior art keywords: aspartyl; methyl ester; neohexyl; imidazolidin; contain
Prior art date: 1998-11-19

Application number

AT99960417T

Other languages

English (en)

Inventor

Vladislav Orlovski

Indra Prakash

Mike G Scaros

Christine M V Moore

Original Assignee

Nutrasweet Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-11-19

Filing date

1999-11-18

Publication date

2007-01-15

1999-11-18 Application filed by Nutrasweet Co filed Critical Nutrasweet Co

2007-01-15 Application granted granted Critical

2007-01-15 Publication of ATE350388T1 publication Critical patent/ATE350388T1/de

Links

150000001875 compounds Chemical class 0.000 title 1
GVONPBONFIJAHJ-UHFFFAOYSA-N imidazolidin-4-one Chemical compound O=C1CNCN1 GVONPBONFIJAHJ-UHFFFAOYSA-N 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
230000015572 biosynthetic process Effects 0.000 abstract 1
238000006243 chemical reaction Methods 0.000 abstract 1
YAMHXTCMCPHKLN-UHFFFAOYSA-N imidazolidin-2-one Chemical compound O=C1NCCN1 YAMHXTCMCPHKLN-UHFFFAOYSA-N 0.000 abstract 1
HLIAVLHNDJUHFG-HOTGVXAUSA-N neotame Chemical compound CC(C)(C)CCN[C@@H](CC(O)=O)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 HLIAVLHNDJUHFG-HOTGVXAUSA-N 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06104—Dipeptides with the first amino acid being acidic
- C07K5/06113—Asp- or Asn-amino acid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Life Sciences & Earth Sciences (AREA)
Peptides Or Proteins (AREA)
Pyrrole Compounds (AREA)
Seasonings (AREA)

AT99960417T 1998-11-19 1999-11-18 Verfahren zur herstellung von n-neohexyl-(a)- aspartyl-l-phenylalaninmethylester aus zwischenverbindungen die imidazolidin-4-on enthalten ATE350388T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US10913298P	1998-11-19	1998-11-19

Publications (1)

Publication Number	Publication Date
ATE350388T1 true ATE350388T1 (de)	2007-01-15

Family

ID=22325963

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99960417T ATE350388T1 (de)	1998-11-19	1999-11-18	Verfahren zur herstellung von n-neohexyl-(a)- aspartyl-l-phenylalaninmethylester aus zwischenverbindungen die imidazolidin-4-on enthalten

Country Status (7)

Country	Link
US (1)	US6465677B1 (de)
EP (1)	EP1133518B1 (de)
AT (1)	ATE350388T1 (de)
AU (1)	AU1730800A (de)
DE (1)	DE69934712T2 (de)
ES (1)	ES2277456T3 (de)
WO (1)	WO2000031117A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE60108745T2 (de) *	2000-05-19	2005-07-07	The Nutrasweet Co., Chicago	Herstellung von N-[N-(3,3-Dimethylbutyl)-L-α-aspartyl]-L-phenylalanin-1-methylester mittels Oxazolidinonderivate
EP1349829A4 (de) *	2000-11-06	2005-11-09	Nutrasweet Co	Katalysatormodifizierung zur verbesserung der neotamherstellung
CN101775066B (zh) *	2010-01-29	2012-05-02	常茂生物化学工程股份有限公司	一种合成纽甜的方法
CN102863511B (zh) *	2012-09-27	2015-07-08	嘉兴百思食品科技有限公司	制备纽甜的一种方法
CN103145796B (zh) *	2013-03-25	2015-02-04	重庆民泰香料化工有限责任公司	一种纽甜合成工艺
CN103333085B (zh) *	2013-07-11	2015-01-07	济南诚汇双达化工有限公司	一种纽甜中间体亚胺的制备分离方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK0478729T3 (da)	1990-03-15	1996-09-16	Nutrasweet Co	Fremgangsmåde til fremstilling af aspartam ud fra et diketopiperazin, og hidtil ukendte mellemprodukter og derivater dertil
FR2697844B1 (fr)	1992-11-12	1995-01-27	Claude Nofre	Nouveaux composés dérivés de dipeptides ou d'analogues dipeptidiques utiles comme agents édulcorants, leur procédé de préparation.
FR2719590B1 (fr)	1994-05-09	1996-07-26	Claude Nofre	Procédé perfectionné de préparation d'un composé dérivé de l'aspartame utile comme agent édulcorant.
US5728862A (en)	1997-01-29	1998-03-17	The Nutrasweet Company	Method for preparing and purifying an N-alkylated aspartame derivative

1999
- 1999-11-17 US US09/441,512 patent/US6465677B1/en not_active Expired - Lifetime
- 1999-11-18 WO PCT/US1999/027235 patent/WO2000031117A1/en not_active Ceased
- 1999-11-18 EP EP99960417A patent/EP1133518B1/de not_active Expired - Lifetime
- 1999-11-18 ES ES99960417T patent/ES2277456T3/es not_active Expired - Lifetime
- 1999-11-18 DE DE69934712T patent/DE69934712T2/de not_active Expired - Lifetime
- 1999-11-18 AU AU17308/00A patent/AU1730800A/en not_active Abandoned
- 1999-11-18 AT AT99960417T patent/ATE350388T1/de not_active IP Right Cessation

Also Published As

Publication number	Publication date
EP1133518A1 (de)	2001-09-19
ES2277456T3 (es)	2007-07-01
WO2000031117A1 (en)	2000-06-02
DE69934712D1 (de)	2007-02-15
AU1730800A (en)	2000-06-13
US6465677B1 (en)	2002-10-15
EP1133518B1 (de)	2007-01-03
DE69934712T2 (de)	2007-10-18

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Legal Events

Date	Code	Title	Description
2007-07-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties