ATE353909T1 - 3-stickstoff-6,7-dioxygenierte steroid verbindungen und verwendungen davon - Google Patents

3-stickstoff-6,7-dioxygenierte steroid verbindungen und verwendungen davon

Info

Publication number
ATE353909T1
ATE353909T1 AT01925262T AT01925262T ATE353909T1 AT E353909 T1 ATE353909 T1 AT E353909T1 AT 01925262 T AT01925262 T AT 01925262T AT 01925262 T AT01925262 T AT 01925262T AT E353909 T1 ATE353909 T1 AT E353909T1
Authority
AT
Austria
Prior art keywords
nitrogen
steroid compounds
dioxygenated steroid
dioxygenated
compounds
Prior art date
Application number
AT01925262T
Other languages
English (en)
Inventor
Jeffery R Raymond
Claudia E Kasserra
Yaping Shen
Original Assignee
Inflazyme Pharm Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inflazyme Pharm Ltd filed Critical Inflazyme Pharm Ltd
Application granted granted Critical
Publication of ATE353909T1 publication Critical patent/ATE353909T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J41/00Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/06Antiarrhythmics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J41/00Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J41/00Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • C07J41/0011Unsubstituted amino radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J43/00Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J71/00Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0036Nitrogen-containing hetero ring
    • C07J71/0042Nitrogen only
    • C07J71/0047Nitrogen only at position 2(3)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J71/00Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0036Nitrogen-containing hetero ring
    • C07J71/0057Nitrogen and oxygen
    • C07J71/0063Nitrogen and oxygen at position 2(3)
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT01925262T 2000-04-28 2001-04-30 3-stickstoff-6,7-dioxygenierte steroid verbindungen und verwendungen davon ATE353909T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US20061700P 2000-04-28 2000-04-28

Publications (1)

Publication Number Publication Date
ATE353909T1 true ATE353909T1 (de) 2007-03-15

Family

ID=22742458

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01925262T ATE353909T1 (de) 2000-04-28 2001-04-30 3-stickstoff-6,7-dioxygenierte steroid verbindungen und verwendungen davon

Country Status (33)

Country Link
US (4) US6635629B2 (de)
EP (1) EP1278763B1 (de)
JP (1) JP2003531916A (de)
KR (1) KR20030045671A (de)
CN (1) CN1214039C (de)
AP (1) AP1825A (de)
AT (1) ATE353909T1 (de)
AU (2) AU2001252084B2 (de)
BG (1) BG107289A (de)
BR (1) BR0110419A (de)
CA (1) CA2418748A1 (de)
CO (1) CO5590904A2 (de)
DE (1) DE60126597T2 (de)
DK (1) DK1278763T3 (de)
DZ (1) DZ3355A1 (de)
EE (1) EE200200613A (de)
ES (1) ES2282247T3 (de)
HR (1) HRP20020944A2 (de)
HU (1) HUP0300908A2 (de)
IL (2) IL152448A0 (de)
MA (1) MA25808A1 (de)
MX (1) MXPA02010645A (de)
NO (1) NO324873B1 (de)
NZ (1) NZ522181A (de)
OA (1) OA12255A (de)
PL (1) PL365798A1 (de)
PT (1) PT1278763E (de)
RU (1) RU2291873C2 (de)
SK (1) SK15692002A3 (de)
UA (1) UA79229C2 (de)
WO (1) WO2001083512A1 (de)
YU (1) YU88102A (de)
ZA (1) ZA200208631B (de)

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US20030083231A1 (en) * 1998-11-24 2003-05-01 Ahlem Clarence N. Blood cell deficiency treatment method
CA2418748A1 (en) * 2000-04-28 2001-11-08 Inflazyme Pharmaceuticals Limited 3-nitrogen-6,7-dioxygen steroids and uses related thereto
AU2002303425A1 (en) * 2001-04-24 2002-11-05 Epigenesis Pharmaceuticals, Inc. Composition, formulations and kit for treatment of respiratory and lung disease with non-glucocorticoid steroids and/or ubiquinone and a bronchodilating agent
NZ546612A (en) 2001-05-22 2007-08-31 Inflazyme Pharm Ltd Process for the production of 6,7-dihydroxy steroid compounds by allylic oxidation of steroid-5-ene compounds to steroid-5-ene-7-one compounds followed by hydroboration and oxidation intermediates of this process
WO2004013173A1 (ja) 2002-08-01 2004-02-12 Yamanouchi Pharmaceutical Co., Ltd. 新規なカリウム依存的ナトリウム−カルシウム交換体
US20050026879A1 (en) * 2003-07-31 2005-02-03 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a tyrosine kinase inhibitor, delta opioid receptor antagonist, neurokinin receptor antagonist, or VCAM inhibitor for treatment of asthma or chronic obstructive pulmonary disease
US20050026884A1 (en) * 2003-07-31 2005-02-03 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a beta-agonist bronchodilator for treatment of asthma or chronic obstructive pulmonary disease
US20090297611A1 (en) * 2003-07-31 2009-12-03 Robinson Cynthia B Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a tyrosine kinase inhibitor, delta opioid receptor antagonist, neurokinin receptor antagonist, or vcam inhibitor for treatment of asthma or chronic obstructive pulmonary disease
US20050026882A1 (en) * 2003-07-31 2005-02-03 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a leukotriene receptor antagonist for treatment of asthma or chronic obstructive pulmonary disease
US20050026881A1 (en) * 2003-07-31 2005-02-03 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with an anti-IgE antibody for treatment of asthma or chronic obstructive pulmonary disease
US20050113318A1 (en) * 2003-07-31 2005-05-26 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a beta-agonist bronchodilator for treatment of asthma or chronic obstructive pulmonary disease
US20050043282A1 (en) * 2003-07-31 2005-02-24 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a lipoxygenase inhibitor for treatment of asthma or chronic obstructive pulmonary disease
US20090285900A1 (en) * 2003-07-31 2009-11-19 Robinson Cynthia B Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a beta-agonist bronchodilator for treatment of asthma or chronic obstructive pulmonary disease
US20110209699A1 (en) * 2003-07-31 2011-09-01 Robinson Cynthia B Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a lipoxygenase inhibitor for treatment of asthma or chronic obstructive pulmonary disease
US20090263381A1 (en) * 2003-07-31 2009-10-22 Robinson Cynthia B Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with an anti-ige antibody for treatment of asthma or chronic obstructive pulmonary disease
US20050101545A1 (en) * 2003-07-31 2005-05-12 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with an anticholinergic bronchodilator for treatment of asthma or chronic obstructive pulmonary disease
US20090317476A1 (en) * 2003-07-31 2009-12-24 Robinson Cynthia B Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a leukotriene receptor antagonist for treatment of asthma or chronic obstructive pulmonary disease
US20050038004A1 (en) * 2003-07-31 2005-02-17 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with an anticholinergic bronchodilator for treatment of asthma or chronic obstructive pulmonary disease
FR2861077B1 (fr) * 2003-10-20 2006-03-03 Aventis Pharma Sa Formes cristallines du chlorydrate de 3-beta-amino, 17-methylene, androstane-6-alpha, 7-beta-diol
EP1680441A1 (de) * 2003-10-20 2006-07-19 Inflazyme Pharmaceuticals, Ltd. Kristalline formen von 3-beta-amino-17-methylenandrostan-6-alpha-7-beta-diol-hydrochlorid
US20080051382A1 (en) * 2003-10-20 2008-02-28 Inflazyme Pharmaceuticals Ltd. Crystalline Forms of 3-Beta-Amino 17-Methylene Androstane-6-Alpha 7-Beta-Diol Hydrochloride
US20090317477A1 (en) * 2004-03-31 2009-12-24 Robinson Cynthia B Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a glucocorticosteroid for treatment of asthma, chronic obstructive pulmonary disease or allergic rhinitis
US20050222049A1 (en) * 2004-03-31 2005-10-06 Robinson Cynthia B Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a glucocorticosteroid for treatment of asthma, chronic obstructive pulmonary disease or allergic rhinitis
US20050227927A1 (en) * 2004-03-31 2005-10-13 Robinson Cynthia B Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a glucocorticosteroid for treatment of asthma, chronic obstructive pulmonary disease or allergic rhinitis
JP2011504184A (ja) * 2007-11-21 2011-02-03 ザ プロクター アンド ギャンブル カンパニー 咳治療に有用な製剤、方法及びキット
JP5655243B2 (ja) * 2009-10-19 2015-01-21 国立大学法人 熊本大学 インドキシル硫酸の産生の阻害剤のスクリーニング方法、インドキシル硫酸代謝産生阻害剤、及び腎障害軽減剤
AU2011206864B2 (en) 2010-01-15 2013-12-19 Suzhou Neupharma Co., Ltd. Certain chemical entities, compositions, and methods
KR20230156435A (ko) 2010-07-09 2023-11-14 바이오버라티브 테라퓨틱스 인크. 인자 ix 폴리펩티드 및 이들의 사용 방법
EP2670763B1 (de) 2011-02-02 2018-08-01 Suzhou Neupharma Co., Ltd Bestimmte chemische stoffe, zusammensetzungen und verfahren
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BR112015022577A2 (pt) 2013-03-14 2017-07-18 Aquinox Pharmaceuticals Canada Inc moduladores ship1 e métodos relacionados a esse
AR095527A1 (es) 2013-03-15 2015-10-21 Biogen Idec Inc Formulaciones de polipéptido fc-factor ix
CN104744547B (zh) * 2013-12-27 2017-02-15 天津医科大学 一种抗乳腺癌转移作用的孕甾烷生物碱衍生物及医药用途
AU2016281658A1 (en) 2015-06-26 2017-12-07 Aquinox Pharmaceuticals (Canada) Inc. Crystalline solid forms of the acetate salt of (1s,3s,4r)-4-((3as,4r,5s,7as)-4-(aminomethyl)-7a-methyl-1-methyleneoctahydro-1h-inden-5-yl)-3-(hydroxymethyl)-4-methylcyclohexanol
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US11420962B2 (en) 2018-04-06 2022-08-23 Taro Pharmaceuticals Inc. Indene derivatives useful in treating pain and inflammation
JP2021526546A (ja) 2018-04-06 2021-10-07 アキノックス ファーマシューティカルス(カナダ)インク. 疼痛及び炎症を治療するのに有用なインデン誘導体
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Also Published As

Publication number Publication date
DE60126597T2 (de) 2007-10-31
CO5590904A2 (es) 2005-12-30
AP1825A (en) 2008-02-03
WO2001083512A1 (en) 2001-11-08
MXPA02010645A (es) 2004-04-20
AP2002002659A0 (en) 2002-12-31
CA2418748A1 (en) 2001-11-08
HUP0300908A2 (hu) 2003-07-28
NO20025106D0 (no) 2002-10-24
CN1430625A (zh) 2003-07-16
YU88102A (sh) 2006-01-16
PT1278763E (pt) 2007-05-31
US20040034216A1 (en) 2004-02-19
IL152448A0 (en) 2003-05-29
UA79229C2 (en) 2007-06-11
DK1278763T3 (da) 2007-06-11
US7112580B2 (en) 2006-09-26
HRP20020944A2 (en) 2004-02-29
ES2282247T3 (es) 2007-10-16
DE60126597D1 (de) 2007-03-29
JP2003531916A (ja) 2003-10-28
US20020072510A1 (en) 2002-06-13
OA12255A (en) 2006-05-11
NO20025106L (no) 2002-12-18
US6635629B2 (en) 2003-10-21
EP1278763B1 (de) 2007-02-14
PL365798A1 (en) 2005-01-10
US20040138186A1 (en) 2004-07-15
CN1214039C (zh) 2005-08-10
ZA200208631B (en) 2004-02-23
US20050215534A9 (en) 2005-09-29
EE200200613A (et) 2004-04-15
KR20030045671A (ko) 2003-06-11
MA25808A1 (fr) 2003-07-01
EP1278763A1 (de) 2003-01-29
AU2001252084B2 (en) 2006-07-06
SK15692002A3 (sk) 2003-11-04
RU2291873C2 (ru) 2007-01-20
IL152448A (en) 2006-12-31
NZ522181A (en) 2005-04-29
AU5208401A (en) 2001-11-12
NO324873B1 (no) 2007-12-17
HK1050694A1 (en) 2003-07-04
US20070060553A1 (en) 2007-03-15
DZ3355A1 (fr) 2001-11-08
BG107289A (bg) 2003-07-31
BR0110419A (pt) 2004-02-25

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