DK1419174T3 - Fremgangsmåde til fremstilling af glycopeptidderivater - Google Patents

Fremgangsmåde til fremstilling af glycopeptidderivater

Info

Publication number: DK1419174T3
Authority: DK; Denmark
Prior art keywords: preparation; glycopeptide derivatives; derivatives; glycopeptide; isolation
Prior art date: 2001-08-24

Application number

DK02759433T

Other languages

English (en)

Inventor

Junning Lee

Jyanwei Liu

Original Assignee

Theravance Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-08-24

Filing date

2002-08-23

Publication date

2007-07-02

2002-08-23 Application filed by Theravance Inc filed Critical Theravance Inc

2007-07-02 Application granted granted Critical

2007-07-02 Publication of DK1419174T3 publication Critical patent/DK1419174T3/da

Links

238000000034 method Methods 0.000 title abstract 3
DQJCDTNMLBYVAY-ZXXIYAEKSA-N (2S,5R,10R,13R)-16-{[(2R,3S,4R,5R)-3-{[(2S,3R,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-5-(ethylamino)-6-hydroxy-2-(hydroxymethyl)oxan-4-yl]oxy}-5-(4-aminobutyl)-10-carbamoyl-2,13-dimethyl-4,7,12,15-tetraoxo-3,6,11,14-tetraazaheptadecan-1-oic acid Chemical class NCCCC[C@H](C(=O)N[C@@H](C)C(O)=O)NC(=O)CC[C@H](C(N)=O)NC(=O)[C@@H](C)NC(=O)C(C)O[C@@H]1[C@@H](NCC)C(O)O[C@H](CO)[C@H]1O[C@H]1[C@H](NC(C)=O)[C@@H](O)[C@H](O)[C@@H](CO)O1 DQJCDTNMLBYVAY-ZXXIYAEKSA-N 0.000 title 1
239000007795 chemical reaction product Substances 0.000 abstract 1
238000002955 isolation Methods 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
MYPYJXKWCTUITO-LYRMYLQWSA-N vancomycin Chemical class O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)NC)[C@H]1C[C@](C)(N)[C@H](O)[C@H](C)O1 MYPYJXKWCTUITO-LYRMYLQWSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
- C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
- C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DK02759433T 2001-08-24 2002-08-23 Fremgangsmåde til fremstilling af glycopeptidderivater DK1419174T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US31471101P	2001-08-24	2001-08-24
PCT/US2002/026831 WO2003018607A2 (en)	2001-08-24	2002-08-23	Process for preparing glycopeptide derivatives

Publications (1)

Publication Number	Publication Date
DK1419174T3 true DK1419174T3 (da)	2007-07-02

Family

ID=23221113

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK02759433T DK1419174T3 (da)	2001-08-24	2002-08-23	Fremgangsmåde til fremstilling af glycopeptidderivater

Country Status (14)

Country	Link
US (2)	US7015305B2 (da)
EP (1)	EP1419174B1 (da)
JP (1)	JP4116546B2 (da)
KR (1)	KR100909435B1 (da)
CN (1)	CN1281619C (da)
AT (1)	ATE360029T1 (da)
AU (1)	AU2002324768A1 (da)
CA (1)	CA2457215C (da)
DE (1)	DE60219638T2 (da)
DK (1)	DK1419174T3 (da)
ES (1)	ES2284907T3 (da)
NO (1)	NO335304B1 (da)
TW (1)	TWI312785B (da)
WO (1)	WO2003018607A2 (da)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2003106399A2 (en)	2002-06-17	2003-12-24	Theravance, Inc.	PROCESS FOR PREPARING N-PROTECTED β-AMINO ALDEHYDE COMPOUNDS
TWI342312B (en) *	2003-10-22	2011-05-21	Theravance Inc	Hydrochloride salts of a glycopeptide phosphonate derivative
EP1771456A2 (fr) *	2004-07-30	2007-04-11	Palumed SA	Molecules hybrides qa ou q est une aminoquinoleine et a est un residu antibiotique, leur synthese et leurs utilisations en tant qu'agent antibacterien
WO2013034675A1 (en)	2011-09-09	2013-03-14	Sandoz Ag	Process for the synthesis of telavancin and its pharmaceutically acceptable salts as well as n-protected derivatives thereof
EP2753637A1 (en)	2011-09-09	2014-07-16	Sandoz AG	Process for the synthesis of telavancin, its pharmaceutically acceptable salts as well as an n-protected imine-derivative of telavancin
TN2017000358A1 (en)	2015-02-23	2019-01-16	Theravance Biopharma Antibiotics Ip Llc	Doses and methods of administering telavancin
CN106467570B (zh) *	2015-08-14	2020-04-07	正大天晴药业集团股份有限公司	糖肽类抗生素的还原烷基化方法
CN106631902A (zh) *	2016-09-23	2017-05-10	上海步越化工科技有限公司	一种特拉万星侧链癸基(2‑氧代乙基)氨基甲酸9h‑芴‑9‑甲基酯的制备方法
GB2577420B (en) *	2017-05-22	2022-07-06	Insmed Inc	Glycopeptide derivative compounds and uses thereof
CN111233713A (zh) *	2020-01-20	2020-06-05	福建康鸿生物科技有限公司	一种特拉万星中间体合成方法
WO2022198009A1 (en) *	2021-03-18	2022-09-22	Insmed Incorporated	Dry powder compositions of glycopeptide derivative compounds and methods of use thereof

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3160632A (en) *	1961-01-30	1964-12-08	Stauffer Chemical Co	Aminomethylenephosphinic acids, salts thereof, and process for their production
IL78597A0 (en)	1985-04-25	1986-08-31	Lilly Co Eli	Novel glycopeptide derivatives
US4698327A (en) *	1985-04-25	1987-10-06	Eli Lilly And Company	Novel glycopeptide derivatives
US4643987A (en) *	1985-08-14	1987-02-17	Eli Lilly And Company	Modified glycopeptides
PT86457B (pt)	1986-12-30	1990-11-20	Smithkline Beecham Corp	Processo para a preparacao de glicopeptidos glicosilados e de composicoes que os contem
ATE134646T1 (de) *	1988-12-27	1996-03-15	Lepetit Spa	C63-amidderivate von 34-de(acetylglucosaminyl)-34-deoxy-teicoplanine
CA2031803C (en) *	1989-12-13	2001-05-29	Ramakrishnan Nagarajan	Improvements in or relating to glycopeptide deriveratives
KR100242682B1 (ko) *	1991-07-29	2000-02-01	클라우디오 쿼르타	항생물질 a 40926의 아미드 유도체
US5750509A (en) *	1991-07-29	1998-05-12	Gruppo Lepetit S.P.A.	Amide derivatives of antibiotic A 40926
US5840684A (en) *	1994-01-28	1998-11-24	Eli Lilly And Company	Glycopeptide antibiotic derivatives
MY128335A (en)	1994-01-28	2007-01-31	Lilly Co Eli	Glycopeptide antibiotic derivatives
US5918873A (en) *	1995-03-30	1999-07-06	Canon Kabushiki Kaisha	Sheet supplying apparatus which regulates tip end of sheet by first and second abutment means
US5919756A (en)	1996-06-28	1999-07-06	Eli Lilly And Company	Amides
US5939382A (en)	1996-11-21	1999-08-17	Eli Lilly And Company	Reducing agent for reductive alkylation of glycopeptide antibiotics
US5952466A (en) *	1997-11-12	1999-09-14	Eli Lilly And Company	Reductive alkylation of glycopeptide antibiotics
US5916873A (en)	1997-04-17	1999-06-29	Eli Lilly And Company	Teicoplanin derivatives
US6518242B1 (en) *	1998-02-20	2003-02-11	Theravance, Inc.	Derivatives of glycopeptide antibacterial agents
FR2778184A1 (fr)	1998-02-20	1999-11-05	Advanced Medicine Inc	Composes a liaisons multiples antibacteriens nouveaux, procede pour leur preparation et compositions pharmaceutiques les contenant
DE69908819T2 (de)	1998-12-23	2004-05-06	Theravance, Inc., South San Francisco	Glycopeptid-derivate und pharmazeutische zusammensetzungen, die sie enthalten
AU4054900A (en)	1999-04-02	2000-10-23	Advanced Medicine East, Inc.	Desleucyl glycopeptide antibiotics and methods of making same
AU2001238020A1 (en) *	2000-02-04	2001-08-14	Advanced Medicine, Inc.	Glycopeptide derivatives having antibiotic activity
JP4870314B2 (ja) *	2000-05-02	2012-02-08	セラヴァンス，インコーポレーテッド	シクロデキストリンを含むグリコペプチド抗生物質組成物
KR100856479B1 (ko) *	2000-05-02	2008-09-04	세라밴스 인코포레이티드	환원성 알킬화 방법
UA75083C2 (uk) *	2000-06-22	2006-03-15	Тераванс, Інк.	Похідні глікопептидфосфонатів

2002
- 2002-08-20 TW TW091118799A patent/TWI312785B/zh not_active IP Right Cessation
- 2002-08-23 JP JP2003523266A patent/JP4116546B2/ja not_active Expired - Fee Related
- 2002-08-23 KR KR1020047002617A patent/KR100909435B1/ko not_active Expired - Fee Related
- 2002-08-23 US US10/226,988 patent/US7015305B2/en not_active Expired - Lifetime
- 2002-08-23 CA CA2457215A patent/CA2457215C/en not_active Expired - Fee Related
- 2002-08-23 WO PCT/US2002/026831 patent/WO2003018607A2/en not_active Ceased
- 2002-08-23 EP EP02759433A patent/EP1419174B1/en not_active Expired - Lifetime
- 2002-08-23 AU AU2002324768A patent/AU2002324768A1/en not_active Abandoned
- 2002-08-23 ES ES02759433T patent/ES2284907T3/es not_active Expired - Lifetime
- 2002-08-23 DK DK02759433T patent/DK1419174T3/da active
- 2002-08-23 AT AT02759433T patent/ATE360029T1/de not_active IP Right Cessation
- 2002-08-23 DE DE60219638T patent/DE60219638T2/de not_active Expired - Lifetime
- 2002-08-23 CN CNB028166140A patent/CN1281619C/zh not_active Expired - Fee Related
2004
- 2004-02-23 NO NO20040779A patent/NO335304B1/no not_active IP Right Cessation
2005
- 2005-11-08 US US11/268,913 patent/US7160984B2/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
EP1419174A2 (en)	2004-05-19
NO335304B1 (no)	2014-11-10
DE60219638T2 (de)	2007-12-20
US7160984B2 (en)	2007-01-09
EP1419174B1 (en)	2007-04-18
TWI312785B (en)	2009-08-01
ES2284907T3 (es)	2007-11-16
KR100909435B1 (ko)	2009-07-28
CN1610692A (zh)	2005-04-27
DE60219638D1 (de)	2007-05-31
JP2005525997A (ja)	2005-09-02
JP4116546B2 (ja)	2008-07-09
WO2003018607A2 (en)	2003-03-06
CA2457215C (en)	2011-12-13
KR20040028997A (ko)	2004-04-03
US7015305B2 (en)	2006-03-21
WO2003018607A3 (en)	2003-11-27
CA2457215A1 (en)	2003-03-06
ATE360029T1 (de)	2007-05-15
US20030045457A1 (en)	2003-03-06
NO20040779L (no)	2004-02-23
AU2002324768A1 (en)	2003-03-10
CN1281619C (zh)	2006-10-25
US20060058503A1 (en)	2006-03-16
EP1419174A4 (en)	2005-10-12

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