ATE359276T1 - Aryloxyphenyl und arylsulfanylphenylderivate - Google Patents

Aryloxyphenyl und arylsulfanylphenylderivate

Info

Publication number
ATE359276T1
ATE359276T1 AT02787451T AT02787451T ATE359276T1 AT E359276 T1 ATE359276 T1 AT E359276T1 AT 02787451 T AT02787451 T AT 02787451T AT 02787451 T AT02787451 T AT 02787451T AT E359276 T1 ATE359276 T1 AT E359276T1
Authority
AT
Austria
Prior art keywords
arylsulfanylphenyl
aryloxyphenyl
derivatives
compounds
valuable
Prior art date
Application number
AT02787451T
Other languages
English (en)
Inventor
Garrick Paul Smith
Gitte Mikkelsen
Kim Andersen
Daniel Greve
Thomas Ruhland
Stephen P Wren
Original Assignee
Lundbeck & Co As H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H
Application granted granted Critical
Publication of ATE359276T1 publication Critical patent/ATE359276T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT02787451T 2001-12-20 2002-12-16 Aryloxyphenyl und arylsulfanylphenylderivate ATE359276T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US34265301P 2001-12-20 2001-12-20
DKPA200101927 2001-12-20

Publications (1)

Publication Number Publication Date
ATE359276T1 true ATE359276T1 (de) 2007-05-15

Family

ID=26069114

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02787451T ATE359276T1 (de) 2001-12-20 2002-12-16 Aryloxyphenyl und arylsulfanylphenylderivate

Country Status (15)

Country Link
US (1) US7067501B2 (de)
EP (1) EP1458689B1 (de)
JP (1) JP2005513128A (de)
CN (1) CN100457738C (de)
AT (1) ATE359276T1 (de)
AU (1) AU2002351734A1 (de)
CA (1) CA2467118A1 (de)
DE (1) DE60219521T2 (de)
ES (1) ES2280595T3 (de)
HU (1) HUP0402320A2 (de)
IL (1) IL161966A0 (de)
IS (1) IS7258A (de)
MX (1) MXPA04005989A (de)
NO (1) NO20042885L (de)
WO (1) WO2003053942A1 (de)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA81749C2 (uk) 2001-10-04 2008-02-11 Х. Луннбек А/С Фенілпіперазинові похідні як інгібітори зворотного захоплення серотоніну
CA2536275A1 (en) * 2003-08-21 2005-03-03 H. Lundbeck A/S The combination of a serotonin reuptake inhibitor and a glycine transporter type 1 inhibitor for the treatment of depression
WO2005058885A2 (en) * 2003-12-18 2005-06-30 Glaxo Group Limited Piperidine derivatives and their use as glycine transporter inhibitors
WO2005058317A1 (en) * 2003-12-18 2005-06-30 Glaxo Group Limited Glycine transporter-1 inhibirors
CA2553938A1 (en) * 2004-01-08 2005-07-28 F. Hoffmann-La Roche Ag Diaza-spiropiperidine derivatives as inhibitors of glycine transporter 1 and glycine transporter 2
WO2006000222A2 (en) * 2004-06-24 2006-01-05 H. Lundbeck A/S The combination of an antipsychotic and a glycine transporter type i inhibitor for the treatment of schizophrenia
US7485637B2 (en) * 2005-01-04 2009-02-03 Hoffmann-La Roche Inc. Benzoyl-tetrahydropiperidine derivatives
MY150647A (en) 2006-06-16 2014-02-14 Lundbeck & Co As H 1-[2-(2,4-dimethylphenylsulfanyl)-phenyl] piperazine as a compound with combined serotonin reuptake, 5-ht3 and 5-ht1a activity for the treatment of cognitive impairment
SG172685A1 (en) 2006-06-28 2011-07-28 Amgen Inc Glycine transporter-1 inhibitors
TW200848411A (en) * 2007-03-20 2008-12-16 Lundbeck & Co As H Novel therapeutic uses of 1-[2-(2, 4-dimethylphenylsulfanyl)phenyl]-piperazine
CN101784533B (zh) 2007-08-22 2013-08-21 艾博特股份有限两合公司 4-苄基氨基喹啉、含有它们的药物组合物和它们在治疗中的用途
TW200932233A (en) * 2007-11-13 2009-08-01 Lundbeck & Co As H Therapeutic uses of compounds having combined SERT, 5-HT3 and 5-HT1a activity
AU2008335788B2 (en) * 2007-12-12 2012-11-29 Amgen Inc. Glycine transporter-1 inhibitors
EP2271625B1 (de) 2008-04-01 2012-09-12 Abbott GmbH & Co. KG Tetrahydroisochinoline, pharmazeutische zusammensetzungen damit und ihre therapeutische verwendung
AR075442A1 (es) 2009-02-16 2011-03-30 Abbott Gmbh & Co Kg Derivados de aminotetralina, composiciones farmaceuticas que las contienen y sus usos en terapia
TW201038569A (en) 2009-02-16 2010-11-01 Abbott Gmbh & Co Kg Heterocyclic compounds, pharmaceutical compositions containing them, and their use in therapy
EP2539706B1 (de) * 2010-02-24 2015-03-04 Research Triangle Institute Arylpiperazin-opioid-rezeptor-antagonisten
US9051280B2 (en) 2010-08-13 2015-06-09 AbbVie Deutschland GmbH & Co. KG Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy
US9045459B2 (en) 2010-08-13 2015-06-02 AbbVie Deutschland GmbH & Co. KG Phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy
US8877794B2 (en) 2010-08-13 2014-11-04 Abbott Laboratories Phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy
US8883839B2 (en) 2010-08-13 2014-11-11 Abbott Laboratories Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy
US8846743B2 (en) 2010-08-13 2014-09-30 Abbott Laboratories Aminoindane derivatives, pharmaceutical compositions containing them, and their use in therapy
US9309200B2 (en) 2011-05-12 2016-04-12 AbbVie Deutschland GmbH & Co. KG Benzazepine derivatives, pharmaceutical compositions containing them, and their use in therapy
MX2014001457A (es) 2011-08-05 2014-08-21 Abbvie Deutschland Derivados de aminocromano, de aminotiocromano y de amino-1,2,3,4-tetrahidroquinolina composiciones farmaceuticas que los contienen, y su uso en terapia.
WO2013072520A1 (en) 2011-11-18 2013-05-23 AbbVie Deutschland GmbH & Co. KG N-substituted aminobenzocycloheptene, aminotetraline, aminoindane and phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy
MX344144B (es) * 2012-01-03 2016-12-07 H Lundbeck As Proceso para la fabricacion de 1-[2-(2,4-dimetilfenilsulfanil)feni l] piperazina.
US9365512B2 (en) 2012-02-13 2016-06-14 AbbVie Deutschland GmbH & Co. KG Isoindoline derivatives, pharmaceutical compositions containing them, and their use in therapy
HRP20170607T1 (hr) * 2013-02-22 2017-06-30 H. Lundbeck A/S Proizvodni postupak vortioksetina
US9656955B2 (en) 2013-03-15 2017-05-23 Abbvie Inc. Pyrrolidine derivatives, pharmaceutical compositions containing them, and their use in therapy
US9650334B2 (en) 2013-03-15 2017-05-16 Abbvie Inc. Pyrrolidine derivatives, pharmaceutical compositions containing them, and their use in therapy
CA2924689A1 (en) 2013-10-17 2015-04-23 AbbVie Deutschland GmbH & Co. KG Aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquinoline derivatives, pharmaceutical compositions containing them, and their use in therapy
JP2016533375A (ja) 2013-10-17 2016-10-27 アッヴィ・ドイチュラント・ゲー・エム・ベー・ハー・ウント・コー・カー・ゲー アミノテトラリン誘導体およびアミノインダン誘導体、これらを含有する医薬組成物、および治療におけるこれらの使用
US9550754B2 (en) 2014-09-11 2017-01-24 AbbVie Deutschland GmbH & Co. KG 4,5-dihydropyrazole derivatives, pharmaceutical compositions containing them, and their use in therapy
KR101753617B1 (ko) 2016-05-10 2017-07-11 주식회사 뉴로벤티 피페라진-1-카복사미딘 또는 이의 약학적으로 허용가능한 염을 유효성분으로 포함하는 자폐 범주성 장애 예방 및 치료용 약학적 조성물
WO2017215636A1 (zh) 2016-06-16 2017-12-21 广东东阳光药业有限公司 二芳基硫醚哌嗪类化合物及其制备方法和用途
CN106279071B (zh) * 2016-08-10 2019-01-04 广东东阳光药业有限公司 苯基哌嗪衍生物及其使用方法和用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5730738A (en) 1995-12-04 1998-03-24 The Procter & Gamble Company Absorbent article with angled band structural elastic-like film cuffs
JPH10152470A (ja) * 1996-09-25 1998-06-09 Yoshitomi Pharmaceut Ind Ltd ピペラジン化合物
AU726447B2 (en) * 1996-10-21 2000-11-09 Neurosearch A/S 1-phenyl-benzimidazole compounds and their use as BAGA-A receptor modulators
CA2536275A1 (en) * 2003-08-21 2005-03-03 H. Lundbeck A/S The combination of a serotonin reuptake inhibitor and a glycine transporter type 1 inhibitor for the treatment of depression

Also Published As

Publication number Publication date
HK1076807A1 (zh) 2006-01-27
IL161966A0 (en) 2005-11-20
MXPA04005989A (es) 2004-09-27
AU2002351734A1 (en) 2003-07-09
EP1458689A1 (de) 2004-09-22
US7067501B2 (en) 2006-06-27
CA2467118A1 (en) 2003-07-03
EP1458689B1 (de) 2007-04-11
DE60219521T2 (de) 2007-08-16
HUP0402320A2 (hu) 2005-03-29
IS7258A (is) 2004-05-10
CN100457738C (zh) 2009-02-04
DE60219521D1 (de) 2007-05-24
ES2280595T3 (es) 2007-09-16
JP2005513128A (ja) 2005-05-12
WO2003053942A1 (en) 2003-07-03
CN1606548A (zh) 2005-04-13
NO20042885L (no) 2004-07-07
US20050171061A1 (en) 2005-08-04

Similar Documents

Publication Publication Date Title
DE60219521D1 (de) Aryloxyphenyl und arylsulfanylphenylderivate
CY1109006T1 (el) Παραγωγα πουρινης ως αναστολεις κινασης
CY1106132T1 (el) Παραγωγα πιπepιδινης ως αναστολεις καναλιου καλιου
ATE420879T1 (de) Indolizine als kinaseproteinhemmer
PL372926A1 (en) Piperidine-pyridazones and phthalazones as pde4 inhibitors
CY1105386T1 (el) Βενζοϋλοσουλφοναμιδια και σουλφονυλβενζαμιδινες για χρηση σαν παραγοντες κατα του ογκου
EE200300459A (et) Uued spirotritsüklilised derivaadid ja nende kasutamine fosfodiesteraas-7 inhibiitoritena
CY1112780T1 (el) Νεα σουλφονυλοπυρρολια ως αναστολεις της ηdac
DK1836201T3 (da) Pyrrolidininhibitorer af IAP
CY1114284T1 (el) Σουλφονυλοπυρρολες ως hdac αναστολεις
DE60135919D1 (de) Farnesyl transferase-hemmende 6-heterocyclylmethyl-chinolin und chinazol-derivate
CY1110498T1 (el) Παραγωγα πυραζολης ως αναστολεις των κινασων τυροσινης υποδοχεα
IL163777A0 (en) Kinase inhibitors
NO20043016L (no) 6-aminomorfinan-derivater, fremgangsmate for fremstilling og anvendelse derav
SE0103710D0 (sv) Compounds
DE60316984D1 (de) Benzoylsulfonamide als antitumor-mittel
EA201000566A1 (ru) Гетероциклические сетр ингибиторы
EA200600607A1 (ru) Производные имидазопиридина в качестве ингибиторов индуцируемой no-синтазы
CY1111081T1 (el) Νεα μεθοδος συνθεσης του (7-μεθοξυ-1-ναφθυλ) ακετονιτριλιου και εφαρμογη στη συνθεση της αγκομελατινης
DK1377574T3 (da) 6-phenylbenzonaphtyridiner
EA200600601A1 (ru) Производные аминопиридина в качестве ингибиторов индуцируемой no-синтазы
ATE371662T1 (de) Siliziumverbindungen und deren verwendung
EA200600608A1 (ru) Производные имидазопиридина как ингибиторы индуцируемой no-синтазы
EA200600609A1 (ru) Производные имидазопиридина в качестве ингибиторов индуцируемой no-синтазы
ATE321760T1 (de) N-aryl-2-oxazolidinone und deren derivate

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties