ATE358717T1 - Herstellung enzymatisch aktiver, rekombinanter carboxypeptidase b - Google Patents

Herstellung enzymatisch aktiver, rekombinanter carboxypeptidase b

Info

Publication number
ATE358717T1
ATE358717T1 AT96905218T AT96905218T ATE358717T1 AT E358717 T1 ATE358717 T1 AT E358717T1 AT 96905218 T AT96905218 T AT 96905218T AT 96905218 T AT96905218 T AT 96905218T AT E358717 T1 ATE358717 T1 AT E358717T1
Authority
AT
Austria
Prior art keywords
procpb
enzymatically active
production
active cpb
recombinant carboxypeptidase
Prior art date
Application number
AT96905218T
Other languages
English (en)
Inventor
Jacob Hartman
Netta Fulga
Simona Mendelovitch
Marian Gorecki
Original Assignee
Ferring Int Ct Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ferring Int Ct Sa filed Critical Ferring Int Ct Sa
Application granted granted Critical
Publication of ATE358717T1 publication Critical patent/ATE358717T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT96905218T 1995-01-25 1996-01-25 Herstellung enzymatisch aktiver, rekombinanter carboxypeptidase b ATE358717T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US37823395A 1995-01-25 1995-01-25

Publications (1)

Publication Number Publication Date
ATE358717T1 true ATE358717T1 (de) 2007-04-15

Family

ID=23492292

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96905218T ATE358717T1 (de) 1995-01-25 1996-01-25 Herstellung enzymatisch aktiver, rekombinanter carboxypeptidase b

Country Status (21)

Country Link
US (1) US5948668A (de)
EP (1) EP0871718B1 (de)
JP (1) JP4250716B2 (de)
KR (1) KR100566136B1 (de)
CN (1) CN1144874C (de)
AT (1) ATE358717T1 (de)
AU (1) AU698889B2 (de)
BR (1) BR9606795A (de)
CA (1) CA2210242C (de)
CZ (1) CZ292541B6 (de)
DE (1) DE69637011T2 (de)
DK (1) DK0871718T3 (de)
ES (1) ES2284167T3 (de)
HU (1) HU225673B1 (de)
IL (1) IL116696A (de)
MX (1) MX9705279A (de)
NZ (1) NZ302874A (de)
PL (1) PL183228B1 (de)
PT (1) PT871718E (de)
WO (1) WO1996023064A1 (de)
ZA (1) ZA96515B (de)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP9900062A3 (en) 1995-08-16 1999-11-29 Zeneca Ltd Chemical compounds
ATE498409T1 (de) 1998-08-06 2011-03-15 Mountain View Pharmaceuticals Peg-uricase konjugate und verwendung davon
US20040117863A1 (en) * 1998-09-18 2004-06-17 Edge Michael D. Transgenically produced fusion proteins
DE19915938A1 (de) * 1999-04-09 2000-10-19 Aventis Pharma Gmbh Herstellung von pankreatischer Procarboxypeptidase B, Isoformen und Muteinen davon und ihre Verwendung
RU2002110121A (ru) * 1999-09-17 2004-03-10 Джитиси Байотерапьютикс, Инк. (Us) Слитые белки, полученные трансгенным способом
CA2385883A1 (en) * 1999-09-29 2001-04-05 Lexicon Genetics Incorporated Human carboxypeptidases and polynucleotides encoding the same
EP1632575B1 (de) * 1999-09-29 2009-01-28 Lexicon Pharmaceuticals, Inc. Humane Carboxypeptidasen und diese kodierende Polynukleotide
AU2001229253A1 (en) * 2000-01-12 2001-07-24 Eli Lilly And Company Carboxypeptidase b free of animal products and contaminating enyzme activity
ES2337684T3 (es) * 2003-12-05 2010-04-28 F. Hoffmann-La Roche Ag Carboxipeptidasa b recombinante y su purificacion.
EP1538203B1 (de) * 2003-12-05 2010-01-20 Roche Diagnostics GmbH Rekombinante Carboxypeptidase B und ihre Aufreinigung
PT1794294E (pt) * 2004-09-27 2011-10-13 Sanofi Aventis Deutschland Carboxipeptidase b recombinante
MX2007012548A (es) 2005-04-11 2008-03-11 Savient Pharmaceuticals Inc Formas variantes de urato oxidasa y uso de las mismas.
US20080159976A1 (en) * 2005-04-11 2008-07-03 Jacob Hartman Methods for lowering elevated uric acid levels using intravenous injections of PEG-uricase
US8148123B2 (en) 2005-04-11 2012-04-03 Savient Pharmaceuticals, Inc. Methods for lowering elevated uric acid levels using intravenous injections of PEG-uricase
SG161247A1 (en) 2005-04-11 2010-05-27 Savient Pharmaceuticals Inc Variant forms of urate oxidase and use thereof
EP1883425A1 (de) * 2005-05-23 2008-02-06 Universite De Geneve Injizierbare superparamagnetische nanoteilchen zur behandlung von hyperthermie und verwendung zur bildung eines hyperthermischen implantats
JP5033177B2 (ja) 2006-04-12 2012-09-26 サビエント ファーマセウティカルズ インク． 陽イオン界面活性剤によるタンパク質の精製
CN101058805B (zh) * 2007-03-21 2011-09-07 北京贯虹科技有限公司 突变羧肽酶原b及突变羧肽酶b的生产方法
US8993714B2 (en) * 2007-10-26 2015-03-31 Imiplex Llc Streptavidin macromolecular adaptor and complexes thereof
US9102526B2 (en) 2008-08-12 2015-08-11 Imiplex Llc Node polypeptides for nanostructure assembly
US9285363B2 (en) 2009-05-11 2016-03-15 Imiplex Llc Method of protein nanostructure fabrication
US9377454B2 (en) 2009-06-25 2016-06-28 Crealta Pharmaceuticals Llc Methods and kits for predicting infusion reaction risk and antibody-mediated loss of response by monitoring serum uric acid during pegylated uricase therapy
CN101967467B (zh) * 2009-07-28 2012-11-14 上海雅心生物技术有限公司 一种高稳定性的重组羧肽酶b的生产及应用
CN116637177A (zh) 2016-11-11 2023-08-25 好利恩治疗美国公司 泼尼松和尿酸酶分子的组合疗法及其用途
WO2020160325A1 (en) 2019-01-30 2020-08-06 Horizon Pharma Rheumatology Llc Reducing immunogenicity to pegloticase
WO2020160322A1 (en) 2019-01-30 2020-08-06 Horizon Pharma Rheumatology Llc Tolerization reduces intolerance to pegloticase and prolongs the urate lowering effect (triple)
US11918624B2 (en) * 2020-06-10 2024-03-05 Kelsius Laboratories LLC Therapeutic composition for use in the treatment of COVID-19 and other cytokine storm associated disorders
US12269875B2 (en) 2023-08-03 2025-04-08 Jeff R. Peterson Gout flare prevention methods using IL-1BETA blockers
CN121022890A (zh) * 2025-08-01 2025-11-28 合肥美诺生物科技有限公司 羧肽酶b前体基因序列、重组羧肽酶b前体及羧肽酶b的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3625829A (en) * 1967-12-04 1971-12-07 Bayer Ag Purification of carboxypeptidase b
US4511503A (en) * 1982-12-22 1985-04-16 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
HU190129B (en) * 1983-07-11 1986-08-28 Reanal Finomvegyszergyar,Hu Process for the isolation of carboxypeptidase b enzyme from mammal pancreas
US5206161A (en) * 1991-02-01 1993-04-27 Genentech, Inc. Human plasma carboxypeptidase B
FR2692907B1 (fr) * 1992-06-25 1995-06-30 Rhone Poulenc Rorer Sa Levures kluyveromyces modifiees, preparation et utilisation.
JP3472587B2 (ja) * 1992-08-28 2003-12-02 アベンティス ファーマ株式会社 骨関連カルボキシペプチダーゼ様タンパク質およびその製造法
JPH09505998A (ja) * 1993-11-16 1997-06-17 イーライ・リリー・アンド・カンパニー ブタ膵臓カルボキシペプチダーゼｂをコードするｄｎａ配列

Also Published As

Publication number Publication date
JP4250716B2 (ja) 2009-04-08
BR9606795A (pt) 1997-12-30
AU4903496A (en) 1996-08-14
PT871718E (pt) 2007-06-26
DK0871718T3 (da) 2007-07-02
EP0871718A1 (de) 1998-10-21
HU225673B1 (en) 2007-06-28
MX9705279A (es) 1998-06-30
PL321499A1 (en) 1997-12-08
CN1177377A (zh) 1998-03-25
HUP9800091A3 (en) 2004-03-29
JPH11503002A (ja) 1999-03-23
HUP9800091A2 (hu) 1998-05-28
CA2210242C (en) 2010-04-27
CZ292541B6 (cs) 2003-10-15
NZ302874A (en) 1998-11-25
PL183228B1 (pl) 2002-06-28
HK1014986A1 (en) 1999-10-08
US5948668A (en) 1999-09-07
DE69637011D1 (de) 2007-05-16
WO1996023064A1 (en) 1996-08-01
CN1144874C (zh) 2004-04-07
ZA96515B (en) 1996-08-15
CZ225897A3 (cs) 1998-10-14
IL116696A0 (en) 1996-05-14
IL116696A (en) 1999-08-17
ES2284167T3 (es) 2007-11-01
KR100566136B1 (ko) 2006-11-10
AU698889B2 (en) 1998-11-12
KR19980701652A (ko) 1998-06-25
EP0871718B1 (de) 2007-04-04
EP0871718A4 (de) 2000-06-07
DE69637011T2 (de) 2007-12-13
CA2210242A1 (en) 1996-08-01

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