ATE361289T1 - Piperazinsubstituierte arylbenzodiazepine - Google Patents

Piperazinsubstituierte arylbenzodiazepine

Info

Publication number
ATE361289T1
ATE361289T1 AT03784411T AT03784411T ATE361289T1 AT E361289 T1 ATE361289 T1 AT E361289T1 AT 03784411 T AT03784411 T AT 03784411T AT 03784411 T AT03784411 T AT 03784411T AT E361289 T1 ATE361289 T1 AT E361289T1
Authority
AT
Austria
Prior art keywords
sup
sub
alkyl
optionally substituted
hydrogen
Prior art date
Application number
AT03784411T
Other languages
English (en)
Inventor
Thomas Daniel Aicher
Zhaogen Chen
Huerou Yvan Le
Fionna Mitchell Martin
Marta Maria Pineiro-Nunez
Vincent Patrick Rocco
Kevin Michael Ruley
John Mehnert Schaus
Patrick Gianpietro Spinazze
David Edward Tupper
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of ATE361289T1 publication Critical patent/ATE361289T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
AT03784411T 2002-08-05 2003-07-28 Piperazinsubstituierte arylbenzodiazepine ATE361289T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US40129702P 2002-08-05 2002-08-05

Publications (1)

Publication Number Publication Date
ATE361289T1 true ATE361289T1 (de) 2007-05-15

Family

ID=31715704

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03784411T ATE361289T1 (de) 2002-08-05 2003-07-28 Piperazinsubstituierte arylbenzodiazepine

Country Status (10)

Country Link
US (1) US7384934B2 (de)
EP (1) EP1546134B1 (de)
AT (1) ATE361289T1 (de)
AU (1) AU2003264915A1 (de)
CY (1) CY1110382T1 (de)
DE (1) DE60313634T2 (de)
DK (1) DK1546134T3 (de)
ES (1) ES2285227T3 (de)
PT (1) PT1546134E (de)
WO (1) WO2004014895A1 (de)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1243262B1 (de) 2001-03-20 2006-05-31 Schwarz Pharma Ag Neue Verwendung von Peptidverbindungen bei der Behandlung von nicht-neuropathischem Entzündungsschmerz
DE60100055T2 (de) 2001-03-21 2003-07-24 Schwarz Pharma Ag Neue Verwendung einer Klasse von Peptidverbindungen zur Behandlung von Allodynie oder andere Arten von chronischen oder Phantomschmerzen
EP1664063A1 (de) * 2003-09-09 2006-06-07 Eli Lilly And Company Substituierte piperazine von azepinen, oxazepinen und thiazepinen
AR048272A1 (es) * 2004-03-18 2006-04-12 Lek Pharmaceuticals Sintesis de 2 metil - 4- (4- metil -1- piperazinil) - 10 h- tieno ( 2,3-b) (1,5) benzodiazepina y sus sales, metodos para su preparacion, composiciones farmaceuticas que la contienen y su uso en la fabricacion de medicamentos para el tratamiento de enfermedades mentales.
WO2006021412A2 (en) 2004-08-27 2006-03-02 Schwarz Pharma Ag Use of peptide compounds for treating bone cancer pain, chemotherapy-and nucleoside-induced pain
EP1642889A1 (de) * 2004-10-02 2006-04-05 Schwarz Pharma Ag Verbessertes Syntheseschema für Lacosamid
MY147756A (en) 2005-05-25 2013-01-15 Theravance Inc Benzimidazole-carboxamide compounds as 5-ht4 receptor agonists
US8735356B2 (en) 2006-06-15 2014-05-27 Ucb Pharma Gmbh Anticonvulsant combination therapy
BRPI0808828A8 (pt) 2007-03-15 2017-11-28 Aryx Therapeutics Inc Compostos de dibenzo[b,f][1,4]oxazapina
EP2245021B1 (de) * 2008-01-31 2012-09-12 Fermion Oy Verfahren zur herstellung von quetiapin
PL395468A1 (pl) * 2011-06-29 2013-01-07 Adamed Spólka Z Ograniczona Odpowiedzialnoscia Zwiazki amidoalkilopiperazynylowe do leczenia chorób osrodkowego ukladu nerwowego
CA2882454C (en) * 2012-08-21 2020-08-11 Matthew Garrett DONAHUE Haptens of olanzapine
AU2013305930B2 (en) 2012-08-21 2017-08-24 Saladax Biomedical Inc. Haptens of paliperidone
EP2888263B1 (de) 2012-08-21 2018-05-09 Janssen Pharmaceutica NV Haptene aus risperidon und paliperidon
HK1211958A1 (en) 2012-08-21 2016-06-03 Ortho-Clinical Diagnostics, Inc. Antibodies to paliperidone and use thereof
US20140057303A1 (en) 2012-08-21 2014-02-27 Janssen Pharmaceutica Nv Antibodies to Olanzapine Haptens and Use Thereof
CN110054694B (zh) 2012-08-21 2024-02-20 詹森药业有限公司 阿立哌唑半抗原的抗体及其用途
CA2882489A1 (en) 2012-08-21 2014-02-27 Ortho-Clinical Diagnostics, Inc. Antibodies to paliperidone haptens and use thereof
EP3305784B1 (de) 2012-08-21 2020-08-12 Janssen Pharmaceutica NV Haptene von quetiapin zur verwendung bei immunoassays
PL3321254T3 (pl) 2012-08-21 2021-01-11 Janssen Pharmaceutica Nv Hapteny arypiprazolu i ich zastosowanie w testach immunologicznych
PT3462173T (pt) 2012-08-21 2021-04-28 Janssen Pharmaceutica Nv Anticorpos contra risperidona e utilização dos mesmos
AU2013305879B2 (en) 2012-08-21 2017-10-12 Saladax Biomedical Inc. Antibodies to aripiprazole and use thereof
PL3663317T3 (pl) 2012-08-21 2023-06-05 Janssen Pharmaceutica Nv Przeciwciała skierowane przeciwko haptenom kwetiapinowym i ich zastosowanie
PL3333195T3 (pl) 2012-08-21 2021-02-22 Janssen Pharmaceutica Nv Przeciwciała względem kwetiapiny i ich zastosowania
JP6216926B2 (ja) 2012-08-21 2017-10-25 ヤンセン ファーマシューティカ エヌ．ベー． オランザピンに対する抗体及びその使用
WO2014031645A1 (en) 2012-08-21 2014-02-27 Ortho-Clinical Diagnostics, Inc Antibodies to risperidone haptens and use thereof
CA2886973C (en) 2012-10-15 2017-08-15 Albemarle Corporation Processes for the synthesis of 2-amino-4,6-dimethoxybenzamide and other benzamide compounds
WO2014078568A1 (en) 2012-11-14 2014-05-22 The Johns Hopkins University Methods and compositions for treating schizophrenia
RU2610169C2 (ru) 2014-09-11 2017-02-08 Общество С Ограниченной Ответственностью "Валентек" ПРОИЗВОДНЫЕ 7-ФТОРО-8-ХЛОРО-5Н-ДИБЕНЗО[b, е][1, 4]ДИАЗЕПИНА И ИХ ПРИМЕНЕНИЕ
CN104530077A (zh) * 2014-12-29 2015-04-22 杭州师范大学 一种奥氮平中间体的合成方法
GB201510010D0 (en) 2015-06-09 2015-07-22 King S College London PDD and BPD compounds
US20180339985A1 (en) 2015-08-21 2018-11-29 Femtogenix Limited Pdd compounds
GB201514928D0 (en) 2015-08-21 2015-10-07 King S College London PDD compounds
AU2016372069A1 (en) 2015-12-17 2018-06-07 Saladax Biomedical Inc. Antibodies to risperidone and use thereof
WO2017106508A1 (en) 2015-12-17 2017-06-22 Janssen Pharmaceutica Nv Antibodies to quetiapine and use thereof
RU2667954C2 (ru) 2016-03-04 2018-09-25 Общество С Ограниченной Ответственностью "Валентек" Фармацевтическая композиция для лечения функциональных психических расстройств
CN110452183B (zh) * 2019-09-04 2023-03-14 中国科学院上海有机化学研究所 一种手性杂环化合物的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4115568A (en) * 1974-11-26 1978-09-19 Lilly Industries Limited Thieno[3,2-b]-[1,5]benzodiazepines
GB8819059D0 (en) * 1988-08-11 1988-09-14 Lilly Industries Ltd Benzodiazepine compounds & their use as pharmaceuticals
US5602124A (en) * 1994-12-12 1997-02-11 Allelix Biopharmaceuticals, Inc. 5-HT2 receptor ligands
US5602121A (en) * 1994-12-12 1997-02-11 Allelix Biopharmaceuticals, Inc. Alkyl-substituted compounds having dopamine receptor affinity
US6271225B1 (en) * 1997-09-02 2001-08-07 Welfide Corporation Fused thiophene compounds and medicinal use thereof
WO2003082877A1 (en) 2002-03-28 2003-10-09 Eli Lilly And Company Piperazine substituted aryl benzodiazepines and their use as dopamine receptor antagonists for the treatment of psychotic disorders

Also Published As

Publication number Publication date
EP1546134B1 (de) 2007-05-02
EP1546134A1 (de) 2005-06-29
ES2285227T3 (es) 2007-11-16
AU2003264915A1 (en) 2004-02-25
US7384934B2 (en) 2008-06-10
US20060084643A1 (en) 2006-04-20
DE60313634D1 (de) 2007-06-14
CY1110382T1 (el) 2015-04-29
DK1546134T3 (da) 2007-09-10
WO2004014895A1 (en) 2004-02-19
PT1546134E (pt) 2007-08-10
DE60313634T2 (de) 2008-01-31

Similar Documents

Publication Publication Date Title
CY1110382T1 (el) Πυραζινο υποκατεστημενες αρυλοβενζοδιαζεπινες
AU2003217936A1 (en) Piperazine substituted aryl benzodiazepines and their use as dopamine receptor antagonists for the treatment of psychotic disorders
YU73300A (sh) Biciklični pirimidini i biciklični 3,4-dihidropirimidini kao inhibitori ćelijske proliferacije
SE0203754D0 (sv) New compounds
TW200510440A (en) Novel compounds
AU6581990A (en) New 1,2-benzisoxazole derivatives, processes for preparing them and pharmaceutical compositions containing them
ES8708224A1 (es) Un procedimiento para la preparacion de nuevos derivados de carbazolona
MXPA06001274A (es) Compuestos novedosos que poseen actividad inhibitoria contra transporador dependiente de sodio.
TR200400541T4 (tr) Terapide faydalı tropan türevleri.
FI942635A0 (fi) Piperatsiinijohdannaiset 5HT1A-antagonisteina
EA200100553A1 (ru) Замещенные бициклические производные, полезные в качестве противораковых агентов
JO2294B1 (en) 4 - Phenylpyridine derivatives
FI962155A0 (fi) Uudet 9-hydroksipyrido (1,2-a) pyrimidin-4-onieetterijohdannaiset
FI970317A0 (fi) Antiproliferatiivisina aineina ja Garft-inhibiittoreina käyttökelpoisia yhdisteitä
HUP0303568A2 (hu) Benzotiofénszármazékok, eljárás előállításukra és alkalmazásuk
FI915970A0 (fi) Laekemedel, som aer nyttiga vid vaord av cancer och som har antihistaminegenskaper.
BR0010139A (pt) Heterociclos bicìclicos substituìdos, processo para seu preparo e seu uso como agentes anti-obesidade e hipocolesterolêmico
AR028475A1 (es) Derivados de azaindol y uso de los mismos para la manufactura de un medicamento para el tratamiento de la depresion.
ES2132761T3 (es) Derivados del acido piperidin acetico utiles como antagonistas del fibrinogeno.
MXPA04006113A (es) Derivados de triazoloquinolina utiles como ligandos receptores de adenosina.
NO890440D0 (no) Fremgangsmaate for fremstilling av terapeutisk aktive isokinolinderivater.
ATE388945T1 (de) Benzoxazolderivate und deren verwendung als adenosinrezeptorliganden
NO159379C (no) Analogifremgangsmaate ved fremstilling av terapeutisk aktive nye bicyklo (4.2.0)1,3,5-oktatrienderivater.
ES2103590T3 (es) Derivados del acido 3-(indol-3-il) propenoico utilizables como antagonistas nmda.
DE50013571D1 (de) Arzneimittel zur behandlung von neuropathien

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1546134

Country of ref document: EP