ATE360086T1 - Verfahren zur herstellung von avermectinderivaten - Google Patents

Verfahren zur herstellung von avermectinderivaten

Info

Publication number: ATE360086T1
Authority: AT; Austria
Prior art keywords: dihydroavermectin; medicine; avermectin; avermectin derivatives; production
Prior art date: 2000-02-24

Application number

AT01906278T

Other languages

English (en)

Inventor

Hirofumi Endo

Hiroyuki Yamaguchi

Yutaka Kanda

Shinichi Hashimoto

Satoshi Omura

Haruo Ikeda

Original Assignee

Kyowa Hakko Kogyo Kk

Kitasato Inst

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-02-24

Filing date

2001-02-23

Publication date

2007-05-15

2001-02-23 Application filed by Kyowa Hakko Kogyo Kk, Kitasato Inst filed Critical Kyowa Hakko Kogyo Kk

2007-05-15 Application granted granted Critical

2007-05-15 Publication of ATE360086T1 publication Critical patent/ATE360086T1/de

Links

RRZXIRBKKLTSOM-XPNPUAGNSA-N avermectin B1a Chemical class C1=C[C@H](C)[C@@H]([C@@H](C)CC)O[C@]11O[C@H](C\C=C(C)\[C@@H](O[C@@H]2O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](OC)C3)[C@@H](OC)C2)[C@@H](C)\C=C\C=C/2[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\2)O)C[C@H]4C1 RRZXIRBKKLTSOM-XPNPUAGNSA-N 0.000 title abstract 3
238000004519 manufacturing process Methods 0.000 title abstract 2
AZSNMRSAGSSBNP-UHFFFAOYSA-N 22,23-dihydroavermectin B1a Natural products C1CC(C)C(C(C)CC)OC21OC(CC=C(C)C(OC1OC(C)C(OC3OC(C)C(O)C(OC)C3)C(OC)C1)C(C)C=CC=C1C3(C(C(=O)O4)C=C(C)C(O)C3OC1)O)CC4C2 AZSNMRSAGSSBNP-UHFFFAOYSA-N 0.000 abstract 2
SPBDXSGPUHCETR-JFUDTMANSA-N 8883yp2r6d Chemical compound O1[C@@H](C)[C@H](O)[C@@H](OC)C[C@@H]1O[C@@H]1[C@@H](OC)C[C@H](O[C@@H]2C(=C/C[C@@H]3C[C@@H](C[C@@]4(O[C@@H]([C@@H](C)CC4)C(C)C)O3)OC(=O)[C@@H]3C=C(C)[C@@H](O)[C@H]4OC\C([C@@]34O)=C/C=C/[C@@H]2C)/C)O[C@H]1C.C1C[C@H](C)[C@@H]([C@@H](C)CC)O[C@@]21O[C@H](C\C=C(C)\[C@@H](O[C@@H]1O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](OC)C3)[C@@H](OC)C1)[C@@H](C)\C=C\C=C/1[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\1)O)C[C@H]4C2 SPBDXSGPUHCETR-JFUDTMANSA-N 0.000 abstract 2
RRZXIRBKKLTSOM-UHFFFAOYSA-N avermectin B1a Natural products C1=CC(C)C(C(C)CC)OC11OC(CC=C(C)C(OC2OC(C)C(OC3OC(C)C(O)C(OC)C3)C(OC)C2)C(C)C=CC=C2C3(C(C(=O)O4)C=C(C)C(O)C3OC2)O)CC4C1 RRZXIRBKKLTSOM-UHFFFAOYSA-N 0.000 abstract 2
239000003814 drug Substances 0.000 abstract 2
238000009472 formulation Methods 0.000 abstract 1
238000009776 industrial production Methods 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
239000000575 pesticide Substances 0.000 abstract 1
239000000273 veterinary drug Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C327/00—Thiocarboxylic acids
- C07C327/20—Esters of monothiocarboxylic acids
- C07C327/30—Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by nitrogen atoms, not being part of nitro or nitroso groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Molecular Biology (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Biotechnology (AREA)
General Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Plant Pathology (AREA)
Microbiology (AREA)
Biophysics (AREA)
Physics & Mathematics (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Enzymes And Modification Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Saccharide Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

AT01906278T 2000-02-24 2001-02-23 Verfahren zur herstellung von avermectinderivaten ATE360086T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP2000047405		2000-02-24

Publications (1)

Publication Number	Publication Date
ATE360086T1 true ATE360086T1 (de)	2007-05-15

Family

ID=18569657

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT01906278T ATE360086T1 (de)	2000-02-24	2001-02-23	Verfahren zur herstellung von avermectinderivaten

Country Status (7)

Country	Link
US (1)	US20040101936A1 (de)
EP (1)	EP1270728B1 (de)
AT (1)	ATE360086T1 (de)
AU (1)	AU2001234164A1 (de)
CA (1)	CA2402398A1 (de)
DE (1)	DE60127948T2 (de)
WO (1)	WO2001062939A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2002006345A2 (en) *	2000-07-18	2002-01-24	Curagen Corporation	G-protein coupled receptor proteins (gpcr) and nucleic acids encoding same
US7081213B2 (en)	2002-05-14	2006-07-25	Clariant Finance (Bvi) Limited	Stabilizer mixtures for the protection of polymer substrates
CN102144163A (zh) *	2008-04-10	2011-08-03	麻省理工学院	关于鉴定和使用靶向癌症干细胞的试剂的方法
US10106778B2 (en)	2012-11-08	2018-10-23	Whitehead Institute For Biomedical Research	Selective targeting of cancer stem cells
US10398672B2 (en)	2014-04-29	2019-09-03	Whitehead Institute For Biomedical Research	Methods and compositions for targeting cancer stem cells
CN113930407B (zh) *	2021-05-28	2025-04-01	湖北中农华威生物工程有限公司	一种水解酶及其在生物催化合成4″-甲氨基-5′-羟基-阿维菌素中的应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2079436T3 (es) *	1989-03-31	1996-01-16	Merck & Co Inc	Clonacion de genes de streptomyces avermitilis para biosintesis de avermectinas y procedimientos para su uso.
JP3002347B2 (ja) *	1992-12-24	2000-01-24	社団法人北里研究所	５−オキソ−エバーメクチン誘導体の直接醗酵法ならびにその生産微生物
US6066721A (en) *	1995-07-06	2000-05-23	Stanford University	Method to produce novel polyketides
GB9814622D0 (en) *	1998-07-06	1998-09-02	Biotica Tech Ltd	Polyketides,their preparation,and materials for use therein
US6197591B1 (en) *	1998-09-14	2001-03-06	Pfizer Inc.	Streptomyces avermitilis regulatory genes for increased avermectin production
WO2000044717A2 (en) *	1999-01-27	2000-08-03	Kosan Biosciences, Inc.	Synthesis of oligoketides
JP2000245457A (ja) *	1999-02-24	2000-09-12	Kitasato Inst:The	エバーメクチンアグリコン合成酵素遺伝子

2001
- 2001-02-23 CA CA002402398A patent/CA2402398A1/en not_active Abandoned
- 2001-02-23 AT AT01906278T patent/ATE360086T1/de not_active IP Right Cessation
- 2001-02-23 AU AU2001234164A patent/AU2001234164A1/en not_active Abandoned
- 2001-02-23 EP EP01906278A patent/EP1270728B1/de not_active Expired - Lifetime
- 2001-02-23 US US10/204,862 patent/US20040101936A1/en not_active Abandoned
- 2001-02-23 DE DE60127948T patent/DE60127948T2/de not_active Expired - Fee Related
- 2001-02-23 WO PCT/JP2001/001381 patent/WO2001062939A1/ja not_active Ceased

Also Published As

Publication number	Publication date
US20040101936A1 (en)	2004-05-27
EP1270728A4 (de)	2004-11-24
DE60127948D1 (de)	2007-05-31
DE60127948T2 (de)	2008-01-17
CA2402398A1 (en)	2001-08-30
AU2001234164A1 (en)	2001-09-03
EP1270728A1 (de)	2003-01-02
WO2001062939A1 (fr)	2001-08-30
EP1270728B1 (de)	2007-04-18

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Legal Events

Date	Code	Title	Description
2007-10-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties