ATE353921T1 - Chimäre polypeptide, verfahren zur herstellung und verwendung dafür - Google Patents

Chimäre polypeptide, verfahren zur herstellung und verwendung dafür

Info

Publication number: ATE353921T1
Authority: AT; Austria
Prior art keywords: production; chimeric polypeptides; chimeric; polypeptides
Prior art date: 1999-08-02

Application number

AT00948017T

Other languages

English (en)

Inventor

Hauke Lilie

Susanne Richter

Rainer Rudolph

Kay-Gunnar Stubenrauch

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-08-02

Filing date

2000-07-31

Publication date

2007-03-15

2000-07-31 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2007-03-15 Application granted granted Critical

2007-03-15 Publication of ATE353921T1 publication Critical patent/ATE353921T1/de

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/624—Disulfide-stabilized antibody (dsFv)
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/22011—Polyomaviridae, e.g. polyoma, SV40, JC
- C12N2710/22022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/22011—Polyomaviridae, e.g. polyoma, SV40, JC
- C12N2710/22023—Virus like particles [VLP]

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Wood Science & Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
Zoology (AREA)
Immunology (AREA)
Virology (AREA)
Engineering & Computer Science (AREA)
General Engineering & Computer Science (AREA)
Gastroenterology & Hepatology (AREA)
Biomedical Technology (AREA)
Microbiology (AREA)
Biotechnology (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

AT00948017T 1999-08-02 2000-07-31 Chimäre polypeptide, verfahren zur herstellung und verwendung dafür ATE353921T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP99115022A EP1074563A1 (de)	1999-08-02	1999-08-02	Erhöhte Bildung von Chimären Polypeptiden durch Ausbildung von Dimeren mittels elektrostatischen wechselwirkungen und Disulfidbindungen sowie Verfahren zur Herstellung und Anwendungen

Publications (1)

Publication Number	Publication Date
ATE353921T1 true ATE353921T1 (de)	2007-03-15

Family

ID=8238697

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT00948017T ATE353921T1 (de)	1999-08-02	2000-07-31	Chimäre polypeptide, verfahren zur herstellung und verwendung dafür

Country Status (17)

Country	Link
US (1)	US6437095B1 (de)
EP (2)	EP1074563A1 (de)
JP (1)	JP4011914B2 (de)
KR (1)	KR100484084B1 (de)
CN (1)	CN1184235C (de)
AR (1)	AR021448A1 (de)
AT (1)	ATE353921T1 (de)
AU (1)	AU768645B2 (de)
BR (1)	BR0012926A (de)
CA (1)	CA2380569C (de)
DE (1)	DE60033405T2 (de)
DK (1)	DK1206495T3 (de)
ES (1)	ES2280231T3 (de)
MX (1)	MXPA02001139A (de)
TR (1)	TR200200252T2 (de)
WO (1)	WO2001009193A1 (de)
ZA (1)	ZA200109746B (de)

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US20030157091A1 (en) *	2002-02-14	2003-08-21	Dyax Corporation	Multi-functional proteins
US7335361B2 (en) *	2003-06-09	2008-02-26	Animal Technology Institute Taiwan	Fusion antigen used as vaccine
US7544770B2 (en) *	2003-08-29	2009-06-09	Louisiana Tech Foundation, Inc.	Multilayer films, coatings, and microcapsules comprising polypeptides
US7348399B2 (en) *	2003-08-29	2008-03-25	Louisiana Tech University Foundation, Inc.	Nanofabricated polypeptide multilayer films, coatings, and microcapsules
US7550557B2 (en)	2003-08-29	2009-06-23	Louisiana Tech University Foundation, Inc.	Multilayer films, coatings, and microcapsules comprising polypeptides
AU2004325199B2 (en) *	2004-11-22	2011-09-08	Louisiana Tech University Foundation	Method for designing polypeptides for the nanofabrication of thin films, coatings and microcapsules by electrostatic layer-by-layer self assembly.
CN101080241A (zh) *	2004-12-17	2007-11-28	皇家飞利浦电子股份有限公司	用于分子成像的靶向剂
WO2011034605A2 (en)	2009-09-16	2011-03-24	Genentech, Inc.	Coiled coil and/or tether containing protein complexes and uses thereof
AR080793A1 (es)	2010-03-26	2012-05-09	Roche Glycart Ag	Anticuerpos biespecificos
CN103384825B (zh)	2010-12-23	2017-05-24	霍夫曼-拉罗奇有限公司	通过二价结合剂检测经翻译后修饰的多肽
EP2659275B1 (de)	2010-12-23	2017-11-22	Roche Diagnostics GmbH	Erkennung eines polypeptiddimers durch ein bivalentes bindemittel
JP5766296B2 (ja)	2010-12-23	2015-08-19	エフ．ホフマン−ラロシュアーゲーＦ．Ｈｏｆｆｍａｎｎ−ＬａＲｏｃｈｅＡｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ	ポリペプチド−ポリヌクレオチド複合体、およびエフェクター成分の標的化された送達におけるその使用
EP2655414B1 (de)	2010-12-23	2018-08-29	Roche Diagniostics GmbH	Bispezifisches bindungsmolekül
WO2012107932A1 (en) *	2011-02-11	2012-08-16	Transgene Biotek Ltd.	B cell clonal immunotoxin and use thereof
KR101629073B1 (ko)	2011-06-15	2016-06-09	에프. 호프만-라 로슈 아게	항-인간 에리스로포이에틴 수용체 항체 및 이의 사용 방법
MX2014009565A (es)	2012-02-10	2014-11-10	Genentech Inc	Anticuerpos monocatenarios y otros heteromultimeros.
CA2871386A1 (en)	2012-06-27	2014-01-03	F. Hoffmann-La Roche Ag	Method for the selection and production of tailor-made, selective and multi-specific therapeutic molecules comprising at least two different targeting entities and uses thereof
RU2015100656A (ru)	2012-06-27	2016-08-20	Ф. Хоффманн-Ля Рош Аг	Способ получения конъюгатов fc-фрагмента антитела, включающих по меньшей мере одну связывающую группировку, которая специфически связывается с мишенью, и их применения
JP6203838B2 (ja)	2012-06-27	2017-09-27	エフ．ホフマン−ラロシュアーゲーＦ．Ｈｏｆｆｍａｎｎ−ＬａＲｏｃｈｅＡｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ	少なくとも２つの異なる結合実体を含む、テーラーメイドの高度に選択的かつ多重特異的なターゲティング実体を選択および作製するための方法、ならびにその使用
CN115322253A (zh)	2014-03-20	2022-11-11	百时美施贵宝公司	稳定化的基于纤连蛋白的支架分子
JP6449338B2 (ja)	2014-06-06	2019-01-09	ブリストル−マイヤーズスクイブカンパニーＢｒｉｓｔｏｌ−ＭｙｅｒｓＳｑｕｉｂｂＣｏｍｐａｎｙ	グルココルチコイド誘導腫瘍壊死因子受容体（ｇｉｔｒ）に対する抗体およびその使用
HUE050596T2 (hu)	2014-11-21	2020-12-28	Bristol Myers Squibb Co	Antitestek CD73 ellen és azok felhasználásai
ES2822990T3 (es)	2014-11-25	2021-05-05	Bristol Myers Squibb Co	Novedosos polipéptidos de unión a PD-L1 para obtención de imágenes
WO2016087416A1 (en)	2014-12-03	2016-06-09	F. Hoffmann-La Roche Ag	Multispecific antibodies
AU2015365583B2 (en)	2014-12-19	2021-10-28	Regenesance B.V.	Antibodies that bind human C6 and uses thereof
WO2016127052A1 (en)	2015-02-05	2016-08-11	Bristol-Myers Squibb Company	Cxcl11 and smica as predictive biomarkers for efficacy of anti-ctla4 immunotherapy
UY36687A (es)	2015-05-29	2016-11-30	Bristol Myers Squibb Company Una Corporación Del Estado De Delaware	Anticuerpos contra ox40 y sus usos
ES2809125T3 (es)	2015-09-23	2021-03-03	Bristol Myers Squibb Co	Moléculas de armazón a base de fibronectina de unión a glipicano-3
CN108738324B (zh)	2015-11-19	2022-06-21	百时美施贵宝公司	抗糖皮质激素诱导的肿瘤坏死因子受体(gitr)抗体及其用途
IL295230A (en)	2016-03-04	2022-10-01	Bristol Myers Squibb Co	Combination therapy with anti-cd73 antibodies
KR102397783B1 (ko)	2016-06-01	2022-05-12	브리스톨-마이어스 스큅 컴퍼니	Pd-l1 결합 폴리펩티드에 의한 pet 영상화
JP7027401B2 (ja)	2016-07-14	2022-03-01	ブリストル－マイヤーズスクイブカンパニー	Ｔｉｍ３に対する抗体およびその使用
KR102539159B1 (ko)	2016-11-07	2023-06-02	주식회사 뉴라클사이언스	서열 유사성을 가진 항-패밀리 19, 멤버 a5 항체 및 그것의 사용 방법
TW202506185A (zh)	2017-01-20	2025-02-16	法商賽諾菲公司	抗TGF-β抗體及其用途
AR110755A1 (es) *	2017-01-20	2019-05-02	Genzyme Corp	Anticuerpos dirigidos a hueso
BR112019016374A2 (pt)	2017-02-17	2020-04-07	Bristol-Myers Squibb Company	anticorpos para alfa-sinucleína e usos dos mesmos
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BR112020018539A2 (pt)	2018-03-23	2020-12-29	Bristol-Myers Squibb Company	Anticorpos contra mica e/ou micb e usos dos mesmos
TWI790370B (zh)	2018-04-02	2023-01-21	美商必治妥美雅史谷比公司	抗trem-1抗體及其用途
EP3841124A4 (de)	2018-06-29	2022-03-23	ApitBio, Inc.	Anti-l1cam-antikörper und verwendungen davon
CN117964756A (zh)	2019-01-02	2024-05-03	纽洛可科学有限公司	抗序列相似家族19成员a5的抗体及其使用方法
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CN114805598A (zh) *	2019-04-28	2022-07-29	广州市雷德生物科技有限公司	促进蛋白二聚体形成的拉链扣结构及其应用
WO2021011681A1 (en)	2019-07-15	2021-01-21	Bristol-Myers Squibb Company	Antibodies against human trem-1 and uses thereof
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CN112694527B (zh) *	2020-12-25	2022-09-09	山东睿鹰制药集团有限公司	一种重组人干扰素-κ包涵体的纯化和复性方法
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US5747654A (en) *	1993-06-14	1998-05-05	The United States Of America As Represented By The Department Of Health And Human Services	Recombinant disulfide-stabilized polypeptide fragments having binding specificity
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1999
- 1999-08-02 EP EP99115022A patent/EP1074563A1/de not_active Withdrawn
2000
- 2000-07-24 AR ARP000103808A patent/AR021448A1/es active IP Right Grant
- 2000-07-26 US US09/625,570 patent/US6437095B1/en not_active Expired - Lifetime
- 2000-07-31 WO PCT/EP2000/007378 patent/WO2001009193A1/en not_active Ceased
- 2000-07-31 AU AU61610/00A patent/AU768645B2/en not_active Ceased
- 2000-07-31 BR BR0012926-7A patent/BR0012926A/pt not_active IP Right Cessation
- 2000-07-31 ES ES00948017T patent/ES2280231T3/es not_active Expired - Lifetime
- 2000-07-31 MX MXPA02001139A patent/MXPA02001139A/es active IP Right Grant
- 2000-07-31 KR KR10-2002-7001377A patent/KR100484084B1/ko not_active Expired - Fee Related
- 2000-07-31 EP EP00948017A patent/EP1206495B1/de not_active Expired - Lifetime
- 2000-07-31 CN CNB008095159A patent/CN1184235C/zh not_active Expired - Fee Related
- 2000-07-31 CA CA002380569A patent/CA2380569C/en not_active Expired - Fee Related
- 2000-07-31 DK DK00948017T patent/DK1206495T3/da active
- 2000-07-31 JP JP2001513999A patent/JP4011914B2/ja not_active Expired - Lifetime
- 2000-07-31 AT AT00948017T patent/ATE353921T1/de active
- 2000-07-31 TR TR2002/00252T patent/TR200200252T2/xx unknown
- 2000-07-31 DE DE60033405T patent/DE60033405T2/de not_active Expired - Lifetime
2001
- 2001-11-27 ZA ZA200109746A patent/ZA200109746B/en unknown

Also Published As

Publication number	Publication date
ES2280231T3 (es)	2007-09-16
JP2003506028A (ja)	2003-02-18
DE60033405D1 (de)	2007-03-29
CN1358198A (zh)	2002-07-10
EP1074563A1 (de)	2001-02-07
US6437095B1 (en)	2002-08-20
AU768645B2 (en)	2003-12-18
TR200200252T2 (tr)	2002-05-21
CA2380569C (en)	2008-01-22
KR20020026558A (ko)	2002-04-10
EP1206495B1 (de)	2007-02-14
CA2380569A1 (en)	2001-02-08
AR021448A1 (es)	2002-07-17
DK1206495T3 (da)	2007-06-11
CN1184235C (zh)	2005-01-12
KR100484084B1 (ko)	2005-04-20
DE60033405T2 (de)	2007-10-31
AU6161000A (en)	2001-02-19
BR0012926A (pt)	2002-04-30
JP4011914B2 (ja)	2007-11-21
ZA200109746B (en)	2003-03-12
WO2001009193A1 (en)	2001-02-08
EP1206495A1 (de)	2002-05-22
MXPA02001139A (es)	2002-08-20

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2007-09-15

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