ATE354592T1 - Vegf-antagonisten zur behandlung von diabetes - Google Patents
Vegf-antagonisten zur behandlung von diabetesInfo
- Publication number
- ATE354592T1 ATE354592T1 AT04758372T AT04758372T ATE354592T1 AT E354592 T1 ATE354592 T1 AT E354592T1 AT 04758372 T AT04758372 T AT 04758372T AT 04758372 T AT04758372 T AT 04758372T AT E354592 T1 ATE354592 T1 AT E354592T1
- Authority
- AT
- Austria
- Prior art keywords
- vegf
- treating diabetes
- vegf antagonists
- blocking
- mediated activity
- Prior art date
Links
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 title abstract 6
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 title abstract 6
- 239000005557 antagonist Substances 0.000 title abstract 2
- 206010012601 diabetes mellitus Diseases 0.000 title abstract 2
- 230000000903 blocking effect Effects 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 230000001404 mediated effect Effects 0.000 abstract 2
- 241000124008 Mammalia Species 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Cell Biology (AREA)
- Immunology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Emergency Medicine (AREA)
- Reproductive Health (AREA)
- Child & Adolescent Psychology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US45879003P | 2003-03-28 | 2003-03-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE354592T1 true ATE354592T1 (de) | 2007-03-15 |
Family
ID=33131825
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04758372T ATE354592T1 (de) | 2003-03-28 | 2004-03-26 | Vegf-antagonisten zur behandlung von diabetes |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US7052691B2 (de) |
| EP (1) | EP1608685B1 (de) |
| JP (2) | JP4730909B2 (de) |
| AT (1) | ATE354592T1 (de) |
| AU (1) | AU2004226417B2 (de) |
| BR (1) | BRPI0408749B1 (de) |
| CA (1) | CA2519787C (de) |
| CY (1) | CY1106530T1 (de) |
| DE (1) | DE602004004883T2 (de) |
| DK (1) | DK1608685T3 (de) |
| ES (1) | ES2278333T3 (de) |
| MX (1) | MXPA05008972A (de) |
| PL (1) | PL1608685T3 (de) |
| PT (1) | PT1608685E (de) |
| SI (1) | SI1608685T1 (de) |
| WO (1) | WO2004087206A2 (de) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1997386B (zh) * | 2004-07-30 | 2012-05-30 | 瑞泽恩制药公司 | 通过阻断vegf介导的活性来治疗i型糖尿病的方法 |
| CA3142945A1 (en) | 2005-03-25 | 2006-10-05 | Regeneron Pharmaceuticals, Inc. | Histidine-buffered formulations of vegf antagonist |
| CA2654510C (en) | 2006-06-16 | 2015-03-17 | Regeneron Pharmaceuticals, Inc. | Vegf antagonist formulations suitable for intravitreal administration |
| ES2345596B1 (es) * | 2009-03-26 | 2011-07-13 | Fundacion Progreso Y Salud | Composicion para la prevencion o el tratamiento de la diabetes mellitus. |
| US20100330098A1 (en) * | 2009-06-29 | 2010-12-30 | Kuo Calvin J | Methods to regulate glucose metabolism |
| KR20180023015A (ko) | 2011-01-13 | 2018-03-06 | 리제너론 파아마슈티컬스, 인크. | 혈관신생 눈 장애를 치료하기 위한 vegf 길항제의 용도 |
| JO3283B1 (ar) | 2011-04-26 | 2018-09-16 | Sanofi Sa | تركيب يتضمن أفليبيرسيبت, حمض فولينيك, 5- فلورويوراسيل (5- Fu) وإرينوسيتان (FOLFIRI) |
| JP6071099B1 (ja) | 2014-01-25 | 2017-02-01 | ツェンドゥー カンホン バイオテクノロジーズ カンパニー リミテッド | 血管の新生又は成長を抑制する融合タンパク質及びその用途 |
| WO2015200905A2 (en) | 2014-06-28 | 2015-12-30 | Oligasis, Llc | Dual pdgf/vegf antagonists |
| RS58957B1 (sr) | 2014-07-18 | 2019-08-30 | Sanofi Sa | Postupak za predviđanje ishoda tretmana sa afliberceptom kod pacijenta za kog se sumnja da boluje od raka |
| IL290457B2 (en) | 2015-12-30 | 2025-02-01 | Kodiak Sciences Inc | Antibodies and their conjugates |
| ITUB20169928A1 (it) * | 2016-01-12 | 2017-07-12 | Medical And Biotechnological Services In Sigla M B S Srl | Formulazioni farmaceutiche per il trattamento del diabete |
| KR20200093621A (ko) | 2017-11-30 | 2020-08-05 | 리제너론 파아마슈티컬스, 인크. | 혈관형성 눈 장애를 치료하기 위한 vegf 길항제의 용도 |
| CA3092588A1 (en) | 2018-03-02 | 2019-09-06 | Kodiak Sciences Inc. | Il-6 antibodies and fusion constructs and conjugates thereof |
| CA3157509A1 (en) | 2019-10-10 | 2021-04-15 | Kodiak Sciences Inc. | Methods of treating an eye disorder |
| MX2022013812A (es) | 2020-05-08 | 2022-12-15 | Regeneron Pharma | Trampas y mini-trampas de vegf y metodos para el tratamiento de trastornos oculares y cancer. |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9410533D0 (en) * | 1994-05-26 | 1994-07-13 | Lynxvale Ltd | In situ hybridisation and immuno-Chemical localisation of a growth factor |
| EP1179541B1 (de) * | 1999-04-28 | 2004-06-16 | Board Of Regents, The University Of Texas System | Zusammensetzungen und Verfahren zur Krebsbehandlung durch die selektive Hemmung von VEGF |
| CN101433715B (zh) * | 1999-06-08 | 2013-04-17 | 里珍纳龙药品有限公司 | 具有改善的药物动力学特性的修饰嵌合多肽 |
| US6833349B2 (en) * | 1999-06-08 | 2004-12-21 | Regeneron Pharmaceuticals, Inc. | Methods of treating inflammatory skin diseases |
-
2004
- 2004-03-26 JP JP2006509325A patent/JP4730909B2/ja not_active Expired - Fee Related
- 2004-03-26 AU AU2004226417A patent/AU2004226417B2/en not_active Ceased
- 2004-03-26 SI SI200430312T patent/SI1608685T1/sl unknown
- 2004-03-26 BR BRPI0408749A patent/BRPI0408749B1/pt not_active IP Right Cessation
- 2004-03-26 EP EP04758372A patent/EP1608685B1/de not_active Expired - Lifetime
- 2004-03-26 MX MXPA05008972A patent/MXPA05008972A/es active IP Right Grant
- 2004-03-26 US US10/811,170 patent/US7052691B2/en not_active Expired - Lifetime
- 2004-03-26 ES ES04758372T patent/ES2278333T3/es not_active Expired - Lifetime
- 2004-03-26 DK DK04758372T patent/DK1608685T3/da active
- 2004-03-26 PT PT04758372T patent/PT1608685E/pt unknown
- 2004-03-26 PL PL04758372T patent/PL1608685T3/pl unknown
- 2004-03-26 CA CA2519787A patent/CA2519787C/en not_active Expired - Fee Related
- 2004-03-26 AT AT04758372T patent/ATE354592T1/de active
- 2004-03-26 WO PCT/US2004/009246 patent/WO2004087206A2/en not_active Ceased
- 2004-03-26 DE DE602004004883T patent/DE602004004883T2/de not_active Expired - Lifetime
-
2007
- 2007-04-19 CY CY20071100538T patent/CY1106530T1/el unknown
-
2010
- 2010-10-20 JP JP2010235790A patent/JP2011037894A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CA2519787A1 (en) | 2004-10-14 |
| EP1608685A2 (de) | 2005-12-28 |
| HK1080092A1 (en) | 2006-04-21 |
| BRPI0408749B1 (pt) | 2016-10-04 |
| MXPA05008972A (es) | 2005-11-04 |
| AU2004226417A1 (en) | 2004-10-14 |
| PT1608685E (pt) | 2007-05-31 |
| WO2004087206A3 (en) | 2004-12-16 |
| JP2006521397A (ja) | 2006-09-21 |
| JP2011037894A (ja) | 2011-02-24 |
| EP1608685B1 (de) | 2007-02-21 |
| US20040213787A1 (en) | 2004-10-28 |
| PL1608685T3 (pl) | 2007-07-31 |
| BRPI0408749A (pt) | 2006-03-28 |
| DK1608685T3 (da) | 2007-06-11 |
| US7052691B2 (en) | 2006-05-30 |
| JP4730909B2 (ja) | 2011-07-20 |
| AU2004226417B2 (en) | 2009-01-22 |
| WO2004087206A2 (en) | 2004-10-14 |
| SI1608685T1 (sl) | 2007-08-31 |
| ES2278333T3 (es) | 2007-08-01 |
| DE602004004883D1 (de) | 2007-04-05 |
| DE602004004883T2 (de) | 2007-11-15 |
| CA2519787C (en) | 2012-06-05 |
| CY1106530T1 (el) | 2012-01-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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