ATE490332T1 - Verfahren zur vitaminherstellung - Google Patents
Verfahren zur vitaminherstellungInfo
- Publication number
- ATE490332T1 ATE490332T1 AT08003596T AT08003596T ATE490332T1 AT E490332 T1 ATE490332 T1 AT E490332T1 AT 08003596 T AT08003596 T AT 08003596T AT 08003596 T AT08003596 T AT 08003596T AT E490332 T1 ATE490332 T1 AT E490332T1
- Authority
- AT
- Austria
- Prior art keywords
- geranylgeraniol
- microorganism
- farnesol
- producing vitamins
- producing
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- 229940088594 vitamin Drugs 0.000 title 1
- 229930003231 vitamin Natural products 0.000 title 1
- 235000013343 vitamin Nutrition 0.000 title 1
- 239000011782 vitamin Substances 0.000 title 1
- CRDAMVZIKSXKFV-FBXUGWQNSA-N (2-cis,6-cis)-farnesol Chemical compound CC(C)=CCC\C(C)=C/CC\C(C)=C/CO CRDAMVZIKSXKFV-FBXUGWQNSA-N 0.000 abstract 2
- 239000000260 (2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-ol Substances 0.000 abstract 2
- OJISWRZIEWCUBN-QIRCYJPOSA-N (E,E,E)-geranylgeraniol Chemical compound CC(C)=CCC\C(C)=C\CC\C(C)=C\CC\C(C)=C\CO OJISWRZIEWCUBN-QIRCYJPOSA-N 0.000 abstract 2
- 229940043259 farnesol Drugs 0.000 abstract 2
- 229930002886 farnesol Natural products 0.000 abstract 2
- XWRJRXQNOHXIOX-UHFFFAOYSA-N geranylgeraniol Natural products CC(C)=CCCC(C)=CCOCC=C(C)CCC=C(C)C XWRJRXQNOHXIOX-UHFFFAOYSA-N 0.000 abstract 2
- OJISWRZIEWCUBN-UHFFFAOYSA-N geranylnerol Natural products CC(C)=CCCC(C)=CCCC(C)=CCCC(C)=CCO OJISWRZIEWCUBN-UHFFFAOYSA-N 0.000 abstract 2
- 244000005700 microbiome Species 0.000 abstract 2
- CRDAMVZIKSXKFV-UHFFFAOYSA-N trans-Farnesol Natural products CC(C)=CCCC(C)=CCCC(C)=CCO CRDAMVZIKSXKFV-UHFFFAOYSA-N 0.000 abstract 2
- ALEWCKXBHSDCCT-YFVJMOTDSA-N (2E,6E)-farnesyl monophosphate Chemical compound CC(C)=CCC\C(C)=C\CC\C(C)=C\COP(O)(O)=O ALEWCKXBHSDCCT-YFVJMOTDSA-N 0.000 abstract 1
- 108010022535 Farnesyl-Diphosphate Farnesyltransferase Proteins 0.000 abstract 1
- 102100037997 Squalene synthase Human genes 0.000 abstract 1
- 238000012258 culturing Methods 0.000 abstract 1
- 238000000855 fermentation Methods 0.000 abstract 1
- 230000004151 fermentation Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- DPBMYHRTNHKGIT-XGVVNRHLSA-N triazanium;[oxido-[(2e,6e,10e)-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraenoxy]phosphoryl] phosphate Chemical compound [NH4+].[NH4+].[NH4+].CC(C)=CCC\C(C)=C\CC\C(C)=C\CC\C(C)=C\COP([O-])(=O)OP([O-])([O-])=O DPBMYHRTNHKGIT-XGVVNRHLSA-N 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
- C07C403/06—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by singly-bound oxygen atoms
- C07C403/08—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by singly-bound oxygen atoms by hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
- C07C403/24—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by six-membered non-aromatic rings, e.g. beta-carotene
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
- C07D311/72—3,4-Dihydro derivatives having in position 2 at least one methyl radical and in position 6 one oxygen atom, e.g. tocopherols
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1085—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P23/00—Preparation of compounds containing a cyclohexene ring having an unsaturated side chain containing at least ten carbon atoms bound by conjugated double bonds, e.g. carotenes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P9/00—Preparation of organic compounds containing a metal or atom other than H, N, C, O, S or halogen
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01Q—ANTENNAS, i.e. RADIO AERIALS
- H01Q1/00—Details of, or arrangements associated with, antennas
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrane Compounds (AREA)
- Epoxy Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9196498P | 1998-07-06 | 1998-07-06 | |
| US9198398P | 1998-07-06 | 1998-07-06 | |
| US9195198P | 1998-07-06 | 1998-07-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE490332T1 true ATE490332T1 (de) | 2010-12-15 |
Family
ID=27377004
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT09004155T ATE537265T1 (de) | 1998-07-06 | 1999-07-06 | Verfahren zur vitaminherstellung |
| AT08003596T ATE490332T1 (de) | 1998-07-06 | 1999-07-06 | Verfahren zur vitaminherstellung |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT09004155T ATE537265T1 (de) | 1998-07-06 | 1999-07-06 | Verfahren zur vitaminherstellung |
Country Status (11)
| Country | Link |
|---|---|
| EP (3) | EP1095002A4 (de) |
| JP (1) | JP4579415B2 (de) |
| CN (1) | CN1330621A (de) |
| AT (2) | ATE537265T1 (de) |
| AU (1) | AU4863099A (de) |
| CA (2) | CA2831321C (de) |
| DE (1) | DE69943009D1 (de) |
| DK (3) | DK2305825T3 (de) |
| ES (2) | ES2534937T3 (de) |
| MX (2) | MX276941B (de) |
| WO (1) | WO2000001650A1 (de) |
Families Citing this family (64)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6531303B1 (en) | 1998-07-06 | 2003-03-11 | Arkion Life Sciences Llc | Method of producing geranylgeraniol |
| JP2003527077A (ja) * | 1999-04-15 | 2003-09-16 | カルジーン エルエルシー | トコフェロール合成に関与するタンパク質の核酸配列 |
| DE60126587D1 (de) * | 2000-03-02 | 2007-03-29 | Toudai Tlo Ltd | Verfahren zum screening nach substanzen, die spezifisch den "nicht-mevalonat"-pfad inhibieren |
| US6872815B1 (en) | 2000-10-14 | 2005-03-29 | Calgene Llc | Nucleic acid sequences to proteins involved in tocopherol synthesis |
| AU2001278098A1 (en) | 2000-07-31 | 2002-02-13 | Frederick M. Hahn | Manipulation of genes of the mevalonate and isoprenoid pathways to create novel traits in transgenic organisms |
| AR030124A1 (es) | 2000-08-07 | 2003-08-13 | Monsanto Technology Llc | Genes de la via del fosfato de metil-d-eritritol |
| JP3838033B2 (ja) * | 2000-12-28 | 2006-10-25 | トヨタ自動車株式会社 | プレニルアルコールの製造方法 |
| JP4013535B2 (ja) * | 2000-12-28 | 2007-11-28 | トヨタ自動車株式会社 | 微生物によるプレニルアルコールの高生産方法 |
| EP1354955A4 (de) * | 2000-12-28 | 2005-01-05 | Toyota Motor Co Ltd | Verfahren zur herstellung von prenylalkohol |
| JP2002253284A (ja) * | 2000-12-28 | 2002-09-10 | Toyota Motor Corp | 微生物によるゲラニルゲラニオール及びその類縁化合物の製造方法 |
| JP2003088368A (ja) * | 2001-09-18 | 2003-03-25 | Toyota Motor Corp | プレニルアルコールの製造方法 |
| WO2002053747A1 (fr) | 2000-12-28 | 2002-07-11 | Toyota Jidosha Kabushiki Kaisha | Procede de production d'alcool de prenyl |
| US7161061B2 (en) | 2001-05-09 | 2007-01-09 | Monsanto Technology Llc | Metabolite transporters |
| DE60230608D1 (de) | 2001-05-09 | 2009-02-12 | Monsanto Technology Llc | Tyra-gene und ihre verwendung |
| DE60228439D1 (de) * | 2001-06-06 | 2008-10-02 | Dsm Ip Assets Bv | Verbesserte isoprenoid herstellung |
| WO2003016482A2 (en) | 2001-08-17 | 2003-02-27 | Monsanto Technology Llc | Methyltransferase genes and uses thereof |
| WO2003034812A2 (en) | 2001-10-25 | 2003-05-01 | Monsanto Technology Llc | Aromatic methyltransferases and uses thereof |
| US7172886B2 (en) | 2001-12-06 | 2007-02-06 | The Regents Of The University Of California | Biosynthesis of isopentenyl pyrophosphate |
| US7192751B2 (en) | 2001-12-06 | 2007-03-20 | The Regents Of The University Of California | Biosynthesis of amorpha-4,11-diene |
| US7112717B2 (en) | 2002-03-19 | 2006-09-26 | Monsanto Technology Llc | Homogentisate prenyl transferase gene (HPT2) from arabidopsis and uses thereof |
| CA2487144C (en) | 2002-06-21 | 2012-06-12 | Dsm Ip Assets B.V. | Increased carotenoid production by inhibition of squalene biosynthesis |
| EP1546334A4 (de) | 2002-08-05 | 2007-01-03 | Monsanto Technology Llc | Gene in verbindung mit tocopherol-biosynthese und verwendungen davon |
| CA2498800C (en) | 2002-09-27 | 2012-01-03 | Dsm Ip Assets B.V. | Sqs gene |
| CN101023181A (zh) | 2004-05-21 | 2007-08-22 | 加利福尼亚大学董事会 | 提高类异戊二烯化合物的产生的方法 |
| BRPI0513837B1 (pt) | 2004-07-27 | 2021-10-13 | The Regents Of The University Of California | Célula hospedeira saccharomyces cerevisiae geneticamente modificada; composição compreendendo a mesma e método para aumentar a produção de isoprenoides |
| CN103589650A (zh) | 2005-03-18 | 2014-02-19 | 米克罗比亚公司 | 产油酵母和真菌中类胡萝卜素的产生 |
| JP4824985B2 (ja) * | 2005-10-13 | 2011-11-30 | 株式会社Ａｄｅｋａ | ファルネシル二リン酸の製造方法 |
| WO2008042338A2 (en) | 2006-09-28 | 2008-04-10 | Microbia, Inc. | Production of carotenoids in oleaginous yeast and fungi |
| US20090004715A1 (en) | 2007-06-01 | 2009-01-01 | Solazyme, Inc. | Glycerol Feedstock Utilization for Oil-Based Fuel Manufacturing |
| JP2010539902A (ja) | 2007-09-20 | 2010-12-24 | アミリス バイオテクノロジーズ，インコーポレイティド | イソプレノイドの生産 |
| JP5174430B2 (ja) * | 2007-11-06 | 2013-04-03 | 花王株式会社 | ２−フェニルエチルアルコールの製造方法 |
| CA2737195A1 (en) * | 2008-09-15 | 2010-03-18 | The Goodyear Tire & Rubber Company | Conversion of prenyl derivatives to isoprene |
| AU2009319722B2 (en) * | 2008-11-28 | 2016-08-04 | Corbion Biotech, Inc. | Production of tailored oils in heterotrophic microorganisms |
| US8592188B2 (en) | 2010-05-28 | 2013-11-26 | Solazyme, Inc. | Tailored oils produced from recombinant heterotrophic microorganisms |
| CN105671108A (zh) | 2010-06-02 | 2016-06-15 | 沃维公司 | 甜菊糖苷的重组生产 |
| EP2635663B1 (de) | 2010-11-03 | 2019-05-08 | Corbion Biotech, Inc. | Mikrobielle öle mit redzuzierten giesspunkten, dielektrische flüssigkeiten daraus und zugehörige verfahren |
| KR101964965B1 (ko) | 2011-02-02 | 2019-04-03 | 테라비아 홀딩스 인코포레이티드 | 재조합 유지성 미생물로부터 생산된 맞춤 오일 |
| MX339607B (es) | 2011-05-06 | 2016-05-31 | Solazyme Inc | Microorganismos geneticamente modificados que metabolizan xilosa. |
| JP5989098B2 (ja) * | 2011-05-09 | 2016-09-07 | アミリス， インコーポレイテッド | アセチル−補酵素ａ誘導化合物の産生 |
| CN108396044A (zh) | 2011-08-08 | 2018-08-14 | 埃沃尔瓦公司 | 甜菊醇糖苷类的重组生产 |
| US8945908B2 (en) | 2012-04-18 | 2015-02-03 | Solazyme, Inc. | Tailored oils |
| SG11201505597SA (en) | 2013-02-06 | 2015-08-28 | Evolva Sa | Methods for improved production of rebaudioside d and rebaudioside m |
| CA2900882A1 (en) | 2013-02-11 | 2014-08-14 | Evolva Sa | Efficient production of steviol glycosides in recombinants hosts |
| EP2993993A2 (de) | 2013-04-26 | 2016-03-16 | Solazyme, Inc. | Öle mit niedrigem gehalt an mehrfach ungesättigten fettsäuren und verwendungen davon |
| MX369685B (es) | 2013-10-04 | 2019-11-19 | Terravia Holdings Inc | Aceites adaptables. |
| US9969990B2 (en) | 2014-07-10 | 2018-05-15 | Corbion Biotech, Inc. | Ketoacyl ACP synthase genes and uses thereof |
| AU2015303294A1 (en) | 2014-08-11 | 2017-02-02 | Evolva Sa. | Production of steviol glycosides in recombinant hosts |
| AU2015314251A1 (en) | 2014-09-09 | 2017-03-16 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| SG11201705606PA (en) | 2015-01-30 | 2017-08-30 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| CA2979931A1 (en) | 2015-03-16 | 2016-09-22 | Dsm Ip Assets B.V. | Udp-glycosyltransferases |
| AU2016307066A1 (en) | 2015-08-07 | 2018-02-08 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| CN105153102A (zh) * | 2015-09-30 | 2015-12-16 | 宜春大海龟生命科学有限公司 | 以混合生育酚为原料制备α-生育酚的方法 |
| US10982249B2 (en) | 2016-04-13 | 2021-04-20 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| WO2017198682A1 (en) | 2016-05-16 | 2017-11-23 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| US11396669B2 (en) | 2016-11-07 | 2022-07-26 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| CA3084263A1 (en) | 2017-12-07 | 2019-06-13 | Zymergen Inc. | Engineered biosynthetic pathways for production of (6e)-8-hydroxygeraniol by fermentation |
| BR112020012704A8 (pt) | 2017-12-21 | 2022-03-03 | Zymergen Inc | Nepetalactol oxidorredutases, nepetalactol sintases, e micróbios capazes de produzir nepetalactona |
| CN109609579B (zh) * | 2018-12-31 | 2022-04-05 | 陕西师范大学 | 一种产β-胡萝卜素的基因工程菌及其构建方法 |
| CN109884216A (zh) * | 2019-04-10 | 2019-06-14 | 西南医科大学 | 一种高效液相色谱测定载药胶束中法尼醛含量的方法 |
| CN110950791B (zh) * | 2019-12-09 | 2021-12-14 | 万华化学集团股份有限公司 | 一种维生素a及维生素a酯制备方法 |
| CN110903190B (zh) * | 2019-12-09 | 2022-07-12 | 万华化学集团股份有限公司 | 一种维生素a及维生素a酯的制备方法 |
| JP2023506144A (ja) * | 2019-12-23 | 2023-02-15 | ディーエスエム アイピー アセッツ ビー．ブイ． | 脱水素化方法 |
| CN113621631A (zh) * | 2021-08-11 | 2021-11-09 | 昆明理工大学 | 一种甲羟戊酸激酶基因rkmk及其应用 |
| CN113969288B (zh) * | 2021-10-29 | 2024-09-17 | 湖北冠众通科技有限公司 | 一种产法尼醇基因工程菌及其构建方法与应用 |
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| US4225734A (en) | 1978-08-08 | 1980-09-30 | The Regents Of The University Of California | Process for producing symmetrical olefins |
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| US5460949A (en) * | 1990-11-15 | 1995-10-24 | Amoco Corporation | Method and composition for increasing the accumulation of squalene and specific sterols in yeast |
| US5475029A (en) | 1993-07-08 | 1995-12-12 | The Board Of Trustees Of The Leland Stanford Junior University | Farnesyl compounds as cholesterol lowering agents |
| JP3657298B2 (ja) | 1994-11-08 | 2005-06-08 | 株式会社クラレ | ゲラニルゲラニオ−ルの製造方法 |
| US5556990A (en) | 1994-12-16 | 1996-09-17 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Polyarylcarbamoylaza- and -carbamoylalkanedioic acids |
| JP3120684B2 (ja) | 1995-02-14 | 2000-12-25 | トヨタ自動車株式会社 | ゲラニルゲラニル二リン酸を合成する変異型ファルネシル二リン酸合成酵素及びそれをコードするｄｎａ |
| JP3151371B2 (ja) * | 1995-03-10 | 2001-04-03 | 麒麟麦酒株式会社 | カロチノイド生産量の増量に有用なｄｎａ鎖 |
| MX9606257A (es) | 1995-12-07 | 1998-04-30 | Univ Yale | Proteinas de sintasa de difosfato de geranilgeranilo, moleculas de acido nucleico, y usos de las mismas. |
| DE69633343T2 (de) * | 1995-12-22 | 2005-09-22 | Dsm Ip Assets B.V. | Verbesserte verfahren zur transformation von phaffiastämmen,transformierte phaffiastämme auf diese weise erhaltend, und rekominante dns in besagtem verfahren verwendbar |
| US5744341A (en) * | 1996-03-29 | 1998-04-28 | University Of Maryland College Park | Genes of carotenoid biosynthesis and metabolism and a system for screening for such genes |
| EP0955363A3 (de) * | 1998-05-06 | 2004-01-28 | F. Hoffmann-La Roche Ag | DNS Sequenzen kodierend für Enzyme für die Herstellung von Isoprenoiden |
-
1999
- 1999-07-06 JP JP2000558056A patent/JP4579415B2/ja not_active Expired - Lifetime
- 1999-07-06 CN CN99810559A patent/CN1330621A/zh active Pending
- 1999-07-06 AT AT09004155T patent/ATE537265T1/de active
- 1999-07-06 EP EP99932295A patent/EP1095002A4/de not_active Withdrawn
- 1999-07-06 CA CA2831321A patent/CA2831321C/en not_active Expired - Lifetime
- 1999-07-06 ES ES10180179.3T patent/ES2534937T3/es not_active Expired - Lifetime
- 1999-07-06 AT AT08003596T patent/ATE490332T1/de not_active IP Right Cessation
- 1999-07-06 EP EP08003596A patent/EP1947189B1/de not_active Expired - Lifetime
- 1999-07-06 DK DK10180179T patent/DK2305825T3/en active
- 1999-07-06 MX MXPA04002408 patent/MX276941B/es unknown
- 1999-07-06 DE DE69943009T patent/DE69943009D1/de not_active Expired - Lifetime
- 1999-07-06 MX MXPA01000216 patent/MX219130B/es unknown
- 1999-07-06 CA CA2331343A patent/CA2331343C/en not_active Expired - Lifetime
- 1999-07-06 DK DK08003596.7T patent/DK1947189T3/da active
- 1999-07-06 WO PCT/US1999/015264 patent/WO2000001650A1/en not_active Ceased
- 1999-07-06 EP EP09004155A patent/EP2100963B1/de not_active Expired - Lifetime
- 1999-07-06 ES ES09004155T patent/ES2379212T3/es not_active Expired - Lifetime
- 1999-07-06 AU AU48630/99A patent/AU4863099A/en not_active Abandoned
- 1999-07-06 DK DK09004155.9T patent/DK2100963T3/da active
Also Published As
| Publication number | Publication date |
|---|---|
| EP2100963B1 (de) | 2011-12-14 |
| EP1095002A1 (de) | 2001-05-02 |
| MX219130B (es) | 2004-02-10 |
| CA2831321A1 (en) | 2000-01-13 |
| EP1095002A4 (de) | 2005-08-03 |
| ES2379212T3 (es) | 2012-04-23 |
| DK2305825T3 (en) | 2015-03-02 |
| JP4579415B2 (ja) | 2010-11-10 |
| DE69943009D1 (de) | 2011-01-13 |
| EP1947189B1 (de) | 2010-12-01 |
| CA2331343A1 (en) | 2000-01-13 |
| MX276941B (es) | 2010-06-28 |
| ATE537265T1 (de) | 2011-12-15 |
| CA2831321C (en) | 2018-05-15 |
| AU4863099A (en) | 2000-01-24 |
| DK2100963T3 (da) | 2012-04-02 |
| JP2002519049A (ja) | 2002-07-02 |
| DK1947189T3 (da) | 2011-03-14 |
| EP1947189A3 (de) | 2008-10-08 |
| ES2534937T3 (es) | 2015-04-30 |
| CN1330621A (zh) | 2002-01-09 |
| MXPA01000216A (es) | 2002-10-17 |
| CA2331343C (en) | 2014-01-14 |
| WO2000001650A1 (en) | 2000-01-13 |
| EP2100963A1 (de) | 2009-09-16 |
| EP1947189A2 (de) | 2008-07-23 |
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| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |