ATE356115T1 - Verfahren zur herstellung von 1-benzyl-4- (5,6- dimethoxy-1-indanon)-2-ylö methylpiperidin hydrochlorid (donepezil hcl) - Google Patents
Verfahren zur herstellung von 1-benzyl-4- (5,6- dimethoxy-1-indanon)-2-ylö methylpiperidin hydrochlorid (donepezil hcl)Info
- Publication number
- ATE356115T1 ATE356115T1 AT04016772T AT04016772T ATE356115T1 AT E356115 T1 ATE356115 T1 AT E356115T1 AT 04016772 T AT04016772 T AT 04016772T AT 04016772 T AT04016772 T AT 04016772T AT E356115 T1 ATE356115 T1 AT E356115T1
- Authority
- AT
- Austria
- Prior art keywords
- dimethoxy
- benzyl
- ylo
- indanone
- producing
- Prior art date
Links
- ADEBPBSSDYVVLD-UHFFFAOYSA-N donepezil Chemical compound O=C1C=2C=C(OC)C(OC)=CC=2CC1CC(CC1)CCN1CC1=CC=CC=C1 ADEBPBSSDYVVLD-UHFFFAOYSA-N 0.000 title abstract 3
- 229960003530 donepezil Drugs 0.000 title abstract 2
- QDUXDCXILAPLAG-UHFFFAOYSA-N hydron;1-methylpiperidine;chloride Chemical compound Cl.CN1CCCCC1 QDUXDCXILAPLAG-UHFFFAOYSA-N 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- PAMIQIKDUOTOBW-UHFFFAOYSA-N 1-methylpiperidine Chemical compound CN1CCCCC1 PAMIQIKDUOTOBW-UHFFFAOYSA-N 0.000 abstract 1
- ROLMZTIHUMKEAI-UHFFFAOYSA-N 4,5-difluoro-2-hydroxybenzonitrile Chemical compound OC1=CC(F)=C(F)C=C1C#N ROLMZTIHUMKEAI-UHFFFAOYSA-N 0.000 abstract 1
- VNQHPBBIPXOBPJ-UHFFFAOYSA-N 5,6-dimethoxy-3-methylidene-2-pyridin-4-ylinden-1-one Chemical compound O=C1C=2C=C(OC)C(OC)=CC=2C(=C)C1C1=CC=NC=C1 VNQHPBBIPXOBPJ-UHFFFAOYSA-N 0.000 abstract 1
- 229940100198 alkylating agent Drugs 0.000 abstract 1
- 239000002168 alkylating agent Substances 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 229910000510 noble metal Inorganic materials 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- NQRYJNQNLNOLGT-UHFFFAOYSA-N tetrahydropyridine hydrochloride Natural products C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
- C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/714,724 US6953856B2 (en) | 2003-02-12 | 2003-11-17 | Process for the preparation of 1-benzyl-4-(5,6-dimethoxy-1-indanon)-2-yl) methyl piperidine hydrochloride (Donepezil HCI) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE356115T1 true ATE356115T1 (de) | 2007-03-15 |
Family
ID=34435702
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04016772T ATE356115T1 (de) | 2003-11-17 | 2004-07-15 | Verfahren zur herstellung von 1-benzyl-4- (5,6- dimethoxy-1-indanon)-2-ylö methylpiperidin hydrochlorid (donepezil hcl) |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6953856B2 (de) |
| EP (1) | EP1531151B1 (de) |
| AT (1) | ATE356115T1 (de) |
| DE (1) | DE602004005129T2 (de) |
| DK (1) | DK1531151T3 (de) |
| ES (1) | ES2282766T3 (de) |
| PL (1) | PL1531151T3 (de) |
| PT (1) | PT1531151E (de) |
| SI (1) | SI1531151T1 (de) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2005288521A1 (en) * | 2004-09-29 | 2006-04-06 | Chemagis Ltd. | Use of purified donepezil maleate for preparing pharmaceutically pure amorphous donepezil hydrochloride |
| CA2591894C (en) * | 2004-12-30 | 2013-08-20 | Jubilant Organosys Limited | Process for producing 1-benzyl-4-[(5,6-dimethoxy-1-indanon2-yl)methyl] piperidine or its salt thereof via novel intermediate |
| AU2006300492B2 (en) * | 2005-10-14 | 2011-08-25 | Eisai R & D Management Co., Ltd. | Process for producing 1-benzyl-4-[(5,6-dimethoxy-1indanon)-2-yl]methylpiperidine or hydrochloride thereof |
| NZ569532A (en) | 2006-01-04 | 2010-11-26 | Cipla Ltd | Process and intermediate for preparation of donepezil |
| WO2007108011A2 (en) * | 2006-03-20 | 2007-09-27 | Ind-Swift Laboratories Limited | Process for the preparation of highly pure donepezil |
| RU2478619C2 (ru) * | 2006-12-11 | 2013-04-10 | Ривайва Фармасьютикалс, Инк. | Композиции, синтез и способы применения ингибиторов холинэстеразы на основе инданона |
| KR20110011606A (ko) * | 2008-03-25 | 2011-02-08 | 시플라 리미티드 | 도네페질 염산염의 제조방법 |
| WO2011151359A1 (en) | 2010-06-02 | 2011-12-08 | Noscira, S.A. | Combined treatment with a cholinesterase inhibitor and a thiadiazolidinedione derivative |
| CN102367236A (zh) * | 2011-11-30 | 2012-03-07 | 陕西方舟制药有限公司 | 一种盐酸多奈哌齐的合成工艺 |
| CN105367483B (zh) * | 2015-11-20 | 2017-12-26 | 山东淄博新达制药有限公司 | 盐酸多奈哌齐的制备方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI95572C (fi) * | 1987-06-22 | 1996-02-26 | Eisai Co Ltd | Menetelmä lääkeaineena käyttökelpoisen piperidiinijohdannaisten tai sen farmaseuttisen suolan valmistamiseksi |
| DE4439822A1 (de) * | 1994-11-08 | 1996-08-29 | Bayer Ag | Verfahren zur Herstellung von Benzyl-piperidylmethyl-indanonen |
| PL197306B1 (pl) | 1995-12-15 | 2008-03-31 | Pfizer | Nowe pochodne 4-[2-(3,4-dimetoksybenzoilo)allilo]piperydyny |
| EP1047674B1 (de) * | 1998-01-16 | 2005-03-30 | Eisai Co., Ltd. | Verfahren zur herstellung von donepezilderivaten |
| US6649765B1 (en) * | 2003-02-12 | 2003-11-18 | Usv Limited, Bsd Marg. | Process for the preparation of 1-benzyl-4(5,6-dimethoxy-1-indanon)-2-yl) methyl piperidine hydrochloride (Donepezil HCL) |
-
2003
- 2003-11-17 US US10/714,724 patent/US6953856B2/en not_active Expired - Fee Related
-
2004
- 2004-07-15 EP EP04016772A patent/EP1531151B1/de not_active Expired - Lifetime
- 2004-07-15 DK DK04016772T patent/DK1531151T3/da active
- 2004-07-15 PL PL04016772T patent/PL1531151T3/pl unknown
- 2004-07-15 DE DE602004005129T patent/DE602004005129T2/de not_active Expired - Fee Related
- 2004-07-15 ES ES04016772T patent/ES2282766T3/es not_active Expired - Lifetime
- 2004-07-15 AT AT04016772T patent/ATE356115T1/de not_active IP Right Cessation
- 2004-07-15 SI SI200430244T patent/SI1531151T1/sl unknown
- 2004-07-15 PT PT04016772T patent/PT1531151E/pt unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2282766T3 (es) | 2007-10-16 |
| US20040158070A1 (en) | 2004-08-12 |
| EP1531151B1 (de) | 2007-03-07 |
| EP1531151A1 (de) | 2005-05-18 |
| SI1531151T1 (sl) | 2007-06-30 |
| PT1531151E (pt) | 2007-05-31 |
| DE602004005129D1 (de) | 2007-04-19 |
| DE602004005129T2 (de) | 2007-12-06 |
| US6953856B2 (en) | 2005-10-11 |
| DK1531151T3 (da) | 2007-04-02 |
| PL1531151T3 (pl) | 2007-05-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1531151 Country of ref document: EP |
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| REN | Ceased due to non-payment of the annual fee |