ATE361306T1 - 4-(oxazolopyridin-2-yl)-1,4-diazabicyclo-(3.2.2 - nonanderivate, deren herstellung und deren therapeutische verwendung - Google Patents

4-(oxazolopyridin-2-yl)-1,4-diazabicyclo-(3.2.2 - nonanderivate, deren herstellung und deren therapeutische verwendung

Info

Publication number: ATE361306T1
Authority: AT; Austria
Prior art keywords: nonanderivates; oxazolopyridine; diazabicyclo; production; therapeutic use
Prior art date: 2001-11-23

Application number

AT02803450T

Other languages

English (en)

Inventor

Frederic Galli

Odile Leclerc

Alistair Lochead

Original Assignee

Sanofi Aventis

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-11-23

Filing date

2002-11-20

Publication date

2007-05-15

2002-11-20 Application filed by Sanofi Aventis filed Critical Sanofi Aventis

2007-05-15 Application granted granted Critical

2007-05-15 Publication of ATE361306T1 publication Critical patent/ATE361306T1/de

Links

230000001225 therapeutic effect Effects 0.000 title 1
KURACQMCGUJQNC-UHFFFAOYSA-N 2-(2-cyclononyldiazonan-1-yl)-[1,3]oxazolo[5,4-b]pyridine Chemical class N1=C(OC2=C1C=CC=N2)N1N(CCCCCCC1)C1CCCCCCCC1 KURACQMCGUJQNC-UHFFFAOYSA-N 0.000 abstract 1
125000001541 3-thienyl group Chemical group S1C([H])=C([*])C([H])=C1[H] 0.000 abstract 1
-1 4-(6-Substituted oxazolo(5,4-b)pyridin-2-yl)-1,4-diaza-bicyclo(3.2.2)nonane Chemical class 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Neurosurgery (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biomedical Technology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Neurology (AREA)
Veterinary Medicine (AREA)
Psychiatry (AREA)
Addiction (AREA)
Psychology (AREA)
Pain & Pain Management (AREA)
Hospice & Palliative Care (AREA)
Toxicology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT02803450T 2001-11-23 2002-11-20 4-(oxazolopyridin-2-yl)-1,4-diazabicyclo-(3.2.2 - nonanderivate, deren herstellung und deren therapeutische verwendung ATE361306T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR0115152A FR2832714B1 (fr)	2001-11-23	2001-11-23	Derives de 4-(oxazolopyridin-2-yl)-1,4-diazabicyclo[3.2.2] nonane, leur preparation et leur application en therapeutique

Publications (1)

Publication Number	Publication Date
ATE361306T1 true ATE361306T1 (de)	2007-05-15

Family

ID=8869704

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT02803450T ATE361306T1 (de)	2001-11-23	2002-11-20	4-(oxazolopyridin-2-yl)-1,4-diazabicyclo-(3.2.2 - nonanderivate, deren herstellung und deren therapeutische verwendung

Country Status (8)

Country	Link
US (1)	US7119087B2 (de)
EP (1)	EP1451197B1 (de)
JP (1)	JP5134755B2 (de)
AT (1)	ATE361306T1 (de)
AU (1)	AU2002356251A1 (de)
DE (1)	DE60219946T2 (de)
FR (1)	FR2832714B1 (de)
WO (1)	WO2003044024A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20020086871A1 (en)	2000-12-29	2002-07-04	O'neill Brian Thomas	Pharmaceutical composition for the treatment of CNS and other disorders
DE10164139A1 (de)	2001-12-27	2003-07-10	Bayer Ag	2-Heteroarylcarbonsäureamide
DE60326894D1 (de)	2002-09-30	2009-05-07	Neurosearch As	1,4-Diazabicycloalkanderivate, deren Herstellung und Verwendung
WO2004043960A1 (en) *	2002-11-11	2004-05-27	Neurosearch A/S	1,4-diazabicyclo (3,2,2)nonane derivatives, preparation and therapeutical use thereof
US7223753B2 (en)	2002-11-11	2007-05-29	Neurosearch A/S	Diazabicyclic biaryl derivatives
JP2007520526A (ja)	2004-02-04	2007-07-26	ノイロサーチアクティーゼルスカブ	コリン作動性受容体モジュレーターとしてのジアザビシクロアリール誘導体
WO2006051413A1 (en) *	2004-11-15	2006-05-18	Pfizer Inc.	Azabenoxazoles for the treatment of cns disorders
WO2006051410A1 (en) *	2004-11-15	2006-05-18	Pfizer Inc.	Azabenzoxazoles for the treatment of cns disorders
CA2587826A1 (en) *	2004-11-15	2006-05-18	Pfizer Products Inc.	Azabenzoxazoles for the treatment of cns disorders
EP1814888A1 (de) *	2004-11-15	2007-08-08	Pfizer Products Incorporated	Azabenzoxazole zur behandlung von erkrankungen des zentralen nervensystems
ATE495178T1 (de)	2005-02-16	2011-01-15	Neurosearch As	Diazabicyclische arylderivate und ihre verwendung als chinolinergische liganden an nikotin- acetylcholin-rezeptoren
RU2333211C1 (ru) *	2006-11-01	2008-09-10	Институт физиологически активных веществ Российской Академии наук	N,n`-замещенные 3, 7-диазабицикло[3.3.1]нонаны, обладающие фармакологической активностью, фармацевтические композиции на их основе и способ их применения
CN105687190A (zh)	2008-11-19	2016-06-22	福拉姆医药股份有限公司	用(R)-7-氯-N-(奎宁环-3-基)苯并[b]噻吩-2-甲酰胺及其可药用盐治疗认知障碍
PE20120324A1 (es) *	2009-05-11	2012-04-17	Envivo Pharmaceuticals Inc	Combinacion que comprende (r)-7-cloro-n-(quinuclidin-3-il)benzo[b]tiofeno-2-carboxamida y donezepilo como moduladora de trastornos cognitivos
KR20180101641A (ko)	2010-05-17	2018-09-12	포럼 파마슈티칼즈 인크.	(R)-7-클로로-N-(퀴누클리딘-3-일)벤조[b]티오펜-2-카르복사미드 히드로클로리드 모노히드레이트의 결정질 형태
EP3461481A1 (de)	2012-05-08	2019-04-03	Forum Pharmaceuticals Inc.	Verfahren zur aufrechterhaltung, behandlung oder verbesserung der kognitiven funktion

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4826848A (en) *	1985-04-15	1989-05-02	Janssen Pharmaceutica N.V.	Antidepressive substituted N-[(4-piperidinyl)alkyl] bicyclic condensed oxazol- and thiazolamines
FR2786770B1 (fr)	1998-12-04	2001-01-19	Synthelabo	Derives de 1,4-diazabicyclo[3.2.2.]nonane, leur preparation et leur application en therapeutique
FR2809730B1 (fr)	2000-05-31	2002-07-19	Sanofi Synthelabo	Derives de 1,4-diazabicyclo[3.2.2] nonanebenzoxazole, -benzothiazole et -benzimidazole, leur preparation et leur application therapeutique
US20020086871A1 (en) *	2000-12-29	2002-07-04	O'neill Brian Thomas	Pharmaceutical composition for the treatment of CNS and other disorders

2001
- 2001-11-23 FR FR0115152A patent/FR2832714B1/fr not_active Expired - Fee Related
2002
- 2002-11-20 DE DE60219946T patent/DE60219946T2/de not_active Expired - Lifetime
- 2002-11-20 JP JP2003545661A patent/JP5134755B2/ja not_active Expired - Fee Related
- 2002-11-20 WO PCT/FR2002/003978 patent/WO2003044024A1/fr not_active Ceased
- 2002-11-20 AU AU2002356251A patent/AU2002356251A1/en not_active Abandoned
- 2002-11-20 EP EP02803450A patent/EP1451197B1/de not_active Expired - Lifetime
- 2002-11-20 AT AT02803450T patent/ATE361306T1/de not_active IP Right Cessation
- 2002-11-20 US US10/495,936 patent/US7119087B2/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
JP2005509681A (ja)	2005-04-14
FR2832714B1 (fr)	2004-07-16
US20050004128A1 (en)	2005-01-06
FR2832714A1 (fr)	2003-05-30
EP1451197A1 (de)	2004-09-01
AU2002356251A1 (en)	2003-06-10
EP1451197B1 (de)	2007-05-02
DE60219946D1 (de)	2007-06-14
WO2003044024A1 (fr)	2003-05-30
US7119087B2 (en)	2006-10-10
JP5134755B2 (ja)	2013-01-30
DE60219946T2 (de)	2008-01-10

Legal Events

Date	Code	Title	Description
2007-11-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE361306T1 (de)	2007-05-15	4-(oxazolopyridin-2-yl)-1,4-diazabicyclo-(3.2.2 - nonanderivate, deren herstellung und deren therapeutische verwendung
DK1864975T3 (da)	2011-01-24	Nikotinamid-derivater anvendelige som P38-inhibitorer
NO20055887L (no)	2006-01-19	Pyrido'2, 1-A-isokinoliderivater som DPP-IV-inhibitorer
NO20055421L (no)	2005-12-20	Kinolinderivater som fosfodiestrase-inhibitorer
NO20084129L (no)	2008-10-29	Pyridin(3,4-B)Pyrazinoner
NO20073393L (no)	2007-09-03	[1,2,4]tnazolo [4,3-A] pyridin derivater for behandlingen av hyperproliferative sykdommer
NO20054852L (no)	2005-12-13	GFAT inhibitorer
NO20056007L (no)	2006-01-19	Dobbel NK1/NK3 antagonister for behandling av schizofreni
CY1111692T1 (el)	2015-10-07	ΠΑΡΑΓΩΓΑ ΙΝΔΟΛΗΣ Ή ΒΕΝΖΙΜΙΔΑΖΟΛΗΣ ΓΙΑ ΤΗ ΡΥΘΜΙΣΗ ΤΗΣ ΙκΒ ΚΙΝΑΣΗΣ
NZ533310A (en)	2004-12-24	Benzimidazoles useful as protein kinase inhibitors
NO20053748L (no)	2005-10-07	Pyrrolopyridazinderivater.
ATE302775T1 (de)	2005-09-15	Carbolinderivate
NO20035583D0 (no)	2003-12-15	Imidazo` 1,2-A pyridinderivater for profylakse og behandling av herpes virale infeksjoner
WO2006005609A3 (de)	2006-03-16	Substituierte oxindol-derivate und diese enthaltende arzneimittel
ATE346067T1 (de)	2006-12-15	Carbolinderivate
NO20061839L (no)	2006-06-26	Benzimidazolderivater, sammensetninger inneholdende dem, fremstilling derav, og anvendelse derav
NO20080033L (no)	2008-01-03	Kinolinderivater som NK3-antagonister
NO20060147L (no)	2006-03-07	Benzimidazolderivater, sammensetninger som inneholder slike, fremstilling derav og anvendelse derav
NO20054598L (no)	2005-10-27	Beta-karboliner anvendbare for behandling av betennelsessykdommer
ATE311389T1 (de)	2005-12-15	Wirkstoffvorläufer von imidazopyridin-derivaten
NO20065327L (no)	2006-12-18	Fremgangsmate for fremstilling av derivarer av 5-'4-(2-hydroksy-propyl)-3,5-dihydro-3H'1, 2,4(triazin-2-yl)-benzamid.
NO20080110L (no)	2008-04-11	Benzimidazolderivativer som 5-HT6,5-HT24
NO20062417L (no)	2006-05-26	N-tiazol-2-yl-benzamidderivater
ATE556712T1 (de)	2012-05-15	A2a antagonisten zur behandlung von motorischen störungen
NO20073758L (no)	2007-10-19	2-okso-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl-piperidiner anvendt som CGRP-antagonister