ATE297393T1 - Carbamoyltetrahydropyridin-derivate - Google Patents

Carbamoyltetrahydropyridin-derivate

Info

Publication number: ATE297393T1
Authority: AT; Austria
Prior art keywords: group; atom; derivatives; alkyl group; carbamoyltetrahydropyridine
Prior art date: 1999-03-11

Application number

AT00907999T

Other languages

English (en)

Inventor

Atsuro Nakazato

Taketoshi Okubo

Toshihito Kumagai

Kazuyuki Tomisawa

Original Assignee

Taisho Pharmaceutical Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-03-11

Filing date

2000-03-10

Publication date

2005-06-15

2000-03-10 Application filed by Taisho Pharmaceutical Co Ltd filed Critical Taisho Pharmaceutical Co Ltd

2005-06-15 Application granted granted Critical

2005-06-15 Publication of ATE297393T1 publication Critical patent/ATE297393T1/de

Links

KTXSODKVFJNBQU-UHFFFAOYSA-N 3,4-dihydro-2h-pyridine-1-carboxamide Chemical class NC(=O)N1CCCC=C1 KTXSODKVFJNBQU-UHFFFAOYSA-N 0.000 title abstract 2
125000006527 (C1-C5) alkyl group Chemical group 0.000 abstract 3
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
150000004944 pyrrolopyrimidines Chemical class 0.000 abstract 2
ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical group [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 abstract 1
WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000004414 alkyl thio group Chemical group 0.000 abstract 1
229910052801 chlorine Inorganic materials 0.000 abstract 1
125000001309 chloro group Chemical group Cl* 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
229910052740 iodine Inorganic materials 0.000 abstract 1
125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Epidemiology (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Immunology (AREA)
Hematology (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Rheumatology (AREA)
Psychology (AREA)
Hospice & Palliative Care (AREA)
Addiction (AREA)
Dermatology (AREA)
Diabetes (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Hydrogenated Pyridines (AREA)
Plural Heterocyclic Compounds (AREA)

AT00907999T 1999-03-11 2000-03-10 Carbamoyltetrahydropyridin-derivate ATE297393T1 (de)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
JP6500499		1999-03-11
JP18562899		1999-06-30
JP25835399		1999-09-13
PCT/JP2000/001468 WO2000053604A1 (en)	1999-03-11	2000-03-10	Carbamoyl tetrahydropyridine derivatives

Publications (1)

Publication Number	Publication Date
ATE297393T1 true ATE297393T1 (de)	2005-06-15

Family

ID=27298632

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT00907999T ATE297393T1 (de)	1999-03-11	2000-03-10	Carbamoyltetrahydropyridin-derivate

Country Status (10)

Country	Link
US (2)	US6600038B1 (de)
EP (2)	EP1176146B1 (de)
KR (1)	KR20010102544A (de)
CN (1)	CN1174984C (de)
AT (1)	ATE297393T1 (de)
AU (1)	AU756702B2 (de)
CA (1)	CA2366642A1 (de)
DE (1)	DE60020692T2 (de)
ES (1)	ES2239592T3 (de)
WO (1)	WO2000053604A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AR028782A1 (es)	2000-07-05	2003-05-21	Taisho Pharmaceutical Co Ltd	Derivados heterociclicos tetrahidropiridino o piperidino
MXPA05005983A (es)	2002-12-04	2005-08-18	Eisai Co Ltd	Compuestos de anillo fusionado 1,3-dihidroimidazol.
TWI270549B (en) *	2002-12-26	2007-01-11	Taisho Pharmaceutical Co Ltd	Pyrrolopyrimidine and pyrrolopyridine derivatives substituted with cyclic amino group
US7112585B2 (en)	2003-04-18	2006-09-26	Bristol-Myers Squibb Company	Pyrimidine derivatives as corticotropin releasing factor inhibitors
US7030145B2 (en)	2003-04-18	2006-04-18	Bristol-Myers Squibb Company	Pyridinyl derivatives for the treatment of depression
WO2005066142A2 (en) *	2004-01-06	2005-07-21	Taisho Pharmaceutical Co., Ltd.	Pyrrolopyrimidine and pyrrolotriazine derivatives as crf receptor antagonists
DE602005000676T2 (de)	2004-01-06	2007-11-22	Taisho Pharmaceutical Co., Ltd.	Triazacyclopenta[cd]indenderivate
EP1701961A1 (de) *	2004-01-06	2006-09-20	Taisho Pharmaceutical Co., Ltd	Mit einer cyclischen aminogruppe substituierte thienopyrimidin- und thienopyridinderivate
WO2005085253A1 (en) *	2004-03-05	2005-09-15	Taisho Pharmaceutical Co., Ltd.	Pyrrolopyrimidine derivatives
JP2007161585A (ja)	2004-06-25	2007-06-28	Taisho Pharmaceut Co Ltd	環状アミノ基で置換されているピロロピリミジン及びピロロピリジン誘導体
ZA200610043B (en) *	2004-06-25	2008-06-25	Taisho Pharmaceutical Co Ltd	Pyrrolopyrimidine and pyrrolopyridine derivatives substituted with tetrahydropyridine as CRF antagonists
WO2006073610A2 (en) *	2004-11-23	2006-07-13	Reddy Us Therapeutics, Inc.	Novel bicyclic heterocyclic compounds, process for their preparation and compositions containing them

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2818676A1 (de) *	1978-04-27	1979-11-08	Troponwerke Gmbh & Co Kg	Substituierte 5,6-dimethylpyrrolo 2,3-d pyrimidine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
ES2128544T3 (es) *	1992-12-17	1999-05-16	Pfizer	Pirrolopirimidinas como antagonistas del crf.
CN1142931C (zh) *	1997-03-26	2004-03-24	大正制药株式会社	4-四氢吡啶基嘧啶衍生物
JPH11335376A (ja) *	1998-05-25	1999-12-07	Taisho Pharmaceut Co Ltd	アリールテトラヒドロピリジン誘導体
JP2000086663A (ja)	1998-09-09	2000-03-28	Taisho Pharmaceut Co Ltd	アリールテトラヒドロピリジン誘導体

2000
- 2000-03-10 AU AU29414/00A patent/AU756702B2/en not_active Ceased
- 2000-03-10 KR KR1020017011455A patent/KR20010102544A/ko not_active Ceased
- 2000-03-10 WO PCT/JP2000/001468 patent/WO2000053604A1/ja not_active Ceased
- 2000-03-10 CA CA002366642A patent/CA2366642A1/en not_active Abandoned
- 2000-03-10 US US09/914,534 patent/US6600038B1/en not_active Expired - Fee Related
- 2000-03-10 AT AT00907999T patent/ATE297393T1/de not_active IP Right Cessation
- 2000-03-10 EP EP00907999A patent/EP1176146B1/de not_active Expired - Lifetime
- 2000-03-10 CN CNB008074542A patent/CN1174984C/zh not_active Expired - Fee Related
- 2000-03-10 DE DE60020692T patent/DE60020692T2/de not_active Expired - Fee Related
- 2000-03-10 ES ES00907999T patent/ES2239592T3/es not_active Expired - Lifetime
- 2000-03-10 EP EP04005593A patent/EP1449843A1/de not_active Withdrawn
2003
- 2003-01-21 US US10/347,288 patent/US6894168B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP1176146A1 (de)	2002-01-30
DE60020692D1 (de)	2005-07-14
EP1176146A4 (de)	2003-07-09
ES2239592T3 (es)	2005-10-01
US20030191122A1 (en)	2003-10-09
AU756702B2 (en)	2003-01-23
US6600038B1 (en)	2003-07-29
KR20010102544A (ko)	2001-11-15
EP1176146B1 (de)	2005-06-08
CA2366642A1 (en)	2000-09-14
CN1350536A (zh)	2002-05-22
DE60020692T2 (de)	2006-03-23
CN1174984C (zh)	2004-11-10
EP1449843A1 (de)	2004-08-25
US6894168B2 (en)	2005-05-17
HK1046683A1 (en)	2003-01-24
AU2941400A (en)	2000-09-28
WO2000053604A1 (en)	2000-09-14

Legal Events

Date	Code	Title	Description
2005-12-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

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