ATE356129T1 - Triazacyclopenta(cd)indenderivate - Google Patents

Triazacyclopenta(cd)indenderivate

Info

Publication number: ATE356129T1
Authority: AT; Austria
Prior art keywords: diseases; crf; involved; disease; considered
Prior art date: 2004-01-06

Application number

AT05703562T

Other languages

English (en)

Inventor

Atsuro Nakazato

Taketoshi Okubo

Dai Nozawa

Tomoko Tamita

Ludo E J Kennis

Original Assignee

Taisho Pharmaceutical Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-01-06

Filing date

2005-01-06

Publication date

2007-03-15

2005-01-06 Application filed by Taisho Pharmaceutical Co Ltd filed Critical Taisho Pharmaceutical Co Ltd

2007-03-15 Application granted granted Critical

2007-03-15 Publication of ATE356129T1 publication Critical patent/ATE356129T1/de

Links

201000010099 disease Diseases 0.000 abstract 4
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 4
108010056643 Corticotropin-Releasing Hormone Receptors Proteins 0.000 abstract 2
206010008118 cerebral infarction Diseases 0.000 abstract 2
208000024827 Alzheimer disease Diseases 0.000 abstract 1
208000019901 Anxiety disease Diseases 0.000 abstract 1
201000006474 Brain Ischemia Diseases 0.000 abstract 1
206010048962 Brain oedema Diseases 0.000 abstract 1
206010008120 Cerebral ischaemia Diseases 0.000 abstract 1
201000004624 Dermatitis Diseases 0.000 abstract 1
208000030814 Eating disease Diseases 0.000 abstract 1
208000019454 Feeding and Eating disease Diseases 0.000 abstract 1
208000023105 Huntington disease Diseases 0.000 abstract 1
206010020772 Hypertension Diseases 0.000 abstract 1
206010061218 Inflammation Diseases 0.000 abstract 1
208000002193 Pain Diseases 0.000 abstract 1
208000018737 Parkinson disease Diseases 0.000 abstract 1
206010052428 Wound Diseases 0.000 abstract 1
208000027418 Wounds and injury Diseases 0.000 abstract 1
239000005557 antagonist Substances 0.000 abstract 1
230000036506 anxiety Effects 0.000 abstract 1
208000006752 brain edema Diseases 0.000 abstract 1
208000026106 cerebrovascular disease Diseases 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
235000014632 disordered eating Nutrition 0.000 abstract 1
206010013663 drug dependence Diseases 0.000 abstract 1
206010015037 epilepsy Diseases 0.000 abstract 1
230000036039 immunity Effects 0.000 abstract 1
125000003454 indenyl group Chemical class C1(C=CC2=CC=CC=C12)* 0.000 abstract 1
230000004054 inflammatory process Effects 0.000 abstract 1
208000002551 irritable bowel syndrome Diseases 0.000 abstract 1
230000000069 prophylactic effect Effects 0.000 abstract 1
201000000980 schizophrenia Diseases 0.000 abstract 1
208000019116 sleep disease Diseases 0.000 abstract 1
208000011117 substance-related disease Diseases 0.000 abstract 1
230000001225 therapeutic effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/16—Peri-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/40—Mineralocorticosteroids, e.g. aldosterone; Drugs increasing or potentiating the activity of mineralocorticosteroids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Dermatology (AREA)
Psychology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Addiction (AREA)
Vascular Medicine (AREA)
Rheumatology (AREA)
Urology & Nephrology (AREA)
Endocrinology (AREA)
Anesthesiology (AREA)
Diabetes (AREA)
Hospice & Palliative Care (AREA)
Immunology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Photoreceptors In Electrophotography (AREA)
Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT05703562T 2004-01-06 2005-01-06 Triazacyclopenta(cd)indenderivate ATE356129T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP2004001312		2004-01-06

Publications (1)

Publication Number	Publication Date
ATE356129T1 true ATE356129T1 (de)	2007-03-15

Family

ID=34746978

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT05703562T ATE356129T1 (de)	2004-01-06	2005-01-06	Triazacyclopenta(cd)indenderivate

Country Status (10)

Country	Link
US (1)	US7365078B2 (de)
EP (1)	EP1704149B1 (de)
JP (1)	JP4766393B2 (de)
CN (1)	CN1910187A (de)
AT (1)	ATE356129T1 (de)
CA (1)	CA2552600C (de)
DE (1)	DE602005000676T2 (de)
ES (1)	ES2282986T3 (de)
RU (1)	RU2006128600A (de)
WO (1)	WO2005066178A1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AR042667A1 (es) *	2002-12-26	2005-06-29	Taisho Pharmaceutical Co Ltd	Derivados de pirrolopirimidina y pirrolopiridina sustituidos con un grupo amino ciclico
JP4742273B2 (ja)	2004-01-06	2011-08-10	大正製薬株式会社	ピロロピリミジン及びピロロトリアジン誘導体
CA2552600C (en)	2004-01-06	2011-08-30	Taisho Pharmaceutical Co., Ltd.	Triaza-cyclopenta[cd]indene derivatives
JP2007517793A (ja) *	2004-01-06	2007-07-05	大正製薬株式会社	環状アミノ基によって置換されたチエノピリミジン及びチエノピリジン誘導体
CN1926140A (zh) *	2004-03-05	2007-03-07	大正制药株式会社	吡咯并嘧啶衍生物
CN1972941A (zh) *	2004-06-25	2007-05-30	大正制药株式会社	作为crf拮抗剂的四氢吡啶取代的吡咯并嘧啶和吡咯并吡啶衍生物
JP2007161585A (ja)	2004-06-25	2007-06-28	Taisho Pharmaceut Co Ltd	環状アミノ基で置換されているピロロピリミジン及びピロロピリジン誘導体
CA2693369A1 (en) *	2007-07-17	2009-01-22	Allergan, Inc.	Methods for treating anxiety

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6853732B2 (en)	1994-03-08	2005-02-08	Sonics Associates, Inc.	Center channel enhancement of virtual sound images
ES2203937T3 (es)	1997-03-26	2004-04-16	Taisho Pharmaceutical Co., Ltd	Derivados de 4-tetrahidropiridilpirimidina.
ATE297393T1 (de)	1999-03-11	2005-06-15	Taisho Pharmaceutical Co Ltd	Carbamoyltetrahydropyridin-derivate
EP1278751A1 (de)	2000-05-01	2003-01-29	Bristol-Myers Squibb Pharma Company	Tricyclische kondensierte pyridin- und pyrimidin-derivate als crf rezeptor antagonisten
US6541469B2 (en)	2000-05-18	2003-04-01	Neurocrine Biosciences, Inc.	CRF receptor antagonists and methods relating thereto
AR028782A1 (es)	2000-07-05	2003-05-21	Taisho Pharmaceutical Co Ltd	Derivados heterociclicos tetrahidropiridino o piperidino
PL367771A1 (en)	2001-05-21	2005-03-07	Neurocrine Biosciences Inc.	Tri-and tetraaza-acenaphthylen derivatives as crf receptor antagonists
AR042667A1 (es)	2002-12-26	2005-06-29	Taisho Pharmaceutical Co Ltd	Derivados de pirrolopirimidina y pirrolopiridina sustituidos con un grupo amino ciclico
JP4742273B2 (ja)	2004-01-06	2011-08-10	大正製薬株式会社	ピロロピリミジン及びピロロトリアジン誘導体
CA2552600C (en)	2004-01-06	2011-08-30	Taisho Pharmaceutical Co., Ltd.	Triaza-cyclopenta[cd]indene derivatives
JP2007517793A (ja)	2004-01-06	2007-07-05	大正製薬株式会社	環状アミノ基によって置換されたチエノピリミジン及びチエノピリジン誘導体
CN1926140A (zh)	2004-03-05	2007-03-07	大正制药株式会社	吡咯并嘧啶衍生物
CN1972941A (zh)	2004-06-25	2007-05-30	大正制药株式会社	作为crf拮抗剂的四氢吡啶取代的吡咯并嘧啶和吡咯并吡啶衍生物
JP2007161585A (ja)	2004-06-25	2007-06-28	Taisho Pharmaceut Co Ltd	環状アミノ基で置換されているピロロピリミジン及びピロロピリジン誘導体

2005
- 2005-01-06 CA CA2552600A patent/CA2552600C/en not_active Expired - Fee Related
- 2005-01-06 RU RU2006128600/04A patent/RU2006128600A/ru not_active Application Discontinuation
- 2005-01-06 CN CNA2005800020377A patent/CN1910187A/zh active Pending
- 2005-01-06 US US10/584,952 patent/US7365078B2/en not_active Expired - Fee Related
- 2005-01-06 EP EP05703562A patent/EP1704149B1/de not_active Expired - Lifetime
- 2005-01-06 WO PCT/JP2005/000323 patent/WO2005066178A1/en not_active Ceased
- 2005-01-06 DE DE602005000676T patent/DE602005000676T2/de not_active Expired - Lifetime
- 2005-01-06 JP JP2006546615A patent/JP4766393B2/ja not_active Expired - Fee Related
- 2005-01-06 ES ES05703562T patent/ES2282986T3/es not_active Expired - Lifetime
- 2005-01-06 AT AT05703562T patent/ATE356129T1/de not_active IP Right Cessation

Also Published As

Publication number	Publication date
EP1704149B1 (de)	2007-03-07
CA2552600A1 (en)	2005-07-21
CN1910187A (zh)	2007-02-07
ES2282986T3 (es)	2007-10-16
JP2007517795A (ja)	2007-07-05
RU2006128600A (ru)	2008-02-20
US20070060602A1 (en)	2007-03-15
DE602005000676D1 (de)	2007-04-19
CA2552600C (en)	2011-08-30
US7365078B2 (en)	2008-04-29
WO2005066178A1 (en)	2005-07-21
DE602005000676T2 (de)	2007-11-22
JP4766393B2 (ja)	2011-09-07
EP1704149A1 (de)	2006-09-27

Legal Events

Date	Code	Title	Description
2007-09-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
TW200505921A (en)	2005-02-16	Pyrrolopyrimidine and pyrrolopyridine derivatives substituted with cyclic amino group
UA89192C2 (ru)	2010-01-11	Производные пиролопиримидина и пиролопиридина, замещенные циклической аминогруппой, как антагонисты crf
CY1109069T1 (el)	2014-07-02	Ενωσεις ιμιδαζοπυριδαζινης
NO20070467L (no)	2007-01-24	Pyrrolopyrimidin og pyrrolopyridinderivater substituert med tetrahydropyridin som CRF antagonister
EA200901160A1 (ru)	2010-04-30	Производные 3-циано-4-(4-тетрагидропиранфенил)пиридин-2-она
ATE438632T1 (de)	2009-08-15	Aryl-4-ethinylisoxazolderivate
MX2009003098A (es)	2009-04-01	Compuestos de tiofen pirazolopirimidina.
EA200901162A1 (ru)	2010-04-30	Производные 1,4-дизамещённого 3-цианопиридона и их применение в качестве положительных модуляторов рецептора mglur2
EA200901159A1 (ru)	2010-04-30	Производные 3-циано-4-(4-фенилпиперидин-1-ил)пиридин-2-она
EA201000331A1 (ru)	2011-02-28	1',3-двузамещенные 4-(арил-х-фенил)-1h-пиридин-2-оны
TW200633982A (en)	2006-10-01	Novel pyridinone derivatives and their use as positive allosteric modulators of mglur2-receptors
MX2011005242A (es)	2011-09-06	Derivados de indol y benzoxazina como moduladores de los receptores de glutamato metabotropicos.
EA201190301A1 (ru)	2012-06-29	ПРОИЗВОДНЫЕ 1,2,4-ТРИАЗОЛО[4,3-а]ПИРИДИНА И ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ ПОЛОЖИТЕЛЬНЫХ АЛЛОСТЕРИЧЕСКИХ МОДУЛЯТОРОВ РЕЦЕПТОРОВ mGluR2
MA30798B1 (fr)	2009-10-01	Thiazole pyrazolopyrimidines comme antigonistes du recepteur crf1
EA200802054A1 (ru)	2009-04-28	Ингибиторы фермента
TW200633708A (en)	2006-10-01	Thieno-pyridine derivatives as gaba-b allosteric enhancers
WO2006047237A3 (en)	2006-11-02	Heterocyclic indanone potentiators of metabotropic glutamate receptors
NO20074977L (no)	2007-12-11	Fuserte tiazolderivater med affinitet for histamin H3 receptoren
ATE478876T1 (de)	2010-09-15	Thienopyridine als allosterische verstärker des m4-muscarinrezeptors
DE602005000676D1 (de)	2007-04-19	Triazacyclopentaäcdüindenderivate
EP1599201A4 (de)	2007-01-24	Selektive nichtsteroidale glucocorticoid-rezeptor- modulatoren
DE602007011434D1 (de)	2011-02-03	1h-indol-5-ylpiperazin-1-ylmethanonderivate
ATE466858T1 (de)	2010-05-15	3-arylisoxazol-4-carbonylbenzofuranderivative
WO2005066142A3 (en)	2005-10-13	Pyrrolopyrimidine and pyrrolotriazine derivatives as crf receptor antagonists
TW200630341A (en)	2006-09-01	Quinoline as allosteric enhancers of the GABA-B receptors