ATE361316T1 - Kristallstruktur einer deacetylase und deren inhibitoren - Google Patents

Kristallstruktur einer deacetylase und deren inhibitoren

Info

Publication number
ATE361316T1
ATE361316T1 AT00968344T AT00968344T ATE361316T1 AT E361316 T1 ATE361316 T1 AT E361316T1 AT 00968344 T AT00968344 T AT 00968344T AT 00968344 T AT00968344 T AT 00968344T AT E361316 T1 ATE361316 T1 AT E361316T1
Authority
AT
Austria
Prior art keywords
hdlp
structural information
present
deacetylase
dimensional structural
Prior art date
Application number
AT00968344T
Other languages
English (en)
Inventor
Nikola Pavletich
Michael Finnin
Jill Donigian
Victoria Richon
Richard A Rifkind
Paul A Marks
Ronald Breslow
Original Assignee
Sloan Kettering Inst Cancer
Univ Columbia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sloan Kettering Inst Cancer, Univ Columbia filed Critical Sloan Kettering Inst Cancer
Application granted granted Critical
Publication of ATE361316T1 publication Critical patent/ATE361316T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT00968344T 1999-09-08 2000-09-08 Kristallstruktur einer deacetylase und deren inhibitoren ATE361316T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US15275399P 1999-09-08 1999-09-08

Publications (1)

Publication Number Publication Date
ATE361316T1 true ATE361316T1 (de) 2007-05-15

Family

ID=22544290

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00968344T ATE361316T1 (de) 1999-09-08 2000-09-08 Kristallstruktur einer deacetylase und deren inhibitoren

Country Status (8)

Country Link
US (3) US7124068B2 (de)
EP (1) EP1212357B1 (de)
JP (1) JP2003518923A (de)
AT (1) ATE361316T1 (de)
CA (1) CA2383885A1 (de)
DE (1) DE60034688T2 (de)
ES (1) ES2287033T3 (de)
WO (1) WO2001018045A1 (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6822267B1 (en) * 1997-08-20 2004-11-23 Advantest Corporation Signal transmission circuit, CMOS semiconductor device, and circuit board
ATE361316T1 (de) * 1999-09-08 2007-05-15 Sloan Kettering Inst Cancer Kristallstruktur einer deacetylase und deren inhibitoren
EP1409661A4 (de) 2001-06-14 2006-02-01 Sloan Kettering Inst Cancer Hdac9-polypeptide und -polynukleotide und verwendungen davon
US6706686B2 (en) 2001-09-27 2004-03-16 The Regents Of The University Of Colorado Inhibition of histone deacetylase as a treatment for cardiac hypertrophy
EP1443928B1 (de) 2001-10-16 2011-07-27 Sloan-Kettering Institute For Cancer Research Behandlung von neurodegenerativen erkrankungen und krebs im gehirn
US7566535B2 (en) 2002-03-07 2009-07-28 University Of Delaware Enhanced oligonucleotide-mediated nucleic acid sequence alteration
US7154002B1 (en) 2002-10-08 2006-12-26 Takeda San Diego, Inc. Histone deacetylase inhibitors
US7250514B1 (en) 2002-10-21 2007-07-31 Takeda San Diego, Inc. Histone deacetylase inhibitors
US7375228B2 (en) 2003-03-17 2008-05-20 Takeda San Diego, Inc. Histone deacetylase inhibitors
WO2005065681A1 (en) * 2003-12-19 2005-07-21 Takeda San Diego, Inc. N- hydroxy-3-(3-(1h-imidazol-2-yl)-phenyl)-acrylamide derivatives and related compounds as histone deacetylase (hdac) inhibitors for the treatment of cancer
US20050137234A1 (en) * 2003-12-19 2005-06-23 Syrrx, Inc. Histone deacetylase inhibitors
US7642275B2 (en) 2004-12-16 2010-01-05 Takeda San Diego, Inc. Histone deacetylase inhibitors
JP2008540574A (ja) 2005-05-11 2008-11-20 タケダ サン ディエゴ インコーポレイテッド ヒストンデアセチラーゼ阻害剤
CA2615105A1 (en) * 2005-07-14 2007-01-25 Takeda San Diego, Inc. Histone deacetylase inhibitors
EP1976835A2 (de) * 2006-01-13 2008-10-08 Takeda San Diego, Inc. Histondeacetylase-inhibitoren
KR20090064400A (ko) * 2006-09-28 2009-06-18 머크 앤드 캄파니 인코포레이티드 Ｈｄａｃ 억제제 및 킬레이트화 가능한 금속 화합물 및 금속-ｈｄａｃ 억제제 킬레이트 착물의 약제학적 조성물
WO2009137499A1 (en) * 2008-05-05 2009-11-12 Envivo Pharmaceuticals, Inc. Inhibitors of histone deacetylase
WO2009137503A1 (en) * 2008-05-05 2009-11-12 Envivo Pharmaceuticals, Inc. Hdac inhibitors and uses thereof
WO2009140164A1 (en) * 2008-05-16 2009-11-19 Chipscreen Biosciences Ltd. 6-aminonicotinamide derivatives as potent and selective histone deacetylase inhibitors
WO2011053876A1 (en) 2009-10-30 2011-05-05 Massachusetts Institute Of Technology The use of ci-994 and dinaline for the treatment of memory/cognition and anxiety disorders
EP2523664A4 (de) * 2010-01-13 2013-06-26 Tempero Pharmaceuticals Inc Verbindungen und verfahren
JP2013517279A (ja) * 2010-01-13 2013-05-16 テンペロ、ファーマシューティカルズ、インコーポレイテッド 化合物及び方法
KR101781663B1 (ko) * 2010-01-13 2017-09-25 템페로 파마슈티칼즈, 인크. 히스톤 데아세틸라제 효소를 억제하기 위한 화합물 및 이를 제조하는 방법
WO2013009827A1 (en) * 2011-07-13 2013-01-17 Tempero Pharmaceuticals, Inc. Methods of treatment
WO2013009830A1 (en) * 2011-07-13 2013-01-17 Tempero Pharmaceuticals, Inc. Methods of treatment
WO2013009812A1 (en) * 2011-07-13 2013-01-17 Tempero Pharmaceuticals, Inc Methods of treatment
WO2013009810A1 (en) * 2011-07-13 2013-01-17 Tempero Pharmaceuticals, Inc. Methods of treatment
WO2015051035A1 (en) 2013-10-01 2015-04-09 The J. David Gladstone Institutes Compositions, systems and methods for gene expression noise drug screening and uses thereof

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5608108A (en) 1988-11-14 1997-03-04 Sloan-Kettering Institute For Cancer Research Potent inducers of terminal differentiation and method of use thereof
US5055608A (en) 1988-11-14 1991-10-08 Sloan-Kettering Institute For Cancer Research Novel potent inducers of thermal differentiation and method of use thereof
US5550316A (en) 1991-01-02 1996-08-27 Fox Chase Cancer Center Transgenic animal model system for human cutaneous melanoma
US5700811A (en) 1991-10-04 1997-12-23 Sloan-Kettering Institute For Cancer Research Potent inducers of terminal differentiation and method of use thereof
US5780594A (en) * 1993-03-01 1998-07-14 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Biologically active protein fragments containing specific binding regions of serum albumin or related proteins
EP0791061A4 (de) 1994-03-04 1998-07-15 Ludwig Inst Cancer Res Tiere mit gezielter genunterbrechung
US5709844A (en) 1994-06-09 1998-01-20 The Regents Of The University Of California Transgenic mice expressing HPV early region oncogene develop progressive cervico-vaginal neoplasia
US5698764A (en) 1994-06-09 1997-12-16 The Regents Of The University Of California Transgenic mice expressing HPV early region oncogene develop progressive epithelial neoplasia
JP2714537B2 (ja) * 1994-08-17 1998-02-16 コナミ株式会社 ゲーム機の昇降装置
US5919940A (en) 1995-01-20 1999-07-06 British Biotech Pharmaceuticals Limited Metalloproteinase inhibitors
US5917090A (en) 1995-06-30 1999-06-29 British Biotech Pharmaceuticals Ltd. Matrix metalloproteinase inhibitors
US5811634A (en) 1995-09-12 1998-09-22 Thomas G. O'Brien Transgenic mammal encoding ornithine decarboxylase
JPH09185385A (ja) * 1995-11-02 1997-07-15 Victor Co Of Japan Ltd 音楽情報の記録方法及び再生方法並びに音楽情報再生装置
ATE361316T1 (de) * 1999-09-08 2007-05-15 Sloan Kettering Inst Cancer Kristallstruktur einer deacetylase und deren inhibitoren

Also Published As

Publication number Publication date
EP1212357B1 (de) 2007-05-02
WO2001018045A1 (en) 2001-03-15
US20070100559A1 (en) 2007-05-03
US7124068B2 (en) 2006-10-17
EP1212357A4 (de) 2004-03-17
US20070087427A1 (en) 2007-04-19
DE60034688T2 (de) 2008-01-17
CA2383885A1 (en) 2001-03-15
ES2287033T3 (es) 2007-12-16
EP1212357A1 (de) 2002-06-12
US20030013176A1 (en) 2003-01-16
DE60034688D1 (de) 2007-06-14
WO2001018045A9 (en) 2002-11-07
JP2003518923A (ja) 2003-06-17

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