ATE356179T1 - Chemilumineszente markierungsverbindungen - Google Patents

Chemilumineszente markierungsverbindungen

Info

Publication number
ATE356179T1
ATE356179T1 AT99919759T AT99919759T ATE356179T1 AT E356179 T1 ATE356179 T1 AT E356179T1 AT 99919759 T AT99919759 T AT 99919759T AT 99919759 T AT99919759 T AT 99919759T AT E356179 T1 ATE356179 T1 AT E356179T1
Authority
AT
Austria
Prior art keywords
compounds
chemiluminescent
conjugates
labeled
assays
Prior art date
Application number
AT99919759T
Other languages
English (en)
Inventor
Hashem Tafti-Akhavan
Original Assignee
Lumigen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lumigen Inc filed Critical Lumigen Inc
Application granted granted Critical
Publication of ATE356179T1 publication Critical patent/ATE356179T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/08—Aza-anthracenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/02—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with only hydrogen, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/113—Esters of phosphoric acids with unsaturated acyclic alcohols
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/64—Acridine or hydrogenated acridine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms
    • C07F9/655363—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms the sulfur atom being part of a six-membered ring
    • C07F9/655372—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms the sulfur atom being part of a six-membered ring condensed with carbocyclic rings or carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K11/00—Luminescent materials, e.g. electroluminescent or chemiluminescent
    • C09K11/06—Luminescent materials, e.g. electroluminescent or chemiluminescent containing organic luminescent materials
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Materials Engineering (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Luminescent Compositions (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
AT99919759T 1998-06-17 1999-05-03 Chemilumineszente markierungsverbindungen ATE356179T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/099,657 US6126870A (en) 1997-09-12 1998-06-17 Chemiluminescent labeling compounds

Publications (1)

Publication Number Publication Date
ATE356179T1 true ATE356179T1 (de) 2007-03-15

Family

ID=22276034

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99919759T ATE356179T1 (de) 1998-06-17 1999-05-03 Chemilumineszente markierungsverbindungen

Country Status (9)

Country Link
US (1) US6126870A (de)
EP (1) EP1029016B1 (de)
JP (1) JP2002518410A (de)
AT (1) ATE356179T1 (de)
AU (1) AU760023C (de)
CA (1) CA2301120A1 (de)
DE (1) DE69935408T2 (de)
ES (1) ES2283111T3 (de)
WO (1) WO1999066005A1 (de)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999014220A1 (en) * 1997-09-12 1999-03-25 Lumigen, Inc. Novel compounds for generating chemiluminescence with a peroxidase
EP1186886A3 (de) * 2000-09-04 2004-01-07 Fuji Photo Film Co., Ltd. Verfahren zur biochemischen Analyse und dazu geeignetes Gerät
US7247726B2 (en) * 2001-02-26 2007-07-24 Lumigen, Inc. Compounds for generating chemiluminescence with a peroxidase
US6872828B2 (en) * 2001-12-20 2005-03-29 Lumigen, Inc. Compounds for generating chemiluminescence with a peroxidase
WO2003053934A1 (en) 2001-12-20 2003-07-03 Lumigen, Inc. Improved compounds for generating chemiluminescence with a peroxidase
KR100496776B1 (ko) * 2001-06-21 2005-06-22 삼성토탈 주식회사 에틸렌 중합 및 공중합용 촉매
US7560556B2 (en) * 2001-12-20 2009-07-14 Lumigen, Inc. Assay methods using chemiluminescent detection of peroxidase
DE10212805A1 (de) * 2002-03-22 2003-10-02 Leica Microsystems Schweiz Ag Operationsmikroskop mit Informationssystem
US7390670B2 (en) 2003-02-20 2008-06-24 Lumigen, Inc. Signalling compounds and methods for detecting hydrogen peroxide
US7846676B2 (en) 2004-07-19 2010-12-07 Cell Biosciences, Inc. Methods and devices for analyte detection
US7935479B2 (en) 2004-07-19 2011-05-03 Cell Biosciences, Inc. Methods and devices for analyte detection
WO2006014680A1 (en) 2004-07-19 2006-02-09 Cell Biosciences, Inc. Methods and devices for analyte detection
US20060205094A1 (en) * 2005-03-14 2006-09-14 Lumigen, Inc. Methods using novel chemiluminescent labels
US7682839B2 (en) 2005-03-14 2010-03-23 Lumigen, Inc. Methods using novel chemiluminescent labels
WO2006116683A1 (en) * 2005-04-27 2006-11-02 The Trustees Of The University Of Pennsylvania Nanostructure enhanced luminescence
WO2006116686A2 (en) * 2005-04-27 2006-11-02 The Trustees Of The University Of Pennsylvania Nanostructure enhanced luminescent devices
WO2006116687A2 (en) * 2005-04-27 2006-11-02 The Trustees Of The University Of Pennsylvania Nanoassays
US8945361B2 (en) 2005-09-20 2015-02-03 ProteinSimple Electrophoresis standards, methods and kits
US7799534B2 (en) * 2006-05-09 2010-09-21 Beckman Coulter, Inc. Nonseparation assay methods
DE202007010668U1 (de) 2007-07-30 2008-12-18 Follmann & Co. Gesellschaft Für Chemie-Werkstoffe Und -Verfahrenstechnik Mbh & Co. Kg Verbesserte Mikrokapseln
CN105153115B (zh) * 2009-11-16 2021-08-03 西门子医疗保健诊断公司 含两性离子的吖啶鎓化合物
US9766206B2 (en) 2013-09-27 2017-09-19 ProteinSimple Apparatus, systems, and methods for capillary electrophoresis
US20150093757A1 (en) 2013-09-27 2015-04-02 Protein Simple Methods. apparatus and systems for detection of total protein using capillary electrophoresis
JP7107842B6 (ja) 2016-01-13 2023-08-18 プロテインシンプル システム
CN106749404B (zh) * 2016-12-07 2019-01-04 湖南远璟生物技术有限公司 一种与碱性磷酸酶反应产生化学发光的化合物的制备方法
WO2019005764A1 (en) 2017-06-27 2019-01-03 Institute For Cancer Research D/B/A The Research Institute Of Fox Chase Cancer Center MHC-I GENOTYPE LIMITING THE ONCOGEN MUTATIONAL LANDSCAPE
US12163918B1 (en) 2018-08-23 2024-12-10 ProteinSimple Compositions and methods for protein electrophoresis
US11782023B2 (en) 2018-12-19 2023-10-10 Regeneron Pharmaceuticals, Inc. Ce-western applications for antibody development
US20200393455A1 (en) 2019-05-21 2020-12-17 Regeneron Pharmaceuticals, Inc. Methods for identifying and quantitating host cell protein
US11420202B1 (en) 2021-08-31 2022-08-23 ProteinSimple Systems and methods for fractionation and collection of analytes in a sample
US20230075533A1 (en) 2021-09-03 2023-03-09 ProteinSimple Methods and systems for analysis of samples containing particles used for gene delivery
AU2024255895A1 (en) 2023-04-14 2025-10-30 Revivicor, Inc. Serology assay for the detection of porcine viruses
CN116500021B (zh) * 2023-05-09 2025-09-09 华东师范大学 一种利用化学发光检测水中对苯二酚的方法
GB202416562D0 (en) * 2024-11-11 2024-12-25 Minton Treharne & Davies Ltd Resilient marker compounds
WO2026112070A1 (en) 2024-11-19 2026-05-28 Life Technologies Corporation A method for separating analytes in a separation matrix
CN119899212A (zh) * 2025-04-01 2025-04-29 江苏康普生物医药科技有限公司 一种碱性磷酸酶发光底物、其组合物、试剂盒、制备方法和应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0082636B2 (de) * 1981-12-11 2006-10-18 The Welsh National School of Medicine Lumineszierende Markierungssubstanzen und -verfahren
US4745181A (en) * 1986-10-06 1988-05-17 Ciba Corning Diagnostics Corp. Polysubstituted aryl acridinium esters
CA2213317C (en) * 1996-01-16 2001-07-03 Lumigen, Inc. Chemiluminescent compositions for reaction with phosphatase enzymes, and methods of use
US5772926A (en) * 1997-05-13 1998-06-30 Lumigen, Inc. Chemiluminescent reactions using dihydroxyaromatic compounds and heterocyclic enol phosphates
US5840963A (en) * 1997-05-13 1998-11-24 Lumigen, Inc. Chemiluminescent reactions using dihydroxyaromatic compounds and heterocyclic enol phosphates
US5922558A (en) * 1997-09-12 1999-07-13 Lumigen, Inc. Methods and compositions for generating chemiluminescence with a peroxidase

Also Published As

Publication number Publication date
AU760023B2 (en) 2003-05-08
AU3740999A (en) 2000-01-05
EP1029016B1 (de) 2007-03-07
ES2283111T3 (es) 2007-10-16
EP1029016A1 (de) 2000-08-23
DE69935408D1 (de) 2007-04-19
US6126870A (en) 2000-10-03
AU760023C (en) 2003-12-04
CA2301120A1 (en) 1999-12-23
JP2002518410A (ja) 2002-06-25
EP1029016A4 (de) 2003-06-25
WO1999066005A1 (en) 1999-12-23
DE69935408T2 (de) 2007-11-08

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