ATE356819T1 - Herstellung von codein aus morphin - Google Patents

Herstellung von codein aus morphin

Info

Publication number: ATE356819T1
Authority: AT; Austria
Prior art keywords: codeine; approximately; reaction mixture; hydrocarbon solvent; morphine
Prior art date: 2002-10-21

Application number

AT03770770T

Other languages

English (en)

Inventor

Lloyd P Hill

Original Assignee

Mallinckrodt Internat Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-10-21

Filing date

2003-10-14

Publication date

2007-04-15

2003-10-14 Application filed by Mallinckrodt Internat Corp filed Critical Mallinckrodt Internat Corp

2007-04-15 Application granted granted Critical

2007-04-15 Publication of ATE356819T1 publication Critical patent/ATE356819T1/de

Links

BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 title abstract 6
229960005181 morphine Drugs 0.000 title abstract 3
OROGSEYTTFOCAN-DNJOTXNNSA-N codeine Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC OROGSEYTTFOCAN-DNJOTXNNSA-N 0.000 abstract 8
239000004215 Carbon black (E152) Substances 0.000 abstract 4
229960004126 codeine Drugs 0.000 abstract 4
229930195733 hydrocarbon Natural products 0.000 abstract 4
150000002430 hydrocarbons Chemical class 0.000 abstract 4
OROGSEYTTFOCAN-UHFFFAOYSA-N hydrocodone Natural products C1C(N(CCC234)C)C2C=CC(O)C3OC2=C4C1=CC=C2OC OROGSEYTTFOCAN-UHFFFAOYSA-N 0.000 abstract 4
239000011541 reaction mixture Substances 0.000 abstract 4
239000002904 solvent Substances 0.000 abstract 4
JLTDJTHDQAWBAV-UHFFFAOYSA-N N,N-dimethylaniline Chemical compound CN(C)C1=CC=CC=C1 JLTDJTHDQAWBAV-UHFFFAOYSA-N 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
HGPQAWTZLJXCTC-SSTWWWIQSA-N (4r,4ar,7s,7ar,12bs)-7,9-dimethoxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1h-4,12-methanobenzofuro[3,2-e]isoquinoline Chemical compound C([C@@H](N(CC1)C)[C@@H]2C=C[C@@H]3OC)C4=CC=C(OC)C5=C4[C@@]21[C@H]3O5 HGPQAWTZLJXCTC-SSTWWWIQSA-N 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
238000001816 cooling Methods 0.000 abstract 1
229910052500 inorganic mineral Inorganic materials 0.000 abstract 1
239000012022 methylating agents‎ Substances 0.000 abstract 1
239000011707 mineral Substances 0.000 abstract 1
150000007522 mineralic acids Chemical class 0.000 abstract 1
150000007524 organic acids Chemical class 0.000 abstract 1
238000002360 preparation method Methods 0.000 abstract 1
238000010992 reflux Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT03770770T 2002-10-21 2003-10-14 Herstellung von codein aus morphin ATE356819T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US10/274,702 US6579985B1 (en)	2002-10-21	2002-10-21	Preparation of codeine from morphine

Publications (1)

Publication Number	Publication Date
ATE356819T1 true ATE356819T1 (de)	2007-04-15

Family

ID=23049276

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT03770770T ATE356819T1 (de)	2002-10-21	2003-10-14	Herstellung von codein aus morphin

Country Status (11)

Country	Link
US (1)	US6579985B1 (de)
EP (1)	EP1560833B1 (de)
JP (1)	JP2006505588A (de)
CN (1)	CN1692117A (de)
AT (1)	ATE356819T1 (de)
AU (1)	AU2003279287B2 (de)
CA (1)	CA2502935A1 (de)
DE (1)	DE60312543T2 (de)
ES (1)	ES2282689T3 (de)
MX (1)	MXPA05004162A (de)
WO (1)	WO2004037826A2 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6972332B1 (en) *	2004-05-20	2005-12-06	Acura Pharmaceuticals, Inc.	Process for the production of opiates
US6949645B1 (en)	2004-05-20	2005-09-27	Acura Pharmaceuticals, Inc.	Process for the production of opiates
CA2661302A1 (en) *	2006-08-16	2008-02-21	Auspex Pharmaceuticals, Inc.	Preparation and utility of opioid analgesics
DK3553177T3 (da)	2013-03-15	2021-02-15	Univ Leland Stanford Junior	Benzylisoquinolinalkaloider (bia) som producerer mikrober, og fremgangsmåder til fremstilling og anvendelse deraf
CN112410379B (zh)	2013-11-04	2024-12-31	小利兰·斯坦福大学托管委员会	产生苄基异喹啉生物碱(bia)前体的微生物以及制备和使用所述前体的方法
JP7266966B2 (ja)	2015-05-08	2023-05-01	ザボードオブトラスティーズオブザレランドスタンフォードジュニアユニバーシティー	エピメラーゼ及びベンジルイソキノリンアルカロイドを産生する方法
CN120399912A (zh)	2019-03-08	2025-08-01	小利兰·斯坦福大学托管委员会	产生莨菪烷生物碱(ta)的非植物宿主细胞及其制备和使用方法
CN110261194B (zh) *	2019-06-06	2022-02-22	深圳砺剑防卫技术有限公司	一种毒品探测设备校验品的制备方法及毒品探测设备校验品
TR2021022252A2 (tr) *	2021-12-31	2022-01-21	Toprak Mahsulleri Ofisi Genel Mueduerluegue	Kodei̇n kamphosulfonat üreti̇mi̇ne dai̇r yeni̇ bi̇r yöntem

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0268710B1 (de) *	1986-11-25	1991-05-15	Council of Scientific and Industrial Research	Verfahren zur Herstellung von Codein aus Morphin
CS277517B6 (sk) *	1990-12-12	1993-02-17	Slovakofarma S P	Spósob čistenia kodeinu připraveného metylizáciou morfínu
US6204337B1 (en) *	1996-11-19	2001-03-20	The Board Of Regents Of The University And Community College System Of Neveda	Solid-phase synthesis of codeine from morphine

2002
- 2002-10-21 US US10/274,702 patent/US6579985B1/en not_active Expired - Lifetime
2003
- 2003-10-14 JP JP2004546881A patent/JP2006505588A/ja not_active Withdrawn
- 2003-10-14 DE DE60312543T patent/DE60312543T2/de not_active Expired - Fee Related
- 2003-10-14 WO PCT/US2003/032698 patent/WO2004037826A2/en not_active Ceased
- 2003-10-14 MX MXPA05004162A patent/MXPA05004162A/es active IP Right Grant
- 2003-10-14 CA CA002502935A patent/CA2502935A1/en not_active Abandoned
- 2003-10-14 AU AU2003279287A patent/AU2003279287B2/en not_active Ceased
- 2003-10-14 AT AT03770770T patent/ATE356819T1/de not_active IP Right Cessation
- 2003-10-14 ES ES03770770T patent/ES2282689T3/es not_active Expired - Lifetime
- 2003-10-14 EP EP03770770A patent/EP1560833B1/de not_active Expired - Lifetime
- 2003-10-14 CN CN200380100724.3A patent/CN1692117A/zh active Pending

Also Published As

Publication number	Publication date
AU2003279287B2 (en)	2009-01-29
WO2004037826A2 (en)	2004-05-06
US6579985B1 (en)	2003-06-17
DE60312543D1 (de)	2007-04-26
CN1692117A (zh)	2005-11-02
EP1560833B1 (de)	2007-03-14
MXPA05004162A (es)	2005-06-22
AU2003279287A1 (en)	2004-05-13
CA2502935A1 (en)	2004-05-06
JP2006505588A (ja)	2006-02-16
ES2282689T3 (es)	2007-10-16
WO2004037826A3 (en)	2004-07-01
EP1560833A2 (de)	2005-08-10
DE60312543T2 (de)	2007-11-15

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Legal Events

Date	Code	Title	Description
2007-09-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties