ATE63554T1 - Verfahren zur herstellung von codein aus morphin. - Google Patents
Verfahren zur herstellung von codein aus morphin.Info
- Publication number
- ATE63554T1 ATE63554T1 AT86309180T AT86309180T ATE63554T1 AT E63554 T1 ATE63554 T1 AT E63554T1 AT 86309180 T AT86309180 T AT 86309180T AT 86309180 T AT86309180 T AT 86309180T AT E63554 T1 ATE63554 T1 AT E63554T1
- Authority
- AT
- Austria
- Prior art keywords
- codeine
- morphine
- production
- analgesic
- recovered
- Prior art date
Links
- OROGSEYTTFOCAN-DNJOTXNNSA-N codeine Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC OROGSEYTTFOCAN-DNJOTXNNSA-N 0.000 title abstract 8
- 229960004126 codeine Drugs 0.000 title abstract 4
- OROGSEYTTFOCAN-UHFFFAOYSA-N hydrocodone Natural products C1C(N(CCC234)C)C2C=CC(O)C3OC2=C4C1=CC=C2OC OROGSEYTTFOCAN-UHFFFAOYSA-N 0.000 title abstract 4
- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 title abstract 4
- 229960005181 morphine Drugs 0.000 title abstract 2
- 239000004215 Carbon black (E152) Substances 0.000 abstract 1
- 229910000288 alkali metal carbonate Inorganic materials 0.000 abstract 1
- 150000008041 alkali metal carbonates Chemical class 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 229940035676 analgesics Drugs 0.000 abstract 1
- 239000000730 antalgic agent Substances 0.000 abstract 1
- 239000003434 antitussive agent Substances 0.000 abstract 1
- 229940124584 antitussives Drugs 0.000 abstract 1
- 229930195733 hydrocarbon Natural products 0.000 abstract 1
- 150000002430 hydrocarbons Chemical class 0.000 abstract 1
- 239000011541 reaction mixture Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- MQAYPFVXSPHGJM-UHFFFAOYSA-M trimethyl(phenyl)azanium;chloride Chemical compound [Cl-].C[N+](C)(C)C1=CC=CC=C1 MQAYPFVXSPHGJM-UHFFFAOYSA-M 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP86309180A EP0268710B1 (de) | 1986-11-25 | 1986-11-25 | Verfahren zur Herstellung von Codein aus Morphin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE63554T1 true ATE63554T1 (de) | 1991-06-15 |
Family
ID=8196228
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT86309180T ATE63554T1 (de) | 1986-11-25 | 1986-11-25 | Verfahren zur herstellung von codein aus morphin. |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US4764615A (de) |
| EP (1) | EP0268710B1 (de) |
| AT (1) | ATE63554T1 (de) |
| DE (1) | DE3679327D1 (de) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5981750A (en) * | 1995-11-21 | 1999-11-09 | The Board Of Regents Of The University And Community College System Of Nevada | Solid-phase synthesis of codeine from morphine |
| US6204337B1 (en) | 1996-11-19 | 2001-03-20 | The Board Of Regents Of The University And Community College System Of Neveda | Solid-phase synthesis of codeine from morphine |
| AU2001296651A1 (en) * | 2000-10-06 | 2002-04-15 | Robert C. Corcoran | Resin and its use in converting morphine to codeine |
| CN1639166A (zh) * | 2002-02-28 | 2005-07-13 | 马林克罗特公司 | 通过反相制备色谱法分离和纯化至少一种麻醉生物碱的方法和系统 |
| US6579985B1 (en) * | 2002-10-21 | 2003-06-17 | Mallinckrodt Inc. | Preparation of codeine from morphine |
| CN100396685C (zh) * | 2003-09-25 | 2008-06-25 | 中国医药集团总公司四川抗菌素工业研究所 | 一种由吗啡合成可待因的新方法 |
| US6972332B1 (en) * | 2004-05-20 | 2005-12-06 | Acura Pharmaceuticals, Inc. | Process for the production of opiates |
| US6949645B1 (en) | 2004-05-20 | 2005-09-27 | Acura Pharmaceuticals, Inc. | Process for the production of opiates |
| SI3553177T1 (sl) * | 2013-03-15 | 2021-03-31 | The Board Of Trustees Of The Leland Stanford Junior University | Mikrobi, ki proizvajajo benzilizokinolinske alkaloide (BIA), in postopka za pripravo in uporabo le-teh |
| CA2983445A1 (en) | 2015-05-08 | 2016-11-17 | The Board Of Trustees Of The Leland Stanford Junior University | Methods of producing epimerases and benzylisoquinoline alkaloids |
| MX2021010797A (es) | 2019-03-08 | 2021-12-10 | Univ Leland Stanford Junior | Células hospederas no vegetales productoras de alcaloides del tropano (ta), y métodos de preparacion y uso de los mismos. |
| CN113874435B (zh) * | 2019-06-03 | 2023-10-20 | 陶氏环球技术有限责任公司 | 涂覆的导体 |
| CN116217641A (zh) * | 2023-03-01 | 2023-06-06 | 上海原思标物科技有限公司 | 吗啡-D3-6-β-D-葡萄糖醛酸苷的合成方法及其中间体化合物 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE247180C (de) * | ||||
| DD15069A (de) * | ||||
| GB191122611A (en) * | 1911-10-13 | 1912-04-18 | Philip Arthur Newton | Improvements in and relating to the Manufacture and Production of Alkylderivatives of Morphine. |
-
1986
- 1986-11-25 AT AT86309180T patent/ATE63554T1/de not_active IP Right Cessation
- 1986-11-25 DE DE8686309180T patent/DE3679327D1/de not_active Expired - Lifetime
- 1986-11-25 EP EP86309180A patent/EP0268710B1/de not_active Expired
- 1986-12-10 US US06/940,517 patent/US4764615A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP0268710A1 (de) | 1988-06-01 |
| US4764615A (en) | 1988-08-16 |
| EP0268710B1 (de) | 1991-05-15 |
| DE3679327D1 (de) | 1991-06-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| EELA | Cancelled due to lapse of time |