UA73276C2 - A humanized antiboby being specifically bonded to the protein of alpha-activation of fibroplasts (fap?). - Google Patents

A humanized antiboby being specifically bonded to the protein of alpha-activation of fibroplasts (fap?). Download PDF

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Publication number
UA73276C2
UA73276C2 UA2000116786A UA2000116786A UA73276C2 UA 73276 C2 UA73276 C2 UA 73276C2 UA 2000116786 A UA2000116786 A UA 2000116786A UA 2000116786 A UA2000116786 A UA 2000116786A UA 73276 C2 UA73276 C2 UA 73276C2
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UA
Ukraine
Prior art keywords
bek
antibody
cells
human
mai
Prior art date
Application number
UA2000116786A
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English (en)
Ukrainian (uk)
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Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of UA73276C2 publication Critical patent/UA73276C2/uk

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/026—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a baculovirus

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
UA2000116786A 1998-04-30 1999-04-22 A humanized antiboby being specifically bonded to the protein of alpha-activation of fibroplasts (fap?). UA73276C2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98107925A EP0953639A1 (de) 1998-04-30 1998-04-30 FAPalpha-spezifischer Antikörper mit verbesserter Produzierbarkeit
PCT/EP1999/002711 WO1999057151A2 (en) 1998-04-30 1999-04-22 FAP α-SPECIFIC ANTIBODY WITH IMPROVED PRODUCIBILITY

Publications (1)

Publication Number Publication Date
UA73276C2 true UA73276C2 (en) 2005-07-15

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
UA2000116786A UA73276C2 (en) 1998-04-30 1999-04-22 A humanized antiboby being specifically bonded to the protein of alpha-activation of fibroplasts (fap?).

Country Status (27)

Country Link
EP (2) EP0953639A1 (de)
JP (1) JP4421779B2 (de)
KR (1) KR100580936B1 (de)
CN (1) CN1303430A (de)
AR (1) AR016243A1 (de)
AT (1) ATE356873T1 (de)
AU (1) AU760305B2 (de)
BG (1) BG65034B1 (de)
BR (1) BR9910577A (de)
CA (1) CA2327586C (de)
CO (1) CO5050255A1 (de)
DE (1) DE69935516T2 (de)
EA (1) EA005401B1 (de)
EE (1) EE200000642A (de)
ES (1) ES2283114T3 (de)
HU (1) HUP0101501A3 (de)
ID (1) ID26555A (de)
IL (1) IL138701A0 (de)
NO (1) NO20005412L (de)
NZ (1) NZ508456A (de)
PL (1) PL358087A1 (de)
SK (1) SK16192000A3 (de)
TR (1) TR200003181T2 (de)
UA (1) UA73276C2 (de)
WO (1) WO1999057151A2 (de)
YU (1) YU66300A (de)
ZA (1) ZA200005506B (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN118496382A (zh) * 2024-05-22 2024-08-16 山东第一医科大学附属省立医院(山东省立医院) 一种靶向fap的嵌合抗原受体、car-t细胞及其在肝纤维化中的应用

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CN118496382A (zh) * 2024-05-22 2024-08-16 山东第一医科大学附属省立医院(山东省立医院) 一种靶向fap的嵌合抗原受体、car-t细胞及其在肝纤维化中的应用

Also Published As

Publication number Publication date
JP4421779B2 (ja) 2010-02-24
EP1098979B1 (de) 2007-03-14
TR200003181T2 (tr) 2001-04-20
EA005401B1 (ru) 2005-02-24
CA2327586A1 (en) 1999-11-11
WO1999057151A3 (en) 2000-03-16
HUP0101501A2 (hu) 2001-08-28
IL138701A0 (en) 2001-10-31
NZ508456A (en) 2004-03-26
EP0953639A1 (de) 1999-11-03
WO1999057151A2 (en) 1999-11-11
CO5050255A1 (es) 2001-06-27
AU4032299A (en) 1999-11-23
HUP0101501A3 (en) 2004-01-28
YU66300A (sh) 2004-03-12
NO20005412D0 (no) 2000-10-27
ES2283114T3 (es) 2007-10-16
ID26555A (id) 2001-01-18
SK16192000A3 (sk) 2001-04-09
BG65034B1 (bg) 2006-12-29
EP1098979A2 (de) 2001-05-16
DE69935516T2 (de) 2008-01-31
BR9910577A (pt) 2001-09-11
DE69935516D1 (de) 2007-04-26
KR20010042826A (ko) 2001-05-25
JP2002513556A (ja) 2002-05-14
EE200000642A (et) 2002-04-15
BG104828A (en) 2001-09-28
CN1303430A (zh) 2001-07-11
NO20005412L (no) 2000-12-06
KR100580936B1 (ko) 2006-05-17
CA2327586C (en) 2013-02-26
AU760305B2 (en) 2003-05-15
ATE356873T1 (de) 2007-04-15
AR016243A1 (es) 2001-06-20
PL358087A1 (en) 2004-08-09
ZA200005506B (en) 2002-05-14
EA200001023A1 (ru) 2001-06-25

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