ATE513040T1 - Zinkfingerdomänenbibliotheken - Google Patents

Zinkfingerdomänenbibliotheken

Info

Publication number
ATE513040T1
ATE513040T1 AT02758924T AT02758924T ATE513040T1 AT E513040 T1 ATE513040 T1 AT E513040T1 AT 02758924 T AT02758924 T AT 02758924T AT 02758924 T AT02758924 T AT 02758924T AT E513040 T1 ATE513040 T1 AT E513040T1
Authority
AT
Austria
Prior art keywords
zinc finger
finger domains
finger domain
libraries
domain libraries
Prior art date
Application number
AT02758924T
Other languages
English (en)
Inventor
Jin-Soo Kim
Kwang-Hee Bae
Kyung-Soon Park
Young-Do Kwon
Eun-Huyn Ryu
Moon-Sun Hwang
Original Assignee
Toolgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toolgen Inc filed Critical Toolgen Inc
Application granted granted Critical
Publication of ATE513040T1 publication Critical patent/ATE513040T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6811—Selection methods for production or design of target specific oligonucleotides or binding molecules

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AT02758924T 2001-08-17 2002-08-17 Zinkfingerdomänenbibliotheken ATE513040T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US31340201P 2001-08-17 2001-08-17
US37435502P 2002-04-22 2002-04-22
PCT/KR2002/001560 WO2003016571A1 (en) 2001-08-17 2002-08-17 Zinc finger domain libraries

Publications (1)

Publication Number Publication Date
ATE513040T1 true ATE513040T1 (de) 2011-07-15

Family

ID=26978841

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02758924T ATE513040T1 (de) 2001-08-17 2002-08-17 Zinkfingerdomänenbibliotheken

Country Status (9)

Country Link
US (2) US20030165997A1 (de)
EP (1) EP1417344B1 (de)
JP (1) JP4128955B2 (de)
KR (1) KR100961722B1 (de)
CN (1) CN1289522C (de)
AT (1) ATE513040T1 (de)
AU (1) AU2002324352B2 (de)
CA (1) CA2457095A1 (de)
WO (1) WO2003016571A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2469477A1 (en) * 2001-12-07 2003-06-12 Toolgen, Inc. Phenotypic screen of chimeric proteins
KR100766952B1 (ko) * 2002-12-09 2007-10-17 주식회사 툴젠 조절성 징크 핑거 단백질
CN1836048A (zh) * 2003-06-10 2006-09-20 图尔金株式会社 可转导的dna结合蛋白
EP1720911A1 (de) * 2004-01-20 2006-11-15 Man-Wook Hur Tatdmt-polypeptid enthaltendes fusionsprotein
US8618054B2 (en) * 2004-05-05 2013-12-31 Valorisation-Rechereche Société en Commandite Interleukin-1 receptor antagonists, compositions, and methods of treatment
KR100812110B1 (ko) * 2006-10-24 2008-03-12 한국과학기술원 징크 핑거 단백질과 원핵 생물의 전사 인자를 포함하는인공 전사 인자의 제조 및 이의 이용
JP5763341B2 (ja) 2007-09-27 2015-08-12 サンガモ バイオサイエンシーズ， インコーポレイテッド 生物学的活性のあるヌクレアーゼの迅速なインビボ同定法
US11235026B2 (en) 2007-09-27 2022-02-01 Sangamo Therapeutics, Inc. Methods and compositions for modulating PD1
US8563314B2 (en) * 2007-09-27 2013-10-22 Sangamo Biosciences, Inc. Methods and compositions for modulating PD1
WO2012134241A2 (ko) * 2011-03-30 2012-10-04 주식회사 툴젠 Ｃｍａｈ 유전자를 표적으로 하는 징크 핑거 뉴클레아제 및 이의 용도
EP3526326A4 (de) * 2016-10-12 2020-07-29 The Regents of The University of Colorado, A Body Corporate Neuartige manipulierte und chimäre nukleasen
CN107012174A (zh) * 2017-05-04 2017-08-04 昆明理工大学 CRISPR/Cas9技术在获得家蚕锌指蛋白基因突变体中的应用
US9982279B1 (en) 2017-06-23 2018-05-29 Inscripta, Inc. Nucleic acid-guided nucleases
US10011849B1 (en) 2017-06-23 2018-07-03 Inscripta, Inc. Nucleic acid-guided nucleases
GB201710620D0 (en) 2017-07-03 2017-08-16 Glaxosmithkline Intellectual Property Ltd Targeted protein degradation

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US567973A (en) * 1896-09-22 Island
US5763209A (en) * 1988-09-26 1998-06-09 Arch Development Corporation Methods and materials relating to the functional domains of DNA binding proteins
US6107059A (en) * 1992-04-29 2000-08-22 Affymax Technologies N.V. Peptide library and screening method
JP3537141B2 (ja) * 1992-10-30 2004-06-14 ザ ゼネラル ホスピタル コーポレーション 新種蛋白質分離のための相互作用を用いる補捉システム
US6242568B1 (en) * 1994-01-18 2001-06-05 The Scripps Research Institute Zinc finger protein derivatives and methods therefor
US6140466A (en) * 1994-01-18 2000-10-31 The Scripps Research Institute Zinc finger protein derivatives and methods therefor
US5882941A (en) * 1994-05-04 1999-03-16 Massachusette Institute Of Technology Programmable genotoxic agents and uses therefor
CA2196419C (en) * 1994-08-20 2007-08-21 Yen Choo Improvements in or relating to binding proteins for recognition of dna
US6326166B1 (en) * 1995-12-29 2001-12-04 Massachusetts Institute Of Technology Chimeric DNA-binding proteins
US5789538A (en) * 1995-02-03 1998-08-04 Massachusetts Institute Of Technology Zinc finger proteins with high affinity new DNA binding specificities
US5869250A (en) * 1996-12-02 1999-02-09 The University Of North Carolina At Chapel Hill Method for the identification of peptides that recognize specific DNA sequences
GB9710809D0 (en) * 1997-05-23 1997-07-23 Medical Res Council Nucleic acid binding proteins
US6410248B1 (en) * 1998-01-30 2002-06-25 Massachusetts Institute Of Technology General strategy for selecting high-affinity zinc finger proteins for diverse DNA target sites
DE69942334D1 (de) * 1998-03-02 2010-06-17 Massachusetts Inst Technology Poly-zinkfinger-proteine mit verbesserten linkern
WO2000015777A1 (en) * 1998-09-14 2000-03-23 Aston University Gene and protein libraries and methods relating thereto
US6503717B2 (en) * 1999-12-06 2003-01-07 Sangamo Biosciences, Inc. Methods of using randomized libraries of zinc finger proteins for the identification of gene function
WO2001025417A2 (en) * 1999-10-01 2001-04-12 Sangamo Biosciences, Inc. Dna library and its use in methods of selecting and designing polypeptides
WO2001053480A1 (en) * 2000-01-24 2001-07-26 Sangamo Biosciences, Inc. Nucleic acid binding polypeptides characterized by flexible linkers connected nucleic acid binding modules
US20030050231A1 (en) * 2000-01-31 2003-03-13 Rosen Craig A. Nucleic acids, proteins, and antibodies
US20020061512A1 (en) * 2000-02-18 2002-05-23 Kim Jin-Soo Zinc finger domains and methods of identifying same
US20040259258A1 (en) * 2001-12-07 2004-12-23 Kim Jin-Soo Regulation of prokaryotic gene expression with zinc finger proteins
CA2469477A1 (en) * 2001-12-07 2003-06-12 Toolgen, Inc. Phenotypic screen of chimeric proteins

Also Published As

Publication number Publication date
JP2005500068A (ja) 2005-01-06
EP1417344A1 (de) 2004-05-12
US20030165997A1 (en) 2003-09-04
EP1417344B1 (de) 2011-06-15
JP4128955B2 (ja) 2008-07-30
AU2002324352B2 (en) 2006-06-15
US20090176653A1 (en) 2009-07-09
CN1543510A (zh) 2004-11-03
WO2003016571A1 (en) 2003-02-27
KR100961722B1 (ko) 2010-06-10
EP1417344A4 (de) 2005-01-26
CN1289522C (zh) 2006-12-13
CA2457095A1 (en) 2003-02-27
KR20040030133A (ko) 2004-04-08

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