ATE353972T1 - VERFAHREN ZUM SCREENING NACH SUBSTANZEN, DIE SPEZIFISCH DEN ßNICHT-MEVALONATß-PFAD INHIBIEREN - Google Patents
VERFAHREN ZUM SCREENING NACH SUBSTANZEN, DIE SPEZIFISCH DEN ßNICHT-MEVALONATß-PFAD INHIBIERENInfo
- Publication number
- ATE353972T1 ATE353972T1 AT01908140T AT01908140T ATE353972T1 AT E353972 T1 ATE353972 T1 AT E353972T1 AT 01908140 T AT01908140 T AT 01908140T AT 01908140 T AT01908140 T AT 01908140T AT E353972 T1 ATE353972 T1 AT E353972T1
- Authority
- AT
- Austria
- Prior art keywords
- screening
- specifically inhibit
- pathway
- substances
- mevalonate pathway
- Prior art date
Links
- 230000037361 pathway Effects 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 3
- 238000012216 screening Methods 0.000 title abstract 3
- 239000000126 substance Substances 0.000 title abstract 2
- CBIDRCWHNCKSTO-UHFFFAOYSA-N prenyl diphosphate Chemical compound CC(C)=CCO[P@](O)(=O)OP(O)(O)=O CBIDRCWHNCKSTO-UHFFFAOYSA-N 0.000 abstract 8
- NUHSROFQTUXZQQ-UHFFFAOYSA-N isopentenyl diphosphate Chemical compound CC(=C)CCO[P@](O)(=O)OP(O)(O)=O NUHSROFQTUXZQQ-UHFFFAOYSA-N 0.000 abstract 6
- KJTLQQUUPVSXIM-ZCFIWIBFSA-M (R)-mevalonate Chemical compound OCC[C@](O)(C)CC([O-])=O KJTLQQUUPVSXIM-ZCFIWIBFSA-M 0.000 abstract 4
- KJTLQQUUPVSXIM-UHFFFAOYSA-N DL-mevalonic acid Natural products OCCC(O)(C)CC(O)=O KJTLQQUUPVSXIM-UHFFFAOYSA-N 0.000 abstract 4
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 239000003430 antimalarial agent Substances 0.000 abstract 1
- 230000006696 biosynthetic metabolic pathway Effects 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 238000006911 enzymatic reaction Methods 0.000 abstract 1
- 239000004009 herbicide Substances 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5097—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving plant cells
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N61/00—Biocides, pest repellants or attractants, or plant growth regulators containing substances of unknown or undetermined composition, e.g. substances characterised only by the mode of action
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
- C12Q1/025—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
- C12Q1/18—Testing for antimicrobial activity of a material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/25—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving enzymes not classifiable in groups C12Q1/26 - C12Q1/66
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
- C12Q1/485—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
- G01N2333/32—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Bacillus (G)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2407/00—Assays, e.g. immunoassays or enzyme assays, involving terpenes
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Toxicology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Dentistry (AREA)
- Food Science & Technology (AREA)
- Plant Pathology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Botany (AREA)
- Pest Control & Pesticides (AREA)
- Agronomy & Crop Science (AREA)
- Pathology (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2000056753 | 2000-03-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE353972T1 true ATE353972T1 (de) | 2007-03-15 |
Family
ID=18577645
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01908140T ATE353972T1 (de) | 2000-03-02 | 2001-02-28 | VERFAHREN ZUM SCREENING NACH SUBSTANZEN, DIE SPEZIFISCH DEN ßNICHT-MEVALONATß-PFAD INHIBIEREN |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20030170662A1 (de) |
| EP (1) | EP1260590B1 (de) |
| AT (1) | ATE353972T1 (de) |
| AU (1) | AU2001235995A1 (de) |
| DE (1) | DE60126587D1 (de) |
| WO (1) | WO2001064943A1 (de) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030033626A1 (en) * | 2000-07-31 | 2003-02-13 | Hahn Frederick M. | Manipulation of genes of the mevalonate and isoprenoid pathways to create novel traits in transgenic organisms |
| AU2002215352A1 (en) | 2000-10-13 | 2002-04-22 | University Of Utah Research Foundation | Systems for screening antibacterial and herbicidal compounds |
| EP2310490B1 (de) * | 2008-07-02 | 2019-01-02 | Danisco US Inc. | Verfahren zur herstellung von isopren |
| CN110268058B (zh) * | 2017-02-27 | 2023-11-21 | 积水化学工业株式会社 | 重组细胞、重组细胞的制备方法以及异戊二烯或萜烯的生产方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4693742A (en) * | 1983-12-20 | 1987-09-15 | Rohm And Hass Company | Herbicidal hydroxyamino phosphonic acids and derivatives |
| US6352757B1 (en) * | 1997-03-24 | 2002-03-05 | Boardman Molded Products, Inc. | Floor mat system for supporting heavy loads |
| US6410755B1 (en) * | 1998-07-06 | 2002-06-25 | Dcv, Inc. | Method of vitamin production |
| ATE490332T1 (de) * | 1998-07-06 | 2010-12-15 | Dcv Inc | Verfahren zur vitaminherstellung |
| US6531303B1 (en) * | 1998-07-06 | 2003-03-11 | Arkion Life Sciences Llc | Method of producing geranylgeraniol |
-
2001
- 2001-02-28 AT AT01908140T patent/ATE353972T1/de not_active IP Right Cessation
- 2001-02-28 DE DE60126587T patent/DE60126587D1/de not_active Expired - Fee Related
- 2001-02-28 EP EP01908140A patent/EP1260590B1/de not_active Expired - Lifetime
- 2001-02-28 AU AU2001235995A patent/AU2001235995A1/en not_active Abandoned
- 2001-02-28 WO PCT/JP2001/001501 patent/WO2001064943A1/ja not_active Ceased
- 2001-02-28 US US10/204,434 patent/US20030170662A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| DE60126587D1 (de) | 2007-03-29 |
| WO2001064943A1 (fr) | 2001-09-07 |
| EP1260590A1 (de) | 2002-11-27 |
| US20030170662A1 (en) | 2003-09-11 |
| EP1260590A4 (de) | 2005-02-16 |
| EP1260590B1 (de) | 2007-02-14 |
| AU2001235995A1 (en) | 2001-09-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MXPA04001350A (es) | COMPUESTOS DE FOSFITO NOVEDOSOS Y COMPLEJOS METaLICOS DE FOSFITO NOVEDOSOS. | |
| IL128666A0 (en) | Substituted cyclic amine metalloprotease inhibitors | |
| DE60232752D1 (de) | 1-(4-amino-cyclohexyl)-1,3-dihydro-2h-benzimidazole-2-on derivate und verwandte verbindungen als nociceptin analoge und orl1 liganden zur behandlung von schmerz | |
| ATE449168T1 (de) | Rekonstituierter histon-methyltransferase-komplex und verfahren zur identifizierung von modulatoren dafür | |
| EA200702443A1 (ru) | Замещенные гетероароилом серин-амиды | |
| ATE325871T1 (de) | Verfahren zur erkennung des produkts einer nukleinsäuresynthetisierungsreaktion | |
| EP1219716A3 (de) | Diacylglycerinacyltransferase-Assay | |
| DE60126587D1 (de) | Verfahren zum screening nach substanzen, die spezifisch den "nicht-mevalonat"-pfad inhibieren | |
| Hecht et al. | Studies on the non-mevalonate isoprenoid biosynthetic pathway. Simple methods for preparation of isotope-labeled (E)-1-hydroxy-2-methylbut-2-enyl 4-diphosphate | |
| GR3033624T3 (en) | A scintillation proximity assay for n-acetylgalactosaminyltransferase activity | |
| MXPA03002029A (es) | Metodo para intensificar el aclarado de la piel. | |
| ATE509269T1 (de) | Verfahren und verbindungen zur modulierung von apoptosis | |
| TR200003065T2 (tr) | Nöraminidazların inhibitörleri olarak pirolidinler. | |
| BR0304575A (pt) | Compostos [3,4-a:3,4-c]carbazol, processo para sua preparação e composições farmacêuticas contendo os mesmos | |
| AU2003211040A8 (en) | The eaat2 promoter and uses thereof | |
| Heliński et al. | Ring-opening of 3-benzyloxyazetidinium salts with organophosphorus nucleophiles Application to the synthesis of poly functional aminophosphonic acids analogues | |
| CY1110156T1 (el) | Υποκατεστημενες ενωσεις 4,5,6,7-τετραϋδρο-βενζοθειαζολ-2-υλαμινης | |
| DE502004009136D1 (de) | NEUE HETEROARYLSUBSTITUIERTE ACETONDERIVATE ALS HEMMSTOFFE DER PHOSPHOLIPASE A sb 2 /sb | |
| EP1330645A4 (de) | Sichtungssysteme und -verfahren zum identifizieren von modulatoren eines xenobiotischen metabolismus | |
| AU2003222426A1 (en) | Methods and compositions for modulating beta-catenin phosphorylation | |
| BRPI0601725A (pt) | compostos de fenilpiridilpiperazina, um processo para sua preparação e composições farmacêuticas contendo-os | |
| WO2003076621A3 (en) | Vpr modulators and uses thereof | |
| ATE245161T1 (de) | Verfahren zur synthese von phosphororganischen verbindungen | |
| WO2002062297A3 (en) | Methods and compositions for modulating gluconeogenesis using pgc-1 | |
| MXPA04003085A (es) | Proceso estereoespecifico para sintesis de derivados de 2-il cromano. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |