ATE360014T1 - Bicyclische pyrrolidinverbindungen - Google Patents
Bicyclische pyrrolidinverbindungenInfo
- Publication number
- ATE360014T1 ATE360014T1 AT02762286T AT02762286T ATE360014T1 AT E360014 T1 ATE360014 T1 AT E360014T1 AT 02762286 T AT02762286 T AT 02762286T AT 02762286 T AT02762286 T AT 02762286T AT E360014 T1 ATE360014 T1 AT E360014T1
- Authority
- AT
- Austria
- Prior art keywords
- treatment
- pyrrolidine compounds
- 7alkanes
- bicyclic pyrrolidine
- bicyclic
- Prior art date
Links
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical class C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 title 1
- -1 hydroxyaminocarbonyl Chemical group 0.000 abstract 2
- 208000035143 Bacterial infection Diseases 0.000 abstract 1
- 208000022362 bacterial infectious disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000003396 thiol group Chemical class [H]S* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pyrrole Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29841801P | 2001-06-15 | 2001-06-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE360014T1 true ATE360014T1 (de) | 2007-05-15 |
Family
ID=23150431
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02762286T ATE360014T1 (de) | 2001-06-15 | 2002-06-14 | Bicyclische pyrrolidinverbindungen |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US6987104B2 (de) |
| EP (1) | EP1406893B1 (de) |
| JP (1) | JP4314340B2 (de) |
| CN (1) | CN1512991A (de) |
| AT (1) | ATE360014T1 (de) |
| BR (1) | BR0210422A (de) |
| CA (1) | CA2446931A1 (de) |
| CY (1) | CY1107688T1 (de) |
| DE (1) | DE60219630T2 (de) |
| DK (1) | DK1406893T3 (de) |
| ES (1) | ES2283589T3 (de) |
| PT (1) | PT1406893E (de) |
| WO (1) | WO2002102791A1 (de) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE360014T1 (de) * | 2001-06-15 | 2007-05-15 | Vicuron Pharm Inc | Bicyclische pyrrolidinverbindungen |
| WO2004026824A1 (en) * | 2002-09-19 | 2004-04-01 | Novartis Ag | Process for preparing intermediates |
| BRPI0407448A (pt) * | 2003-02-21 | 2006-01-31 | Novartis Ag | Processo quìmico |
| AU2004266896B2 (en) | 2003-08-23 | 2010-08-19 | Merck Serono Sa | Derivatives of hydroxamic acid as metalloproteinase inhibitors |
| GB0319917D0 (en) * | 2003-08-23 | 2003-09-24 | British Biotech Pharm | Metalloproteinase inhibitors |
| EP1732907A1 (de) * | 2004-03-26 | 2006-12-20 | Arpida A/S | Peptid-deformylase-hemmer |
| US7638513B2 (en) | 2004-06-02 | 2009-12-29 | Schering Corporation | Compounds for the treatment of inflammatory disorders |
| PE20060426A1 (es) | 2004-06-02 | 2006-06-28 | Schering Corp | DERIVADOS DE ACIDO TARTARICO COMO INHIBIDORES DE MMPs, ADAMs, TACE Y TNF-alfa |
| US20080161249A1 (en) * | 2004-11-17 | 2008-07-03 | Smithkline Beecham Corporation | Use of Novel Antibacterial Compounds |
| GT200600196A (es) * | 2005-05-23 | 2007-01-15 | Compuestos n-formil de hidroxilamina | |
| US7553864B2 (en) | 2005-12-01 | 2009-06-30 | Schering Corporation | Compounds for the treatment of inflammatory disorders and microbial diseases |
| SG133452A1 (en) * | 2005-12-30 | 2007-07-30 | Novartis Ag | Peptide deformylase inhibitors for treatment of mycobacterial and other parasitic diseases |
| US9085566B2 (en) * | 2007-02-02 | 2015-07-21 | Baylor College Of Medicine | Compositions and methods for the treatment of metabolic and related disorders |
| US9187485B2 (en) | 2007-02-02 | 2015-11-17 | Baylor College Of Medicine | Methods and compositions for the treatment of cancer and related hyperproliferative disorders |
| EP2315746A1 (de) * | 2008-08-04 | 2011-05-04 | Schering Corporation | Harnstoffderivate als antibakterielle mittel |
| US10738028B2 (en) | 2016-05-11 | 2020-08-11 | Rudong Ruien Pharmaceutical Technology Co. Ltd | Spiro three-membered ring, spiro five-membered ring peptide deformylase inhibitor and use thereof in antibacteria and anti-tumor |
| CN109475525A (zh) * | 2016-07-21 | 2019-03-15 | 荷兰联合利华有限公司 | 4-(4-氯苯基)-5-亚甲基-吡咯-2-酮和5-亚甲基-4-(对甲苯基)吡咯-2-酮用于治疗革兰氏阴性细菌感染 |
| US11083706B2 (en) | 2016-07-21 | 2021-08-10 | Conopco, Inc. | Lactams for use in the treatment of skin lesions |
Family Cites Families (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4052511A (en) | 1976-02-13 | 1977-10-04 | E. R. Squibb & Sons, Inc. | Carboxyacylproline derivatives |
| US4290952A (en) * | 1980-06-23 | 1981-09-22 | American Home Products Corporation | Aryl-1-mercaptoalkanoylproline and homoproline derivatives |
| US4320057A (en) * | 1980-06-23 | 1982-03-16 | American Home Products Corporation | Aryl--pyrrolo--thiazepin--diones and aryl--piperidino--thiazepin--diones |
| US4311705A (en) | 1980-10-06 | 1982-01-19 | E. R. Squibb & Sons, Inc. | Carboxyalkanoyl and hydroxycarbamoylalkanoyl derivatives of substituted prolines |
| US4321383A (en) | 1980-11-24 | 1982-03-23 | E. R. Squibb & Sons, Inc. | Heterobicyclo intermediates |
| US4303662A (en) | 1980-11-24 | 1981-12-01 | E. R. Squibb & Sons, Inc. | Carboxyacyl, mercapto and acylmercapto derivatives of heterobicyclo compounds |
| JPS6188884A (ja) | 1984-10-04 | 1986-05-07 | Sankyo Co Ltd | エンケフアリナ−ゼｂ阻害物質およびその製法 |
| US4599361A (en) | 1985-09-10 | 1986-07-08 | G. D. Searle & Co. | Hydroxamic acid based collagenase inhibitors |
| DK77487A (da) | 1986-03-11 | 1987-09-12 | Hoffmann La Roche | Hydroxylaminderivater |
| FR2609289B1 (fr) | 1987-01-06 | 1991-03-29 | Bellon Labor Sa Roger | Nouveaux composes a activite d'inhibiteurs de collagenase, procede pour les preparer et compositions pharmaceutiques contenant ces composes |
| US5128346A (en) | 1987-09-21 | 1992-07-07 | Abbott Laboratories | Derivatives of D-glutamic acid and D-aspartic acid |
| EP0334244A3 (de) | 1988-03-25 | 1991-05-29 | The Procter & Gamble Company | Peptide-Antagonisten von Bradykinin |
| GB8827308D0 (en) | 1988-11-23 | 1988-12-29 | British Bio Technology | Compounds |
| GB8827305D0 (en) | 1988-11-23 | 1988-12-29 | British Bio Technology | Compounds |
| GB8919251D0 (en) | 1989-08-24 | 1989-10-04 | British Bio Technology | Compounds |
| GB8921326D0 (en) | 1989-09-21 | 1989-11-08 | Beecham Group Plc | Novel treatment |
| US5268384A (en) | 1990-11-21 | 1993-12-07 | Galardy Richard E | Inhibition of angiogenesis by synthetic matrix metalloprotease inhibitors |
| CA2073510A1 (en) | 1990-12-03 | 1992-06-04 | Celltech Therapeutics Limited | Peptidyl derivatives |
| CA2058797A1 (en) | 1991-02-01 | 1992-08-02 | Michael John Broadhurst | Amino acid derivatives |
| GB9102635D0 (en) | 1991-02-07 | 1991-03-27 | British Bio Technology | Compounds |
| IT1245712B (it) | 1991-04-09 | 1994-10-14 | Boehringer Mannheim Italia | Ammine eterocicliche utili terapia dell'asma e dell'infiammazione delle vie aeree |
| AU2228292A (en) | 1991-06-14 | 1993-01-12 | Research Corporation Technologies, Inc. | Peptide derivatives of collagenase inhibitor |
| US5256657A (en) | 1991-08-19 | 1993-10-26 | Sterling Winthrop, Inc. | Succinamide derivative matrix-metalloprotease inhibitors |
| JPH05125029A (ja) | 1991-11-06 | 1993-05-21 | Yamanouchi Pharmaceut Co Ltd | 新規なアミド化合物又はその塩 |
| CZ112694A3 (en) | 1991-11-08 | 1994-12-15 | Sankyo Co | Derivatives of piperizinecarboxylic acids and process for preparing thereof |
| JP3348725B2 (ja) | 1992-04-07 | 2002-11-20 | ブリティッシュ バイオテック ファーマシューティカルズ リミテッド | ヒドロキサム酸ベースのコラゲナーゼとサイトカイン阻害剤 |
| GB9211707D0 (en) | 1992-06-03 | 1992-07-15 | Celltech Ltd | Peptidyl derivatives |
| GB9211706D0 (en) | 1992-06-03 | 1992-07-15 | Celltech Ltd | Peptidyl derivatives |
| US5318964A (en) | 1992-06-11 | 1994-06-07 | Hoffmann-La Roche Inc. | Hydroxamic derivatives and pharmaceutical compositions |
| GB9215665D0 (en) | 1992-07-23 | 1992-09-09 | British Bio Technology | Compounds |
| US5552419A (en) | 1993-01-06 | 1996-09-03 | Ciba-Geigy Corporation | Arylsulfonamido-substituted hydroxamic acids |
| WO1994021612A1 (en) | 1993-03-18 | 1994-09-29 | Otsuka Pharmaceutical Co., Ltd. | Carbostyril derivatives as matrix metalloproteinases inhibitors |
| EP0648205B1 (de) | 1993-04-27 | 1999-07-14 | Celltech Therapeutics Limited | Peptidylderivate als inhibitoren von metalloproteinase |
| GB9308695D0 (en) | 1993-04-27 | 1993-06-09 | Celltech Ltd | Peptidyl derivatives |
| GB9501737D0 (en) | 1994-04-25 | 1995-03-22 | Hoffmann La Roche | Hydroxamic acid derivatives |
| GB9411598D0 (en) | 1994-06-09 | 1994-08-03 | Hoffmann La Roche | Hydroxamic acid derivatives |
| GB9502858D0 (en) | 1995-02-14 | 1995-04-05 | British Biotech Pharm | Novel use of matrix metalloproteinase inhibitors |
| GB9504084D0 (en) | 1995-03-01 | 1995-04-19 | British Biotech Pharm | Synthesis of carboxylic and hydroxamic acid derivatives |
| US5876727A (en) * | 1995-03-31 | 1999-03-02 | Immulogic Pharmaceutical Corporation | Hapten-carrier conjugates for use in drug-abuse therapy and methods for preparation of same |
| FR2733750B1 (fr) | 1995-05-03 | 1997-06-13 | Synthelabo | Derives de l'acide gamma-oxo-alpha-(phenylmethyl)-5,6- dihydro-4h-thieno(3,4-c)pyrrole-5-butanoique, leur preparation et leur application en therapeutique |
| DE69734321T2 (de) | 1996-02-23 | 2006-08-10 | Eli Lilly And Co., Indianapolis | Non-peptidische vasopressin via antagonisten |
| TW448172B (en) | 1996-03-08 | 2001-08-01 | Pharmacia & Upjohn Co Llc | Novel hydroxamic acid derivatives useful for the treatment of diseases related to connective tissue degradation |
| GB9613547D0 (en) | 1996-06-27 | 1996-08-28 | Pharmacia Spa | Matrix metalloproteinase inhibitors |
| AUPO721997A0 (en) | 1997-06-06 | 1997-07-03 | Queensland Institute Of Medical Research, The | Anticancer compounds |
| AU8858398A (en) | 1997-07-10 | 1999-02-08 | Pharmacia & Upjohn S.P.A. | Matrix metalloproteinase inhibitors |
| CN1298299A (zh) * | 1998-02-07 | 2001-06-06 | 英国生物技术药物有限公司 | 抗菌剂 |
| US6797820B2 (en) * | 1999-12-17 | 2004-09-28 | Vicuron Pharmaceuticals Inc. | Succinate compounds, compositions and methods of use and preparation |
| AU2268401A (en) * | 1999-12-17 | 2001-06-25 | Versicor Inc | Novel succinate compounds, compositions and methods of use and preparation |
| US6852752B2 (en) * | 1999-12-17 | 2005-02-08 | Vicuron Pharmaceuticals Inc. | Urea compounds, compositions and methods of use and preparation |
| AU2002230385A1 (en) * | 2000-09-25 | 2002-04-15 | Questcor Pharmaceuticals, Inc. | Peptide deformylase inhibitors |
| ATE360014T1 (de) * | 2001-06-15 | 2007-05-15 | Vicuron Pharm Inc | Bicyclische pyrrolidinverbindungen |
| AR036053A1 (es) * | 2001-06-15 | 2004-08-04 | Versicor Inc | Compuestos de n-formil-hidroxilamina, un proceso para su preparacion y composiciones farmaceuticas |
| WO2004026824A1 (en) | 2002-09-19 | 2004-04-01 | Novartis Ag | Process for preparing intermediates |
| BRPI0407448A (pt) | 2003-02-21 | 2006-01-31 | Novartis Ag | Processo quìmico |
| TW200427458A (en) | 2003-04-02 | 2004-12-16 | Novartis Ag | Crystalline N-formyl hydroxylamine compounds |
| EP1641778A1 (de) | 2003-06-26 | 2006-04-05 | Novartis AG | Verfahren zur herstellung von zwischenprodukten für antibakterielle n-formyl hydroxylamine |
| GT200600196A (es) | 2005-05-23 | 2007-01-15 | Compuestos n-formil de hidroxilamina |
-
2002
- 2002-06-14 AT AT02762286T patent/ATE360014T1/de not_active IP Right Cessation
- 2002-06-14 ES ES02762286T patent/ES2283589T3/es not_active Expired - Lifetime
- 2002-06-14 EP EP02762286A patent/EP1406893B1/de not_active Expired - Lifetime
- 2002-06-14 CA CA002446931A patent/CA2446931A1/en not_active Abandoned
- 2002-06-14 DK DK02762286T patent/DK1406893T3/da active
- 2002-06-14 CN CNA028109902A patent/CN1512991A/zh active Pending
- 2002-06-14 JP JP2003506264A patent/JP4314340B2/ja not_active Expired - Fee Related
- 2002-06-14 BR BR0210422-9A patent/BR0210422A/pt not_active IP Right Cessation
- 2002-06-14 WO PCT/EP2002/006586 patent/WO2002102791A1/en not_active Ceased
- 2002-06-14 US US10/171,705 patent/US6987104B2/en not_active Expired - Fee Related
- 2002-06-14 PT PT02762286T patent/PT1406893E/pt unknown
- 2002-06-14 DE DE60219630T patent/DE60219630T2/de not_active Expired - Lifetime
-
2005
- 2005-06-13 US US11/151,131 patent/US7612059B2/en not_active Expired - Fee Related
-
2007
- 2007-06-28 CY CY20071100856T patent/CY1107688T1/el unknown
-
2008
- 2008-12-03 US US12/327,245 patent/US20090149509A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| DE60219630T2 (de) | 2007-12-27 |
| CN1512991A (zh) | 2004-07-14 |
| JP4314340B2 (ja) | 2009-08-12 |
| US20030069223A1 (en) | 2003-04-10 |
| EP1406893B1 (de) | 2007-04-18 |
| EP1406893A1 (de) | 2004-04-14 |
| US7612059B2 (en) | 2009-11-03 |
| CA2446931A1 (en) | 2002-12-27 |
| PT1406893E (pt) | 2007-07-12 |
| WO2002102791A1 (en) | 2002-12-27 |
| US20090149509A1 (en) | 2009-06-11 |
| ES2283589T3 (es) | 2007-11-01 |
| DK1406893T3 (da) | 2007-08-06 |
| JP2005501020A (ja) | 2005-01-13 |
| US6987104B2 (en) | 2006-01-17 |
| CY1107688T1 (el) | 2013-04-18 |
| US20050277683A1 (en) | 2005-12-15 |
| BR0210422A (pt) | 2004-08-17 |
| DE60219630D1 (de) | 2007-05-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CY1107688T1 (el) | Δικυκλικες ενωσεις πυρρολιδινης | |
| CY1116754T1 (el) | Παραγωγα νιτροκατεχολης ως αναστολεις της comt | |
| SE0202241D0 (sv) | Novel Compounds | |
| ATE484508T1 (de) | Furylverbindungen | |
| BR0316350A (pt) | Diaminotriazóis úteis como inibidores de proteìna cinases | |
| ME00572A (en) | Trisubstituted aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto | |
| NO20073783L (no) | Pyrrolidininhibitorer for IAP | |
| BR0116804A (pt) | Derivados fenìlicos | |
| BR0313634A (pt) | Derivados de benzimidazol | |
| DE60333746D1 (de) | Thienylverbindungen | |
| ATE461923T1 (de) | Substituierte 1h-benzimidazol-4-carbonsäureamide sind wirksame parp-inhibitoren | |
| CY1105085T1 (el) | Ενωσεις τυπου ν-φορμυλο υδροξυλαμινης ως αναστολεις της pdf | |
| CY1110537T1 (el) | Ενωσεις και μεθοδοι για την αγωγη της δυσλιπιδαιμιας | |
| NO20064325L (no) | Heteroarylaminopyrazolderivativer nyttige for behandling av diabetes | |
| BR0316723A (pt) | Derivados de anilinopirazol úteis para o tratamento de diabetes | |
| NO20056161L (no) | Formuleringer for behandling av artrittilstander | |
| PE20030061A1 (es) | 1-biaril-1,8-naftiridin-4-ona como inhibidores de fosfodiesterasa-4 | |
| NO20055741D0 (no) | Nye kjemiske forbindelser | |
| NO20054361D0 (no) | Benzensylfonamidderivater, fremgangsmate for fremstilling og anvendelse derav for behandlig av smerte | |
| CY1111432T1 (el) | Τετραϋδροκινολινες για χρηση ως διαμορφωτες της μιτοτικης κινητικης πρωτεϊνης eg5 | |
| DK1362045T3 (da) | 2-Thio-substituerede imidazolderivater og deres anvendelse inden for farmacien | |
| ECSP055844A (es) | Nuevos compuestos triciclicos | |
| DE60317935D1 (de) | Alpha-aminoamid-derivate als mittel gegen migräne | |
| EA200700400A1 (ru) | Производные n-(1h-индолил)-1н-индол-2-карбоксамидов, их получение и их применение в терапии | |
| BRPI0409405A (pt) | compostos 7-aza-quinazolina substituìdos |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1406893 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |