ATE356873T1 - Antikörper mit verbesserter produzierbarkeit - Google Patents

Antikörper mit verbesserter produzierbarkeit

Info

Publication number
ATE356873T1
ATE356873T1 AT99923439T AT99923439T ATE356873T1 AT E356873 T1 ATE356873 T1 AT E356873T1 AT 99923439 T AT99923439 T AT 99923439T AT 99923439 T AT99923439 T AT 99923439T AT E356873 T1 ATE356873 T1 AT E356873T1
Authority
AT
Austria
Prior art keywords
producability
antibodies
improved
improved producability
Prior art date
Application number
AT99923439T
Other languages
English (en)
Inventor
John Edward Park
Pilar Garin-Chesa
Uwe Bamberger
Wolfgang J Rettig
Olivier Leger
Jose Saldanha
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Application granted granted Critical
Publication of ATE356873T1 publication Critical patent/ATE356873T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/026—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a baculovirus

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
AT99923439T 1998-04-30 1999-04-22 Antikörper mit verbesserter produzierbarkeit ATE356873T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP98107925A EP0953639A1 (de) 1998-04-30 1998-04-30 FAPalpha-spezifischer Antikörper mit verbesserter Produzierbarkeit

Publications (1)

Publication Number Publication Date
ATE356873T1 true ATE356873T1 (de) 2007-04-15

Family

ID=8231860

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99923439T ATE356873T1 (de) 1998-04-30 1999-04-22 Antikörper mit verbesserter produzierbarkeit

Country Status (27)

Country Link
EP (2) EP0953639A1 (de)
JP (1) JP4421779B2 (de)
KR (1) KR100580936B1 (de)
CN (1) CN1303430A (de)
AR (1) AR016243A1 (de)
AT (1) ATE356873T1 (de)
AU (1) AU760305B2 (de)
BG (1) BG65034B1 (de)
BR (1) BR9910577A (de)
CA (1) CA2327586C (de)
CO (1) CO5050255A1 (de)
DE (1) DE69935516T2 (de)
EA (1) EA005401B1 (de)
EE (1) EE200000642A (de)
ES (1) ES2283114T3 (de)
HU (1) HUP0101501A3 (de)
ID (1) ID26555A (de)
IL (1) IL138701A0 (de)
NO (1) NO20005412L (de)
NZ (1) NZ508456A (de)
PL (1) PL358087A1 (de)
SK (1) SK16192000A3 (de)
TR (1) TR200003181T2 (de)
UA (1) UA73276C2 (de)
WO (1) WO1999057151A2 (de)
YU (1) YU66300A (de)
ZA (1) ZA200005506B (de)

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EP2365004B1 (de) * 2002-06-21 2016-01-06 Johns Hopkins University School of Medicine Membranassoziierte Tumorendothel-Marker
WO2004016750A2 (en) * 2002-08-14 2004-02-26 Macrogenics, Inc. FcϜRIIB-SPECIFIC ANTIBODIES AND METHODS OF USE THEREOF
US8968730B2 (en) 2002-08-14 2015-03-03 Macrogenics Inc. FcγRIIB specific antibodies and methods of use thereof
US8946387B2 (en) 2002-08-14 2015-02-03 Macrogenics, Inc. FcγRIIB specific antibodies and methods of use thereof
US8187593B2 (en) 2002-08-14 2012-05-29 Macrogenics, Inc. FcγRIIB specific antibodies and methods of use thereof
US8193318B2 (en) 2002-08-14 2012-06-05 Macrogenics, Inc. FcγRIIB specific antibodies and methods of use thereof
US8044180B2 (en) 2002-08-14 2011-10-25 Macrogenics, Inc. FcγRIIB specific antibodies and methods of use thereof
US8530627B2 (en) 2002-08-14 2013-09-10 Macrogenics, Inc. FcγRIIB specific antibodies and methods of use thereof
US7384744B2 (en) 2002-11-29 2008-06-10 Boehringer Ingelheim Pharma Gmbh & Co., Kg Expression vector, methods for the production of heterologous gene products and for the selection of recombinant cells producing high levels of such products
US7960512B2 (en) 2003-01-09 2011-06-14 Macrogenics, Inc. Identification and engineering of antibodies with variant Fc regions and methods of using same
EP2368578A1 (de) 2003-01-09 2011-09-28 Macrogenics, Inc. Identifizierung und Herstellung von Antikörpern mit abweichenden FC-Regionen und Anwendungsverfahren dafür
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JP2007536932A (ja) 2004-05-10 2007-12-20 マクロジェニクス，インコーポレーテッド ヒト化ＦｃγＲＩＩＢ特異的抗体とその利用法
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US10155816B2 (en) * 2005-11-28 2018-12-18 Genmab A/S Recombinant monovalent antibodies and methods for production thereof
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CA2660592C (en) 2006-05-26 2016-07-12 Macrogenics, Inc. Humanized fc.gamma.riib-specific antibodies and methods of use thereof
AU2007281876B2 (en) 2006-06-26 2013-09-05 Macrogenics, Inc. FcgammaRIIB-specific antibodies and methods of use thereof
CA2656224C (en) 2006-06-26 2018-01-09 Macrogenics, Inc. Combination of fc.gamma.riib antibodies and cd20-specific antibodies and methods of use thereof
WO2008140603A2 (en) 2006-12-08 2008-11-20 Macrogenics, Inc. METHODS FOR THE TREATMENT OF DISEASE USING IMMUNOGLOBULINS HAVING FC REGIONS WITH ALTERED AFFINITIES FOR FCγR ACTIVATING AND FCγR INHIBITING
AU2008205512B2 (en) 2007-01-16 2014-06-12 Abbvie Inc. Methods for treating psoriasis
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EP2185591B1 (de) * 2007-08-20 2014-05-14 Glaxo Group Limited Herstellungsverfahren
EP2071337A1 (de) * 2007-12-10 2009-06-17 F.Hoffmann-La Roche Ag Seprase als Krebsmarker
CN101896817A (zh) * 2007-12-10 2010-11-24 霍夫曼-拉罗奇有限公司 用于结直肠癌的标记物组
CN101896818B (zh) 2007-12-10 2016-01-20 霍夫曼-拉罗奇有限公司 作为癌症的标记物的Seprase
BRPI0908715A2 (pt) 2008-03-18 2016-05-03 Abbott Lab métodos para tratamento da psoríase
JP5785490B2 (ja) 2008-04-02 2015-09-30 マクロジェニクス，インコーポレーテッド Ｂｃｒ複合体特異的抗体およびその使用方法
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JP6498600B2 (ja) 2012-06-08 2019-04-10 ストロ バイオファーマ インコーポレーテッド 部位特異的な非天然アミノ酸残基を含む抗体、その調製方法、及びその使用方法
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US9487587B2 (en) 2013-03-05 2016-11-08 Macrogenics, Inc. Bispecific molecules that are immunoreactive with immune effector cells of a companion animal that express an activating receptor and cells that express B7-H3 and uses thereof
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CN103267852B (zh) * 2013-05-15 2015-03-25 中国医学科学院北京协和医院 成纤维激活蛋白α在制备胰腺癌预后试剂盒中的用途
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EP3122775B1 (de) * 2014-03-26 2019-11-13 Julius-Maximilians-Universität Würzburg Monoklonale antikörper gegen wachstums- und differenzierungsfaktor 15 (gdf-15) und verwendungen davon zur behandlung von krebsbedingter kachexie und krebs
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CN110526979A (zh) * 2018-05-25 2019-12-03 深圳宾德生物技术有限公司 靶向fap的单链抗体、嵌合抗原受体t细胞及其制备方法和应用
CN109053893B (zh) * 2018-08-15 2021-03-30 智享生物(苏州)有限公司 一种抗d-二聚体单克隆抗体及其制备方法
CN110882385B (zh) * 2018-09-07 2021-07-09 上海君实生物医药科技股份有限公司 抗pd-1抗体在治疗肿瘤中的用途
CN114853908B (zh) * 2019-05-16 2024-06-07 浙江道尔生物科技有限公司 一种治疗代谢疾病的融合蛋白
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CN113512116B (zh) * 2020-04-10 2022-09-20 苏州普乐康医药科技有限公司 一种抗igf-1r抗体及其应用
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CN116390937A (zh) * 2020-08-11 2023-07-04 治纳辅医药科技有限公司 一种包含il-12和抗cd20抗体的融合蛋白及其应用
EP4050018A1 (de) 2021-01-07 2022-08-31 3B Pharmaceuticals GmbH Verbindungen mit fibroblasten-aktivierendem proteinligand und deren verwendung
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WO2023031644A1 (en) 2021-08-31 2023-03-09 Full-Life Technologies Limited Anti-fibroblast activation protein (fap) single domain antibodies and uses thereof
CN118974258A (zh) * 2021-12-30 2024-11-15 乐普创一生物科技（上海）有限公司 抗fap-alpha的人源抗体
CN119604540A (zh) 2022-08-03 2025-03-11 南京维立志博生物科技股份有限公司 靶向FAP和TGFβ的抗体融合蛋白及其用途
CN120112308A (zh) 2022-10-07 2025-06-06 吉尼松公司 使用抗fap car-t细胞免疫治疗骨骼肌病
CN116589566A (zh) * 2022-11-18 2023-08-15 昆明医科大学第一附属医院 一种HIV-1中和抗体的改造重组单克隆IgM抗体及其应用
CN120309735A (zh) * 2024-01-15 2025-07-15 迈威(上海)生物科技股份有限公司 重组抗fap抗体及其应用
CN118496382B (zh) * 2024-05-22 2025-01-07 山东第一医科大学附属省立医院(山东省立医院) 一种靶向fap的嵌合抗原受体、car-t细胞及其在肝纤维化中的应用
CN118812715A (zh) * 2024-07-02 2024-10-22 国睿(广州)生物科技有限公司 一种靶向成纤维活化蛋白α的纳米抗体及其应用
CN119265201A (zh) * 2024-08-23 2025-01-07 中国人民解放军海军军医大学第一附属医院 编码基因、蛋白、表达il-15的nkg2dl-fap双靶点car-nk细胞及其构建方法和用途

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Also Published As

Publication number Publication date
BG65034B1 (bg) 2006-12-29
EP0953639A1 (de) 1999-11-03
AU4032299A (en) 1999-11-23
SK16192000A3 (sk) 2001-04-09
EP1098979A2 (de) 2001-05-16
EA200001023A1 (ru) 2001-06-25
ID26555A (id) 2001-01-18
AU760305B2 (en) 2003-05-15
HUP0101501A2 (hu) 2001-08-28
AR016243A1 (es) 2001-06-20
ZA200005506B (en) 2002-05-14
CO5050255A1 (es) 2001-06-27
NZ508456A (en) 2004-03-26
ES2283114T3 (es) 2007-10-16
EP1098979B1 (de) 2007-03-14
EA005401B1 (ru) 2005-02-24
IL138701A0 (en) 2001-10-31
HUP0101501A3 (en) 2004-01-28
JP4421779B2 (ja) 2010-02-24
KR20010042826A (ko) 2001-05-25
PL358087A1 (en) 2004-08-09
NO20005412D0 (no) 2000-10-27
KR100580936B1 (ko) 2006-05-17
BG104828A (en) 2001-09-28
WO1999057151A3 (en) 2000-03-16
UA73276C2 (en) 2005-07-15
BR9910577A (pt) 2001-09-11
TR200003181T2 (tr) 2001-04-20
NO20005412L (no) 2000-12-06
EE200000642A (et) 2002-04-15
CN1303430A (zh) 2001-07-11
WO1999057151A2 (en) 1999-11-11
DE69935516T2 (de) 2008-01-31
YU66300A (sh) 2004-03-12
JP2002513556A (ja) 2002-05-14
DE69935516D1 (de) 2007-04-26
CA2327586C (en) 2013-02-26
CA2327586A1 (en) 1999-11-11

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