ATE358160T1 - Ph-responsive biologisch abbaubare polymilchsäurederivate, die polymermicellen bilden, und deren verwendung zur zufuhr von schlecht wasserlöslichen arzneistoffen - Google Patents

Ph-responsive biologisch abbaubare polymilchsäurederivate, die polymermicellen bilden, und deren verwendung zur zufuhr von schlecht wasserlöslichen arzneistoffen

Info

Publication number
ATE358160T1
ATE358160T1 AT02788877T AT02788877T ATE358160T1 AT E358160 T1 ATE358160 T1 AT E358160T1 AT 02788877 T AT02788877 T AT 02788877T AT 02788877 T AT02788877 T AT 02788877T AT E358160 T1 ATE358160 T1 AT E358160T1
Authority
AT
Austria
Prior art keywords
polylactic acid
acid derivatives
poorly water
delivery
form polymer
Prior art date
Application number
AT02788877T
Other languages
English (en)
Inventor
Min-Hyo Seo
Bong-Oh Kim
In-Ja Choi
Myung-Seob Shim
Original Assignee
Samyang Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Samyang Corp filed Critical Samyang Corp
Application granted granted Critical
Publication of ATE358160T1 publication Critical patent/ATE358160T1/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
    • C08G63/06—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from hydroxycarboxylic acids
    • C08G63/08—Lactones or lactides
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/78—Preparation processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
    • C08G63/06—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from hydroxycarboxylic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Medicinal Preparation (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Biological Depolymerization Polymers (AREA)
AT02788877T 2001-10-18 2002-10-17 Ph-responsive biologisch abbaubare polymilchsäurederivate, die polymermicellen bilden, und deren verwendung zur zufuhr von schlecht wasserlöslichen arzneistoffen ATE358160T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR20010064164 2001-10-18

Publications (1)

Publication Number Publication Date
ATE358160T1 true ATE358160T1 (de) 2007-04-15

Family

ID=19715213

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02788877T ATE358160T1 (de) 2001-10-18 2002-10-17 Ph-responsive biologisch abbaubare polymilchsäurederivate, die polymermicellen bilden, und deren verwendung zur zufuhr von schlecht wasserlöslichen arzneistoffen

Country Status (13)

Country Link
US (1) US8778322B2 (de)
EP (1) EP1448710B1 (de)
JP (1) JP2005505675A (de)
KR (1) KR100517253B1 (de)
CN (1) CN1260294C (de)
AT (1) ATE358160T1 (de)
AU (1) AU2002353551B2 (de)
CA (1) CA2463517C (de)
DE (1) DE60219194T2 (de)
ES (1) ES2283623T3 (de)
MX (1) MXPA04003513A (de)
NZ (1) NZ532112A (de)
WO (1) WO2003033593A1 (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2463517C (en) * 2001-10-18 2010-03-16 Samyang Corporation Ph responsive biodegradable polylactic acid derivatives forming polymeric micelles and uses thereof for poorly water soluble drug delivery
KR20050054129A (ko) 2003-12-04 2005-06-10 주식회사 삼양사 고분자 미셀을 형성하는 생분해성 분지형 폴리락트산유도체, 및 그의 제조방법 및 용도
KR20050064075A (ko) * 2003-12-23 2005-06-29 주식회사 삼양사 이트라코나졸을 유효성분으로 하는 약학적 조성물
WO2005066238A1 (en) * 2003-12-30 2005-07-21 3M Innovative Properties Company Medicinal compositions and method for the preparation thereof
US7151077B2 (en) 2004-03-29 2006-12-19 Halliburton Energy Services, Inc. Polymersome compositions and associated methods of use
CA2564719C (en) * 2004-05-06 2011-11-01 Samyang Corporation Delivery system for bioactive agents on the basis of a polymeric drug carrier comprising an amphiphilic block polymer and a polylactic acid derivative
KR101118199B1 (ko) * 2004-12-20 2012-03-15 주식회사 삼양홀딩스 타크롤리무스를 가용화하기 위한 고분자 미셀 조성물
US7662753B2 (en) 2005-05-12 2010-02-16 Halliburton Energy Services, Inc. Degradable surfactants and methods for use
US7677315B2 (en) 2005-05-12 2010-03-16 Halliburton Energy Services, Inc. Degradable surfactants and methods for use
US7608567B2 (en) 2005-05-12 2009-10-27 Halliburton Energy Services, Inc. Degradable surfactants and methods for use
US9233078B2 (en) 2007-12-06 2016-01-12 Bend Research, Inc. Nanoparticles comprising a non-ionizable polymer and an Amine-functionalized methacrylate copolymer
RU2459840C2 (ru) * 2007-12-31 2012-08-27 Самъянг Корпорейшн АМФИФИЛЬНЫЙ СОПОЛИМЕР ВЫСОКОЙ ЧИСТОТЫ, СОДЕРЖАЩИЙ ГИДРОФОБНЫЙ БЛОК ИЗ α-ГИДРОКСИКИСЛОТЫ, И СПОСОБ ЕГО ПОЛУЧЕНИЯ
DE102008002471A1 (de) * 2008-06-17 2009-12-24 Biotronik Vi Patent Ag Stent mit einer Beschichtung oder einem Grundkörper, der ein Lithiumsalz enthält, und Verwendung von Lithiumsalzen zur Restenoseprophylaxe
KR101224004B1 (ko) 2009-12-29 2013-01-22 주식회사 삼양바이오팜 단백질, 폴리펩타이드 또는 펩타이드 약물 전달용 고분자 및 그 제조방법, 및 단백질, 폴리펩타이드 또는 펩타이드 약물의 서방형 조성물 및 그 제조 방법
KR101424163B1 (ko) * 2010-12-24 2014-08-01 주식회사 삼양바이오팜 수난용성 약물 함유 서방성 마이크로입자 및 그 제조방법
KR101411349B1 (ko) 2010-12-24 2014-06-25 주식회사 삼양바이오팜 생리활성 펩타이드를 포함하는 마이크로입자 및 그의 제조방법, 및 그를 포함하는 약제학적 조성물
KR101508275B1 (ko) 2011-12-16 2015-04-08 주식회사 삼양바이오팜 고분자 나노입자 수용액 조성물 및 그 제조방법
US9260601B2 (en) 2012-09-26 2016-02-16 General Electric Company Single drum oil and aqueous products and methods of use
AU2013303110B2 (en) 2012-08-14 2018-02-22 Bl Technologies, Inc. Demulsifying compositions and methods of use
JP6564369B2 (ja) 2013-12-09 2019-08-21 デュレクト コーポレイション 薬学的活性剤複合体、ポリマー複合体、ならびにこれらを伴う組成物及び方法
US10160896B2 (en) 2015-04-27 2018-12-25 Halliburton Energy Services, Inc. Delayed-release additives in a degradable matrix
WO2017041095A1 (en) * 2015-09-03 2017-03-09 Allegheny-Singer Research Institute Hydrophilic fentanyl derivatives
KR101971672B1 (ko) 2016-11-18 2019-04-23 주식회사 삼양바이오팜 화학색전용 에멀전 조성물 및 그의 제조방법
CN112791068B (zh) * 2021-02-08 2022-06-21 郑州大学 一种co2响应性微纳米给药系统的制备方法及其应用
US12272846B2 (en) * 2021-12-28 2025-04-08 Toyota Motor Engineering & Manufacturing North America, Inc. Fuel cell system
CN118957803A (zh) * 2024-07-30 2024-11-15 睿特维新材料科技(上海)有限公司 一种生物可降解丝束

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4010196A (en) * 1975-06-25 1977-03-01 American Home Products Corporation Linear polyester salts
JPS588098A (ja) * 1981-07-03 1983-01-18 Nisshin Oil Mills Ltd:The エステル化生成物ならびにこれらを含む化粧料及び外用剤
US4479911A (en) 1982-01-28 1984-10-30 Sandoz, Inc. Process for preparation of microspheres and modification of release rate of core material
JP2670680B2 (ja) * 1988-02-24 1997-10-29 株式会社ビーエムジー 生理活性物質含有ポリ乳酸系微小球およびその製造法
US5023349A (en) * 1990-05-08 1991-06-11 E. I. Du Pont De Nemours And Company Continuous process for rapid conversion of oligomers to cyclic esters
JP3353853B2 (ja) * 1994-06-01 2002-12-03 東洋紡績株式会社 実質的に全末端水酸基をエステル封鎖したポリ乳酸およびその製造法
US6447796B1 (en) * 1994-05-16 2002-09-10 The United States Of America As Represented By The Secretary Of The Army Sustained release hydrophobic bioactive PLGA microspheres
KR100369764B1 (ko) * 1994-07-20 2003-05-22 키너톤 리미티드 생분해성폴리에스테르및생활성폴리펩티드의이온성분자결합체
JP3426432B2 (ja) * 1995-02-22 2003-07-14 ベーガン通商株式会社 繊維柔軟処理剤及び繊維や繊維製品の柔軟処理方法
AU726749B2 (en) * 1995-08-10 2000-11-16 Kazunori Kataoka Block polymer having functional groups on its both ends
JPH0959218A (ja) * 1995-08-25 1997-03-04 Shimadzu Corp Ｌ−乳酸オリゴマー誘導体
US5665428A (en) * 1995-10-25 1997-09-09 Macromed, Inc. Preparation of peptide containing biodegradable microspheres by melt process
KR100190230B1 (ko) * 1996-06-19 1999-06-01 김윤 생분해성 폴리락트산의 제조방법
JPH10110019A (ja) * 1996-10-08 1998-04-28 Kazunori Kataoka 安定化高分子ミセルおよび生理活性物質のキヤリヤーとしてのその使用
CA2463517C (en) * 2001-10-18 2010-03-16 Samyang Corporation Ph responsive biodegradable polylactic acid derivatives forming polymeric micelles and uses thereof for poorly water soluble drug delivery
KR100492805B1 (ko) * 2001-10-18 2005-06-07 주식회사 삼양사 안정성이 향상된 고분자 미셀 조성물
KR20050054129A (ko) * 2003-12-04 2005-06-10 주식회사 삼양사 고분자 미셀을 형성하는 생분해성 분지형 폴리락트산유도체, 및 그의 제조방법 및 용도

Also Published As

Publication number Publication date
EP1448710A1 (de) 2004-08-25
JP2005505675A (ja) 2005-02-24
KR100517253B1 (ko) 2005-09-28
CN1260294C (zh) 2006-06-21
US20040247561A1 (en) 2004-12-09
CN1571817A (zh) 2005-01-26
NZ532112A (en) 2005-09-30
EP1448710B1 (de) 2007-03-28
KR20030032896A (ko) 2003-04-26
US8778322B2 (en) 2014-07-15
MXPA04003513A (es) 2004-07-23
AU2002353551B2 (en) 2005-09-08
ES2283623T3 (es) 2007-11-01
CA2463517C (en) 2010-03-16
WO2003033593A1 (en) 2003-04-24
HK1071390A1 (en) 2005-07-15
DE60219194T2 (de) 2008-01-03
CA2463517A1 (en) 2003-04-24
DE60219194D1 (de) 2007-05-10

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